T H Elsasser

Summary

Affiliation: Agricultural Research Service
Country: USA

Publications

  1. ncbi request reprint Underlying disease stress augments plasma and tissue adrenomedullin (AM) responses to endotoxin: colocalized increases in AM and inducible nitric oxide synthase within pancreatic islets
    T H Elsasser
    U S Department of Argiculture, Agricultural Research Service, Beltsville, Maryland 20705, USA
    Endocrinology 140:5402-11. 1999
  2. ncbi request reprint The effect of roasted soybeans in the diet of feedlot steers and Synovex-S ear implants on carcass characteristics and estimated composition
    T S Rumsey
    Growth Biology Laboratory, Livestock and Poultry Sciences Institute, ARS, USDA, Beltsville, MD 20705 2350, USA
    J Anim Sci 77:1726-34. 1999
  3. ncbi request reprint Effects of oral chlortetracycline and dietary protein level on plasma concentrations of growth hormone and thyroid hormones in beef steers before and after challenge with a combination of thyrotropin-releasing hormone and growth hormone-releasing hormone
    T S Rumsey
    Growth Biology Laboratory, USDA, Livestock and Poultry Sciences Institute, Beltsville, MD 20705 2350, USA
    J Anim Sci 77:2079-87. 1999
  4. doi request reprint Modeling the effects of estradiol and progesterone on the acute phase proinflammatory axis: variability in tumor necrosis factor-α, nitric oxide, and xanthine oxidase responses to endotoxin challenge in steers
    S Kahl
    Bovine Functional Genomics Laboratory, US Department of Agriculture, Agricultural Research Service, Animal and Natural Resources Institute, Beltsville, MD 20705, USA
    Domest Anim Endocrinol 40:213-21. 2011
  5. ncbi request reprint Modulation of growth performance in disease: reactive nitrogen compounds and their impact on cell proteins
    T H Elsasser
    U S Department of Agriculture, Agricultural Research Service Growth Biology Laboratory, Beltsville, MD, USA
    Domest Anim Endocrinol 19:75-84. 2000
  6. ncbi request reprint Responses to an estrogenic growth promoter in beef steers fed varying nutritional regimens
    T S Rumsey
    Growth Biology Laboratory, USDA, Beltsville, MD 20705, USA
    J Anim Sci 77:2865-72. 1999
  7. ncbi request reprint Effect of endotoxin challenge on hepatic 5'-deiodinase activity in cattle
    S Kahl
    Growth Biology Laboratory, US Department of Agriculture, Agricultural Research Service, Livestock and Poultry Sciences Institute, Beltsville, MD 20705, USA
    Domest Anim Endocrinol 18:133-43. 2000
  8. doi request reprint Variability in tumor necrosis factor-alpha, nitric oxide, and xanthine oxidase responses to endotoxin challenge in heifers: effect of estrous cycle stage
    S Kahl
    Bovine Functional Genomics Laboratory, U S Department of Agriculture, Agricultural Research Service, Animal and Natural Resources Institute, BARC E, Beltsville, MD 20705, USA
    Domest Anim Endocrinol 36:82-8. 2009
  9. ncbi request reprint Exogenous testosterone modulates tumor necrosis factor-alpha and acute phase protein responses to repeated endotoxin challenge in steers
    S Kahl
    Growth Biology Laboratory, U S Department of Agriculture, Agricultural Research Service, Animal and Natural Resources Institute, Building 200, Room 211E, Beltsville, MD 20705, USA
    Domest Anim Endocrinol 31:301-11. 2006
  10. ncbi request reprint Effect of progressive cachectic parasitism and growth hormone treatment on hepatic 5'-deiodinase activity in calves
    Stanislaw Kahl
    Growth Biology Laboratory, US Department of Agriculture, Agricultural Research Service, Animal and Natural Resources Institute, Building 200, Room 211E, Beltsville, MD 20705, USA
    Domest Anim Endocrinol 22:211-21. 2002

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Underlying disease stress augments plasma and tissue adrenomedullin (AM) responses to endotoxin: colocalized increases in AM and inducible nitric oxide synthase within pancreatic islets
    T H Elsasser
    U S Department of Argiculture, Agricultural Research Service, Beltsville, Maryland 20705, USA
    Endocrinology 140:5402-11. 1999
    ..The pancreatic responses in AM and iNOS may play a major role in mediating prolonged disturbances in nutrient use by tissues through their influences on temporal patterns of pancreatic hormone secretion during chronic illness...
