Robert B Moreland

Summary

Affiliation: Abbott Laboratories
Country: USA

Publications

  1. ncbi request reprint Correlation between brain/plasma ratios and efficacy in neuropathic pain models of selective metabotropic glutamate receptor 1 antagonists
    Guo Zhu Zheng
    Neuroscience Research, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 6115, USA
    Bioorg Med Chem Lett 16:4936-40. 2006
  2. ncbi request reprint 1-aryl-3-(4-pyridine-2-ylpiperazin-1-yl)propan-1-one oximes as potent dopamine D4 receptor agonists for the treatment of erectile dysfunction
    Teodozyj Kolasa
    Neuroscience Research, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064 6101, USA
    J Med Chem 49:5093-109. 2006
  3. doi request reprint Molecular determinants of species-specific activation or blockade of TRPA1 channels
    Jun Chen
    Neuroscience, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064 6125, USA
    J Neurosci 28:5063-71. 2008
  4. ncbi request reprint Comparative pharmacology of human dopamine D(2)-like receptor stable cell lines coupled to calcium flux through Galpha(qo5)
    Robert B Moreland
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Biochem Pharmacol 68:761-72. 2004
  5. ncbi request reprint Expression of functional prostaglandin D (DP) receptors in human corpus cavernosum smooth muscle
    R B Moreland
    Department of Urology, Boston University School of Medicine, Boston, Massachusetts, USA
    Int J Impot Res 14:446-52. 2002
  6. pmc In vitro models: research in physiology and pharmacology of the lower urinary tract
    Robert B Moreland
    Neuroscience Research, Global Pharmaceutical Research and Discovery, Department R4PM, Abbott Laboratories, Abbott Park, IL 60064 6123, USA
    Br J Pharmacol 147:S56-61. 2006
  7. ncbi request reprint A-412997 is a selective dopamine D4 receptor agonist in rats
    Robert B Moreland
    Neuroscience Research, Global Pharmaceutical Research and Development, AP9A Room 219, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois, 60064 6123, USA
    Pharmacol Biochem Behav 82:140-7. 2005
  8. ncbi request reprint Emerging pharmacologic approaches for the treatment of lower urinary tract disorders
    Robert B Moreland
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064 6118, USA
    J Pharmacol Exp Ther 308:797-804. 2004
  9. ncbi request reprint 2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393), a selective dopamine D4 receptor antagonist
    Masaki Nakane
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Neuropharmacology 49:112-21. 2005
  10. ncbi request reprint Analgesic activity of metabotropic glutamate receptor 1 antagonists on spontaneous post-operative pain in rats
    Chang Z Zhu
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 3500, USA
    Eur J Pharmacol 580:314-21. 2008

Collaborators

Detail Information

Publications48

  1. ncbi request reprint Correlation between brain/plasma ratios and efficacy in neuropathic pain models of selective metabotropic glutamate receptor 1 antagonists
    Guo Zhu Zheng
    Neuroscience Research, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 6115, USA
    Bioorg Med Chem Lett 16:4936-40. 2006
    ..34, demonstrating only moderate efficacy in neuropathic pain models. On the other hand, antagonist 4b with a brain/plasma ratio of 2.70 was fully efficacious in neuropathic pain models...
  2. ncbi request reprint 1-aryl-3-(4-pyridine-2-ylpiperazin-1-yl)propan-1-one oximes as potent dopamine D4 receptor agonists for the treatment of erectile dysfunction
    Teodozyj Kolasa
    Neuroscience Research, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064 6101, USA
    J Med Chem 49:5093-109. 2006
    ..Our results suggest that the oximes provide a novel structural linker for 4-arylpiperazine-based D4 agonists, possessing leadlike quality and with potential to develop a new class of potent and selective dopamine D4 receptor agonists...
