Robert Burk

Summary

Affiliation: Albert Einstein College of Medicine
Country: USA

Publications

  1. pmc HIF-2alpha downregulation in the absence of functional VHL is not sufficient for renal cell differentiation
    Michael D Hughes
    Department of Biology, Adelphi University, Garden City, NY 11530 0701, USA
    Cancer Cell Int 7:13. 2007
  2. pmc Ancient papillomavirus-host co-speciation in Felidae
    Annabel Rector
    Laboratory of Clinical and Epidemiological Virology, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium
    Genome Biol 8:R57. 2007
  3. ncbi request reprint Distribution of human papillomavirus types 16 and 18 variants in squamous cell carcinomas and adenocarcinomas of the cervix
    Robert D Burk
    Department of Pediatrics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Cancer Res 63:7215-20. 2003
  4. pmc Human papillomaviruses: genetic basis of carcinogenicity
    Robert D Burk
    Department of Pediatrics, Division of Genetics, Albert Einstein Cancer Center, New York, NY 10461, USA
    Public Health Genomics 12:281-90. 2009
  5. pmc Human papillomavirus (HPV) types 101 and 103 isolated from cervicovaginal cells lack an E6 open reading frame (ORF) and are related to gamma-papillomaviruses
    Zigui Chen
    Department of Microbiology and Immunology, Albert Einstein Cancer Center, Albert Einstein College of Medicine of Yeshiva University, NY 10461, USA
    Virology 360:447-53. 2007
  6. ncbi request reprint Combined human papillomavirus DNA and human papillomavirus-like particle serologic assay to identify women at risk for high-grade cervical intraepithelial neoplasia
    Mark H Einstein
    Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Int J Cancer 120:55-9. 2007
  7. pmc Persistent antibodies to HPV virus-like particles following natural infection are protective against subsequent cervicovaginal infection with related and unrelated HPV
    Zainab A Malik
    Department of Pediatrics and Division of Infectious Diseases, Children s Hospital at Montefiore, Bronx, New York, USA
    Viral Immunol 22:445-9. 2009
  8. ncbi request reprint Association of cutaneous anergy with human papillomavirus and cervical neoplasia in HIV-seropositive and seronegative women
    Tiffany G Harris
    Albert Einstein College of Medicine, Bronx, New York 10461, USA
    AIDS 21:1933-41. 2007
  9. doi request reprint Insulin-like growth factor axis and oncogenic human papillomavirus natural history
    Tiffany G Harris
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Cancer Epidemiol Biomarkers Prev 17:245-8. 2008
  10. doi request reprint Predictors of seropositivity to human papillomavirus type 53: one of the most prevalent high risk-related cervical human papillomaviruses
    Zainab A Malik
    Department of Pediatrics, Division of Infectious Diseases, Children s Hospital at Montefiore, Bronx, New York 10467, USA
    Viral Immunol 21:371-7. 2008

Research Grants

Detail Information

Publications93

  1. pmc HIF-2alpha downregulation in the absence of functional VHL is not sufficient for renal cell differentiation
    Michael D Hughes
    Department of Biology, Adelphi University, Garden City, NY 11530 0701, USA
    Cancer Cell Int 7:13. 2007
    ..Using an RNA interference approach to lower levels of HIF-2alpha in two different renal cell lines that lack functional pVHL, we have tested the contribution of HIF-2alpha toward cellular pVHL activities...
  2. pmc Ancient papillomavirus-host co-speciation in Felidae
    Annabel Rector
    Laboratory of Clinical and Epidemiological Virology, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium
    Genome Biol 8:R57. 2007
    ....
  3. ncbi request reprint Distribution of human papillomavirus types 16 and 18 variants in squamous cell carcinomas and adenocarcinomas of the cervix
    Robert D Burk
    Department of Pediatrics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Cancer Res 63:7215-20. 2003
    ..Non-European HPV16 and/or HPV18 variants are commonly seen in AC. A possible hormonal mechanism is suggested to explain the observed findings...
  4. pmc Human papillomaviruses: genetic basis of carcinogenicity
    Robert D Burk
    Department of Pediatrics, Division of Genetics, Albert Einstein Cancer Center, New York, NY 10461, USA
    Public Health Genomics 12:281-90. 2009
    ....
  5. pmc Human papillomavirus (HPV) types 101 and 103 isolated from cervicovaginal cells lack an E6 open reading frame (ORF) and are related to gamma-papillomaviruses
    Zigui Chen
    Department of Microbiology and Immunology, Albert Einstein Cancer Center, Albert Einstein College of Medicine of Yeshiva University, NY 10461, USA
    Virology 360:447-53. 2007
    ..Moreover, this is the first report of HPVs lacking an E6 ORF and phylogenetic evidence suggests this occurred subsequent to their emergence from the gamma-/pi-PVs...
  6. ncbi request reprint Combined human papillomavirus DNA and human papillomavirus-like particle serologic assay to identify women at risk for high-grade cervical intraepithelial neoplasia
    Mark H Einstein
    Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Int J Cancer 120:55-9. 2007
    ..HPV VLP assays may be useful as an adjunct to HPV DNA testing in a subset of patients that needs to be defined by further studies...
