Steven M Colegate

Summary

Affiliation: Agricultural Research Service
Country: USA

Publications

  1. doi request reprint Dehydropyrrolizidine alkaloids in two Cryptantha species: including two new open chain diesters one of which is amphoteric
    Steven M Colegate
    USDA, ARS, Poisonous Plant Research Laboratory, Logan, Utah, USA
    Phytochem Anal 24:201-12. 2013
  2. pmc Dehydropyrrolizidine alkaloids, including monoesters with an unusual esterifying acid, from cultivated Crotalaria juncea (Sunn Hemp cv.'Tropic Sun')
    Steven M Colegate
    Poisonous Plant Research Laboratory, Agriculture Research Service, US Department of Agriculture, Logan, Utah 84341, United States
    J Agric Food Chem 60:3541-50. 2012
  3. doi request reprint The comparative toxicity of a reduced, crude comfrey (Symphytum officinale) alkaloid extract and the pure, comfrey-derived pyrrolizidine alkaloids, lycopsamine and intermedine in chicks (Gallus gallus domesticus)
    Ammon W Brown
    USDA ARS Poisonous Plant Research Laboratory, Logan, UT, 84341, USA
    J Appl Toxicol 36:716-25. 2016
  4. doi request reprint Heterozygous p53 knockout mouse model for dehydropyrrolizidine alkaloid-induced carcinogenesis
    Ammon W Brown
    USDA ARS Poisonous Plant Research Laboratory, Logan, UT, USA
    J Appl Toxicol 35:1557-63. 2015
  5. doi request reprint Semi-automated separation of the epimeric dehydropyrrolizidine alkaloids lycopsamine and intermedine: preparation of their N-oxides and NMR comparison with diastereoisomeric rinderine and echinatine
    Steven M Colegate
    Poisonous Plant Research Laboratory, Agriculture Research Service, US Department of Agriculture, 1150 East 1400 North, Logan, Utah, 84341, USA
    Phytochem Anal 25:429-38. 2014
  6. pmc Profiling of dehydropyrrolizidine alkaloids and their N-oxides in herbarium-preserved specimens of amsinckia species using HPLC-esi(+)MS
    Steven M Colegate
    Poisonous Plant Research Laboratory, Agricultural Research Service, U S Department of Agriculture, 1150 East 1400 North, Logan, Utah 84341, United States
    J Agric Food Chem 62:7382-92. 2014
  7. doi request reprint An in vitro comparison of the cytotoxic potential of selected dehydropyrrolizidine alkaloids and some N-oxides
    Reuel A Field
    United States Department of Agriculture, Agricultural Research Service, Poisonous Plant Research Laboratory, Logan, UT 84332, USA
    Toxicon 97:36-45. 2015
  8. doi request reprint Monofluoroacetate-containing plants that are potentially toxic to livestock
    Stephen T Lee
    Poisonous Plant Research Laboratory, Agricultural Research Service, U S Department of Agriculture, 1150 East 1400 North, Logan, Utah 84341, United States
    J Agric Food Chem 62:7345-54. 2014
  9. doi request reprint Tremetone and structurally related compounds in white snakeroot ( Ageratina altissima ): a plant associated with trembles and milk sickness
    Stephen T Lee
    Poisonous Plant Research Laboratory, Agricultural Research Service, U S Department of Agriculture, 1150 East 1400 North, Logan, Utah 84341, USA
    J Agric Food Chem 58:8560-5. 2010
  10. pmc Pro-toxic dehydropyrrolizidine alkaloids in the traditional Andean herbal medicine "asmachilca"
    Steven M Colegate
    USDA, ARS, Poisonous Plant Research Laboratory, Logan, UT 84341, USA Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT 84322, USA Electronic address
    J Ethnopharmacol 172:179-94. 2015

