J B Pan

Summary

Affiliation: Abbott Laboratories
Country: USA

Publications

  1. ncbi request reprint A-412997, a selective dopamine D4 agonist, improves cognitive performance in rats
    Kaitlin E Browman
    Neuroscience Research, Abbott Laboratories, AP9A, R4N5, 100 Abbott Park Road, Abbott Park, IL 60064 6115, USA
    Pharmacol Biochem Behav 82:148-55. 2005
  2. ncbi request reprint Histaminergic ligands attenuate barrel rotation in rats following unilateral labyrinthectomy
    J B Pan
    Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, IL, USA
    Methods Find Exp Clin Pharmacol 20:771-7. 1998
  3. ncbi request reprint Evidence for tolerance following repeated dosing in rats with ciproxifan, but not with A-304121
    Jia Bao Pan
    Neuroscience Research, Abbott Laboratories, 100 Abbott Road, Abbott Park, IL 60064 6125, USA
    Life Sci 79:1366-79. 2006
  4. ncbi request reprint Selective H3 receptor (H3R) blockade: broad efficacy in cognition and schizophrenia
    G B Fox
    Neuroscience Research, Abbott Laboratories, AP9A, Global Pharmaceutical Research and Development, Abbott Park, Illinois 60064, USA
    Inflamm Res 54:S23-4. 2005
  5. ncbi request reprint Cognition enhancing effects of novel H(3) receptor (H(3)R) antagonists in several animal models
    G B Fox
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    Inflamm Res 53:S49-50. 2004
  6. ncbi request reprint Identification of novel H3 receptor (H3R) antagonists with cognition enhancing properties in rats
    G B Fox
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, AP9A, R4N5, 100 Abbott Park Rd, Abbott Park, Illinois 60064 6115, USA
    Inflamm Res 52:S31-2. 2003
  7. ncbi request reprint Achievement of behavioral efficacy and improved potency in new heterocyclic analogs of benzofuran H3 antagonists
    M Cowart
    Department R4MN, AP9a 216, Abbott Laboratories, Global Pharmaceutical Research and Development, 100 Abbott Park Road, Abbott Park, IL 60064 6123, USA
    Inflamm Res 54:S25-6. 2005
  8. pmc Blockade of mGluR1 receptor results in analgesia and disruption of motor and cognitive performances: effects of A-841720, a novel non-competitive mGluR1 receptor antagonist
    O El-Kouhen
    Neuroscience Research, Global Pharmaceutical Research Division, Abbott Laboratories, Abbott Park, IL 60064, USA
    Br J Pharmacol 149:761-74. 2006
  9. ncbi request reprint Preclinical profiling and safety studies of ABT-769: a compound with potential for broad-spectrum antiepileptic activity
    William J Giardina
    Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064 6125, USA
    Epilepsia 46:1349-61. 2005
  10. ncbi request reprint Differential effects of ciproxifan and nicotine on impulsivity and attention measures in the 5-choice serial reaction time test
    Mark Day
    Discovery Translational Medicine, Wyeth Research, 500 Arcola Road, PA 19426, USA
    Biochem Pharmacol 73:1123-34. 2007