  7. pmc Persistent antibodies to HPV virus-like particles following natural infection are protective against subsequent cervicovaginal infection with related and unrelated HPV
    Zainab A Malik
    Department of Pediatrics and Division of Infectious Diseases, Children s Hospital at Montefiore, Bronx, New York, USA
    Viral Immunol 22:445-9. 2009
    ....
  8. ncbi request reprint Association of cutaneous anergy with human papillomavirus and cervical neoplasia in HIV-seropositive and seronegative women
    Tiffany G Harris
    Albert Einstein College of Medicine, Bronx, New York 10461, USA
    AIDS 21:1933-41. 2007
    ..This study assessed the relationship of anergy test results with cervical infection by human papillomavirus (HPV) and cervical neoplasia in HIV-seropositive and seronegative women...
  9. doi request reprint Insulin-like growth factor axis and oncogenic human papillomavirus natural history
    Tiffany G Harris
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Cancer Epidemiol Biomarkers Prev 17:245-8. 2008
    ..07; 95% CI, 0.01-0.66). These prospective data provide initial evidence that the IGF axis may influence the natural history of oncogenic HPV...
  10. doi request reprint Predictors of seropositivity to human papillomavirus type 53: one of the most prevalent high risk-related cervical human papillomaviruses
    Zainab A Malik
    Department of Pediatrics, Division of Infectious Diseases, Children s Hospital at Montefiore, Bronx, New York 10467, USA
    Viral Immunol 21:371-7. 2008
    ..3; 95% CI: 5.3, 55.9). In conclusion, host serological responses to HPV53 VLPs are strongly type-specific, and subjects' risk for HPV53 seropositivity is independently associated with sexual behavior and OCP use...
  11. pmc Diversifying selection in human papillomavirus type 16 lineages based on complete genome analyses
    Zigui Chen
    Department of Microbiology and Immunology, Albert Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Virol 79:7014-23. 2005
    ..Whether response to selective pressure upon the E5 and E6 ORFs contributes to the biological success of HPV16, its specific biological niche, and/or its oncogenic potential remains to be established...
  12. ncbi request reprint Overlapping reading frames in closely related human papillomaviruses result in modular rates of selection within E2
    Apurva Narechania
    Department of Microbiology and Immunology, The Albert Einstein Cancer Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Gen Virol 86:1307-13. 2005
    ..E4 appears to be positioned in a part of the HPV genome that can tolerate non-synonymous change and purifying selection of E4 may be indicative of its functional importance...
  13. ncbi request reprint Incidence of and risk factors for genital human papillomavirus infection in women drug users
    Deepti Dev
    Department of Pediatrics, Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, NY 10467, USA
    J Acquir Immune Defic Syndr 41:527-9. 2006
    ..HIV infection was independently associated with a substantial and significantly increased risk for any and for high-risk genital HPV infection and was the most important risk factor found...
  14. pmc Identification and characterization of two novel human papillomaviruses (HPVs) by overlapping PCR: HPV102 and HPV106
    Zigui Chen
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA
    J Gen Virol 88:2952-5. 2007
    ..On the basis of phylogenetic analyses and available clinical information, these two novel HPV types expand the heterogeneity of HPVs detected in the lower genital tract...
  15. ncbi request reprint Lack of the canonical pRB-binding domain in the E7 ORF of artiodactyl papillomaviruses is associated with the development of fibropapillomas
    Apurva Narechania
    Department of Microbiology and Immunology, Albert Einstein Cancer Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Gen Virol 85:1243-50. 2004
    ....
  16. pmc Polymer-based enzyme-linked immunosorbent assay using human papillomavirus type 16 (HPV16) virus-like particles detects HPV16 clade-specific serologic responses
    Yevgeniy Y Studentsov
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA
    J Clin Microbiol 41:2827-34. 2003
    ..Use of HPV16 VLP polymer ELISA detects clade-specific responses and suggests an HPV16 VLP vaccine may have broader protection that initially anticipated...
  17. pmc Heat shock fusion protein-based immunotherapy for treatment of cervical intraepithelial neoplasia III
    Mark H Einstein
    Albert Einstein College of Medicine, and Albert Einstein Cancer Center, Bronx, NY 10461, USA
    Gynecol Oncol 106:453-60. 2007
    ..bovis BCG heat shock protein (Hsp65) covalently linked to the entire sequence of HPV 16 E7. This trial was designed to evaluate the efficacy and toxicities of HspE7 in women with CIN III...
  18. pmc Phylogenetic incongruence among oncogenic genital alpha human papillomaviruses
    Apurva Narechania
    Department of Microbiology, Albert Einstein College of Medicine, Ullman Building, Room 515, 1300 Morris Park Ave, Bronx, NY 10461, USA
    J Virol 79:15503-10. 2005
    ..These data indicate that the phylogeny of the oncogenic HPVs is complex and that their evolution may not be monophyletic across all genes...
