M R Chance

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. ncbi Structural proteomics of macromolecular assemblies using oxidative footprinting and mass spectrometry
    Jing Qu Guan
    Case Center for Proteomics and Mass Spectrometry, 930 BRB, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Trends Biochem Sci 30:583-92. 2005
  2. pmc Modeling of protein binary complexes using structural mass spectrometry data
    J K Amisha Kamal
    Center for Proteomics and Mass Spectrometry, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Protein Sci 17:79-94. 2008
  3. pmc High-throughput computational and experimental techniques in structural genomics
    Mark R Chance
    New York Structural Genomics Research Consortium, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Genome Res 14:2145-54. 2004
  4. ncbi Unfolding of apomyoglobin examined by synchrotron footprinting
    M R Chance
    Center for Synchrotron Biosciences, Department of Physiology, Albert Einstein College of Medicine, Yeshiva University, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Biochem Biophys Res Commun 287:614-21. 2001
  5. pmc Structural genomics: a pipeline for providing structures for the biologist
    Mark R Chance
    Center for Synchrotron Biosciences, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Protein Sci 11:723-38. 2002
  6. ncbi Millisecond radiolytic modification of peptides by synchrotron X-rays identified by mass spectrometry
    S D Maleknia
    Albert Einstein Center for Synchrotron BioSciences, Department of Physiology and Biophysics, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, USA
    Anal Chem 71:3965-73. 1999
  7. ncbi Metalloproteomics: high-throughput structural and functional annotation of proteins in structural genomics
    Wuxian Shi
    New York Structural GenomiX Research Consortium, Bronx, New York 10461, USA
    Structure 13:1473-86. 2005
  8. ncbi Electrospray-assisted modification of proteins: a radical probe of protein structure
    S D Maleknia
    Department of Physiology and Biophysics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Rapid Commun Mass Spectrom 13:2352-8. 1999
  9. ncbi Concerted binding and bending of DNA by Escherichia coli integration host factor
    Gauri M Dhavan
    Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Mol Biol 315:1027-37. 2002
  10. ncbi Hydroxyl radical probe of protein surfaces using synchrotron X-ray radiolysis and mass spectrometry
    J G Kiselar
    Center for Synchrotron Biosciences, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461 1602, USA
    Int J Radiat Biol 78:101-14. 2002

Collaborators

Detail Information

Publications57

  1. ncbi Structural proteomics of macromolecular assemblies using oxidative footprinting and mass spectrometry
    Jing Qu Guan
    Case Center for Proteomics and Mass Spectrometry, 930 BRB, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Trends Biochem Sci 30:583-92. 2005
    ..In addition, the use of footprinting data in conjunction with computational modeling approaches is a powerful new method for testing and refining structural models of macromolecules and their complexes...
  2. pmc Modeling of protein binary complexes using structural mass spectrometry data
    J K Amisha Kamal
    Center for Proteomics and Mass Spectrometry, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Protein Sci 17:79-94. 2008
    ..We demonstrate this method with the actin/gelsolin segment-1 complex. We also provide a structural model for the actin/cofilin complex using this approach which does not have a crystal or NMR structure...
  3. pmc High-throughput computational and experimental techniques in structural genomics
    Mark R Chance
    New York Structural Genomics Research Consortium, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Genome Res 14:2145-54. 2004
    ..This projected resource will provide structural biology information important to understanding the function of most proteins of the cell...
  4. ncbi Unfolding of apomyoglobin examined by synchrotron footprinting
    M R Chance
    Center for Synchrotron Biosciences, Department of Physiology, Albert Einstein College of Medicine, Yeshiva University, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Biochem Biophys Res Commun 287:614-21. 2001
    ....
  5. pmc Structural genomics: a pipeline for providing structures for the biologist
    Mark R Chance
    Center for Synchrotron Biosciences, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Protein Sci 11:723-38. 2002
  6. ncbi Millisecond radiolytic modification of peptides by synchrotron X-rays identified by mass spectrometry
    S D Maleknia
    Albert Einstein Center for Synchrotron BioSciences, Department of Physiology and Biophysics, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, USA
    Anal Chem 71:3965-73. 1999
    ..Phenylalanine and tyrosine residues were modified predominantly by hydroxyl radicals, and the source of modification of proline was exclusively through molecular oxygen...
