Affiliation: Albert Einstein College of Medicine
- Cadherin switch in tumor progressionRachel B Hazan
Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Ann N Y Acad Sci 1014:155-63. 2004..Here, we summarize the various aspects of the E- to N-cadherin switching in epithelial carcinomas and its potential impact on metastatic progression...
- N-cadherin expression in breast cancer: correlation with an aggressive histologic variant--invasive micropapillary carcinomaChandandeep Nagi
Department of Pathology, Mount Sinai School of Medicine, New York, NY, USA
Breast Cancer Res Treat 94:225-35. 2005..005), whereas such changes were not significant in the non-MPAP group (p = 0.10). Thus, N-cadherin is associated with tumor aggressiveness and metastatic potential and may contribute to tumor progression...
- Differential cadherin expression: potential markers for epithelial to mesenchymal transformation during tumor progressionGeorgia Agiostratidou
Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
J Mammary Gland Biol Neoplasia 12:127-33. 2007..Double labeling of individual tumors with specific E- and N-cadherin antibodies suggests that EMT can occur heterogeneously and/or transiently within an invasive tumor...
- Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretionTerence M Williams
Department of Molecular Pharmacology and Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Biol Chem 279:51630-46. 2004..These results demonstrate, for the first time, that caveolin-1 is a potent suppressor of mammary tumor growth and metastasis using novel in vivo animal model approaches...
- N-cadherin signaling potentiates mammary tumor metastasis via enhanced extracellular signal-regulated kinase activationJames Hulit
Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA
Cancer Res 67:3106-16. 2007..Thus, de novo expression of N-cadherin in mammary ducts enhances metastasis of breast tumors via enhanced ERK signaling...
- Loss of retinal cadherin facilitates mammary tumor progression and metastasisGeorgia Agiostratidou
Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Cancer Res 69:5030-8. 2009..The data suggest that R-cad is an adhesion molecule of the mammary epithelium, which acts as a critical regulator of the normal phenotype. As a result, R-cad loss contributes to epithelial suppression and metastatic progression...
- A signaling pathway leading to metastasis is controlled by N-cadherin and the FGF receptorKimita Suyama
Derald H Ruttenberg Cancer Center, The Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
Cancer Cell 2:301-14. 2002..These results suggest that protection of the FGFR-1 from ligand-induced downregulation by N-cadherin enhances receptor signaling and provides a mechanism by which tumor cells can acquire metastatic properties...
- Mechanisms of N-Cadherin Mediated Breast CA MetastasisRachel Hazan; Fiscal Year: 2005..abstract_text> ..