  19. ncbi request reprint Plasma uric acid levels in women with cervical intraepithelial neoplasia
    Jayasri Basu
    Department of Obstetrics and Gynecology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Nutr Cancer 51:25-31. 2005
    ..It may be speculated that chronic free radical-induced tissue damage in the context of persistent HPV infection may be involved in the pathogenesis of CIN...
  20. ncbi request reprint Variants of human papillomaviruses 16 and 18 and their natural history in human immunodeficiency virus-positive women
    Nicolas F Schlecht
    Albert Einstein College of Medicine, Department of Epidemiology and Population Health, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Gen Virol 86:2709-20. 2005
    ..If non-European variants are more oncogenic, the effect may involve a late stage in cervical tumorigenesis...
  21. ncbi request reprint Natural history and possible reactivation of human papillomavirus in human immunodeficiency virus-positive women
    Howard D Strickler
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Ave, Belfer 1308, Bronx, NY 10461, USA
    J Natl Cancer Inst 97:577-86. 2005
    ....
  22. ncbi request reprint Incidence of cervical squamous intraepithelial lesions associated with HIV serostatus, CD4 cell counts, and human papillomavirus test results
    Tiffany G Harris
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    JAMA 293:1471-6. 2005
    ....
  23. ncbi request reprint Development of a non-denaturing electrophoresis system for characterization of neutralizing epitopes on HPV virus-like particles
    Yevgeniy Y Studentsov
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Ullmann Bldg, Rm 519, Bronx, NY 10461, USA
    J Virol Methods 139:208-19. 2007
    ..These data suggest that a structure consistent with the migration pattern of a L1 trimer contains the major neutralizing epitope recognized by the H16.V5 MAb and human sera...
  24. ncbi request reprint Identification of a novel human papillomavirus (HPV97) related to HPV18 and HPV45
    Zigui Chen
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Int J Cancer 121:193-8. 2007
    ..These data suggest that HPV97 shares a most recent common ancestor with HPV18 and HPV45 and should be evaluated in cancer specimens from different geographic populations...
  25. pmc Serological response to an HPV16 E7 based therapeutic vaccine in women with high-grade cervical dysplasia
    Koenraad Van Doorslaer
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Gynecol Oncol 116:208-12. 2010
    ..The induction of a B-cell response by HspE7 and its association with clinical outcome is unknown, and is the purpose of this study...
  26. doi request reprint Illumina DNA test panel-based genotyping of whole genome amplified-DNA extracted from hair samples: performance and agreement with genotyping results from genomic DNA from buccal cells
    Ilir Agalliu
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Clin Chem Lab Med 47:516-22. 2009
    ....
  27. doi request reprint Genetic variants in TAP are associated with high-grade cervical neoplasia
    Mark H Einstein
    Albert Einstein College of Medicine, Bronx, New York, USA
    Clin Cancer Res 15:1019-23. 2009
    ..Consistent with heterogeneity in MHC expression is the individual variability in clearing detectable HPV infections. Genetic polymorphisms in TAP genes may affect protein structure, function, and the ability to clear HPV infection...
  28. pmc Low-level expression of microRNAs let-7d and miR-205 are prognostic markers of head and neck squamous cell carcinoma
    Geoffrey Childs
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Am J Pathol 174:736-45. 2009
    ....
  29. pmc Insulin, insulin-like growth factor-I, and risk of breast cancer in postmenopausal women
    Marc J Gunter
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, New York, NY 10461, USA
    J Natl Cancer Inst 101:48-60. 2009
    ..However, no prospective studies have directly assessed associations between circulating levels of insulin and/or insulin-like growth factor (IGF)-I, a related hormone, and the risk of breast cancer independent of estrogen level...
  30. doi request reprint Genomic characterization of two novel reptilian papillomaviruses, Chelonia mydas papillomavirus 1 and Caretta caretta papillomavirus 1
    Lawrence H Herbst
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Virology 383:131-5. 2009
    ..Rates of evolution among the non-mammalian PVs were generally slower than those estimated for mammalian PVs, perhaps due to lower metabolic rates among the ectothermic reptiles...
  31. pmc A prospective evaluation of insulin and insulin-like growth factor-I as risk factors for endometrial cancer
    Marc J Gunter
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA
    Cancer Epidemiol Biomarkers Prev 17:921-9. 2008
    ..Free IGF-I levels were inversely associated with endometrioid adenocarcinoma, consistent with prior cross-sectional data...
  32. pmc Insulin, insulin-like growth factor-I, endogenous estradiol, and risk of colorectal cancer in postmenopausal women
    Marc J Gunter
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 68:329-37. 2008
    ....
  33. ncbi request reprint Whole genome amplification of DNA extracted from hair samples: potential for use in molecular epidemiologic studies
    Suzanne M Leanza
    Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Ullmann Building, Room 503, 1300 Morris Park Avenue, Bronx, NY 10461, United States
    Cancer Detect Prev 31:480-8. 2007
    ..Therefore, we assessed the feasibility of using whole genome amplification (WGA) on genomic DNA extracted from archived human hairs (stored for 7 to 11 years) to increase the quantity of DNA available for genotyping analysis...