  7. ncbi Metalloproteomics: high-throughput structural and functional annotation of proteins in structural genomics
    Wuxian Shi
    New York Structural GenomiX Research Consortium, Bronx, New York 10461, USA
    Structure 13:1473-86. 2005
    ..The project's goal is to assay at least 1 member from each Pfam family; approximately 500 Pfam families have been characterized with respect to transition metal content so far...
  8. ncbi Electrospray-assisted modification of proteins: a radical probe of protein structure
    S D Maleknia
    Department of Physiology and Biophysics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Rapid Commun Mass Spectrom 13:2352-8. 1999
    ..This facile oxidation process could be applied to investigate the molecular mechanism by which reactive oxygen species interact with a particular protein domain as a means to investigate the onset of certain diseases...
  9. ncbi Concerted binding and bending of DNA by Escherichia coli integration host factor
    Gauri M Dhavan
    Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Mol Biol 315:1027-37. 2002
    ....
  10. ncbi Hydroxyl radical probe of protein surfaces using synchrotron X-ray radiolysis and mass spectrometry
    J G Kiselar
    Center for Synchrotron Biosciences, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461 1602, USA
    Int J Radiat Biol 78:101-14. 2002
    ....
  11. pmc Ageing causes cytoplasmic retention of MaxiK channels in rat corporal smooth muscle cells
    K P Davies
    Department of Urology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Int J Impot Res 19:371-7. 2007
    ..These experiments demonstrate that ageing of the corpora is accompanied by changes in alternative splicing and cellular localization of the MaxiK channel...
  12. pmc Catching RNA polymerase in the act of binding: intermediates in transcription illuminated by synchrotron footprinting
    Michael Brenowitz
    Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 102:4659-60. 2005
  13. ncbi Structural genomics of protein phosphatases
    Steven C Almo
    Albert Einstein College of Medicine, Bronx, NY, USA
    J Struct Funct Genomics 8:121-40. 2007
    ....
  14. ncbi A high-throughput approach to protein structure analysis
    Babu A Manjasetty
    New York Structural GenomiX Research Consortium NYSGXRC, Center for Synchrotron Biosciences, National Synchrotron Light Source, Brookhaven National Laboratory, Upton, NY 11973, USA
    Genet Eng (N Y) 28:105-28. 2007
  15. ncbi Probing the structural dynamics of nucleic acids by quantitative time-resolved and equilibrium hydroxyl radical "footprinting"
    Michael Brenowitz
    Department of Biochemistry, Center for Synchrotron Biosciences, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Curr Opin Struct Biol 12:648-53. 2002
    ..Recently, quantitative applications of this technique have been developed that allow time-resolved and equilibrium analysis of transitions involving nucleic acid ligand binding and conformation change to be analyzed incisively...
  16. pmc The ybeY protein from Escherichia coli is a metalloprotein
    Chenyang Zhan
    New York Structural Genomics Research Consortium NYSGXRC, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 61:959-63. 2005
    ....
  17. pmc Semi-automated, single-band peak-fitting analysis of hydroxyl radical nucleic acid footprint autoradiograms for the quantitative analysis of transitions
    Keiji Takamoto
    Department of Biochemistry, Center for Synchrotron Biosciences, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Nucleic Acids Res 32:E119. 2004
    ..The utility of this new analysis approach is illustrated by its application to the ion-meditated folding of a large RNA molecule...
  18. doi Metallomics and metalloproteomics
    W Shi
    Center for Synchrotron Biosciences, Case Center for Proteomics, Case Western Reserve University, 10900 Euclid Ave, BRB 113, Cleveland, Ohio, 44106, USA
    Cell Mol Life Sci 65:3040-8. 2008
    ..With the advent of genome sequencing, a large database of protein primary structures has been established, and specific tools to identify metalloproteins in the genome sequences have been developed...
  19. ncbi Monovalent ion-mediated folding of the Tetrahymena thermophila ribozyme
    Inna Shcherbakova
    Department of Biochemistry and Center for Synchrotron Biosciences, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Mol Biol 342:1431-42. 2004
    ..The overall portrait painted by these results is that ion valency differentially affects steps in the folding process and that folding in monovalent ion alone for the U273A mutant Tetrahymena ribozyme is fast and direct...
  20. ncbi Structural analysis of gelsolin using synchrotron protein footprinting
    Janna G Kiselar
    Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, New York, 10461 1602, USA
    Mol Cell Proteomics 2:1120-32. 2003
    ..The results demonstrate that radiolytic protein footprinting can provide detailed structural information on the conformational dynamics of ligand-induced structural changes, and the data provide a detailed model for gelsolin activation...
