Michael P Heaton

Summary

Affiliation: Agricultural Research Service
Country: USA

Publications

  1. ncbi request reprint Use of bovine single nucleotide polymorphism markers to verify sample tracking in beef processing
    Michael P Heaton
    USDA, Agricultural Research Service, US Meat Animal Research Center, State Spur 18D, PO Box 166, Clay Center, NE 68933 0166, USA
    J Am Vet Med Assoc 226:1311-4. 2005
  2. pmc Complete Closed Genome Sequences of a Mannheimia haemolytica Serotype A1 Leukotoxin Deletion Mutant and Its Wild-Type Parent Strain
    Michael P Heaton
    Meat Animal Research Center USMARC, Clay Center, USDA, ARS, Clay Center, Nebraska, USA
    Genome Announc 3:. 2015
  3. pmc Genetic testing for TMEM154 mutations associated with lentivirus susceptibility in sheep
    Michael P Heaton
    U S Meat Animal Research Center USMARC, Clay Center, Nebraska, USA
    PLoS ONE 8:e55490. 2013
  4. pmc Reduced lentivirus susceptibility in sheep with TMEM154 mutations
    Michael P Heaton
    U S Meat Animal Research Center, Agriculture Research Service, United States Department of Agriculture, Clay Center, Nebraska, USA
    PLoS Genet 8:e1002467. 2012
  5. pmc Ovine reference materials and assays for prion genetic testing
    Michael P Heaton
    USDA, ARS, United States Meat Animal Research Center State Spur 18D, Clay Center, NE 68933, USA
    BMC Vet Res 6:23. 2010
  6. pmc Prevalence of the prion protein gene E211K variant in U.S. cattle
    Michael P Heaton
    USDA, ARS, U, S, Meat Animal Research Center USMARC, State Spur 18D, P O Box 166, Clay Center, NE 68933, USA
    BMC Vet Res 4:25. 2008
  7. ncbi request reprint Beta-2-microglobulin haplotypes in U.S. beef cattle and association with failure of passive transfer in newborn calves
    Michael L Clawson
    United States Department of Agriculture, Agricultural Research Service, U S Meat Animal Research Center MARC, Spur 18D, P O Box 166, Clay Center, Nebraska 68933, USA
    Mamm Genome 15:227-36. 2004
  8. pmc Prion gene haplotypes of U.S. cattle
    Michael L Clawson
    United States Department of Agriculture, Agricultural Research Service, U, S, Meat Animal Research Center, Clay Center, NE 68933, USA
    BMC Genet 7:51. 2006
  9. pmc Characterization of 954 bovine full-CDS cDNA sequences
    Gregory P Harhay
    USDA ARS U, S, Meat Animal Research Center, Clay Center, NE 68901, USA
    BMC Genomics 6:166. 2005
  10. ncbi request reprint Association of bovine neonatal Fc receptor alpha-chain gene (FCGRT) haplotypes with serum IgG concentration in newborn calves
    William W Laegreid
    United States Department of Agriculture, Agricultural Research Service, U S Meat Animal Research Center MARC, P O Box 166, State Spur 18D, Clay Center, Nebraska 68933, USA
    Mamm Genome 13:704-10. 2002