  34. pmc Marginal and mixed-effects models in the analysis of human papillomavirus natural history data
    Xiaonan Xue
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Belfer 1308, Bronx, NY 10461, USA
    Cancer Epidemiol Biomarkers Prev 19:159-69. 2010
    ..Overall, the results show that marginal and mixed-effects models are efficient for studying HPV natural history, but also highlight the importance of understanding how these models differ...
  35. pmc Contribution of HPC1 (RNASEL) and HPCX variants to prostate cancer in a founder population
    Ilir Agalliu
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Prostate 70:1716-27. 2010
    ..The RNASEL gene and HPCX locus have been implicated in hereditary prostate cancer; however, their contributions to sporadic forms of this malignancy remain uncertain...
  36. pmc Genomic diversity and interspecies host infection of alpha12 Macaca fascicularis papillomaviruses (MfPVs)
    Zigui Chen
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Virology 393:304-10. 2009
    ..Moreover, identification of an overlapping set of MfPVs in rhesus and cynomolgus macaques indicates that non-human primate alpha-PVs might not be strictly species-specific and may represent past interspecies infection...
  37. ncbi request reprint Variability of serum levels of tumor necrosis factor-alpha, interleukin 6, and soluble interleukin 6 receptor over 2 years in young women
    Gloria Y F Ho
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Cytokine 30:1-6. 2005
    ..The ICC of 0.36 (95% CI=0.10-0.47) for sIL-6R was relatively low, and multiple samples would need to be collected in prospective studies for this receptor...
  38. ncbi request reprint Natural history of human papillomavirus type 16 virus-like particle antibodies in young women
    Gloria Y F Ho
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA
    Cancer Epidemiol Biomarkers Prev 13:110-6. 2004
    ..4 for IgA). The median duration for both types of antibodies was approximately 36 months. Antibodies could persist for a long period of time if the initial antibody levels were high or if there was continued antigenic exposure...
  39. ncbi request reprint Identification and characterization of 3 novel genital human papillomaviruses by overlapping polymerase chain reaction: candHPV89, candHPV90, and candHPV91
    Masanori Terai
    Department of Microbiology and Immunology, Comprehensive Cancer Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Infect Dis 185:1794-7. 2002
    ..On the basis of phylogenetic analyses and available clinical data, these 3 novel HPV genomes appear to have a low oncogenic risk and expand the heterogeneity of HPVs detected in the lower genital tract...
  40. ncbi request reprint Toward a reduction of the global burden of cervical cancer
    Thomas E Rohan
    Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10461, USA
    Am J Obstet Gynecol 189:S37-9. 2003
    ....
  41. ncbi request reprint Regression of cervical intraepithelial neoplasia and loss of human papillomavirus (HPV) infection is associated with cell-mediated immune responses to an HPV type 16 E7 peptide
    Anna S Kadish
    Department of Pathology, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, USA
    Cancer Epidemiol Biomarkers Prev 11:483-8. 2002
    ....
  42. ncbi request reprint Risk factors for subsequent cervicovaginal human papillomavirus (HPV) infection and the protective role of antibodies to HPV-16 virus-like particles
    Gloria Y F Ho
    Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, Bronx, New York, USA
    J Infect Dis 186:737-42. 2002
    ..A sustained high level of IgG antibody to HPV-16 VLPs was associated with reduced risk for subsequent infection with HPV-16 and its genetically related types (i.e., HPV-31, -33, -35, -52, and -58)...
  43. ncbi request reprint Felis domesticus papillomavirus, isolated from a skin lesion, is related to canine oral papillomavirus and contains a 1.3 kb non-coding region between the E2 and L2 open reading frames
    Masanori Terai
    Department of Microbiology and Immunology, Comprehensive Cancer Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Gen Virol 83:2303-7. 2002
    ..3 kbp NCR was located between the end of E2 and the beginning of L2. Phylogenetic analysis placed FdPV in the E3 clade with COPV. Both viruses contain the atypical second NCR, which has no homology with sequences in existing databases...
  44. pmc Enhanced enzyme-linked immunosorbent assay for detection of antibodies to virus-like particles of human papillomavirus
    Yevgeniy Y Studentsov
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Clin Microbiol 40:1755-60. 2002
    ..It is anticipated that the enhanced ELISA conditions will have wide application to a large number of clinical diagnostic assays...
  45. ncbi request reprint Human papillomavirus type 16 and immune status in human immunodeficiency virus-seropositive women
    Howard D Strickler
    Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Natl Cancer Inst 95:1062-71. 2003
    ..To address this issue, we examined HPV test results from repeated study visits in the WIHS and from an independent study, the HIV Epidemiology Research Study (HERS)...
