Vivian O'Donnell

Summary

Affiliation: Agricultural Research Service
Country: USA

Publications

  1. pmc Heparan sulfate-binding foot-and-mouth disease virus enters cells via caveola-mediated endocytosis
    Vivian O'Donnell
    USDA, ARS, Plum Island Animal Disease Center, P O Box 848, Greenport, NY 11944 0848, USA
    J Virol 82:9075-85. 2008
  2. doi request reprint Analysis of foot-and-mouth disease virus integrin receptor expression in tissues from naïve and infected cattle
    V O'DONNELL
    United States Department of Agriculture, Agricultural Research Service, Plum Island Animal Disease Center, Greenport, NY, USA
    J Comp Pathol 141:98-112. 2009
  3. doi request reprint Foot-and-mouth disease virus utilizes an autophagic pathway during viral replication
    Vivian O'Donnell
    Foreign Animal Disease Research Unit, United States Department of Agriculture, Agricultural Research Service, Plum Island Animal Disease Center, Greenport, NY 11944, USA
    Virology 410:142-50. 2011
  4. doi request reprint African swine fever virus Georgia isolate harboring deletions of 9GL and MGF360/505 genes is highly attenuated in swine but does not confer protection against parental virus challenge
    Vivian O'Donnell
    Agricultural Research Service, Plum Island Animal Disease Center, Greenport, NY 11944, USA Department of Pathobiology and Veterinary Science, University of Connecticut, Storrs, CT 06269, USA
    Virus Res 221:8-14. 2016
  5. doi request reprint Recoding structural glycoprotein E2 in classical swine fever virus (CSFV) produces complete virus attenuation in swine and protects infected animals against disease
    Lauro Velazquez-Salinas
    Plum Island Animal Disease Center, ARS, USDA, Greenport, NY 11944, USA Electronic address
    Virology 494:178-89. 2016
  6. doi request reprint The Ep152R ORF of African swine fever virus strain Georgia encodes for an essential gene that interacts with host protein BAG6
    Manuel V Borca
    Agricultural Research Service and Department of Homeland Security, Plum Island Animal Disease Center, Greenport, NY 11944, USA
    Virus Res 223:181-9. 2016
  7. pmc African Swine Fever Virus Georgia Isolate Harboring Deletions of MGF360 and MGF505 Genes Is Attenuated in Swine and Confers Protection against Challenge with Virulent Parental Virus
    Vivian O'Donnell
    Agricultural Research Service, USDA, Plum Island Animal Disease Center, Greenport, New York, USA Department of Pathobiology and Veterinary Science, CAHNR, University of Connecticut, Storrs, Connecticut, USA
    J Virol 89:6048-56. 2015
  8. pmc Association of the Host Immune Response with Protection Using a Live Attenuated African Swine Fever Virus Model
    Jolene Carlson
    Agricultural Research Service, U S Department of Agriculture, Plum Island Animal Disease Center, Greenport, NY 11944, USA
    Viruses 8:. 2016
  9. pmc African Swine Fever Virus Georgia 2007 with a Deletion of Virulence-Associated Gene 9GL (B119L), when Administered at Low Doses, Leads to Virus Attenuation in Swine and Induces an Effective Protection against Homologous Challenge
    Vivian O'Donnell
    Agricultural Research Service, U S Department of Agriculture, Plum Island Animal Disease Center, Greenport, New York, USA Department of Pathobiology and Veterinary Science, CAHNR, University of Connecticut, Storrs, Connecticut, USA
    J Virol 89:8556-66. 2015
  10. pmc Simultaneous deletion of the 9GL and UK genes from the African swine fever virus Georgia 2007 isolate offers increased safety and protection against homologous challenge
    Vivian O'Donnell
    Agricultural Research Service, U S Department of Agriculture, Plum Island Animal Disease Center, Greenport, NY 11944, USA
    J Virol . 2016