  3. doi request reprint Molecular determinants of species-specific activation or blockade of TRPA1 channels
    Jun Chen
    Neuroscience, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064 6125, USA
    J Neurosci 28:5063-71. 2008
    ..Therefore, our findings reveal a molecular basis of species-specific channel gating and provide novel insights into how TRPA1 respond to stimuli...
  4. ncbi request reprint Comparative pharmacology of human dopamine D(2)-like receptor stable cell lines coupled to calcium flux through Galpha(qo5)
    Robert B Moreland
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Biochem Pharmacol 68:761-72. 2004
    ....
  5. ncbi request reprint Expression of functional prostaglandin D (DP) receptors in human corpus cavernosum smooth muscle
    R B Moreland
    Department of Urology, Boston University School of Medicine, Boston, Massachusetts, USA
    Int J Impot Res 14:446-52. 2002
    ..These data are consistent with the expression of functional DP receptors in human corpus cavernosum. This suggests the presence of an intact prostanoid autocrine system that may play a role in regulating penile erectile function...
  6. pmc In vitro models: research in physiology and pharmacology of the lower urinary tract
    Robert B Moreland
    Neuroscience Research, Global Pharmaceutical Research and Discovery, Department R4PM, Abbott Laboratories, Abbott Park, IL 60064 6123, USA
    Br J Pharmacol 147:S56-61. 2006
    ..In this review, representative assays are presented based on our experience in male erectile dysfunction...
  7. ncbi request reprint A-412997 is a selective dopamine D4 receptor agonist in rats
    Robert B Moreland
    Neuroscience Research, Global Pharmaceutical Research and Development, AP9A Room 219, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois, 60064 6123, USA
    Pharmacol Biochem Behav 82:140-7. 2005
    ..A-412997 is a highly selective dopamine D4 receptor agonist and a useful tool to understand the role of dopamine D4 receptors in rat models of central nervous system processes and disease...
  8. ncbi request reprint Emerging pharmacologic approaches for the treatment of lower urinary tract disorders
    Robert B Moreland
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064 6118, USA
    J Pharmacol Exp Ther 308:797-804. 2004
    ..New peripheral targets as well as centrally acting agents represent potential emerging therapies. In this review, the pharmacologic basis of treatment of these disorders is discussed with special emphasis on emerging new therapeutics...
  9. ncbi request reprint 2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393), a selective dopamine D4 receptor antagonist
    Masaki Nakane
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Neuropharmacology 49:112-21. 2005
    ..A-381393 inhibited penile erection induced by the selective D4 agonist PD168077 in conscious rats. Thus, A-381393 is a novel selective D4 antagonist that will enhance the ability to study dopamine D4 receptors both in vitro and in vivo...
  10. ncbi request reprint Analgesic activity of metabotropic glutamate receptor 1 antagonists on spontaneous post-operative pain in rats
    Chang Z Zhu
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 3500, USA
    Eur J Pharmacol 580:314-21. 2008
    ....
  11. ncbi request reprint [3H]A-778317 [1-((R)-5-tert-butyl-indan-1-yl)-3-isoquinolin-5-yl-urea]: a novel, stereoselective, high-affinity antagonist is a useful radioligand for the human transient receptor potential vanilloid-1 (TRPV1) receptor
    Bruce R Bianchi
    Department of Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, R4PM, AP9A 2, 100 Abbott Park Rd, Abbott Park, IL 60064 6123, USA
    J Pharmacol Exp Ther 323:285-93. 2007
    ....
  12. ncbi request reprint Acrylamide analog as a novel nitric oxide-independent soluble guanylyl cyclase activator
    Masaki Nakane
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, USA
    J Pharmacol Sci 102:231-8. 2006
    ..This novel activator of sGC may have potential efficacy for the treatment of a variety of disorders associated with reduced NO signaling...