  46. ncbi request reprint Codetection of a mixed population of candHPV62 containing wild-type and disrupted E1 open-reading frame in a 45-year-old woman with normal cytology
    Leiping Fu
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, New York 10461, USA
    J Infect Dis 190:1303-9. 2004
    ..A search of the HPV database identified disruption of the E1 ORF in the cloned reference isolates of HPV16, HPV53, HPV56, and HPV72. These data suggest that disruption of the E1 ORF in genital HPVs is not uncommon...
  47. pmc Evolution of human papillomavirus carcinogenicity
    Koenraad Van Doorslaer
    Department of Microbiology and Immunology, Albert Einstein Cancer Center, Albert Einstein College of Medicine, New York, USA
    Adv Virus Res 77:41-62. 2010
    ..We continue by interpreting some recent results using this paradigm and end by suggesting directions for future inquiries...
  48. ncbi request reprint Stage of change behavioral assessment tool fails to predict the prevalence of chlamydia in an urban adolescent health clinic
    Andrea R Kasowitz
    Department of Pediatrics, Mount Sinai School of Medicine, New York City, NY 10029, USA
    J Pediatr Adolesc Gynecol 19:277-83. 2006
    ..Thus, the Stage of Change Transtheoretical Model has been advocated. This study was conducted to determine whether staging could be accomplished in an urban adolescent clinic and whether it provides a tool to predict STI risk...
  49. ncbi request reprint Utilization of the human genome sequence localizes human papillomavirus type 16 DNA integrated into the TNFAIP2 gene in a fatal cervical cancer from a 39-year-old woman
    Mark H Einstein
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology and Women s Health, Albert Einstein College of Medicine Montefiore Medical Center, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Clin Cancer Res 8:549-54. 2002
    ..The purpose of our study was to characterize a human papillomavirus (HPV) 16 DNA integration in the genome of a rapidly progressive, lethal cervical cancer in a 39-year-old woman...
  50. pmc In vitro inhibition of human papillomavirus following use of a carrageenan-containing vaginal gel
    Akiva P Novetsky
    Department of Obstetrics and Gynecology and Women s Health, Montefiore Medical Center and Albert Einstein College of Medicine, 1695 Eastchester Road, Suite 601, Bronx, NY 10461, USA Electronic address
    Gynecol Oncol 143:313-318. 2016
    ..To assess in vitro efficacy of Divine 9, a carrageenan-based vaginal lubricant that is being studied as a microbicide to inhibit HPV16 pseudovirus (PsV) infection...
  51. ncbi request reprint Relationship between smoking and human papillomavirus infections in HIV-infected and -uninfected women
    Howard Minkoff
    Department of Obstetrics and Gynecology, Maimonides Medical Center, Brooklyn, New York, USA
    J Infect Dis 189:1821-8. 2004
    ..Among HIV-infected women, smoking is associated with a significantly higher prevalence and incidence of HPV infection. Smoking during HIV infection may alter the natural history of HPV infection and increase the risk of cervical disease...
  52. ncbi request reprint Role of family history and ethnicity on the mode and age of prostate cancer presentation
    Michael P Cotter
    Albert Einstein College of Medicine, Bronx, New York 10461 1602, USA
    Prostate 50:216-21. 2002
    ..This study was conducted to investigate the role of family history of prostate cancer and ethnic variation on age at diagnosis and the mode of prostate cancer presentation among a multiracial cohort of men in the Bronx and on Long Island...
  53. pmc Lack of canonical E6 and E7 open reading frames in bird papillomaviruses: Fringilla coelebs papillomavirus and Psittacus erithacus timneh papillomavirus
    Masanori Terai
    Department of Microbiology and Immunology, Comprehensive Cancer Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Virol 76:10020-3. 2002
    ..The lack of canonical E6-E7 open reading frames suggests that they serve adaptive functions during papillomavirus evolution...
  54. pmc Evolutionary dynamics of variant genomes of human papillomavirus types 18, 45, and 97
    Zigui Chen
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA
    J Virol 83:1443-55. 2009
    ....
  55. doi request reprint Evidence for a distinct gut microbiome in kidney stone formers compared to non-stone formers
    Joshua M Stern
    Department of Urology, Albert Einstein College of Medicine, Montefiore Medical Center, Greene Medical Arts Pavilion, 5th Floor, 3400 Bainbridge Avenue, Bronx, NY, 10467, USA
    Urolithiasis 44:399-407. 2016
    ..These preliminary studies for the first time associate differences in the GMB with kidney stone formation. Further studies are warranted to evaluate the potential causative role of preexisting dysbiosis in kidney stone disease. ..
  56. pmc Evolutionary and biophysical relationships among the papillomavirus E2 proteins
    Dukagjin M Blakaj
    Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx NY 10461, USA
    Front Biosci (Landmark Ed) 14:900-17. 2009
    ..Rather, regions of high conservation are localized to small surface patches. Implications to cancer biology are discussed...
  57. pmc Treating cancer as an infectious disease--viral antigens as novel targets for treatment and potential prevention of tumors of viral etiology
    Xing Guo Wang
    Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 2:e1114. 2007
    ..There is an urgent need to find new approaches to treatment and prevention of virus-associated cancers...
