J F Waring

Summary

Affiliation: Abbott Laboratories
Country: USA

Publications

  1. ncbi request reprint The promise of toxicogenomics
    Jeffrey F Waring
    Department of Cellular and Molecular Toxicology, Abbott Laboratories, Abbott Park, IL 60064 6123, USA
    Curr Opin Mol Ther 4:229-35. 2002
  2. ncbi request reprint Trovafloxacin-induced gene expression changes in liver-derived in vitro systems: comparison of primary human hepatocytes to HepG2 cells
    Michael J Liguori
    Department of Cellular, Molecular, and Exploratory Toxicology, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    Drug Metab Dispos 36:223-33. 2008
  3. ncbi request reprint Gene expression analysis in rats treated with experimental acetyl-coenzyme A carboxylase inhibitors suggests interactions with the peroxisome proliferator-activated receptor alpha pathway
    Jeffrey F Waring
    Molecular and Cellular Toxicology, Abbott Laboratories, Building AP9A R463, 100 Abbott Park Road, Abbott Park, IL 60064 6125, USA
    J Pharmacol Exp Ther 324:507-16. 2008
  4. pmc The Relationship between Different Assays for Detection and Quantification of Amyloid Beta 42 in Human Cerebrospinal Fluid
    Teresa A Ellis
    Neuroscience Biomarkers Group, Abbott Laboratories, Global Pharmaceutical Research and Abbot Park, Development, IL 60064 6123, USA
    Int J Alzheimers Dis 2012:984746. 2012
  5. ncbi request reprint The impact of genomics-based technologies on drug safety evaluation
    J F Waring
    Strategic and Exploratory Sciences, Abbott Laboratories, Abbott Park, Illinois 60064 6123, USA
    Annu Rev Pharmacol Toxicol 40:335-52. 2000
  6. ncbi request reprint Idiosyncratic toxicity: mechanistic insights gained from analysis of prior compounds
    Jeffrey F Waring
    Molecular and Cellular Toxicology, Abbott Laboratories Building AP9A, Abbott Park, IL 60064, USA
    Curr Opin Drug Discov Devel 8:59-65. 2005
  7. doi request reprint Analysis of gene expression profiles in rat hippocampus following treatment with nicotine and an alpha7 nAChR selective agonist
    Jeffrey F Waring
    Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Neurosci Res 60:266-74. 2008
  8. pmc Interlaboratory evaluation of rat hepatic gene expression changes induced by methapyrilene
    Jeffrey F Waring
    Abbott Laboratories, 100 Abbott Park Road, Department R463, Abbott Park, IL 60064 6123, USA
    Environ Health Perspect 112:439-48. 2004
  9. ncbi request reprint Isolated human hepatocytes in culture display markedly different gene expression patterns depending on attachment status
    Jeffrey F Waring
    Department of Cellular and Molecular Toxicology, Abbott Laboratories, Abbott Park, IL 60064 6123, USA
    Toxicol In Vitro 17:693-701. 2003
  10. ncbi request reprint Development of a DNA microarray for toxicology based on hepatotoxin-regulated sequences
    Jeffrey F Waring
    Dept of Cellular and Molecular Toxicology, Abbott Laboratories, D463, Abbott Park, IL 60064 6104, USA
    EHP Toxicogenomics 111:53-60. 2003

Detail Information

Publications45

  1. ncbi request reprint The promise of toxicogenomics
    Jeffrey F Waring
    Department of Cellular and Molecular Toxicology, Abbott Laboratories, Abbott Park, IL 60064 6123, USA
    Curr Opin Mol Ther 4:229-35. 2002
    ..This review focuses on recent studies in toxicogenomics, and discusses the promises and future challenges in this field...
  2. ncbi request reprint Trovafloxacin-induced gene expression changes in liver-derived in vitro systems: comparison of primary human hepatocytes to HepG2 cells
    Michael J Liguori
    Department of Cellular, Molecular, and Exploratory Toxicology, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    Drug Metab Dispos 36:223-33. 2008
    ....
  3. ncbi request reprint Gene expression analysis in rats treated with experimental acetyl-coenzyme A carboxylase inhibitors suggests interactions with the peroxisome proliferator-activated receptor alpha pathway
    Jeffrey F Waring
    Molecular and Cellular Toxicology, Abbott Laboratories, Building AP9A R463, 100 Abbott Park Road, Abbott Park, IL 60064 6125, USA
    J Pharmacol Exp Ther 324:507-16. 2008
    ..Overall, the gene expression analysis suggests a plausible mechanism for the similar pharmacological findings with active and inactive enantiomers of an ACC2 inhibitor...