  2. ncbi request reprint The effect of roasted soybeans in the diet of feedlot steers and Synovex-S ear implants on carcass characteristics and estimated composition
    T S Rumsey
    Growth Biology Laboratory, Livestock and Poultry Sciences Institute, ARS, USDA, Beltsville, MD 20705 2350, USA
    J Anim Sci 77:1726-34. 1999
    ....
  3. ncbi request reprint Effects of oral chlortetracycline and dietary protein level on plasma concentrations of growth hormone and thyroid hormones in beef steers before and after challenge with a combination of thyrotropin-releasing hormone and growth hormone-releasing hormone
    T S Rumsey
    Growth Biology Laboratory, USDA, Livestock and Poultry Sciences Institute, Beltsville, MD 20705 2350, USA
    J Anim Sci 77:2079-87. 1999
    ....
  4. doi request reprint Modeling the effects of estradiol and progesterone on the acute phase proinflammatory axis: variability in tumor necrosis factor-α, nitric oxide, and xanthine oxidase responses to endotoxin challenge in steers
    S Kahl
    Bovine Functional Genomics Laboratory, US Department of Agriculture, Agricultural Research Service, Animal and Natural Resources Institute, Beltsville, MD 20705, USA
    Domest Anim Endocrinol 40:213-21. 2011
    ..Results indicate that in cattle, P4 and E2, respectively, attenuate or amplify the response to LPS challenge at several points critical to the regulation of the progression of the proinflammatory cascade...
  5. ncbi request reprint Modulation of growth performance in disease: reactive nitrogen compounds and their impact on cell proteins
    T H Elsasser
    U S Department of Agriculture, Agricultural Research Service Growth Biology Laboratory, Beltsville, MD, USA
    Domest Anim Endocrinol 19:75-84. 2000
    ..Identifying biochemical criteria for disease processes provides needed guidance for the further development of intervention strategies to limit the impact of disease on growth...
  6. ncbi request reprint Responses to an estrogenic growth promoter in beef steers fed varying nutritional regimens
    T S Rumsey
    Growth Biology Laboratory, USDA, Beltsville, MD 20705, USA
    J Anim Sci 77:2865-72. 1999
    ....
  7. ncbi request reprint Effect of endotoxin challenge on hepatic 5'-deiodinase activity in cattle
    S Kahl
    Growth Biology Laboratory, US Department of Agriculture, Agricultural Research Service, Livestock and Poultry Sciences Institute, Beltsville, MD 20705, USA
    Domest Anim Endocrinol 18:133-43. 2000
    ..The data also suggest that the impact of LPS on 5'D activity in liver can be altered by Arg supplementation...
  8. doi request reprint Variability in tumor necrosis factor-alpha, nitric oxide, and xanthine oxidase responses to endotoxin challenge in heifers: effect of estrous cycle stage
    S Kahl
    Bovine Functional Genomics Laboratory, U S Department of Agriculture, Agricultural Research Service, Animal and Natural Resources Institute, BARC E, Beltsville, MD 20705, USA
    Domest Anim Endocrinol 36:82-8. 2009
    ..Results indicate that the underlying physiological attributes of the estrus and diestrus phases of the estrous cycle constitute a major source of variability in the magnitude of proinflammatory response to bacterial toxins like LPS...