  58. pmc Associations of high-grade prostate cancer with BRCA1 and BRCA2 founder mutations
    Ilir Agalliu
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Clin Cancer Res 15:1112-20. 2009
    ..However, there is still uncertainty about the magnitude of association particularly with Gleason score, and family history of prostate, breast, and ovary cancers...
  59. pmc A recessive gene for primary vesicoureteral reflux maps to chromosome 12p11-q13
    Patricia L Weng
    Department of Medicine, Division of Nephrology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Am Soc Nephrol 20:1633-40. 2009
    ..In conclusion, this study identifies a major new locus for pVUR and suggests that in addition to genetic heterogeneity, recessive contributions should be considered in all pVUR genome scans...
  60. ncbi request reprint Papillomavirus vaccines in perspective
    Jessica A Kahn
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH 45215, USA
    Lancet 369:2135-7. 2007
  61. ncbi request reprint Serum immunoglobulin G response to human papillomavirus type 16 virus-like particles in human immunodeficiency virus (HIV)-positive and risk-matched HIV-negative women
    Raphael P Viscidi
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Infect Dis 187:194-205. 2003
    ..Despite the higher prevalence of HPV infection in this group, most HIV-positive women are able to control HPV-16 replication at the cervix, and reactivation, if it occurs, is not very common...
  62. ncbi request reprint Restricted cross-reactivity of hybrid capture 2 with nononcogenic human papillomavirus types
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer Epidemiol Biomarkers Prev 11:1394-9. 2002
    ....
  63. ncbi request reprint Comparisons of HPV DNA detection by MY09/11 PCR methods
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    J Med Virol 68:417-23. 2002
    ..Our data also suggest that studies reporting HPV DNA detection by PCR need to report the type of polymerase used, as well as other assay specifics, and underscore the need for worldwide standards of testing...
  64. ncbi request reprint Sexual behavior, human papillomavirus type 16 (HPV 16) infection, and HPV 16 seropositivity
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    Sex Transm Dis 29:182-7. 2002
    ..Sexual behaviors have been linked to seropositivity for human papillomavirus (HPV) but not with the magnitude of the seroreactivity...
  65. doi request reprint HPV types present in invasive cervical cancers of HIV-seropositive women
    Howard D Strickler
    Int J Cancer 123:1224-5. 2008
  66. ncbi request reprint Human leukocyte antigen class I alleles and cervical neoplasia: no heterozygote advantage
    Sophia S Wang
    Interdisciplinary Studies Section, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer Epidemiol Biomarkers Prev 11:419-20. 2002
  67. ncbi request reprint Low prevalence of HPV infection and its natural history in normal oral mucosa among volunteers on Miyako Island, Japan
    Kazuyo Kurose
    Department of Oral Restitution, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8549, Japan
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 98:91-6. 2004
    ..To investigate the prevalence of human papillomavirus (HPV) infection in normal oral mucosa, and to observe the natural history in the oral cavity in oral swab samples collected from healthy volunteers on Miyako Island, Okinawa, Japan...
  68. ncbi request reprint Comprehensive analysis of human leukocyte antigen class I alleles and cervical neoplasia in 3 epidemiologic studies
    Sophia S Wang
    Interdisciplinary Studies Section, Division of Cancer Epidemiology and Genetics, Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892 7234, USA
    J Infect Dis 186:598-605. 2002
    ..Given the relationship between HLA-C and its receptors on natural killer (NK) cells, a role is proposed for NK function in human papillomavirus infection and cervical neoplasia...
  69. ncbi request reprint The impact of HIV infection and immunodeficiency on human papillomavirus type 6 or 11 infection and on genital warts
    Michael J Silverberg
    Johns Hopkins School of Public Health, Baltimore, Maryland 21205, USA
    Sex Transm Dis 29:427-35. 2002
    ..HIV infection and associated immunodeficiency are known to alter the course of human papillomavirus (HPV) infections and of associated diseases...
  70. ncbi request reprint A comparison between real-time polymerase chain reaction and hybrid capture 2 for human papillomavirus DNA quantitation
    Patti E Gravitt
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer Epidemiol Biomarkers Prev 12:477-84. 2003
    ..The nonrandom distribution of multiple infections by case-control status and the apparent differential effect of viral load by genotype warrant caution when using HC 2 measurements to infer viral load associations with SIL and cancer...
  71. ncbi request reprint Chlamydia trachomatis, herpes simplex virus 2, and human T-cell lymphotrophic virus type 1 are not associated with grade of cervical neoplasia in Jamaican colposcopy patients
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    Sex Transm Dis 30:575-80. 2003
    ..A few recent studies have suggested that other sexually transmitted infections may increase the likelihood of a human papillomavirus (HPV) infection progressing to high-grade cervical neoplasia and cancer...
  72. ncbi request reprint Relationships of human papillomavirus type, qualitative viral load, and age with cytologic abnormality
    Melinda Butsch Kovacic
    Division of Cancer Epidemiology and Genetics and Cancer Prevention Fellowship Program, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 66:10112-9. 2006
    ..The lack of evident severe abnormalities associated with HPV18 and related HPV types might have implications for screening for poorly detected glandular and alpha7-related lesions...