  13. ncbi request reprint Central mechanisms regulating penile erection in conscious rats: the dopaminergic systems related to the proerectile effect of apomorphine
    Gin C Hsieh
    Neuroscience Research, Abbott Laboratories, Abbott Park, Illinois 60064 6119, USA
    J Pharmacol Exp Ther 308:330-8. 2004
    ..These results suggest that the proerectile action of apomorphine in rats is mediated at supraspinal levels and that this effect is not mimicked by a D2 receptor agonist but associated with activation of D4 receptors...
  14. ncbi request reprint Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a dopaminergic agent with a novel mode of action for the potential treatment of erectile dysfunction
    Marlon Cowart
    Department of Neuroscience Research, Abbott Laboratories, Abbott Park, IL 60064 6123, USA
    J Med Chem 47:3853-64. 2004
    ..Distinctive structural features were discovered that are associated with D4 selective agonism in this series of analogues...
  15. ncbi request reprint Synthesis and activity of 2-[4-(4-[3H]-2-cyanophenyl)piperazinyl]-N-(2,4,6-[3H]3-3-methylphenyl)acetamide: a selective dopamine D4 receptor agonist and radioligand
    Mark A Matulenko
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, AP9A L16, 100 Abbott Park Road, Abbott Park, IL 60064 6115, USA
    Bioorg Med Chem Lett 14:5095-8. 2004
    ..The synthesis, biological, and radioactivity of this new agonist radioligand as well as preliminary SAR will be discussed...
  16. doi request reprint Transient receptor potential A1 mediates an osmotically activated ion channel
    Xu Feng Zhang
    Neuroscience Research, R4PM, AP9A, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 6125, USA
    Eur J Neurosci 27:605-11. 2008
    ..Taken together, these findings indicate that TRPA1 mediates an osmotically-activated ion channel and support a role for TRPA1 in mechanosensation...
  17. ncbi request reprint Activation of TRPA1 channels by the fatty acid amide hydrolase inhibitor 3'-carbamoylbiphenyl-3-yl cyclohexylcarbamate (URB597)
    Wende Niforatos
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064 6125, USA
    Mol Pharmacol 71:1209-16. 2007
    ..In contrast to its effect on TRPA1, URB597 inhibited TRPM8 and had no effects on TRPV1 or TRPV4. Thus, we conclude that URB597 is a novel agonist of TRPA1 and probably activates the channel through a direct gating mechanism...
  18. ncbi request reprint Synthesis and evaluation of 3-aryl piperidine analogs as potent and efficacious dopamine D4 receptor agonists
    Xueqing Wang
    Neuroscience Research, Global Pharmaceutical Research and Development, AP9A L16, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA
    Bioorg Med Chem 13:4667-78. 2005
    ..The synthesis and structure-activity relationship (SAR) studies that led to the identification of these compounds are discussed...
  19. ncbi request reprint [3H] A-369508 ([2-[4-(2-cyanophenyl)-1-piperazinyl]-N-(3-methylphenyl) acetamide): an agonist radioligand selective for the dopamine D4 receptor
    Robert B Moreland
    Neuroscience Research Global Pharmaceutical Research and Development, AP9 Room 1125, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 6118, USA
    Eur J Pharmacol 497:147-54. 2004
    ....
  20. ncbi request reprint Synthesis and functional activity of (2-aryl-1-piperazinyl)-N-(3-methylphenyl)acetamides: selective dopamine D4 receptor agonists
    Mark A Matulenko
    Neuroscience Research, Global Pharmaceutical Research, Abbott Laboratories, Abbott Park, IL 60064, USA
    Bioorg Med Chem 12:3471-83. 2004
    ..Systematic evaluation of the substitution on the aryl piperazine portion revealed a significant effect on functional activity. The synthesis and biological activity of these new dopamine D(4) agonists is discussed...