  9. ncbi request reprint Exogenous testosterone modulates tumor necrosis factor-alpha and acute phase protein responses to repeated endotoxin challenge in steers
    S Kahl
    Growth Biology Laboratory, U S Department of Agriculture, Agricultural Research Service, Animal and Natural Resources Institute, Building 200, Room 211E, Beltsville, MD 20705, USA
    Domest Anim Endocrinol 31:301-11. 2006
    ..The data also suggest a role for testosterone in the development of tolerance to repeated immune challenge through its effect on the increased magnitude and duration of HG response...
  10. ncbi request reprint Effect of progressive cachectic parasitism and growth hormone treatment on hepatic 5'-deiodinase activity in calves
    Stanislaw Kahl
    Growth Biology Laboratory, US Department of Agriculture, Agricultural Research Service, Animal and Natural Resources Institute, Building 200, Room 211E, Beltsville, MD 20705, USA
    Domest Anim Endocrinol 22:211-21. 2002
    ..After recovery from the APR, thyroidal secretion returns to normal but basal and bGH-stimulated generation of T(3) in liver remains impaired...
  11. ncbi request reprint Effect of somatotropin on thyroid hormones and cytokines in lactating dairy cows during ad libitum and restricted feed intake
    A V Capuco
    Gene Evaluation and Mapping Laboratory, USDA ARS, Beltsville, MD 20705, USA
    J Dairy Sci 84:2430-9. 2001
    ..Short-term treatment with bST did not influence thyroid hormone metabolism in lactating cows in positive or negative energy balance...
  12. doi request reprint Glucagon-like peptide 2 therapy reduces negative effects of diarrhea on calf gut
    E E Connor
    Bovine Functional Genomics Laboratory, Agricultural Research Service, Beltsville, MD 20705, USA
    J Dairy Sci 96:1793-802. 2013
    ..Treatment with GLP-2 promotes intestinal growth in neonatal calves and reduces the detrimental effects of nitro-oxidative stress in the ileocecum of calves with coccidiosis...
  13. ncbi request reprint Modeling growth factor activity during proinflammatory stress: methodological considerations in assessing cytokine modulation of IGF binding proteins released by cultured bovine kidney epithelial cells
    T H Elsasser
    US Department of Agriculture, Agricultural Research Service, Growth Biology Laboratory, Beltsville, MD 20705, United States
    Domest Anim Endocrinol 33:390-9. 2007
    ....
  14. doi request reprint Critical control points in the impact of the proinflammatory immune response on growth and metabolism
    T H Elsasser
    United States Department of Agriculture, Agricultural Research Service, Beltsville, MD 20705, USA
    J Anim Sci 86:E105-25. 2008
    ..Attenuation of these overt posttranslational protein modifications at their site of production offers a strategy to minimize their detrimental impact while preserving needed cytokine, NO, and O2(.-) functions...
  15. ncbi request reprint Field method for monitoring blood glucose in beef cattle
    T S Rumsey
    Livestock and Poultry Sciences Institute, Agricultural Research Service, USDA, Beltsville, MD 20705 2350, USA
    J Anim Sci 77:2194-200. 1999
    ..87; Sy.x = 6.9 mg/dL). Even though variation seemed greater for ACE than for YSI, we concluded that a system developed for human self-monitoring of blood glucose, such as the ACE, can be used to monitor the glycemic status of cattle...
  16. ncbi request reprint Performance and digestibilities of beef cattle fed diets supplemented with either soybean meal or roasted soybeans and implanted with Synovex
    T S Rumsey
    Growth Biology Laboratory, Livestock and Poultry Sciences Institute, ARS, USDA, Beltsville, MD 20705 2350, USA
    J Anim Sci 77:1631-7. 1999
    ..The results suggest that there is no improvement in performance under feedlot conditions when RSB replaces SBM in the diet of beef cattle, and, in young cattle, RSB may reduce the response expected by an estrogenic growth promoter...
  17. ncbi request reprint Endotoxin challenge increases xanthine oxidase activity in cattle: effect of growth hormone and vitamin E treatment
    S Kahl
    Growth Biology Laboratory, U S Department of Agriculture, Agricultural Research Service, Animal and Natural Resources Institute, Building 200, Room 211E, Beltsville, MD 20705, USA
    Domest Anim Endocrinol 26:315-28. 2004
    ..The data also suggest that E may be effective in controlling some mediators of immune response associated with increased production of NO via the effect on XO activity and its production of superoxide anion as well as uric acid...