  4. pmc The Relationship between Different Assays for Detection and Quantification of Amyloid Beta 42 in Human Cerebrospinal Fluid
    Teresa A Ellis
    Neuroscience Biomarkers Group, Abbott Laboratories, Global Pharmaceutical Research and Abbot Park, Development, IL 60064 6123, USA
    Int J Alzheimers Dis 2012:984746. 2012
    ..This paper provides essential data for establishing the relationship between these assays and provides an important step towards the validation of Aβ(42) as a biomarker for AD...
  5. ncbi request reprint The impact of genomics-based technologies on drug safety evaluation
    J F Waring
    Strategic and Exploratory Sciences, Abbott Laboratories, Abbott Park, Illinois 60064 6123, USA
    Annu Rev Pharmacol Toxicol 40:335-52. 2000
    ..This review examines the contributions of these and related techniques toward toxicity evaluation of potential drug candidates and their future role in the discovery of new therapeutics...
  6. ncbi request reprint Idiosyncratic toxicity: mechanistic insights gained from analysis of prior compounds
    Jeffrey F Waring
    Molecular and Cellular Toxicology, Abbott Laboratories Building AP9A, Abbott Park, IL 60064, USA
    Curr Opin Drug Discov Devel 8:59-65. 2005
    ..This review will focus on recent evidence supporting these theories, as well as some of the preclinical models that can be used to test and study idiosyncratic drug responses...
  7. doi request reprint Analysis of gene expression profiles in rat hippocampus following treatment with nicotine and an alpha7 nAChR selective agonist
    Jeffrey F Waring
    Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Neurosci Res 60:266-74. 2008
    ..Overall, our results identify gene expression changes that may contribute to further defining the roles of nAChR activation in cognitive function...
  8. pmc Interlaboratory evaluation of rat hepatic gene expression changes induced by methapyrilene
    Jeffrey F Waring
    Abbott Laboratories, 100 Abbott Park Road, Department R463, Abbott Park, IL 60064 6123, USA
    Environ Health Perspect 112:439-48. 2004
    ..These results provide critical information regarding the consistency of microarray results across different laboratories and shed light on the strengths and limitations of expression profiling in drug safety analysis...
  9. ncbi request reprint Isolated human hepatocytes in culture display markedly different gene expression patterns depending on attachment status
    Jeffrey F Waring
    Department of Cellular and Molecular Toxicology, Abbott Laboratories, Abbott Park, IL 60064 6123, USA
    Toxicol In Vitro 17:693-701. 2003
    ..Overall, our results suggest that either significant gene expression changes occur in isolated hepatocytes or that suspended and attached cells represent different populations of hepatocytes found in intact livers...
  10. ncbi request reprint Development of a DNA microarray for toxicology based on hepatotoxin-regulated sequences
    Jeffrey F Waring
    Dept of Cellular and Molecular Toxicology, Abbott Laboratories, D463, Abbott Park, IL 60064 6104, USA
    EHP Toxicogenomics 111:53-60. 2003
    ..Overall, our strategy for design of a new rat toxicology microarray can be applied to other systems as well and should aid greatly in the development of microarrays targeted for specific scientific areas...
  11. ncbi request reprint Microarray analysis of lipopolysaccharide potentiation of trovafloxacin-induced liver injury in rats suggests a role for proinflammatory chemokines and neutrophils
    Jeffrey F Waring
    Department of Cellular and Molecular Toxicology, Abbott Laboratories, Bldg AP9A R463, 100 Abbott Park Road, Abbott Park, IL 60064 6104, USA
    J Pharmacol Exp Ther 316:1080-7. 2006
    ..Furthermore, they identify gene expression changes that could be explored as biomarkers for idiosyncratic toxicity and lead to enhanced understanding of the mechanism(s) underlying hepatotoxicity induced by TVX...
  12. ncbi request reprint Clustering of hepatotoxins based on mechanism of toxicity using gene expression profiles
    J F Waring
    Department of Cellular and Molecular Toxicology, Abbott Laboratories, Abbott Park, Illinois 60064 6104, USA
    Toxicol Appl Pharmacol 175:28-42. 2001
    ..Overall, the results suggest that microarray assays may prove to be a highly sensitive technique for safety screening of drug candidates and for the classification of environmental toxins...
  13. doi request reprint Identification of proteasome gene regulation in a rat model for HIV protease inhibitor-induced hyperlipidemia
    Jeffrey F Waring
    Abbott Laboratories Global Pharmaceuticals Research and Development, 100 Abbott Park Rd, Abbott Park, IL 60064 6123, USA
    Arch Toxicol 84:263-70. 2010
    ..Our results indicate a strong correlation between proteasomal induction and lipid elevations, and have allowed us to develop a rapid screen for identifying novel PIs that do not induce the proteasome...