Collaborators

Detail Information

Publications16

  1. pmc Heparan sulfate-binding foot-and-mouth disease virus enters cells via caveola-mediated endocytosis
    Vivian O'Donnell
    USDA, ARS, Plum Island Animal Disease Center, P O Box 848, Greenport, NY 11944 0848, USA
    J Virol 82:9075-85. 2008
    ..In addition, these results further suggest that the route of FMDV entry into cells is a function solely of the viral receptor...
  2. doi request reprint Analysis of foot-and-mouth disease virus integrin receptor expression in tissues from naïve and infected cattle
    V O'DONNELL
    United States Department of Agriculture, Agricultural Research Service, Plum Island Animal Disease Center, Greenport, NY, USA
    J Comp Pathol 141:98-112. 2009
    ..Thus, at the cellular level the expression of these two integrins correlates with susceptibility to infection and may contribute substantially to viral tropism in FMD pathogenesis...
  3. doi request reprint Foot-and-mouth disease virus utilizes an autophagic pathway during viral replication
    Vivian O'Donnell
    Foreign Animal Disease Research Unit, United States Department of Agriculture, Agricultural Research Service, Plum Island Animal Disease Center, Greenport, NY 11944, USA
    Virology 410:142-50. 2011
    ..Altogether, these studies strongly suggest that autophagy may play an important role during the replication of FMDV...
  4. doi request reprint African swine fever virus Georgia isolate harboring deletions of 9GL and MGF360/505 genes is highly attenuated in swine but does not confer protection against parental virus challenge
    Vivian O'Donnell
    Agricultural Research Service, Plum Island Animal Disease Center, Greenport, NY 11944, USA Department of Pathobiology and Veterinary Science, University of Connecticut, Storrs, CT 06269, USA
    Virus Res 221:8-14. 2016
    ..Results presented here suggest caution towards approaches involving genomic manipulations when developing rationally designed ASFV vaccine strains. ..
  5. doi request reprint Recoding structural glycoprotein E2 in classical swine fever virus (CSFV) produces complete virus attenuation in swine and protects infected animals against disease
    Lauro Velazquez-Salinas
    Plum Island Animal Disease Center, ARS, USDA, Greenport, NY 11944, USA Electronic address
    Virology 494:178-89. 2016
    ..This is the first report describing the development of an attenuated CSFV experimental vaccine by codon usage de-optimization, and one of the few examples of virus attenuation using this methodology that is assessed in a natural host. ..
  6. doi request reprint The Ep152R ORF of African swine fever virus strain Georgia encodes for an essential gene that interacts with host protein BAG6
    Manuel V Borca
    Agricultural Research Service and Department of Homeland Security, Plum Island Animal Disease Center, Greenport, NY 11944, USA
    Virus Res 223:181-9. 2016
    ..Furthermore, fluorescent microscopy analysis confirms that Ep152R-BAG6 interaction actually occurs in cells infected with ASFV. ..
  7. pmc African Swine Fever Virus Georgia Isolate Harboring Deletions of MGF360 and MGF505 Genes Is Attenuated in Swine and Confers Protection against Challenge with Virulent Parental Virus
    Vivian O'Donnell
    Agricultural Research Service, USDA, Plum Island Animal Disease Center, Greenport, New York, USA Department of Pathobiology and Veterinary Science, CAHNR, University of Connecticut, Storrs, Connecticut, USA
    J Virol 89:6048-56. 2015
    ..Additionally, ASFV-G-ΔMGF is the first experimental vaccine reported to induce protection in pigs challenged with highly virulent and epidemiologically relevant ASFV-G...
  8. pmc Association of the Host Immune Response with Protection Using a Live Attenuated African Swine Fever Virus Model
    Jolene Carlson
    Agricultural Research Service, U S Department of Agriculture, Plum Island Animal Disease Center, Greenport, NY 11944, USA
    Viruses 8:. 2016
    ..These results, encompassing data from 65 immunized swine, underscore the complexity of the system under study, suggesting that protection relies on the concurrence of different host immune mechanisms...