  18. doi request reprint Glucagon-like peptide 2 and its beneficial effects on gut function and health in production animals
    E E Connor
    US Department of Agriculture, Agricultural Research Service, Beltsville Agricultural Research Center, Beltsville, MD 20705 USA Electronic address
    Domest Anim Endocrinol 56:S56-65. 2016
    ....
  19. ncbi request reprint Characterization of calves exhibiting a novel inheritable TNF-alpha hyperresponsiveness to endotoxin: associations with increased pathophysiological complications
    T H Elsasser
    Growth Biology Laboratory, US Department of Agriculture, Agricultural Research Service, B 200, Rm 201, B A R C east, Beltsville, MD 20705, USA
    J Appl Physiol (1985) 98:2045-55. 2005
    ....
  20. doi request reprint Effect of growth hormone administration to mature miniature Brahman cattle treated with or without insulin on circulating concentrations of insulin-like growth factor-I and other metabolic hormones and metabolites
    C C Chase
    Agricultural Research Service, Subtropical Agricultural Research Station, USDA, Brooksville, FL 34601, USA
    Domest Anim Endocrinol 41:1-13. 2011
    ..In the miniature Brahman model, both the GH and GH + INS treatments dramatically increased circulating concentrations of IGF-I in mature cattle, suggesting that this line of Brahman cattle is capable of responding to bioactive GH...
  21. ncbi request reprint Design and application of a polyclonal peptide antiserum for the universal detection of leptin protein
    M P Richards
    U S Department of Agriculture, Agricultural Research Service, Livestock and Poultry Sciences Institute, Growth Biology Laboratory, Beltsville, MD 20705 2350, USA
    J Biochem Biophys Methods 45:147-56. 2000
    ..This study is the first to report a polyclonal peptide antiserum that apparently recognizes intact leptin protein, both native and recombinant, regardless of the species of origin...
  22. doi request reprint Effects of stress on endocrine and metabolic processes and redirection: cross talk between subcellular compartments
    T H Elsasser
    United States Department of Agriculture, Agricultural Research Service, Beltsville, MD 20705, USA
    Domest Anim Endocrinol 43:132-45. 2012
    ..Changes in the regulation of metabolism in response to proinflammatory disease states are discussed for GH signal transduction and tissue specificity...
  23. ncbi request reprint Performance and carcass merit of growing beef steers with chlortetracycline-modified sensitivity to pituitary releasing hormones and fed two dietary protein levels
    T S Rumsey
    Growth Laboratory, Livestock and Poultry Sciences Institute, ARS, USDA, Beltsville, MD 20705 2350, USA
    J Anim Sci 78:2765-70. 2000
    ..This would tend to increase energy utilization but may not necessarily produce a measurable increase in BW gain...
  24. ncbi request reprint Epigenetic regulation of genomes: nutrient-specific modulation of genetic networks in bovine cells
    C J Li
    USDA ARS, Bovine Functional Genomics Laboratory, Beltsville, MD 20705, USA
    Dev Biol (Basel) 132:391-8. 2008
    ....
  25. doi request reprint Short communication: Glucagon-like peptide-2 and coccidiosis alter tight junction gene expression in the gastrointestinal tract of dairy calves
    M P Walker
    USDA, Agricultural Research Service, Animal Genomics and Improvement Laboratory, Beltsville, MD 20705
    J Dairy Sci 98:3432-7. 2015
    ..Use of GLP-2 to improve gut barrier function in ruminants during pathogen-induced diarrhea warrants additional study. ..
  26. doi request reprint Identification and characterization of a nuclear factor-κ B-p65 proteolytic fragment in nuclei of porcine hepatocytes in monolayer culture
    T J Caperna
    Animal Biosciences and Biotechnology Laboratory, Beltsville Agricultural Research Center, USDA, Agricultural Research Service, Bldg 200, Rm 202, BARC East, Beltsville, MD 20705, USA Electronic address
    Domest Anim Endocrinol 45:154-62. 2013
    ....