  14. ncbi request reprint PTP1B antisense-treated mice show regulation of genes involved in lipogenesis in liver and fat
    Jeffrey F Waring
    Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 6123, USA
    Mol Cell Endocrinol 203:155-68. 2003
    ..In summary, microarray results suggest that reduction of PTP1B may alleviate hyperglycemia and enhance insulin sensitivity by a different mechanism than TZD treatment...
  15. ncbi request reprint A human immunodeficiency virus protease inhibitor is a novel functional inhibitor of human pregnane X receptor
    Christine Healan-Greenberg
    Abbott Laboratories, Global Pharmaceutical Research and Development, Abbott Park, Illinois 60064 6104, USA
    Drug Metab Dispos 36:500-7. 2008
    ..Among the class of HIV-PIs, which are typically PXR activators, A-792611 seems to have a unique property for PXR antagonism and could be a useful tool for studying nuclear receptor pathway regulation...
  16. ncbi request reprint Identifying toxic mechanisms using DNA microarrays: evidence that an experimental inhibitor of cell adhesion molecule expression signals through the aryl hydrocarbon nuclear receptor
    Jeffrey F Waring
    Drug Safety Research, Abbott Laboratories, Abbott Park, IL 60064, USA
    Toxicology 181:537-50. 2002
    ....
  17. ncbi request reprint Gene expression profiling of multiple histone deacetylase (HDAC) inhibitors: defining a common gene set produced by HDAC inhibition in T24 and MDA carcinoma cell lines
    Keith B Glaser
    Cancer Research and Advanced Technologies, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064 6121, USA
    Mol Cancer Ther 2:151-63. 2003
    ..These data will aide in understanding the complex set of events in cells in response to chromatin remodeling induced by HDAC inhibition, which may be responsible for antitumor effects...
  18. ncbi request reprint Microarray analysis of hepatotoxins in vitro reveals a correlation between gene expression profiles and mechanisms of toxicity
    J F Waring
    Department of Cellular and Molecular Toxicology, Abbott Laboratories, D468 AP13A, 100 Abbott Park Road, Abbott Park, IL 60064-6104, USA
    Toxicol Lett 120:359-68. 2001
    ..These results show that large-scale analysis of gene expression using microarray technology has promise as a diagnostic tool for toxicology...
  19. doi request reprint Use of traditional end points and gene dysregulation to understand mechanisms of toxicity: toxicogenomics in mechanistic toxicology
    Wayne R Buck
    Department of Cellular and Molecular Toxicology, Abbott Laboratories, Abbott Park, Illinois, USA
    Methods Mol Biol 460:23-44. 2008
    ....
  20. doi request reprint Role of GSK-3beta activation and alpha7 nAChRs in Abeta(1-42)-induced tau phosphorylation in PC12 cells
    Min Hu
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064 6125, USA
    J Neurochem 106:1371-7. 2008
    ....
  21. ncbi request reprint Microarray analysis in human hepatocytes suggests a mechanism for hepatotoxicity induced by trovafloxacin
    Michael J Liguori
    Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064 6104, USA
    Hepatology 41:177-86. 2005
    ..Supplementary material for this article can be found on the HEPATOLOGY website (http://interscience. Wiley.com/jpages/0270-9139/suppmat/index.htnd)...
  22. doi request reprint Mice expressing the Swedish APP mutation on a 129 genetic background demonstrate consistent behavioral deficits and pathological markers of Alzheimer's disease
    Nathan R Rustay
    Neuroscience Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Rd, Bldg AP4 2, Abbott Park, IL 60064, USA
    Brain Res 1311:136-47. 2010
    ..These results indicate that mice on the 129 genetic background may generate more consistent and robust behavioral differences, providing a useful model for testing therapeutic agents for Alzheimer's disease...
  23. doi request reprint Evaluation of the effects of serial phlebotomy on the transcriptome of major tissues and on the response to toxicants in rats
    Eric A G Blomme
    Department of Cellular, Molecular and Exploratory Toxicology, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL, USA
    Toxicol Lett 176:138-48. 2008
    ....
  24. pmc PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice
    Bradley A Zinker
    Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 3500, USA
    Proc Natl Acad Sci U S A 99:11357-62. 2002
    ..These findings suggest that PTP1B modulates insulin signaling in liver and fat, and that therapeutic modalities targeting PTP1B inhibition may have clinical benefit in type 2 diabetes...
