Antonio Di Cristofano

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. pmc Mouse models of follicular and papillary thyroid cancer progression
    Marika A Russo
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine Bronx, NY, USA
    Front Endocrinol (Lausanne) 2:119. 2011
  2. pmc Cross-talk between PI3K and estrogen in the mouse thyroid predisposes to the development of follicular carcinomas with a higher incidence in females
    V G Antico-Arciuch
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Oncogene 29:5678-86. 2010
  3. pmc Inhibition of AMPK and Krebs cycle gene expression drives metabolic remodeling of Pten-deficient preneoplastic thyroid cells
    Valeria G Antico Arciuch
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Price Center for Genetic and Translational Medicine, 1301 Morris Park Avenue, Room 302, Bronx, NY 10461, USA
    Cancer Res 73:5459-72. 2013
  4. pmc Thyrocyte-specific inactivation of p53 and Pten results in anaplastic thyroid carcinomas faithfully recapitulating human tumors
    Valeria G Antico Arciuch
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA
    Oncotarget 2:1109-26. 2011
  5. pmc Obatoclax overcomes resistance to cell death in aggressive thyroid carcinomas by countering Bcl2a1 and Mcl1 overexpression
    Devora Champa
    Department of Developmental and Molecular BiologyAlbert Einstein College of Medicine, Price Center for Genetic and Translational Medicine, 1301 Morris Park Avenue, Room 302, Bronx, New York 10461, USADepartments of MedicinePediatrics and Committee on GeneticsUniversity of Chicago, Chicago, Illinois, USADepartment of PathologyMemorial Sloan Kettering Cancer Center, New York, New York, USA
    Endocr Relat Cancer 21:755-67. 2014
  6. pmc The PLK1 inhibitor GSK461364A is effective in poorly differentiated and anaplastic thyroid carcinoma cells, independent of the nature of their driver mutations
    Marika A Russo
    Department of Developmental and Molecular Biology, Price Center for Genetic and Translational Medicine, Albert Einstein College of Medicine, Bronx, New York
    Thyroid 23:1284-93. 2013
  7. pmc Establishment and characterization of cell lines from a novel mouse model of poorly differentiated thyroid carcinoma: powerful tools for basic and preclinical research
    Mariavittoria Dima
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Thyroid 21:1001-7. 2011
  8. pmc Modeling anaplastic thyroid carcinoma in the mouse
    Devora Champa
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, 1301 Morris Park Avenue, Room 302, Bronx, NY, 10461, USA
    Horm Cancer 6:37-44. 2015

Collaborators

  • Valeria G Antico Arciuch
  • Ronald A Ghossein
  • Marika A Russo
  • Devora Champa
  • Mariavittoria Dima
  • V G Antico-Arciuch
  • Samuel Refetoff
  • Xiao Hui Liao
  • Kristy S Kang
  • Valeria Gabriela Antico-Arciuch
  • Kelly A Miller
  • X H Liao
  • S Refetoff
  • M Dima

Detail Information

Publications8

  1. pmc Mouse models of follicular and papillary thyroid cancer progression
    Marika A Russo
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine Bronx, NY, USA
    Front Endocrinol (Lausanne) 2:119. 2011
    ..In this review, we focus on the lessons learned from models of epithelial cell-derived thyroid cancer showing progression from hyperplastic lesions to locally invasive and metastatic carcinomas...
  2. pmc Cross-talk between PI3K and estrogen in the mouse thyroid predisposes to the development of follicular carcinomas with a higher incidence in females
    V G Antico-Arciuch
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Oncogene 29:5678-86. 2010
    ....
  3. pmc Inhibition of AMPK and Krebs cycle gene expression drives metabolic remodeling of Pten-deficient preneoplastic thyroid cells
    Valeria G Antico Arciuch
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Price Center for Genetic and Translational Medicine, 1301 Morris Park Avenue, Room 302, Bronx, NY 10461, USA
    Cancer Res 73:5459-72. 2013
    ..Our findings define a novel metabolic switch to glycolysis driven by PI3K-dependent AMPK inactivation with a consequent repression in the expression of key metabolic transcription regulators...
  4. pmc Thyrocyte-specific inactivation of p53 and Pten results in anaplastic thyroid carcinomas faithfully recapitulating human tumors
    Valeria G Antico Arciuch
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA
    Oncotarget 2:1109-26. 2011
    ....
  5. pmc Obatoclax overcomes resistance to cell death in aggressive thyroid carcinomas by countering Bcl2a1 and Mcl1 overexpression
    Devora Champa
    Department of Developmental and Molecular BiologyAlbert Einstein College of Medicine, Price Center for Genetic and Translational Medicine, 1301 Morris Park Avenue, Room 302, Bronx, New York 10461, USADepartments of MedicinePediatrics and Committee on GeneticsUniversity of Chicago, Chicago, Illinois, USADepartment of PathologyMemorial Sloan Kettering Cancer Center, New York, New York, USA
    Endocr Relat Cancer 21:755-67. 2014
    ..Thus, our studies in a novel, relevant mouse model have uncovered a promising druggable feature of aggressive thyroid cancers...
  6. pmc The PLK1 inhibitor GSK461364A is effective in poorly differentiated and anaplastic thyroid carcinoma cells, independent of the nature of their driver mutations
    Marika A Russo
    Department of Developmental and Molecular Biology, Price Center for Genetic and Translational Medicine, Albert Einstein College of Medicine, Bronx, New York
    Thyroid 23:1284-93. 2013
    ..PLK1 is a crucial driving force for normal mitotic spindle formation, centrosome maturation, and separation, and its overexpression has been demonstrated in a wide range of tumors...
  7. pmc Establishment and characterization of cell lines from a novel mouse model of poorly differentiated thyroid carcinoma: powerful tools for basic and preclinical research
    Mariavittoria Dima
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Thyroid 21:1001-7. 2011
    ....
  8. pmc Modeling anaplastic thyroid carcinoma in the mouse
    Devora Champa
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, 1301 Morris Park Avenue, Room 302, Bronx, NY, 10461, USA
    Horm Cancer 6:37-44. 2015
    ..In this review, we focus on the relevant characteristics associated with these models and on what we have learned in terms of anaplastic thyroid cancer biology, genetics, and response to targeted therapy. ..