Collaborators

Detail Information

Publications21

  1. ncbi request reprint A-412997, a selective dopamine D4 agonist, improves cognitive performance in rats
    Kaitlin E Browman
    Neuroscience Research, Abbott Laboratories, AP9A, R4N5, 100 Abbott Park Road, Abbott Park, IL 60064 6115, USA
    Pharmacol Biochem Behav 82:148-55. 2005
    ..CP226269 showed a significant enhancement in the 5-trial inhibitory avoidance model. These results support a role for the dopamine D4 receptor subtype in cognition...
  2. ncbi request reprint Histaminergic ligands attenuate barrel rotation in rats following unilateral labyrinthectomy
    J B Pan
    Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, IL, USA
    Methods Find Exp Clin Pharmacol 20:771-7. 1998
    ..These results indicate that this model may be a potential tool for testing novel drugs for antivertigo effects and provide better support to the role of the histaminergic system in the control of vestibular function...
  3. ncbi request reprint Evidence for tolerance following repeated dosing in rats with ciproxifan, but not with A-304121
    Jia Bao Pan
    Neuroscience Research, Abbott Laboratories, 100 Abbott Road, Abbott Park, IL 60064 6125, USA
    Life Sci 79:1366-79. 2006
    ..The implications for potential long-term treatment with H(3) receptor antagonists in CNS disorders such as ADHD are discussed...
  4. ncbi request reprint Selective H3 receptor (H3R) blockade: broad efficacy in cognition and schizophrenia
    G B Fox
    Neuroscience Research, Abbott Laboratories, AP9A, Global Pharmaceutical Research and Development, Abbott Park, Illinois 60064, USA
    Inflamm Res 54:S23-4. 2005
  5. ncbi request reprint Cognition enhancing effects of novel H(3) receptor (H(3)R) antagonists in several animal models
    G B Fox
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    Inflamm Res 53:S49-50. 2004
  6. ncbi request reprint Identification of novel H3 receptor (H3R) antagonists with cognition enhancing properties in rats
    G B Fox
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, AP9A, R4N5, 100 Abbott Park Rd, Abbott Park, Illinois 60064 6115, USA
    Inflamm Res 52:S31-2. 2003
  7. ncbi request reprint Achievement of behavioral efficacy and improved potency in new heterocyclic analogs of benzofuran H3 antagonists
    M Cowart
    Department R4MN, AP9a 216, Abbott Laboratories, Global Pharmaceutical Research and Development, 100 Abbott Park Road, Abbott Park, IL 60064 6123, USA
    Inflamm Res 54:S25-6. 2005
  8. pmc Blockade of mGluR1 receptor results in analgesia and disruption of motor and cognitive performances: effects of A-841720, a novel non-competitive mGluR1 receptor antagonist
    O El-Kouhen
    Neuroscience Research, Global Pharmaceutical Research Division, Abbott Laboratories, Abbott Park, IL 60064, USA
    Br J Pharmacol 149:761-74. 2006
    ..To further assess the clinical potential of the blockade of metabotropic glutamate receptors (mGluR1) for the treatment of pain...
  9. ncbi request reprint Preclinical profiling and safety studies of ABT-769: a compound with potential for broad-spectrum antiepileptic activity
    William J Giardina
    Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064 6125, USA
    Epilepsia 46:1349-61. 2005
    ..The objective of this study was to characterize the antiseizure and safety profiles of ABT-769 [(R)-N-(2 amino-2-oxoethyl)spiro[2,5]octane-1-carboxamide]...
  10. ncbi request reprint Differential effects of ciproxifan and nicotine on impulsivity and attention measures in the 5-choice serial reaction time test
    Mark Day
    Discovery Translational Medicine, Wyeth Research, 500 Arcola Road, PA 19426, USA
    Biochem Pharmacol 73:1123-34. 2007
    ..We also expanded on previous positive findings by others with ciproxifan on attention and both Wyeth and Abbott demonstrate for the first time decreased impulsivity with this mechanism...
  11. ncbi request reprint Effects of histamine H3 receptor antagonists in two models of spatial learning
    Victoria A Komater
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, AP9A, D4N5, Abbott Park, IL 60064, USA
    Behav Brain Res 159:295-300. 2005
    ..Taken together, these data suggest a role for H3 receptors in spatial learning that appears to be task-dependent...
  12. ncbi request reprint Pharmacological properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: II. Neurophysiological characterization and broad preclinical efficacy in cognition and schizophrenia of a potent and selective histamine H3 re
    Gerard B Fox
    Neuroscience Research, Global Pharmaceutical Research Division, Abbott Laboratories, AP9A, R4N5, Abbott Park, IL 60064 6115, USA
    J Pharmacol Exp Ther 313:176-90. 2005
