Genomes and Genes
Derek M Huffman
Affiliation: Albert Einstein College of Medicine
- Aging per se increases the susceptibility to free fatty acid-induced insulin resistanceFrancine H Einstein
Department of Obstetrics and Gynecology and Women s Health at Montefiore Medical Center, Bronx, New York, USA
J Gerontol A Biol Sci Med Sci 65:800-8. 2010..Thus, aging per se increases the inflammatory response to excess nutrients and vulnerability to FFA-induced insulin resistance with aging...
- Exercise as a calorie restriction mimetic: implications for improving healthy aging and longevityDerek M Huffman
Department of Medicine and Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Interdiscip Top Gerontol 37:157-74. 2010..Therefore, in rodents, the ability of CR to slow aging is apparently more dependent on decreasing nutrient flux, rather than changes in energy balance and body composition...
- Abdominal obesity, independent from caloric intake, accounts for the development of intestinal tumors in Apc(1638N/+) female miceDerek M Huffman
Department of Medicine, Division of Endocrinology, Institute for Aging Research, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Golding Building Room 502, Bronx, NY 10461, USA
Cancer Prev Res (Phila) 6:177-87. 2013..Furthermore, these data emphasize that strategies designed to deplete visceral fat stores in humans should be considered in the prevention of intestinal cancer. Cancer Prev Res; 6(3); 177-87. ©2012 AACR...
- Humanin: a novel central regulator of peripheral insulin actionRadhika H Muzumdar
Department of Pediatrics, Children s Hospital at Montefiore, Institute for Aging Research, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, NY, USA
PLoS ONE 4:e6334. 2009..A novel mitochondria-associated peptide, Humanin (HN), has a neuroprotective role against AD-related neurotoxicity. Considering the association between insulin resistance and AD, we investigated if HN influences insulin sensitivity...
- The critical role of metabolic pathways in agingNir Barzilai
Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA
Diabetes 61:1315-22. 2012..Although life span has been the major outcome of interest in the laboratory, a special focus is made in this study on healthspan, as improved quality of life is the goal when translated to humans...
- Distinguishing between longevity and buffered-deleterious genotypes for exceptional human longevity: the case of the MTP geneDerek M Huffman
Department of Medicine, The Albert Einstein College of Medicine of Yeshiva University, New York, NY, USA
J Gerontol A Biol Sci Med Sci 67:1153-60. 2012..05). Thus, we conclude that MTP CC is a buffered-deleterious genotype and that assessing genotype frequency across aging is essential for discerning longevity from buffered-deleterious genotypes...
- Central insulin-like growth factor-1 (IGF-1) restores whole-body insulin action in a model of age-related insulin resistance and IGF-1 declineDerek M Huffman
Division of Endocrinology, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA
Aging Cell 15:181-6. 2016..Therefore, we propose that strategies aimed at 'tipping the balance' of IGF-1 action centrally are the optimal approach to achieve healthy aging and longevity in humans. ..
- Enhanced activation of a "nutrient-sensing" pathway with age contributes to insulin resistanceFrancine H Einstein
Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461, USA
FASEB J 22:3450-7. 2008..These results suggest that altered nutrient sensing by HBP with age may be the link among nutrients, insulin resistance, and age-related diabetes...
- Contribution of adipose tissue to health span and longevityDerek M Huffman
Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Interdiscip Top Gerontol 37:1-19. 2010..Treatments targeting the prevention of fat accrual in these harmful depots should be considered as a primary target for improving human health span and longevity...
- Evolution in health and medicine Sackler colloquium: Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenariansGil Atzmon
Department of Medicine and Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Proc Natl Acad Sci U S A 107:1710-7. 2010..Thus, variations in human telomerase gene that are associated with better maintenance of telomere length may confer healthy aging and exceptional longevity in humans...
- Role of visceral adipose tissue in agingDerek M Huffman
Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Biochim Biophys Acta 1790:1117-23. 2009..Visceral fat (VF) accretion is a hallmark of aging in humans. Epidemiologic studies have implicated abdominal obesity as a major risk factor for insulin resistance, type 2 diabetes, cardiovascular disease, metabolic syndrome and death...
- Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevitySofiya Milman
Department of Medicine, Division of Endocrinology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY, USA Institute for Aging Research, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY, USA
Aging Cell 13:769-71. 2014..01) and individuals with a history of cancer (P < 0.01). We show for the first time that low IGF-1 levels predict life expectancy in exceptionally long-lived individuals. ..
- Visceral adipose tissue modulates mammalian longevityRadhika Muzumdar
Institute for Aging Research, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA
Aging Cell 7:438-40. 2008..13). Taken together, these observations provide the most direct evidence to date that a reduction in fat mass, specifically VF, may be one of the possible underlying mechanisms of the anti-aging effect of CR...