  27. ncbi request reprint Development of anti-bovine TNF-alpha mAb and ELISA for quantitating TNF-alpha in milk after intramammary injection of endotoxin
    M J Paape
    Immunology and Disease Resistance Laboratory, ARS, USDA, Beltsville, Maryland 20705, USA
    J Dairy Sci 85:765-73. 2002
    ..It would appear that these changes were not regulated by TNF-alpha secretion because the changes were also similar after the second injection of LPS into the same mammary quarter...
  28. ncbi request reprint Growth and tissue accretion rates of swine expressing an insulin-like growth factor I transgene
    V G Pursel
    Biotechnology and Germplasm Laboratory, USDA ARS, Beltsville, Maryland 20705, USA
    Anim Biotechnol 15:33-45. 2004
    ..05). Based on these results we conclude that expression of IGF-I in the skeletal muscles gradually altered body composition as pigs became older but did not have a major affect on growth performance...
  29. ncbi request reprint Butyrate-induced apoptosis and cell cycle arrest in bovine kidney epithelial cells: involvement of caspase and proteasome pathways
    C J Li
    Growth Biology Laboratory, Animal and Natural Resources Institute, ARS, USDA, Beltsville, MD 20705, USA
    J Anim Sci 83:89-97. 2005
    ..All these results indicate that butyrate functions as both a nutrient and signaling molecule regulating cell growth and proliferation...
  30. ncbi request reprint Influence of abomasal carbohydrates on subcutaneous, omental, and mesenteric adipose lipogenic and lipolytic rates in growing beef steers
    R L Baldwin
    Bovine Functional Genomics Laboratory Animal and Natural Resources Institute, Agricultural Research Service, USDA, Beltsville, MD 20705 2350, USA
    J Anim Sci 85:2271-82. 2007
    ..These data provide evidence that the postruminal supply of energy, specifically carbohydrate, stimulates lipogenesis from acetate and glucose and is more pronounced in abdominal depots relative to the subcutaneous depot...
  31. ncbi request reprint Leptin, tumor necrosis factor-alpha (TNF), and CD14 in ovine adipose tissue and changes in circulating TNF in lean and fat sheep
    J A Daniel
    South Dakota State University, Brookings, SD 57007, USA
    J Anim Sci 81:2590-9. 2003
    ....
  32. ncbi request reprint IL-4 and IL-10 inhibition of IFN-gamma- and TNF-alpha-dependent nitric oxide production from bovine mononuclear phagocytes exposed to Babesia bovis merozoites
    W L Goff
    Animal Disease Research Unit, USDA ARS, Washington State University, 3003 ADBF, P O Box 646630, Pullman, WA 99164 6630, USA
    Vet Immunol Immunopathol 84:237-51. 2002
    ..However, while merozoites plus IFN-gamma induced TNF-alpha mRNA expression in MDM, NO was not produced. Both IL-4 and IL-10 inhibited expression of iNOS and production of NO in merozoite-stimulated monocytes...
  33. doi request reprint Short communication: suppressor of cytokine signaling-2 mRNA increases after parturition in the liver of dairy cows
    L A Winkelman
    Department of Animal Sciences, The Ohio State University, Wooster 44691, USA
    J Dairy Sci 91:1080-6. 2008
    ..In addition to reduced GHR 1A, increased SOCS-2 mRNA after parturition, perhaps because of increased E(2), may further uncouple GH signaling in the liver of the transition dairy cow...
  34. ncbi request reprint Elevated milk soluble CD14 in bovine mammary glands challenged with Escherichia coli lipopolysaccharide
    J W Lee
    Department of Animal Science, McGill University, Ste Anne de Bellevue, Quebec, H9X 3V9, Canada
    J Dairy Sci 86:2382-9. 2003
    ..The increase was not likely due to serum leakage. Instead, infiltrated neutrophils might be the main source of increased sCD14 in milk during inflammation...