Detail Information

Publications23

  1. ncbi request reprint Use of bovine single nucleotide polymorphism markers to verify sample tracking in beef processing
    Michael P Heaton
    USDA, Agricultural Research Service, US Meat Animal Research Center, State Spur 18D, PO Box 166, Clay Center, NE 68933 0166, USA
    J Am Vet Med Assoc 226:1311-4. 2005
    ....
  2. pmc Complete Closed Genome Sequences of a Mannheimia haemolytica Serotype A1 Leukotoxin Deletion Mutant and Its Wild-Type Parent Strain
    Michael P Heaton
    Meat Animal Research Center USMARC, Clay Center, USDA, ARS, Clay Center, Nebraska, USA
    Genome Announc 3:. 2015
    ..We report the complete closed genome sequences of a leukotoxin mutant and its parent strain that are frequently used in respiratory disease studies. ..
  3. pmc Genetic testing for TMEM154 mutations associated with lentivirus susceptibility in sheep
    Michael P Heaton
    U S Meat Animal Research Center USMARC, Clay Center, Nebraska, USA
    PLoS ONE 8:e55490. 2013
    ..e., diplotypes). The widespread distribution of highly-susceptible TMEM154 alleles suggests that genetic testing and selection may improve the health and productivity of infected flocks...
  4. pmc Reduced lentivirus susceptibility in sheep with TMEM154 mutations
    Michael P Heaton
    U S Meat Animal Research Center, Agriculture Research Service, United States Department of Agriculture, Clay Center, Nebraska, USA
    PLoS Genet 8:e1002467. 2012
    ..Together, these findings indicate that TMEM154 may play a central role in ovine lentivirus infection and removing sheep with the most susceptible genotypes may help eradicate OPP and protect flocks from reinfection...
  5. pmc Ovine reference materials and assays for prion genetic testing
    Michael P Heaton
    USDA, ARS, United States Meat Animal Research Center State Spur 18D, Clay Center, NE 68933, USA
    BMC Vet Res 6:23. 2010
    ..Thus, the fidelity of scrapie genetic testing is enhanced by knowing the position and frequency of PRNP polymorphisms in targeted flocks...
  6. pmc Prevalence of the prion protein gene E211K variant in U.S. cattle
    Michael P Heaton
    USDA, ARS, U, S, Meat Animal Research Center USMARC, State Spur 18D, P O Box 166, Clay Center, NE 68933, USA
    BMC Vet Res 4:25. 2008
    ..S. cattle...
  7. ncbi request reprint Beta-2-microglobulin haplotypes in U.S. beef cattle and association with failure of passive transfer in newborn calves
    Michael L Clawson
    United States Department of Agriculture, Agricultural Research Service, U S Meat Animal Research Center MARC, Spur 18D, P O Box 166, Clay Center, Nebraska 68933, USA
    Mamm Genome 15:227-36. 2004
    ..07-54.24, p = 0.005). These results indicate that this haplotype is in linkage disequilibrium with genetic risk factors affecting passive transfer of IgG in beef calves, an important determinant of neonatal calf morbidity and mortality...
  8. pmc Prion gene haplotypes of U.S. cattle
    Michael L Clawson
    United States Department of Agriculture, Agricultural Research Service, U, S, Meat Animal Research Center, Clay Center, NE 68933, USA
    BMC Genet 7:51. 2006
    ..The objective of this study was to identify polymorphisms and haplotypes within PRNP from the promoter region through the 3'UTR in a diverse sample of U.S. cattle genomes...
  9. pmc Characterization of 954 bovine full-CDS cDNA sequences
    Gregory P Harhay
    USDA ARS U, S, Meat Animal Research Center, Clay Center, NE 68901, USA
    BMC Genomics 6:166. 2005
    ....
  10. ncbi request reprint Association of bovine neonatal Fc receptor alpha-chain gene (FCGRT) haplotypes with serum IgG concentration in newborn calves
    William W Laegreid
    United States Department of Agriculture, Agricultural Research Service, U S Meat Animal Research Center MARC, P O Box 166, State Spur 18D, Clay Center, Nebraska 68933, USA
    Mamm Genome 13:704-10. 2002
    ..These results indicate that the bovine FCGRT haplotype markers are in linkage disequilibrium with genetic risk factors affecting passive transfer of IgG in beef cattle, an important determinant of neonatal calf morbidity and mortality...
  11. pmc Association of Escherichia coli O157:H7 tir polymorphisms with human infection
    James L Bono
    United States Department of Agriculture, Agricultural Research Service, U S Meat Animal Research Center, Clay Center, NE 68933 USA
    BMC Infect Dis 7:98. 2007
    ....
  12. ncbi request reprint Prion gene sequence variation within diverse groups of U.S. sheep, beef cattle, and deer
    Michael P Heaton
    USDA, ARS, U S Meat Animal Research Center MARC, State Spur 18D, P O Box 166, Clay Center, Nebraska 68933 0166, USA
    Mamm Genome 14:765-77. 2003
    ....
  13. ncbi request reprint Linkage disequilibrium across six prion gene regions spanning 20 kbp in U.S. sheep
    Benedict T Green
    U S Department of Agriculture, Agricultural Research Service, U S Meat Animal Research Center, State Spur 18D, P O Box 166, Clay Center, Nebraska 68933, USA
    Mamm Genome 17:1121-9. 2006