  21. ncbi DNA and protein footprinting analysis of the modulation of DNA binding by the N-terminal domain of the Saccharomyces cerevisiae TATA binding protein
    Sayan Gupta
    Center for Synchrotron Biosciences, National Synchrotron Light Source, Brookhaven National Laboratory, Upton, New York 11973, USA
    Biochemistry 46:9886-98. 2007
    ..Taken together, these results are consistent with the N-terminal domain actively modulating TATA box binding by TBP and nonionic detergent modulating the interdomain interaction...
  22. ncbi Multiple monovalent ion-dependent pathways for the folding of the L-21 Tetrahymena thermophila ribozyme
    Takeshi Uchida
    Department of Physiology and Biophysics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Mol Biol 328:463-78. 2003
    ..These results provide a map of the early steps in the ribozyme's folding landscape and the degree to which the preferred pathways are dependent upon the initial reaction conditions...
  23. pmc Structural characterization of HIV gp41 with the membrane-proximal external region
    Wuxian Shi
    Center for Synchrotron Biosciences, Case Western Reserve University, Cleveland, OH 44106, USA
    J Biol Chem 285:24290-8. 2010
    ....
  24. ncbi Monovalent cations mediate formation of native tertiary structure of the Tetrahymena thermophila ribozyme
    Keiji Takamoto
    Department of Physiology and Biophysics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Nat Struct Biol 9:928-33. 2002
    ....
  25. ncbi Solution structure and interdomain interactions of the Saccharomyces cerevisiae "TATA binding protein" (TBP) probed by radiolytic protein footprinting
    Hassan Rashidzadeh
    Department of Physiology and Biophysics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Biochemistry 42:3655-65. 2003
    ..The functional implications of these results are discussed...
  26. ncbi DNA binding provides a molecular strap activating the adenovirus proteinase
    Sayan Gupta
    Center for Synchrotron Biosciences, Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Mol Cell Proteomics 3:950-9. 2004
    ..In addition, both pVIc and DNA may independently alter the active site conformation as well as drive it cooperatively to fully activate AVP...
  27. ncbi Beamline X29: a novel undulator source for X-ray crystallography
    Wuxian Shi
    Center for Synchrotron Biosciences, Case Proteomics Center, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    J Synchrotron Radiat 13:365-72. 2006
    ..X29 is 10(3) times brighter than any existing bending-magnet beamline at NSLS with an actual flux of 2.5 x 10(11) photons s(-1) through a 0.12 mm square aperture at 11.271 keV...
  28. ncbi Structural reorganization of proteins revealed by radiolysis and mass spectrometry: G-actin solution structure is divalent cation dependent
    Jing Qu Guan
    Center for Synchrotron Biosciences, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Biochemistry 42:11992-2000. 2003
    ..These conformational variations for isolated Mg(2+)-G-actin provide a structural basis for its greater tendency to polymerize into filaments as compared to Ca(2+)-G-actin...
  29. ncbi Secondary reactions and strategies to improve quantitative protein footprinting
    Guozhong Xu
    Center for Synchrotron Biosciences, Department of Physiology and Biophysics, and Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Anal Chem 77:3029-37. 2005
    ..The disulfides can be reduced before mass spectrometric analysis by reducing agents such as TCEP, while methionine sulfoxide is refractory to reduction by this reagent under typical reducing conditions...
  30. ncbi Center for Synchrotron Biosciences' U2B beamline: an international resource for biological infrared spectroscopy
    N S Marinkovic
    Center for Synchrotron Biosciences, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Synchrotron Radiat 9:189-97. 2002
    ..This facility is intended as an international resource for biological IR spectroscopy fully available to outside users based on competitive proposal...
  31. pmc Conformational changes during the gating of a potassium channel revealed by structural mass spectrometry
    Sayan Gupta
    Center for Synchrotron Biosciences, Case Western Reserve University, Cleveland, OH 44022, USA
    Structure 18:839-46. 2010
    ..The results provide support for a proposed gating mechanism of the Kir channel and demonstrate a method of probing the dynamic gating mechanism of other integral membrane proteins and ion channels...
  32. ncbi Crystal structure of Escherichia coli L-arabinose isomerase (ECAI), the putative target of biological tagatose production
    Babu A Manjasetty
    New York Structural GenomiX Research Consortium, Center for Synchrotron Biosciences, National Synchrotron Light Source, Brookhaven National Laboratory, Upton, NY 11973, USA
    J Mol Biol 360:297-309. 2006
    ..Further, the crystal structure of ECAI forms a basis for identifying molecular determinants responsible for isomerization of arabinose to ribulose in vivo and galactose to tagatose in vitro...