  35. ncbi request reprint Estradiol plus progesterone treatment modulates select elements of the proinflammatory cytokine cascade in steers: attenuated nitric oxide and thromboxane B2 production in endotoxemia
    J L Sartin
    Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849 5520, USA
    J Anim Sci 81:1546-51. 2003
    ..Although the initiation of responses mediated by TNF, cortisol, and PRC do not seem to be differentially affected by EP, components of the nitric oxide- and TXB-axis responses to LPS are decreased in calves pretreated with EP...
  36. ncbi request reprint Interleukin-1beta and tumor necrosis factor-alpha mediation of endotoxin action on growth hormone
    J A Daniel
    Animal and Range Sciences, South Dakota State University, Brookings, South Dakota, USA
    Am J Physiol Endocrinol Metab 289:E650-7. 2005
    ..These data are consistent with the effects of LPS on GH secretion originating through peripheral cytokine presentation to the pituitary, as well as a potential to act directly on selective populations of pituitary cells via CD14...
  37. ncbi request reprint Effects of additional milk replacer feeding on calf health, growth, and selected blood metabolites in calves
    J D Quigley
    APC, Inc, Ankeny, IA 50021, USA
    J Dairy Sci 89:207-16. 2006
    ..Under conditions of this study, calves fed variable amount of milk replacer and exposed to immunological challenge before weaning had greater BW gain, but also increased incidence of diarrhea that required added veterinary treatments...
  38. ncbi request reprint Clinical responses to intramammary endotoxin infusion in dairy cows subjected to feed restriction
    K H Perkins
    Department of Animal Science, Michigan State University, East Lansing 48824, USA
    J Dairy Sci 85:1724-31. 2002
    ..As such, negative energy balance may not underlie the increases in severe coliform mastitis commonly observed in periparturient dairy cows...
  39. ncbi request reprint Insulin-like growth factor type-1 receptor down-regulation associated with dwarfism in Holstein calves
    J W Blum
    Veterinary Physiology, Vetsuisse Faculty, University of Bern, CH 3012 Bern, Switzerland
    Domest Anim Endocrinol 33:245-68. 2007
    ..02 and P<0.07, respectively) in half-siblings than in dwarfs. The reduced presence of IGF-1R may have been the underlying cause of dwarfism in studied calves...
  40. doi request reprint Limit-feeding a high-energy diet to meet energy requirements in the dry period alters plasma metabolite concentrations but does not affect intake or milk production in early lactation
    L A Winkelman
    Department of Animal Sciences, The Ohio State University, OARDC, Wooster 44691, USA
    J Dairy Sci 91:1067-79. 2008
    ..Apart from a reduction in body energy loss in the first week after calving, limit feeding a higher NE(L) diet during the dry period had little effect on intake and milk production during the first month of lactation...
  41. ncbi request reprint Complement factor H is a serum-binding protein for adrenomedullin, and the resulting complex modulates the bioactivities of both partners
    R Pio
    Department of Cell and Cancer Biology, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 276:12292-300. 2001
    ..In summary, we report on a potentially new regulatory mechanism of AM biology, the influence of factor H on radioimmunoassay quantification of AM, and the possible involvement of AM as a regulator of the complement cascade...
  42. ncbi request reprint Presence of immunoreactive adrenomedullin in human and bovine milk
    R Pio
    Department of Cell and Cancer Biology, National Cancer Institute, NIH, Building 10 Room 12N226, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Peptides 21:1859-63. 2000
    ..5 +/- 3.8 pg/mL. Bovine milk products had AM levels similar to those found in fresh bovine milk. Human milk had growth promoting activity on the human intestinal cell line Int-407 that could be partially blocked with an anti-AM antibody...
  43. doi request reprint Source of dietary lipid may modify the immune response in stressed feeder cattle
    T B Farran
    Department of Animal Sciences and Industry, Kansas State University, Manhattan 66506 1600, USA
    J Anim Sci 86:1382-94. 2008
    ....