Matthew Levy

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. pmc Directed evolution of streptavidin variants using in vitro compartmentalization
    Matthew Levy
    Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA
    Chem Biol 15:979-89. 2008
  2. pmc Deoxyribozymes that recode sequence information
    Jeffrey J Tabor
    Center for Systems and Synthetic Biology and Institute for Cell and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA
    Nucleic Acids Res 34:2166-72. 2006
  3. pmc Direct selection for ribozyme cleavage activity in cells
    Xi Chen
    Department of Chemistry and Biochemistry, University of Texas at Austin, Austin, Texas 78712, USA
    RNA 15:2035-45. 2009
  4. pmc Direct selection of trans-acting ligase ribozymes by in vitro compartmentalization
    Matthew Levy
    Institute for Cellular and Molecular Biology, University of Texas, Austin, TX 78751, USA
    RNA 11:1555-62. 2005
  5. doi request reprint An in vitro autogene
    Eric A Davidson
    Department of Chemistry and Biochemistry, Institute for Cell and Molecular Biology, Center for Systems and Synthetic Biology, University of Texas at Austin, Austin, TX 78712, USA
    ACS Synth Biol 1:190-6. 2012
  6. ncbi request reprint Aptamer:toxin conjugates that specifically target prostate tumor cells
    Ted C Chu
    Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas 78712, USA
    Cancer Res 66:5989-92. 2006
  7. doi request reprint Directed evolution of proteins in vitro using compartmentalization in emulsions
    Eric A Davidson
    University of Texas at Austin, Austin, Texas, USA
    Curr Protoc Mol Biol . 2009
  8. pmc Aptamer mediated siRNA delivery
    Ted C Chu
    Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA
    Nucleic Acids Res 34:e73. 2006
  9. pmc Engineering stochasticity in gene expression
    Jeffrey J Tabor
    Center for Systems and Synthetic Biology and Institute for Cell and Molecular Biology, University of Texas, Austin, TX 78712, USA
    Mol Biosyst 4:754-61. 2008
  10. ncbi request reprint Quantum-dot aptamer beacons for the detection of proteins
    Matthew Levy
    Institute for Cellular and Molecular Biology, University of Texas, Austin, Austin TX 78712, USA
    Chembiochem 6:2163-6. 2005

Collaborators

Detail Information

Publications15

  1. pmc Directed evolution of streptavidin variants using in vitro compartmentalization
    Matthew Levy
    Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA
    Chem Biol 15:979-89. 2008
    ..The methods we have developed should prove to be generally useful for generating a variety of novel SA reagents and for evolving other extremely high-affinity protein:ligand couples...
  2. pmc Deoxyribozymes that recode sequence information
    Jeffrey J Tabor
    Center for Systems and Synthetic Biology and Institute for Cell and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA
    Nucleic Acids Res 34:2166-72. 2006
    ..The binary deoxyribozyme ligases could potentially be used in a variety of applications, including the detection of single nucleotide polymorphisms in genomic DNA or the identification of short nucleic acids such as microRNAs...
  3. pmc Direct selection for ribozyme cleavage activity in cells
    Xi Chen
    Department of Chemistry and Biochemistry, University of Texas at Austin, Austin, Texas 78712, USA
    RNA 15:2035-45. 2009
    ..More importantly, these results have led us to develop a quantitative, kinetic model that can be used to assess the stringency of the hybrid selection scheme and to direct future experiments...
  4. pmc Direct selection of trans-acting ligase ribozymes by in vitro compartmentalization
    Matthew Levy
    Institute for Cellular and Molecular Biology, University of Texas, Austin, TX 78751, USA
    RNA 11:1555-62. 2005
    ....
  5. doi request reprint An in vitro autogene
    Eric A Davidson
    Department of Chemistry and Biochemistry, Institute for Cell and Molecular Biology, Center for Systems and Synthetic Biology, University of Texas at Austin, Austin, TX 78712, USA
    ACS Synth Biol 1:190-6. 2012
    ..Compartmentalization of individual templates within a water-in-oil emulsion links genotype and phenotype, allowing evolution...
  6. ncbi request reprint Aptamer:toxin conjugates that specifically target prostate tumor cells
    Ted C Chu
    Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas 78712, USA
    Cancer Res 66:5989-92. 2006
    ..These results validate the notion that "escort aptamers" may be useful for the treatment of specific tumors expressing unique antigen targets...
  7. doi request reprint Directed evolution of proteins in vitro using compartmentalization in emulsions
    Eric A Davidson
    University of Texas at Austin, Austin, Texas, USA
    Curr Protoc Mol Biol . 2009
    ....
  8. pmc Aptamer mediated siRNA delivery
    Ted C Chu
    Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA
    Nucleic Acids Res 34:e73. 2006
    ..These results suggest new venues for the therapeutic delivery of siRNAs and for the development of reagents that can be used to probe cellular physiology...
  9. pmc Engineering stochasticity in gene expression
    Jeffrey J Tabor
    Center for Systems and Synthetic Biology and Institute for Cell and Molecular Biology, University of Texas, Austin, TX 78712, USA
    Mol Biosyst 4:754-61. 2008
    ..These results demonstrate that synthetic genetic constructs can significantly affect the noise profile of a living cell and, importantly, that operons are a facile genetic strategy for buffering against noise...
  10. ncbi request reprint Quantum-dot aptamer beacons for the detection of proteins
    Matthew Levy
    Institute for Cellular and Molecular Biology, University of Texas, Austin, Austin TX 78712, USA
    Chembiochem 6:2163-6. 2005
  11. pmc Proximity ligation assays with peptide conjugate 'burrs' for the sensitive detection of spores
    Supriya Pai
    Section of Molecular Genetics and Microbiology, School of Biological Sciences, University of Texas at Austin, Austin, TX 78712, USA
    Nucleic Acids Res 33:e162. 2005
    ..Burrs should prove to be generally useful for detecting and mapping interactions and distances between cell surface proteins...
  12. doi request reprint Directed evolution of the substrate specificity of biotin ligase
    Wei Cheng Lu
    Institute of Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas
    Biotechnol Bioeng 111:1071-81. 2014
    ....
  13. pmc Widespread reorganization of metabolic enzymes into reversible assemblies upon nutrient starvation
    Rammohan Narayanaswamy
    Department of Chemistry and Biochemistry, University of Texas, Institute for Cellular and Molecular Biology, Center for Systems and Synthetic Biology, Austin, TX 78712 1064, USA
    Proc Natl Acad Sci U S A 106:10147-52. 2009
    ..Thus, upon nutrient depletion we observe widespread protein assemblies displaying nutrient-specific formation and dissolution...
  14. ncbi request reprint Using a deoxyribozyme ligase and rolling circle amplification to detect a non-nucleic acid analyte, ATP
    Eun Jeong Cho
    Department of Chemistry and Biochemistry, Institute for Cell and Molecular Biology, University of Texas at Austin, Austin, Texas 78712, USA
    J Am Chem Soc 127:2022-3. 2005
    ..Cooperative ATP activation of the deoxyribozyme was faithfully mimicked by RCA, yielding an amplified "switch" that was responsive to ATP concentration...
  15. pmc Aptamer-targeted gold nanoparticles as molecular-specific contrast agents for reflectance imaging
    David J Javier
    Department of Bioengineering, Rice University, Houston, Texas 77005, USA
    Bioconjug Chem 19:1309-12. 2008
    ..This design strategy can easily be modified to incorporate multifunctional agents as part of a multimodal platform for reflectance imaging applications...