  33. ncbi In situ chemistry of osteoporosis revealed by synchrotron infrared microspectroscopy
    Raymond Y Huang
    Department of Physiology and Biophysics, Center for Synchrotron Biosciences, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Bone 33:514-21. 2003
    ..These results demonstrate that bone newly synthesized after ovariectomy is chemically different from healthy bone within specific bone regions, which may contribute to reduced bone quality in osteoporosis...
  34. ncbi Radiolytic modification of acidic amino acid residues in peptides: probes for examining protein-protein interactions
    Guozhong Xu
    Departments of Physiology and Biophysics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461 1602, USA
    Anal Chem 76:1213-21. 2004
    ....
  35. ncbi Linkage of monovalent and divalent ion binding in the folding of the P4-P6 domain of the Tetrahymena ribozyme
    Takeshi Uchida
    Center for Synchrotron Biosciences, Department of Physiology and Biophysics, Albert Einstein College of Medicine of Yeshiva University, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Biochemistry 41:5799-806. 2002
    ..These site-specific footprinting data provide quantitative and site-specific measurements of the ion-linked stability for P4-P6 that are interpreted with respect to crystallographic data...
  36. ncbi High-throughput expression, purification, and characterization of recombinant Caenorhabditis elegans proteins
    Raymond Y Huang
    Center for Synchrotron Biosciences, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Biochem Biophys Res Commun 307:928-34. 2003
    ..The ZipTip purified proteins can be further analyzed under both native and denaturing conditions for functional proteomics efforts...
  37. pmc Visualizing the Ca2+-dependent activation of gelsolin by using synchrotron footprinting
    Janna G Kiselar
    Department of Physiology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461 1602, USA
    Proc Natl Acad Sci U S A 100:3942-7. 2003
    ....
  38. ncbi Structure and dynamics of the actin filament
    Jing Qu Guan
    Center for Synchrotron Biosciences, Albert Einstein College of Medicine of Yeshiva University, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Biochemistry 44:3166-75. 2005
    ..K., and Schriemer, D.C. (2003) J. Mol. Biol. 334, 373-385], which also did not detect any burial of the H plug upon formation of filaments...
  39. ncbi Synchrotron radiolysis and mass spectrometry: a new approach to research on the actin cytoskeleton
    Jing Qu Guan
    Center for Synchrotron Biosciences, Department of Physiology and Biophysics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Acc Chem Res 37:221-9. 2004
    ....
  40. ncbi Mapping the G-actin binding surface of cofilin using synchrotron protein footprinting
    Jing Qu Guan
    Center for Synchrotron Biosciences, Department of Physiology and Biophysics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Biochemistry 41:5765-75. 2002
    ..These results are generally consistent with, and complementary to, the results of previous site-directed mutagenesis studies and extend our understanding of the G-actin binding surface of cofilin...
  41. ncbi Radiolytic modification of basic amino acid residues in peptides: probes for examining protein-protein interactions
    Guozhong Xu
    Department of Physiology and Biophysics, Department of Biochemistry, and Center for Synchrotron Biosciences, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461 1602, USA
    Anal Chem 75:6995-7007. 2003
    ....
  42. ncbi Hydroxyl radical-mediated modification of proteins as probes for structural proteomics
    Guozhong Xu
    Center for Proteomics, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA
    Chem Rev 107:3514-43. 2007
  43. doi Automated technologies and novel techniques to accelerate protein crystallography for structural genomics
    Babu A Manjasetty
    Case Center for Synchrotron Biosciences, National Synchrotron Light Source, Brookhaven National Laboratory, Upton, NY11973, USA
    Proteomics 8:612-25. 2008
    ..In addition, this review aims to give an overview of recent developments in high throughput instrumentation, and technologies and strategies to accelerate protein structure/function analysis...
  44. ncbi C. elegans ORFeome version 1.1: experimental verification of the genome annotation and resource for proteome-scale protein expression
    Jerome Reboul
    Dana Farber Cancer Institute and Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 34:35-41. 2003
    ..We suggest that similar ORFeome projects will be valuable for other organisms, including humans...
  45. ncbi The Beamline X28C of the Center for Synchrotron Biosciences: a national resource for biomolecular structure and dynamics experiments using synchrotron footprinting
    Sayan Gupta
    Center for Proteomics and Mass Spectrometry, Case Western Reserve University, Cleveland, OH, USA
    J Synchrotron Radiat 14:233-43. 2007
    ..Lastly, several examples of published results provide illustrations of the kinds of experiments likely to be successful using these approaches...