  9. pmc African Swine Fever Virus Georgia 2007 with a Deletion of Virulence-Associated Gene 9GL (B119L), when Administered at Low Doses, Leads to Virus Attenuation in Swine and Induces an Effective Protection against Homologous Challenge
    Vivian O'Donnell
    Agricultural Research Service, U S Department of Agriculture, Plum Island Animal Disease Center, Greenport, New York, USA Department of Pathobiology and Veterinary Science, CAHNR, University of Connecticut, Storrs, Connecticut, USA
    J Virol 89:8556-66. 2015
    ..An ASFV-G-Δ9GL HAD50 of 10(3) conferred partial and complete protection at 21 and 28 dpi, respectively. The information provided here adds to our recent report on the first attempts toward experimental vaccines against ASFV-G...
  10. pmc Simultaneous deletion of the 9GL and UK genes from the African swine fever virus Georgia 2007 isolate offers increased safety and protection against homologous challenge
    Vivian O'Donnell
    Agricultural Research Service, U S Department of Agriculture, Plum Island Animal Disease Center, Greenport, NY 11944, USA
    J Virol . 2016
    ..ASFV-G-Δ9GL/ΔUK is the first rationally designed experimental ASFV vaccine that protects against the highly virulent ASFV Georgia 2007 isolate as soon as 2 weeks post-vaccination...
  11. pmc The progressive adaptation of a georgian isolate of African swine fever virus to vero cells leads to a gradual attenuation of virulence in swine corresponding to major modifications of the viral genome
    Peter W Krug
    Agricultural Research Service, U S Department of Agriculture, Plum Island Animal Disease Center, Greenport, New York, USA
    J Virol 89:2324-32. 2015
    ..Mutations that result in amino acid substitutions and frameshift mutations were also observed, though in a rather limited number of genes. The potential importance of these genetic changes in virus adaptation/attenuation is discussed...
  12. doi request reprint Patterns of gene expression in swine macrophages infected with classical swine fever virus detected by microarray
    Douglas P Gladue
    Plum Island Animal Disease Center, Agricultural Research Service, US Department of Agriculture, Greenport, NY 11944, United States
    Virus Res 151:10-8. 2010
    ..VGIv, suggesting that some of these differences are responsible for virulence. The observed gene expression profile might help to explain the immunological and pathological changes associated with infection of pigs with CSFV Brescia...
  13. pmc Persistent Foot-and-Mouth Disease Virus Infection in the Nasopharynx of Cattle; Tissue-Specific Distribution and Local Cytokine Expression
    Juan M Pacheco
    Plum Island Animal Disease Center, Foreign Animal Disease Research Unit, Agricultural Research Service, United States Department of Agriculture, Plum Island, NY, United States of America
    PLoS ONE 10:e0125698. 2015
    ....
  14. pmc Interaction of CSFV E2 protein with swine host factors as detected by yeast two-hybrid system
    Douglas P Gladue
    Plum Island Animal Disease Center, Agriculture Research Service, United States Department of Agriculture, Greenport, New York, United States of America Department of Pathobiology and Veterinary Science, University of Connecticut, Storrs, Connecticut, United States of America
    PLoS ONE 9:e85324. 2014
    ....
  15. doi request reprint Pathogenesis of highly virulent African swine fever virus in domestic pigs exposed via intraoropharyngeal, intranasopharyngeal, and intramuscular inoculation, and by direct contact with infected pigs
    Erin B Howey
    Plum Island Animal Disease Center, Foreign Animal Disease Research Unit, Agricultural Research Service, United States Department of Agriculture, Greenport, NY 11944, USA Oak Ridge Institute for Science and Education, PIADC Research Participation Program, Oak Ridge, TN 37831, USA Electronic address
    Virus Res 178:328-39. 2013
    ....
  16. doi request reprint A partial deletion in non-structural protein 3A can attenuate foot-and-mouth disease virus in cattle
    Juan M Pacheco
    Agricultural Research Service, U S Department of Agriculture, Plum Island Animal Disease Center, Greenport, NY, USA
    Virology 446:260-7. 2013
    ..We describe a direct link between a deletion in the FMDV 3A protein and disease attenuation in cattle. ..