  73. ncbi request reprint Seroreactivity to human papillomavirus (HPV) types 16, 18, or 31 and risk of subsequent HPV infection: results from a population-based study in Costa Rica
    Raphael P Viscidi
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Cancer Epidemiol Biomarkers Prev 13:324-7. 2004
    ..3; 95% CI 1.0-1.8). Thus, we did not observe immunity, although a protective effect from natural infection cannot be excluded because of the limits of available assays and study designs...
  74. ncbi request reprint Description of a seven-year prospective study of human papillomavirus infection and cervical neoplasia among 10000 women in Guanacaste, Costa Rica,
    M Concepcion Bratti
    FUCODOCSA Costa Rican Foundation for Training in Health Sciences, Proyecto Epidemiologico Guanacaste, San Jose, Costa Rica
    Rev Panam Salud Publica 15:75-89. 2004
    ..The purpose of this article is to describe this prospective study in detail and to present the preliminary findings regarding the incidence of cervical neoplasia...
  75. ncbi request reprint Age-related changes of the cervix influence human papillomavirus type distribution
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NIH, 6120 Executive Boulevard, Bethesda, MD 20892 7234, USA
    Cancer Res 66:1218-24. 2006
    ..These patterns need to be confirmed in other studies and populations. We suggest that these genetically distinct groups of HPV types may differ in tissue preferences, which may contribute to their differences in carcinogenic potential...
  76. ncbi request reprint A population-based study of vaginal human papillomavirus infection in hysterectomized women
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 7234, USA
    J Infect Dis 190:458-67. 2004
    ..e., A3/A4/A15) may have a predilection for vaginal epithelium...
  77. ncbi request reprint Highly active antiretroviral therapy and cervical squamous intraepithelial lesions in human immunodeficiency virus-positive women
    Linda Ahdieh-Grant
    Johns Hopkins Bloomberg School of Public Health, Department of Epidemiology, Rm E 7014, Baltimore, MD 21205, USA
    J Natl Cancer Inst 96:1070-6. 2004
    ..We assessed the association between use of highly active antiretroviral therapy (HAART) and regression of SIL in HIV-infected women enrolled in the Women's Interagency HIV Study, a large, multicenter, prospective cohort study...
  78. ncbi request reprint A prospective study of age trends in cervical human papillomavirus acquisition and persistence in Guanacaste, Costa Rica
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 7234, USA
    J Infect Dis 191:1808-16. 2005
    ..In some populations, HPV prevalence demonstrates a second peak in older women. Longitudinal data may help to explain this second peak...
  79. ncbi request reprint Validation of p16INK4a as a marker of oncogenic human papillomavirus infection in cervical biopsies from a population-based cohort in Costa Rica
    Sophia S Wang
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS MSC 7234, Bethesda, MD 20892 7234, USA
    Cancer Epidemiol Biomarkers Prev 13:1355-60. 2004
    ..Whereas our data support the diagnostic potential for p16INK4a, further prospective studies with detailed follow-up determining the prognostic capacity of this marker are needed...
  80. ncbi request reprint Family history as a co-factor for adenocarcinoma and squamous cell carcinoma of the uterine cervix: results from two studies conducted in Costa Rica and the United States
    Alice de M Zelmanowicz
    Programa de Pós Graduação em Epidemiologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Int J Cancer 116:599-605. 2005
    ..These results are consistent with a role of host factors in the pathogenesis of squamous cell cervical cancer, although familial aggregation due to shared environmental exposures cannot be ruled out...
  81. ncbi request reprint Persistent human papillomavirus infection is associated with a generalized decrease in immune responsiveness in older women
    Alfonso J Garcia-Pineres
    HPV Immunology Laboratory, Science Applications International Corporation Frederick, Inc National Cancer Institute Frederick, Frederick, Maryland, USA
    Cancer Res 66:11070-6. 2006
    ..Our results indicate that an impairment in host immunologic responses is associated to persistent HPV infection. The fact that effects were evident for all studied stimuli is suggestive of a generalized effect...
  82. ncbi request reprint Human papillomavirus prevalence in women who have and have not undergone hysterectomies
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
    J Infect Dis 194:1702-5. 2006
    ..5% for WH) between the 2 groups of women. Although WH have a similar prevalence of carcinogenic HPV infection, compared with WNH without a cervix, they have minimal risk of HPV-induced cancer and are unlikely to benefit from HPV testing...
  83. ncbi request reprint Serum immunoglobulin A response to human papillomavirus type 16 virus-like particles in human immunodeficiency virus (HIV)-positive and high-risk HIV-negative women
    Raphael P Viscidi
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Infect Dis 188:1834-44. 2003
    ..9-5.4]), but there was no difference in the risk of incident HPV 16 or HPV 16-related infections. This may be evidence of partial type-specific or clade-specific immunity conferred by seropositivity to HPV 16 capsids...