  25. ncbi request reprint Antisense protein tyrosine phosphatase 1B reverses activation of p38 mitogen-activated protein kinase in liver of ob/ob mice
    Rebecca J Gum
    Abbott Laboratories, Department R 4CK, AP10 1, 100 Abbott Park Road, Abbott Park, Illinois 60064 3502, USA
    Mol Endocrinol 17:1131-43. 2003
    ..This study demonstrates that reduction of PTP1B protein using ASO reduces activation of p38 and its substrates TNFalpha and CREB in liver of diabetic mice, which correlates with decreased hyperglycemia and hyperinsulinemia...
  26. doi request reprint Application of a high-content multiparameter cytotoxicity assay to prioritize compounds based on toxicity potential in humans
    Vivek C Abraham
    Lead Discovery, Abbott Laboratories, Abbott Park, IL 60064 6217, USA
    J Biomol Screen 13:527-37. 2008
    ....
  27. doi request reprint Use of toxicogenomics to understand mechanisms of drug-induced hepatotoxicity during drug discovery and development
    Eric A G Blomme
    Department of Cellular, Molecular and Exploratory Toxicology, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL, USA
    Toxicol Lett 186:22-31. 2009
    ..In general, this technology can not only improve the discipline of toxicology and risk assessment but also represent an extremely effective, hypothesis-generating alternative to rapidly understand mechanisms of hepatotoxicity...
  28. ncbi request reprint Development of a toxicogenomics in vitro assay for the efficient characterization of compounds
    Yi Yang
    Abbott Laboratories, Department of Cellular and Molecular Toxicology, 100 Abbott Park Rd, Abbott Park, IL 60064 6123, USA
    Pharmacogenomics 7:177-86. 2006
    ..Furthermore, by adapting this type of assay to a higher throughput platform, in vitro toxicogenomics can represent an effective approach to generate robust toxicological data early in the drug discovery process...
  29. ncbi request reprint Protein tyrosine phosphatase 1B reduction regulates adiposity and expression of genes involved in lipogenesis
    Cristina M Rondinone
    Metabolic Diseases Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    Diabetes 51:2405-11. 2002
    ..These results demonstrate that PTP1B antisense treatment can modulate fat storage and lipogenesis in adipose tissue and might implicate PTP1B in the enlargement of adipocyte energy stores and development of obesity...
  30. doi request reprint Liver transcriptomic changes associated with ritonavir-induced hyperlipidemia in sensitive and resistant strains of rats
    Yi Yang
    Abbott Laboratories, Abbott Park, IL, USA
    Vet J 185:75-82. 2010
    ..These findings will facilitate the discovery of novel, lipid-neutral HIV PIs and the identification of relevant biomarkers for this adverse event...
  31. doi request reprint Comparing levels of biochemical markers in CSF from cannulated and non-cannulated rats
    Steven C Cassar
    Translational Neuroimaging and Biochemical Biomarkers, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Rd, Abbott Park, IL 60064, USA
    J Neurosci Methods 192:249-53. 2010
    ....
  32. pmc Comparison of TNFα to lipopolysaccharide as an inflammagen to characterize the idiosyncratic hepatotoxicity potential of drugs: Trovafloxacin as an example
    Michael J Liguori
    Department of Cellular, Molecular, and Exploratory Toxicology, Abbott Laboratories Abbott Park, IL 60064, USA E Mails A C D J F W E A G B
    Int J Mol Sci 11:4697-714. 2010
    ..Comparison of TNFα/TVX and LPS/TVX gene expression profiles revealed similarities in the regulation of biochemical pathways. In conclusion, TNFα could be used in lieu of LPS as an inflammatory stimulus in this model of IDRs...
  33. ncbi request reprint Microvesicular steatosis induced by a short chain fatty acid: effects on mitochondrial function and correlation with gene expression
    Robert A Jolly
    Abbott Laboratories, North Chicago, Illinois 60064, USA
    Toxicol Pathol 32:19-25. 2004
    ..Overall, these results support altered hepatic mitochondrial function as a mechanism of the toxicity induced by a short-chain fatty acid and may provide potential biomarkers for this toxicity...
  34. ncbi request reprint N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1-methylprop-2-ynyl}carboxy derivatives as acetyl-coA carboxylase inhibitors--improvement of cardiovascular and neurological liabilities via structural modifications
    Yu Gui Gu
    Global Pharmaceutical Research and Development, Abbott Laboratories, 200 Abbott Park Road, Abbott Park, Illinois 60064, USA
    J Med Chem 50:1078-82. 2007
    ..Replacement of the alkyne with alternative linker groups led to a new series of ACC inhibitors with drastically improved cardiovascular and neurological profiles...
