C Z Zhu

Summary

Affiliation: Abbott Laboratories
Country: USA

Publications

  1. doi request reprint Assessing carrageenan-induced locomotor activity impairment in rats: comparison with evoked endpoint of acute inflammatory pain
    C Z Zhu
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, USA
    Eur J Pain 16:816-26. 2012
  2. ncbi request reprint Role of central and peripheral mGluR5 receptors in post-operative pain in rats
    Chang Z Zhu
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064 3500, USA
    Pain 114:195-202. 2005
  3. ncbi request reprint Assessing the role of metabotropic glutamate receptor 5 in multiple nociceptive modalities
    Chang Z Zhu
    Neuroscience Research, Global Pharmaceutical Research and Development, Dept 4N5, Bldg AP9A, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 3500, USA
    Eur J Pharmacol 506:107-18. 2004
  4. ncbi request reprint Dissociation between post-surgical pain behaviors and spinal Fos-like immunoreactivity in the rat
    Chang Z Zhu
    Neuroscience Research, Global Pharmaceutical Research, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 3500, USA
    Eur J Pharmacol 531:108-17. 2006
  5. ncbi request reprint Analgesic activity of metabotropic glutamate receptor 1 antagonists on spontaneous post-operative pain in rats
    Chang Z Zhu
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 3500, USA
    Eur J Pharmacol 580:314-21. 2008
  6. pmc Peripheral and central sites of action for the non-selective cannabinoid agonist WIN 55,212-2 in a rat model of post-operative pain
    C Z Zhu
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA
    Br J Pharmacol 157:645-55. 2009
  7. doi request reprint Potentiation of analgesic efficacy but not side effects: co-administration of an α4β2 neuronal nicotinic acetylcholine receptor agonist and its positive allosteric modulator in experimental models of pain in rats
    Chang Z Zhu
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 3500, USA
    Biochem Pharmacol 82:967-76. 2011
  8. ncbi request reprint Effects of A-134974, a novel adenosine kinase inhibitor, on carrageenan-induced inflammatory hyperalgesia and locomotor activity in rats: evaluation of the sites of action
    S McGaraughty
    Neurological and Urological Diseases Research, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    J Pharmacol Exp Ther 296:501-9. 2001
  9. pmc In vitro and in vivo characterization of A-796260: a selective cannabinoid CB2 receptor agonist exhibiting analgesic activity in rodent pain models
    B B Yao
    Neurological Diseases Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Br J Pharmacol 153:390-401. 2008
  10. ncbi request reprint A-740003 [N-(1-{[(cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a novel and selective P2X7 receptor antagonist, dose-dependently reduces neuropathic pain in the rat
    Prisca Honore
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    J Pharmacol Exp Ther 319:1376-85. 2006