  84. ncbi request reprint CIN2 is a much less reproducible and less valid diagnosis than CIN3: results from a histological review of population-based cervical samples
    Joseph D Carreon
    Division of Cancer Epidemiology and Genetics, The National Cancer Institute, National Institutes of Health, Department of Health and Human Services Rockville, Maryland 20852, USA
    Int J Gynecol Pathol 26:441-6. 2007
    ..The CIN3 is a substantially more reproducible diagnosis that can be validated more frequently with HPV tests and cytological interpretations than CIN2...
  85. pmc High load for most high risk human papillomavirus genotypes is associated with prevalent cervical cancer precursors but only HPV16 load predicts the development of incident disease
    Patti E Gravitt
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Int J Cancer 121:2787-93. 2007
    ..The extent to which these observations can be translated into clinical practice must be rigorously examined in the context of the method of viral load measurement and the type-specific differences observed for incident >/=CIN2...
  86. pmc Human papillomavirus (HPV) genotyping using paired exfoliated cervicovaginal cells and paraffin-embedded tissues to highlight difficulties in attributing HPV types to specific lesions
    Patti E Gravitt
    Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Room E6535, Baltimore, MD 21205, USA
    J Clin Microbiol 45:3245-50. 2007
    ....
  87. pmc A comparison of cervical and vaginal human papillomavirus
    Philip E Castle
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892 7234, USA
    Sex Transm Dis 34:849-55. 2007
    ..Previous studies have failed to present data on or detect a broad spectrum of HPV genotypes and/or have not carefully sampled the vagina, instead relying on self-collection that is likely contaminated with cervical cells...
  88. ncbi request reprint A comparison of single and combined visual, cytologic, and virologic tests as screening strategies in a region at high risk of cervical cancer
    Catterina Ferreccio
    Departamento de Salud Publica, Universidad Catolica de Chile, Santiago, Chile
    Cancer Epidemiol Biomarkers Prev 12:815-23. 2003
    ..Overall, we conclude that highly accurate screening for cervical cancer and CIN 3 is now technically feasible. The remaining vital issue is to extend improved cervical cancer prevention programs to resource-poor regions...
  89. ncbi request reprint A prospective pilot study of antibodies against human papillomaviruses and cutaneous squamous cell carcinoma nested in the Oxford component of the European Prospective Investigation into Cancer and Nutrition
    Delphine Casabonne
    Cancer Epidemiology Unit, Richard Doll Building, University of Oxford, Old Road Campus, Roosevelt Drive, Headington, Oxford, OX3 7LF, United Kingdom
    Int J Cancer 121:1862-8. 2007
    ..Further and larger prospective studies are needed to clarify the role of HPV in the aetiology of cutaneous SCC...
  90. pmc Serological detection of human papillomavirus type 16 infection in human immunodeficiency virus (HIV)-positive and high-risk HIV-negative women
    Michael J Silverberg
    Department of Epidemiology, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, Maryland, USA
    Clin Vaccine Immunol 13:511-9. 2006
    ..Rises among HIV-positive women may more often result from reactivation of a latent HPV infection in the context of HIV-induced immunosuppression, while rises among HIV-negative women may more often result from reinfection with HPV...
  91. pmc Characterization and experimental transmission of an oncogenic papillomavirus in female macaques
    Charles E Wood
    Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1040, USA
    J Virol 81:6339-45. 2007
    ..These findings identify key similarities between macaque and human oncogenic PVs which should prove useful in the study of viral persistence, carcinogenesis, and therapeutic development...
  92. ncbi request reprint Mediators of the association between age of first sexual intercourse and subsequent human papillomavirus infection
    Jessica A Kahn
    Division of Adolescent Medicine, Children s Hospital Medical Center, Cincinnati, Ohio Division of Psychology, University of Texas at Galveston, Galveston, Texas, USA
    Pediatrics 109:E5. 2002
    ..The objective of this study was to identify a set of risk behaviors and partner characteristics that mediate the association between age of first sexual intercourse and subsequent HPV infection in adolescent and young adult women...
  93. ncbi request reprint A case-control study of risk factors for invasive cervical cancer among U.S. women exposed to oncogenic types of human papillomavirus
    Tammy S Shields
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, 6120 Executive Boulevard, MSC 7234, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 13:1574-82. 2004
    ..It is particularly worth considering further why studies of different designs are inconsistent regarding the effect of oral contraceptive use...

Research Grants3

  1. PERSISTENT HPV IN WOMEN AT RISK FOR CERVIX CANCER
    Robert Burk; Fiscal Year: 2002
    ....
  2. NATURAL HISTORY OF ACUTE HPV INFECTION
    Robert Burk; Fiscal Year: 2001
    ..This will standardize the confirmation epitopes per unit protein so that equivalent amounts of functional antigens are used for each assay. Standardization of the VLP ELISA assay will be performed using validated serum panels. ..
  3. Functional Analysis of the VHL Tumor Suppressor Gene
    Robert Burk; Fiscal Year: 2006
    ....