    ..The haplotype structure within the 20-kbp region of PRNP identified in this study is important for higher-resolution analysis of genetics contributions to scrapie susceptibility...
  14. pmc Association of a bovine prion gene haplotype with atypical BSE
    Michael L Clawson
    United States Department of Agriculture, Agricultural Research Service, US Meat Animal Research Center, Clay Center, Nebraska, United States of America
    PLoS ONE 3:e1830. 2008
    ..Atypical BSEs are rare; approximately 30 cases have been identified worldwide. We tested prion gene (PRNP) haplotypes for an association with atypical BSE...
  15. ncbi request reprint Gene expression profiling of bovine macrophages in response to Escherichia coli O157:H7 lipopolysaccharide
    Carol G Chitko-McKown
    USDA, ARS, Roman L Hruska US Meat Animal Research Center MARC, State Spur 18D, P O Box 166, Clay Center, Nebraska 68933 0166, USA
    Dev Comp Immunol 28:635-45. 2004
    ..This first report of bovine-human cross-species expression profiling by microarray hybridization demonstrates the utility of this technique in bovine gene expression and discovery...
  16. pmc Evaluation of a real-time PCR kit for detecting Escherichia coli O157 in bovine fecal samples
    James L Bono
    U S Meat Animal Research Center, Agricultural Research Service, U S Department of Agriculture, Clay Center, Nebraska 68933 0166, USA
    Appl Environ Microbiol 70:1855-7. 2004
    ..Both the sensitivity and specificity of the assay were 99% for isolates in pure culture. The assay detected 1 CFU of E. coli O157:H7 g(-1) in artificially inoculated bovine feces following enrichment...
  17. pmc Small ruminant lentivirus genetic subgroups associate with sheep TMEM154 genotypes
    Lucia H Sider
    United States Department of Agriculture USDA Agricultural Research Service ARS, U, S, Meat Animal Research Center USMARC, State Spur 18D, Clay Center, NE 68933, USA
    Vet Res 44:64. 2013
    ..001, env p=0.01). These results indicate that SRLVs in the U.S. have adapted to infect sheep with specific TMEM154 E35K genotypes. Consequently, both host and SRLV genotypes affect the relative risk of SRLV infection in sheep...
  18. ncbi request reprint Selection and use of SNP markers for animal identification and paternity analysis in U.S. beef cattle
    Michael P Heaton
    USDA, ARS, U S Meat Animal Research Center MARC, State Spur 18D, P O Box 166, Clay Center, Nebraska 68933 0166, USA
    Mamm Genome 13:272-81. 2002
    ..Knowledge of these additional sites, together with the 32 target SNPs, allows the design of robust, accurate genotype assays on a variety of high-throughput SNP genotyping platforms...
  19. pmc A sequencing strategy for identifying variation throughout the prion gene of BSE-affected cattle
    Michael L Clawson
    United States Department of Agriculture USDA, Agricultural Research Service ARS, US Meat Animal Research Center USMARC, Clay Center, NE 68933, USA
    BMC Res Notes 1:32. 2008
    ....
  20. pmc SNPs for parentage testing and traceability in globally diverse breeds of sheep
    Michael P Heaton
    U S Meat Animal Research Center USMARC, Clay Center, Nebraska, United States of America
    PLoS ONE 9:e94851. 2014
    ....
  21. pmc Using diverse U.S. beef cattle genomes to identify missense mutations in EPAS1, a gene associated with high-altitude pulmonary hypertension
    Michael P Heaton
    U S Meat Animal Research Center USMARC, Clay Center, USA
    F1000Res 5:2003. 2016
    ..S. beef cattle, and provides a means of translating WGS data into a practical biological and evolutionary context for generating and testing hypotheses...
  22. doi request reprint Resolving Bovine viral diarrhea virus subtypes from persistently infected U.S. beef calves with complete genome sequence
    Aspen M Workman
    U S Meat Animal Research Center, Clay Center, NE Workman, Heaton, Harhay, Smith, Chitko McKown Great Plains Veterinary Educational Center, School of Veterinary Medicine and Biomedical Sciences, University of Nebraska Lincoln, Clay Center, NE Grotelueschen Cattle Empire LLC, Satanta, KS Sjeklocha Nebraska Veterinary Diagnostic Center, School of Veterinary Medicine and Biomedical Sciences Brodersen, University of Nebraska Lincoln, Lincoln, NEDepartment of Animal Science Petersen, University of Nebraska Lincoln, Lincoln, NE
    J Vet Diagn Invest 28:519-28. 2016
    ..These results show that a more complex set of BVDV-2 subtypes has been circulating in this region than was previously thought. ..
  23. pmc Genomic signatures of Mannheimia haemolytica that associate with the lungs of cattle with respiratory disease, an integrative conjugative element, and antibiotic resistance genes
    Michael L Clawson
    United States Department of Agriculture, Agricultural Research Service, U S Meat Animal Research Center, Clay Center, NE, USA
    BMC Genomics 17:982. 2016
    ..haemolytica from the genome sequences of 1133 North American isolates, and used to identify genetic differences between isolates from the lungs and upper respiratory tract of cattle with and without clinical signs of respiratory disease...