Collaborators

Detail Information

Publications28

  1. doi request reprint Assessing carrageenan-induced locomotor activity impairment in rats: comparison with evoked endpoint of acute inflammatory pain
    C Z Zhu
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, USA
    Eur J Pain 16:816-26. 2012
    ..Most animal models currently used to evaluate antinociceptive efficacy of analgesics rely on the assessment of evoked pain behaviours as primary endpoints...
  2. ncbi request reprint Role of central and peripheral mGluR5 receptors in post-operative pain in rats
    Chang Z Zhu
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064 3500, USA
    Pain 114:195-202. 2005
    ..In addition, the data suggest that mGluR5 antagonists could offer a new therapeutic approach to the treatment of post-operative pain...
  3. ncbi request reprint Assessing the role of metabotropic glutamate receptor 5 in multiple nociceptive modalities
    Chang Z Zhu
    Neuroscience Research, Global Pharmaceutical Research and Development, Dept 4N5, Bldg AP9A, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 3500, USA
    Eur J Pharmacol 506:107-18. 2004
    ..These results suggest a role for mGlu5 receptors in multiple nociceptive modalities, though CNS side effects may be a limiting factor in developing mGlu5 receptor analgesic compounds...
  4. ncbi request reprint Dissociation between post-surgical pain behaviors and spinal Fos-like immunoreactivity in the rat
    Chang Z Zhu
    Neuroscience Research, Global Pharmaceutical Research, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 3500, USA
    Eur J Pharmacol 531:108-17. 2006
    ....
  5. ncbi request reprint Analgesic activity of metabotropic glutamate receptor 1 antagonists on spontaneous post-operative pain in rats
    Chang Z Zhu
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 3500, USA
    Eur J Pharmacol 580:314-21. 2008
    ....
  6. pmc Peripheral and central sites of action for the non-selective cannabinoid agonist WIN 55,212-2 in a rat model of post-operative pain
    C Z Zhu
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA
    Br J Pharmacol 157:645-55. 2009
    ..However, the effects of CB receptor agonists in post-operative pain remain to be investigated. Here, we characterized the anti-allodynic effects of WIN 55,212-2 (WIN) in a rat model of post-operative pain...
  7. doi request reprint Potentiation of analgesic efficacy but not side effects: co-administration of an α4β2 neuronal nicotinic acetylcholine receptor agonist and its positive allosteric modulator in experimental models of pain in rats
    Chang Z Zhu
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 3500, USA
    Biochem Pharmacol 82:967-76. 2011
    ....
  8. ncbi request reprint Effects of A-134974, a novel adenosine kinase inhibitor, on carrageenan-induced inflammatory hyperalgesia and locomotor activity in rats: evaluation of the sites of action
    S McGaraughty
    Neurological and Urological Diseases Research, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    J Pharmacol Exp Ther 296:501-9. 2001
    ....
  9. pmc In vitro and in vivo characterization of A-796260: a selective cannabinoid CB2 receptor agonist exhibiting analgesic activity in rodent pain models
    B B Yao
    Neurological Diseases Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Br J Pharmacol 153:390-401. 2008
    ..Additionally, its analgesic effects are mu-opioid receptor-dependent. Herein, we describe the in vitro and in vivo pharmacological properties of A-796260, a novel CB2 agonist...
  10. ncbi request reprint A-740003 [N-(1-{[(cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a novel and selective P2X7 receptor antagonist, dose-dependently reduces neuropathic pain in the rat
    Prisca Honore
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    J Pharmacol Exp Ther 319:1376-85. 2006
    ..These data demonstrate that selective blockade of P2X(7) receptors in vivo produces significant antinociception in animal models of neuropathic and inflammatory pain...
  11. ncbi request reprint A-134974: a novel adenosine kinase inhibitor, relieves tactile allodynia via spinal sites of action in peripheral nerve injured rats
    C Z Zhu
    Neurological and Urological Diseases Research, Abbott Laboratories, D 4PM, AP9A LL, 100 Abbott Park Road, Abbott Park, IL 60064, USA
    Brain Res 905:104-10. 2001
    ....
  12. pmc Differential effects of cannabinoid receptor agonists on regional brain activity using pharmacological MRI
    C L Chin
    Advanced Technology, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Br J Pharmacol 153:367-79. 2008
    ..To address selectivity in vivo, we describe non-invasive, non-ionizing, functional data that distinguish CB1 from CB2 receptor neural activity using pharmacological MRI (phMRI) in awake rats...
  13. ncbi request reprint Comparison of antinociceptive actions of standard analgesics in attenuating capsaicin and nerve-injury-induced mechanical hypersensitivity
    S K Joshi
    Abbott Laboratories, Neuroscience Research, GPRD R4N5 100 Abbott Park Road, Abbott Park, IL 60064, USA
    Neuroscience 143:587-96. 2006
    ....
  14. ncbi request reprint P2X7-related modulation of pathological nociception in rats
    S McGaraughty
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, R4PM, AP9 1, 100 Abbott Park Road, Abbott Park, IL 60064 6118, USA
    Neuroscience 146:1817-28. 2007
    ..These effects are likely mediated through immuno-neural interactions that affect the release of endogenous cytokines...
  15. ncbi request reprint ABT-627, an endothelin ET(A) receptor-selective antagonist, attenuates tactile allodynia in a diabetic rat model of neuropathic pain
    M F Jarvis
    Neurological and Urological Diseases Research and Metabolic Diseases Research, Pharmaceutical Products Division, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 6123, USA
    Eur J Pharmacol 388:29-35. 2000