  21. doi request reprint Characterization of A-425619 at native TRPV1 receptors: a comparison between dorsal root ganglia and trigeminal ganglia
    Heath A McDonald
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Eur J Pharmacol 596:62-9. 2008
    ..These data show that A-425619 is a potent TRPV1 antagonist at the native TRPV1 receptors, and suggest that the pharmacological profile for TRPV1 receptors on dorsal root ganglia and trigeminal ganglia is very similar...
  22. ncbi request reprint YC-1 potentiates the nitric oxide/cyclic GMP pathway in corpus cavernosum and facilitates penile erection in rats
    Gin C Hsieh
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 6119, USA
    Eur J Pharmacol 458:183-9. 2003
    ..These biochemical events may be related to the pro-erectile properties of YC-1 in vivo...
  23. pmc Activation of dopamine D4 receptors by ABT-724 induces penile erection in rats
    Jorge D Brioni
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Proc Natl Acad Sci U S A 101:6758-63. 2004
    ..The ability of ABT-724 to facilitate penile erection together with the favorable side-effect profile indicates that ABT-724 could be useful for the treatment of erectile dysfunction...
  24. ncbi request reprint Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction
    Meena V Patel
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064 3500, USA
    J Med Chem 49:7450-65. 2006
    ..The N-oxy-2-pyridinyl moiety not only provided the structural motif required for agonist function but also reduced metabolism rates. The SAR study leading to the discovery of 6b is described herein...
  25. doi request reprint Development of ELISA to measure TRPV1 protein in rat tissues
    Ping Han
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    J Neurosci Methods 200:144-52. 2011
    ..This is the first TRPV1 sandwich ELISA that determines the abundance of TRPV1 protein in different tissues. It provides a powerful tool to quantify changes of TRPV1 protein levels in pathological states...
  26. ncbi request reprint Dopamine D4 receptor signaling in the rat paraventricular hypothalamic nucleus: Evidence of natural coupling involving immediate early gene induction and mitogen activated protein kinase phosphorylation
    Robert S Bitner
    Abbott Laboratories, Neuroscience Research, Abbott Park, IL 60064 3500, USA
    Neuropharmacology 50:521-31. 2006
    ..These findings provide additional evidence that the PVN may be a site of dopamine D4 receptor-mediated proerectile activity...
  27. ncbi request reprint Dopamine D2, but not D4, receptor agonists are emetogenic in ferrets
    Mark A Osinski
    Integrative Pharmacology, Global Pharmaceutical Research and Discovery, Abbott Laboratories, R46R AP9 1, 100 Abbott Park Road, Abbott Park, IL 60064 6119, USA
    Pharmacol Biochem Behav 81:211-9. 2005
    ..Thus, dopamine D2 and/or D3 receptor agonists elicit emesis, while dopamine D1/D5 or D4 receptor-selective agonists are devoid of emetic properties...
  28. ncbi request reprint Structure-activity relationship of triazafluorenone derivatives as potent and selective mGluR1 antagonists
    Guo Zhu Zheng
    Neuroscience Research, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064 6115, USA
    J Med Chem 48:7374-88. 2005
    ..Compound 1n, for example, was a very potent mGluR1 antagonist (IC50 = 3 nM) and demonstrated full efficacy in various in vivo animal pain models...
  29. ncbi request reprint Application of large-scale transiently transfected cells to functional assays of ion channels: different targets and assay formats
    Bruce R Bianchi
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Assay Drug Dev Technol 5:417-24. 2007
    ..Hence, the utilization of LSTT cells could reduce the need for stable cell lines, and enable development of functional assays in a more timely and economic fashion for different ion channels and different assay formats...
  30. doi request reprint Expression and purification of human TRPV1 in baculovirus-infected insect cells for structural studies
    Alla Korepanova
    Department of Structural Biology, R46Y, Abbott Laboratories, Bldg AP10 LL8, 100 Abbott Park Rd, Abbott Park, IL 60064 6098, USA
    Protein Expr Purif 65:38-50. 2009
    ..Specific ligand binding experiments confirmed the protein integrity of the purified human TRPV1...