    ..0 mg/kg), but not striatum. In summary, broad efficacy was observed with ABT-239 across animal models such that potential clinical efficacy may extend beyond disorders such as ADHD to include Alzheimer's disease and schizophrenia...
  13. ncbi request reprint Pharmacological and behavioral properties of A-349821, a selective and potent human histamine H3 receptor antagonist
    Timothy A Esbenshade
    Abbott Laboratories, Global Pharmaceutical Research Division, Department of Neuroscience Research, Abbott Park, IL 60064, USA
    Biochem Pharmacol 68:933-45. 2004
    ..Thus, A-349821 is a novel, selective non-imidazole H3 antagonist/inverse agonist with balanced high potency across species and favorable cognition enhancing effects in rats...
  14. ncbi request reprint D-amino acid homopiperazine amides: discovery of A-320436, a potent and selective non-imidazole histamine H(3)-receptor antagonist
    Michael P Curtis
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Arch Pharm (Weinheim) 337:219-29. 2004
    ..This compound was shown to demonstrate in vitro and in vivo functional antagonism and is non-neurotoxic at doses (i.p.) up to 163 mg/kg in a general observation test...
  15. ncbi request reprint Antiobesity effects of A-331440, a novel non-imidazole histamine H3 receptor antagonist
    Arthur A Hancock
    Abbott Laboratories, Global Pharmaceutical Research and Development, 100 Abbott Park Road, Abbott Park, IL 60064 6125, USA
    Eur J Pharmacol 487:183-97. 2004
    ..The two higher doses reduced body fat and the highest dose also normalized an insulin tolerance test. These data show that the histamine H(3) receptor antagonist, A-331440, has potential as an antiobesity agent...
  16. ncbi request reprint Structure-activity relationships of non-imidazole H(3) receptor ligands. Part 3: 5-Substituted 3-phenyl-1,2,4-oxadiazoles as potent antagonists
    Gregory A Gfesser
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA
    Bioorg Med Chem Lett 14:673-6. 2004
    ..Compound 14bb is a potent antagonist of both the rat cortical and human clone receptors, and is demonstrated to act functionally as an antagonist in an in vivo mouse dipsogenia model...
  17. ncbi request reprint Synthesis and SAR of aminoalkoxy-biaryl-4-carboxamides: novel and selective histamine H3 receptor antagonists
    Ramin Faghih
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park 60064 6123, USA
    Bioorg Med Chem Lett 13:1325-8. 2003
    ..Most compounds were highly potent and selective for human and rat H(3) receptors and selected examples such as A-349821 showed functional antagonism of H(3) receptors in vitro and in a mouse dipsogenia model...
  18. ncbi request reprint Two novel and selective nonimidazole H3 receptor antagonists A-304121 and A-317920: II. In vivo behavioral and neurophysiological characterization
    Gerard B Fox
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, AP9A, R4N5, 100 Abbott Park Road, Abbott Park, IL 60064 6115, USA
    J Pharmacol Exp Ther 305:897-908. 2003
    ..A-304121 and A-317920 represent a series of novel, H3R-selective piperazine amides that enhance cognition in vivo, which could offer advantages over existing H3R antagonists or cognition-enhancing agents...
  19. ncbi request reprint Differential in vivo effects of H3 receptor ligands in a new mouse dipsogenia model
    Gerard B Fox
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, AP9A, R4N5, Abbott Park, IL 60064 6115, USA
    Pharmacol Biochem Behav 72:741-50. 2002
    ..This new dipsogenia model provides the first in vivo behavioral evidence for possible pharmacological differences between three putative H(3) receptor inverse agonists, GT-2331 and proxyfan...
  20. ncbi request reprint Effects of histamine H(3) receptor ligands GT-2331 and ciproxifan in a repeated acquisition avoidance response in the spontaneously hypertensive rat pup
    Gerard B Fox
    CNS Diseases Research, Global Pharmaceutical Research and Development, Abbott Laboratories, AP9A D4N5, Abbott Park, IL 60064, USA
    Behav Brain Res 131:151-61. 2002
    ..c.) blocked the pro-cognitive effects of ciproxifan, suggesting an H(3) receptor site of action for this compound. This model is useful for evaluating the cognition/attention-enhancing potential of H(3) receptor antagonists...
  21. ncbi request reprint Synthesis, potency, and in vivo profiles of quinoline containing histamine H3 receptor inverse agonists
    Robert J Altenbach
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064 6123, USA
    J Med Chem 50:5439-48. 2007
    ..Further studies on the pharmaceutic properties of this series of quinolines discovered a potential problem with photochemical instability, an issue which contributed to the discontinuation of this series from further development...