    ..These results indicate that the selective blockade of endothelin ET(A) receptors results in an attenuation of tactile allodynia in the streptozotocin-treated rat...
  16. ncbi request reprint Alteration of dorsal root ganglion P2X3 receptor expression and function following spinal nerve ligation in the rat
    Karen Kage
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 6123, USA
    Exp Brain Res 147:511-9. 2002
    ..These remaining receptors may provide a P2X(3) receptor-mediated component to neuropathic pain...
  17. doi request reprint Indol-3-ylcycloalkyl ketones: effects of N1 substituted indole side chain variations on CB(2) cannabinoid receptor activity
    Jennifer M Frost
    Neurological Diseases Research, Global Pharmaceutical Research and Development, Abbott Laboratories, R47W, AP9A, 100 Abbott Park Road, Abbott Park, Illinois 60064, USA
    J Med Chem 53:295-315. 2010
    ..N1 aromatic side chains also afforded several high affinity CB(2) receptor agonists (61, 63, 65, and 69) but were generally less potent in an in vitro CB(2) functional assay than were nonaromatic side chain analogues...
  18. doi request reprint H4 receptor antagonism exhibits anti-nociceptive effects in inflammatory and neuropathic pain models in rats
    Gin C Hsieh
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064, USA
    Pharmacol Biochem Behav 95:41-50. 2010
    ..Our results demonstrate that selective blockade of H(4) receptors in vivo produces significant anti-nociception in animal models of inflammatory and neuropathic pain...
  19. doi request reprint Characterization of a cannabinoid CB2 receptor-selective agonist, A-836339 [2,2,3,3-tetramethyl-cyclopropanecarboxylic acid [3-(2-methoxy-ethyl)-4,5-dimethyl-3H-thiazol-(2Z)-ylidene]-amide], using in vitro pharmacological assays, in vivo pain models, and
    Betty B Yao
    Neurological Diseases Research, Global Pharmaceutical Research and Development, Abbott Laboratories, R47W, AP9A, 100 Abbott Park Road, Abbott Park, IL 60064, USA
    J Pharmacol Exp Ther 328:141-51. 2009
    ..These data demonstrate that A-836339 is a useful tool for use of studying CB(2) receptor pharmacology and for investigation of the role of CB(2) receptor modulation for treatment of pain in preclinical animal models...
  20. doi request reprint Contributions of central and peripheral TRPV1 receptors to mechanically evoked and spontaneous firing of spinal neurons in inflamed rats
    Steve McGaraughty
    Neuroscience Research, Abbott Laboratories, Abbott Park, IL 60064 6118, USA
    J Neurophysiol 100:3158-66. 2008
    ..Furthermore this study delineates the differential contribution of central and peripheral TRPV1 receptors to affect spontaneous or mechanically evoked firing of WDR neurons...
  21. doi request reprint Discovery of potent furan piperazine sodium channel blockers for treatment of neuropathic pain
    Irene Drizin
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Bioorg Med Chem 16:6379-86. 2008
    ....
  22. doi request reprint Indol-3-yl-tetramethylcyclopropyl ketones: effects of indole ring substitution on CB2 cannabinoid receptor activity
    Jennifer M Frost
    Neurological Diseases Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA
    J Med Chem 51:1904-12. 2008
    ..Several agonists were active in the complete Freund's adjuvant model of chronic inflammatory thermal hyperalgesia ( 32, 15)...
  23. pmc A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat
    Michael F Jarvis
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064 6123, USA
    Proc Natl Acad Sci U S A 99:17179-84. 2002
    ....
  24. pmc Effects of A-317491, a novel and selective P2X3/P2X2/3 receptor antagonist, on neuropathic, inflammatory and chemogenic nociception following intrathecal and intraplantar administration
    Steve McGaraughty
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, R4PM, AP9 1, 100 Abbott Park Road, Abbott Park, IL 60064 6118, USA
    Br J Pharmacol 140:1381-8. 2003
    ..Intrathecal administration of A-317491 appears to be more effective than intraplantar administration to reduce tactile allodynia following peripheral nerve injury...
  25. ncbi request reprint Differential action potentials and firing patterns in injured and uninjured small dorsal root ganglion neurons after nerve injury
    Xu Feng Zhang
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Brain Res 1009:147-58. 2004
    ....
  26. ncbi request reprint (L)-Phenylglycine, but not necessarily other alpha2delta subunit voltage-gated calcium channel ligands, attenuates neuropathic pain in rats
    James J Lynch
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA
    Pain 125:136-42. 2006
    ..These results suggest that additional mechanisms, besides alpha2delta interactions, may contribute to the effects of compounds like gabapentin, pregabalin and (L)-phenylglycine in neuropathic pain...
  27. ncbi request reprint A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel transient receptor potential type V1 receptor antagonist, relieves pathophysiological pain associated with inflammation and tissue injury in rats
    Prisca Honore
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    J Pharmacol Exp Ther 314:410-21. 2005
    ..o.). Taken together, the present data indicate that A-425619, a potent and selective antagonist of TRPV1 receptors, effectively relieves acute and chronic inflammatory pain and postoperative pain...
  28. pmc Endogenous opioid mechanisms partially mediate P2X3/P2X2/3-related antinociception in rat models of inflammatory and chemogenic pain but not neuropathic pain
    Steve McGaraughty
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, R4PM, AP9 1, 100 Abbott Park Road, Abbott Park, IL 60064, U S A
    Br J Pharmacol 146:180-8. 2005
    ..Taken together, these results indicate that antagonism of spinal P2X3/P2X2/3 receptors results in an indirect activation of the opioid system to alleviate inflammatory hyperalgesia and chemogenic nociception...