Detail Information

Publications10

  1. doi request reprint Dehydropyrrolizidine alkaloids in two Cryptantha species: including two new open chain diesters one of which is amphoteric
    Steven M Colegate
    USDA, ARS, Poisonous Plant Research Laboratory, Logan, Utah, USA
    Phytochem Anal 24:201-12. 2013
    ..A livestock poisoning outbreak near Kingman, Arizona, USA, potentially linked to dehydropyrrolizidine alkaloids, prompted an evaluation of some local plants for the presence of these hepatotoxic alkaloids...
  2. pmc Dehydropyrrolizidine alkaloids, including monoesters with an unusual esterifying acid, from cultivated Crotalaria juncea (Sunn Hemp cv.'Tropic Sun')
    Steven M Colegate
    Poisonous Plant Research Laboratory, Agriculture Research Service, US Department of Agriculture, Logan, Utah 84341, United States
    J Agric Food Chem 60:3541-50. 2012
    ..The dehydropyrrolizidine alkaloid contents of the roots, stems, and leaves of immature plants were estimated to be 0.05, 0.12, and 0.01% w/w, respectively, whereas seeds were estimated to contain 0.15% w/w...
  3. doi request reprint The comparative toxicity of a reduced, crude comfrey (Symphytum officinale) alkaloid extract and the pure, comfrey-derived pyrrolizidine alkaloids, lycopsamine and intermedine in chicks (Gallus gallus domesticus)
    Ammon W Brown
    USDA ARS Poisonous Plant Research Laboratory, Logan, UT, 84341, USA
    J Appl Toxicol 36:716-25. 2016
    ..Published 2015. This article has been contributed to by US Government employees and their work is in the public domain in the USA. ..
  4. doi request reprint Heterozygous p53 knockout mouse model for dehydropyrrolizidine alkaloid-induced carcinogenesis
    Ammon W Brown
    USDA ARS Poisonous Plant Research Laboratory, Logan, UT, USA
    J Appl Toxicol 35:1557-63. 2015
    ..The results of this research demonstrate the utility of the heterozygous p53 knockout mouse model for further investigation of comparative carcinogenesis of structurally and toxicologically different DHPAs and their N-oxides...
  5. doi request reprint Semi-automated separation of the epimeric dehydropyrrolizidine alkaloids lycopsamine and intermedine: preparation of their N-oxides and NMR comparison with diastereoisomeric rinderine and echinatine
    Steven M Colegate
    Poisonous Plant Research Laboratory, Agriculture Research Service, US Department of Agriculture, 1150 East 1400 North, Logan, Utah, 84341, USA
    Phytochem Anal 25:429-38. 2014
    ....
  6. pmc Profiling of dehydropyrrolizidine alkaloids and their N-oxides in herbarium-preserved specimens of amsinckia species using HPLC-esi(+)MS
    Steven M Colegate
    Poisonous Plant Research Laboratory, Agricultural Research Service, U S Department of Agriculture, 1150 East 1400 North, Logan, Utah 84341, United States
    J Agric Food Chem 62:7382-92. 2014
    ..Within a designated species, an inconsistent profile was often observed that may be due to natural variation, taxonomic misassignment, or nonuniform degradation due to plant collection and storage differences. ..
  7. doi request reprint An in vitro comparison of the cytotoxic potential of selected dehydropyrrolizidine alkaloids and some N-oxides
    Reuel A Field
    United States Department of Agriculture, Agricultural Research Service, Poisonous Plant Research Laboratory, Logan, UT 84332, USA
    Toxicon 97:36-45. 2015
    ..Additional studies to better characterize the carcinogenic potential of these alkaloids are essential to better determine the risk they each may pose for human and animal health. ..
  8. doi request reprint Monofluoroacetate-containing plants that are potentially toxic to livestock
    Stephen T Lee
    Poisonous Plant Research Laboratory, Agricultural Research Service, U S Department of Agriculture, 1150 East 1400 North, Logan, Utah 84341, United States
    J Agric Food Chem 62:7345-54. 2014
    ....
  9. doi request reprint Tremetone and structurally related compounds in white snakeroot ( Ageratina altissima ): a plant associated with trembles and milk sickness
    Stephen T Lee
    Poisonous Plant Research Laboratory, Agricultural Research Service, U S Department of Agriculture, 1150 East 1400 North, Logan, Utah 84341, USA
    J Agric Food Chem 58:8560-5. 2010
    ..Elucidation of these chemotypes may explain the sporadic and unpredictable toxicity of white snakeroot to livestock and humans...
  10. pmc Pro-toxic dehydropyrrolizidine alkaloids in the traditional Andean herbal medicine "asmachilca"
    Steven M Colegate
    USDA, ARS, Poisonous Plant Research Laboratory, Logan, UT 84341, USA Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, UT 84322, USA Electronic address
    J Ethnopharmacol 172:179-94. 2015
    ..However, its attractiveness to pyrrolizidine alkaloid-pharmacophagous insects indicated a potential for toxicity for human consumers...