  31. ncbi request reprint Capsaicin causes protein synthesis inhibition and microtubule disassembly through TRPV1 activities both on the plasma membrane and intracellular membranes
    Ping Han
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Biochem Pharmacol 73:1635-45. 2007
    ..Taken together, the present studies demonstrate that intracellular pool of TRPV1 plays an important role in regulating cell morphology and viability upon receptor activation...
  32. ncbi request reprint Rapid hit to lead evaluation of pyrazolo[3,4-d]pyrimidin-4-one as selective and orally bioavailable mGluR1 antagonists
    Xueqing Wang
    Neuroscience Research, Global Pharmaceutical Research and Development, AP9A L16, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL, USA
    Bioorg Med Chem Lett 17:4303-7. 2007
    ..These improvements were paralleled by rat PK study characterized by low clearance and quantitative bioavailability. Compound 2f represented a true lead-like molecule that is amenable for further lead optimization (LO) evaluation...
  33. ncbi request reprint Central oxytocinergic and dopaminergic mechanisms regulating penile erection in conscious rats
    Brenda Martino
    Global Neuroscience Research, Global Pharmaceutical Research and Development, Building AP9A, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064, USA
    Pharmacol Biochem Behav 81:797-804. 2005
    ..Together, these data indicate a possible concomitant role between dopamine and oxytocin in mediating penile erection at both the spinal and supraspinal sites...
  34. ncbi request reprint A-412997, a selective dopamine D4 agonist, improves cognitive performance in rats
    Kaitlin E Browman
    Neuroscience Research, Abbott Laboratories, AP9A, R4N5, 100 Abbott Park Road, Abbott Park, IL 60064 6115, USA
    Pharmacol Biochem Behav 82:148-55. 2005
    ..CP226269 showed a significant enhancement in the 5-trial inhibitory avoidance model. These results support a role for the dopamine D4 receptor subtype in cognition...
  35. ncbi request reprint Electrophysiological and in vivo characterization of A-317567, a novel blocker of acid sensing ion channels
    G R Dube
    Abbott Laboratories, Neuroscience Research, Building AP9A Dept R4ND, Abbott Park, IL 60064 6118, USA
    Pain 117:88-96. 2005
    ..The discovery of A-317567 will greatly help to enhance our understanding of the physiological and pathophysiological role of ASICs...
  36. doi request reprint Quantification of TRPV1 protein levels in rat tissues to understand its physiological roles
    Ping Han
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL, USA
    J Mol Neurosci 50:23-32. 2013
    ..01), no significant difference was detected in the lumbar region of the spinal cord. Quantitative determination of TRPV1 protein levels may help to elucidate the TRPV1 physiological roles and regulatory mechanisms in various pain states...
  37. ncbi request reprint A-350619: a novel activator of soluble guanylyl cyclase
    Loan N Miller
    Neuroscience Research, Global Pharmaceutical Research and Development, AP9, Room 1125, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 6119, USA
    Life Sci 72:1015-25. 2003
    ..Activation of soluble guanylyl cyclase in cavernosum tissue as an alternate method of enhancing the effect of NO may provide a novel treatment of sexual dysfunction...
  38. ncbi request reprint Dopamine D4 ligands and models of receptor activation: 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole and related heteroarylmethylarylpiperazines exhibit a substituent effect responsible for additional efficacy tuning
    Andrew O Stewart
    Department R4ND, Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064 6115, USA
    J Med Chem 47:2348-55. 2004
    ..The structural similarity between partial agonist and antagonist, within this subset of ligands, and lack of bioisosterism for this substituent effect are key phenomena for these hypotheses...
  39. ncbi request reprint TRPV1b overexpression negatively regulates TRPV1 responsiveness to capsaicin, heat and low pH in HEK293 cells
    Melissa H Vos
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    J Neurochem 99:1088-102. 2006
    ..Taken together, these data support the hypothesis that TRPV1b is a naturally existing inhibitory modulator of TRPV1...