  35. pmc Practical preclinical model for assessing the potential for unconjugated hyperbilirubinemia produced by human immunodeficiency virus protease inhibitors
    Dale J Kempf
    Global Pharmaceutical Research and Development, Abbott, Abbott Park, Illinois 60064, USA
    Antimicrob Agents Chemother 50:762-4. 2006
    ..This model was used to disqualify an exploratory protease inhibitor from development...
  36. ncbi request reprint Preclinical profiling and safety studies of ABT-769: a compound with potential for broad-spectrum antiepileptic activity
    William J Giardina
    Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064 6125, USA
    Epilepsia 46:1349-61. 2005
    ..The objective of this study was to characterize the antiseizure and safety profiles of ABT-769 [(R)-N-(2 amino-2-oxoethyl)spiro[2,5]octane-1-carboxamide]...
  37. ncbi request reprint Toxicogenomics in drug discovery: from preclinical studies to clinical trials
    Yi Yang
    Department of Cellular and Molecular Toxicology, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 6123, USA
    Chem Biol Interact 150:71-85. 2004
    ..This review will focus on how toxicogenomics can or has been applied in drug discovery and development, and will discuss some of the challenges that still remain...
  38. ncbi request reprint Investigations toward enhanced understanding of hepatic idiosyncratic drug reactions
    Michael J Liguori
    Abbott Laboratories, Department of Cellular, Molecular, and Exploratory Toxicology, Abbott Park, IL 60064, USA
    Expert Opin Drug Metab Toxicol 2:835-46. 2006
    ..Several examples of informative studies on the nature of IDRs that employ toxicogenomic and proteomic technologies are summarised...
  39. doi request reprint Preclinical characterization of A-582941: a novel alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties
    Karin R Tietje
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    CNS Neurosci Ther 14:65-82. 2008
    ....
  40. ncbi request reprint Development of an approach for ab initio estimation of compound-induced liver injury based on global gene transcriptional profiles
    Xudong Dai
    Rosetta Inpharmatics LLC, Merck and Co, Inc, Seattle, WA 98109, USA
    Genome Inform 17:77-88. 2006
    ..9% sensitivity and 88.4% specificity. Our findings illustrate the feasibility of ab initio estimation of liver toxicity based on transcriptional profiles...
  41. ncbi request reprint Gene expression profiling of rat liver reveals a mechanistic basis for ritonavir-induced hyperlipidemia
    Pek Yee Lum
    Rosetta Inpharmatics LLC, 401 Terry Avenue North, Seattle, WA 98109, USA
    Genomics 90:464-73. 2007
    ....
  42. ncbi request reprint Modest inflammation enhances diclofenac hepatotoxicity in rats: role of neutrophils and bacterial translocation
    Xiaomin Deng
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
    J Pharmacol Exp Ther 319:1191-9. 2006
    ..These results demonstrate that inflammation-DCLF interaction precipitates hepatotoxicity in rats and raise the possibility of creating animal models that predict human IADRs...
  43. ncbi request reprint Gene expression in human hepatocytes in suspension after isolation is similar to the liver of origin, is not affected by hepatocyte cold storage and cryopreservation, but is strongly changed after hepatocyte plating
    Lysiane Richert
    Laboratoire de Biologie Cellulaire, EA3921 Optimisation Métabolique et Cellulaire, UFR des Sciences Médicales et Pharmaceutiques, Place Saint Jacques, 25030 Besancon Cedex, France
    Drug Metab Dispos 34:870-9. 2006
    ..Taken together, these results may aid in the interpretation of data collected from human hepatocyte experiments and suggest additional utility for cold storage and cryopreservation of hepatocytes...
  44. pmc Use of a mixed tissue RNA design for performance assessments on multiple microarray formats
    Karol L Thompson
    Center for Drug Evaluation and Research, US FDA, Silver Spring, MD 20993, USA
    Nucleic Acids Res 33:e187. 2005
    ..The mixed tissue design produces a reagent with known gene expression changes within a complex sample and can serve as a paradigm for performance standards for microarrays that target other species...
  45. pmc G1P3, an IFN-induced survival factor, antagonizes TRAIL-induced apoptosis in human myeloma cells
    Venugopalan Cheriyath
    Center for Hematology and Oncology Molecular Therapeutics, The Cleveland Clinic, Taussig Cancer Center, Cleveland, Ohio, USA
    J Clin Invest 117:3107-17. 2007
    ..Our data identify the direct role of a mitochondria-localized prosurvival ISG in antagonizing the effect of TRAIL. Curtailing G1P3-mediated antiapoptotic signals could improve therapies for myeloma or other malignancies...