  46. ncbi Biochemical implications of a three-dimensional model of monomeric actin bound to magnesium-chelated ATP
    Keiji Takamoto
    Case Center for Proteomics, Case Western Reserve University, 10090 Euclid Avenue, Cleveland, OH 44106, USA
    Structure 15:39-51. 2007
    ..The key conclusion of this study is that the structure of the nucleotide binding cleft defined by subdomains 2 and 4 is essentially closed, with specific contacts between two subdomains predicted by the data...
  47. ncbi New York-Structural GenomiX Research Consortium (NYSGXRC): a large scale center for the protein structure initiative
    Jeffrey B Bonanno
    Structural GenomiX, Inc, 10505 Roselle Street, San Diego, CA 92121, USA
    J Struct Funct Genomics 6:225-32. 2005
    ..An analysis of current and projected consortium metrics reflects progress to date and delineates opportunities for further technology development...
  48. pmc Visualizing Arp2/3 complex activation mediated by binding of ATP and WASp using structural mass spectrometry
    Janna G Kiselar
    Case Center for Proteomics, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 104:1552-7. 2007
    ....
  49. pmc The ClpP N-terminus coordinates substrate access with protease active site reactivity
    Laura D Jennings
    Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Biochemistry 47:11031-40. 2008
    ....
  50. pmc Synchrotron protein footprinting supports substrate translocation by ClpA via ATP-induced movements of the D2 loop
    Jen Bohon
    Center for Proteomics and Center for Synchrotron Biosciences, Case Western Reserve University, Cleveland, OH 44106, USA
    Structure 16:1157-65. 2008
    ..These data provide the first direct experimental support for the nucleotide-dependent D2 loop conformational change previously proposed to mediate substrate translocation...
  51. pmc Inner ear proteomics of mouse models for deafness, a discovery strategy
    Qing Yin Zheng
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609 1500, USA
    Brain Res 1091:113-21. 2006
    ..In this short technical report, we also discuss protein-profiling approaches suitable for SSUMM and briefly discuss other approaches used in the field of proteomics...
  52. pmc Proteomics analysis identifies molecular targets related to diabetes mellitus-associated bladder dysfunction
    Elizabeth Yohannes
    Case Center for Proteomics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Mol Cell Proteomics 7:1270-85. 2008
    ....
  53. doi Installation and testing of a focusing mirror at beamline X28C for high flux x-ray radiolysis of biological macromolecules
    Michael R Sullivan
    Center for Proteomics and Mass Spectrometry and Center for Synchrotron Biosciences, Case Western Reserve University, Cleveland, Ohio 44106 4988, USA
    Rev Sci Instrum 79:025101. 2008
    ....
  54. ncbi Radiolytic protein footprinting with mass spectrometry to probe the structure of macromolecular complexes
    Keiji Takamoto
    Case Center for Proteomics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Annu Rev Biophys Biomol Struct 35:251-76. 2006
    ....
  55. ncbi Principles of RNA compaction: insights from the equilibrium folding pathway of the P4-P6 RNA domain in monovalent cations
    Keiji Takamoto
    Department of Physiology and Biophysics, Albert Einstein College of Medicine of Yeshiva University, New York, NY 10461, USA
    J Mol Biol 343:1195-206. 2004
    ..The folding model derived from these and previous results provides a robust framework for understanding the equilibrium and kinetic folding of RNA...
  56. pmc Alcohol dehydrogenase restricts the ability of the pathogen Candida albicans to form a biofilm on catheter surfaces through an ethanol-based mechanism
    Pranab K Mukherjee
    Center for Medical Mycology, Department of Dermatology, Case Western Reserve University, 11100 Euclid Avenue, LKS 5028, Cleveland, OH 44106, USA
    Infect Immun 74:3804-16. 2006
    ..albicans to form biofilms in vitro and in vivo and that the protein restricts biofilm formation through an ethanol-dependent mechanism. These results are clinically relevant and may suggest novel antibiofilm treatment strategies...
  57. pmc Protein production and purification
    Susanne Gräslund
    Karolinska Institutet, Scheeles vag 2, 171 77 Stockholm, Sweden
    Nat Methods 5:135-46. 2008
    ..This review presents methods that could be applied at the outset of any project, a prioritized list of alternate strategies and a list of pitfalls that trip many new investigators...