  40. doi request reprint Discovery of TRPV1 antagonist ABT-116
    Brian S Brown
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Dept R4PM, AP10 207, 100 Abbott Park Road, Abbott Park, IL 60064 6100, USA
    Bioorg Med Chem Lett 20:3291-4. 2010
    ..Biological studies demonstrated potent in vitro and in vivo activity for 21, as well as suitable physicochemical and pharmacokinetic properties for advancement to clinical development for pain management...
  41. ncbi request reprint A cell-based microarrayed compound screening format for identifying agonists of G-protein-coupled receptors
    Sujatha M Gopalakrishnan
    Advanced Technology, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Anal Biochem 321:192-201. 2003
    ..Excellent confirmation rates coupled with enhanced efficiency and throughput enable microARCS to serve as an alternative platform for the screening and identification of novel GPCR agonists...
  42. ncbi request reprint Antidepressant-like effect of D(2/3) receptor-, but not D(4) receptor-activation in the rat forced swim test
    Ana M Basso
    Abbott Laboratories, Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Park, IL 60064, USA
    Neuropsychopharmacology 30:1257-68. 2005
    ..The pharmacological selectivity of the compounds tested suggests that the antidepressant-like effects of quinpirole are most likely mediated mainly by D(2) and to a lesser extent by D(3) but not D(4) receptors...
  43. ncbi request reprint Effects of selective dopamine receptor subtype agonists on cardiac contractility and regional haemodynamics in rats
    James S Polakowski
    Pharmaceutical Discovery, Global Pharmaceutical R and D, Abbott Laboratories, Abbott Park, Illinois 60064 6119, USA
    Clin Exp Pharmacol Physiol 31:837-41. 2004
    ..Hence, by comparison, agonism of the D4 receptor has little effect in the cardiovascular system of the rat relative to the other dopamine receptor subtype agonists tested...
  44. ncbi request reprint Role of central and peripheral mGluR5 receptors in post-operative pain in rats
    Chang Z Zhu
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064 3500, USA
    Pain 114:195-202. 2005
    ..In addition, the data suggest that mGluR5 antagonists could offer a new therapeutic approach to the treatment of post-operative pain...
  45. ncbi request reprint Utility of large-scale transiently transfected cells for cell-based high-throughput screens to identify transient receptor potential channel A1 (TRPA1) antagonists
    Jun Chen
    Neuroscience Research, Abbott Laboratories, Abbott Park, IL 60064 6125, USA
    J Biomol Screen 12:61-9. 2007
    ..The use of LSTT circumvented issues associated with stable TRPA1 expression, increased flexibility and consistency, and greatly reduced labor and cost. This approach will also be applicable to other pharmaceutical targets...
  46. ncbi request reprint Reperfusion of ischemic corporal tissue: physiologic and biochemical changes in an animal model of ischemic priapism
    Ricardo Munarriz
    Department of Urology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Urology 62:760-4. 2003
    ..Data are limited concerning reperfusion injury of ischemic erectile tissue associated with reactive oxygen species (ROS) and the potential role of ROS scavengers in the clinical therapy of ischemic priapism...
  47. ncbi request reprint Modulation of human TRPV1 receptor activity by extracellular protons and host cell expression system
    Bruce R Bianchi
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Eur J Pharmacol 537:20-30. 2006
    ....
  48. ncbi request reprint Reconstitution of human corpus cavernosum smooth muscle in vitro and in vivo
    Richard T Kershen
    Laboratory for Tissue Engineering and Cellular Therapeutics, Department of Urology, Children s Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Tissue Eng 8:515-24. 2002
    ..This study provides evidence that cultured human corporal smooth muscle cells may be used in conjunction with biodegradable polymer scaffolds to create corpus cavernosum smooth muscle tissue in vitro and in vivo...