Affiliation: Abbott Laboratories
- Generation and therapeutic efficacy of highly oligomer-specific beta-amyloid antibodiesHeinz Hillen
Neuroscience Research, Global Pharmaceutical Research and Development, Abbott, d 67061 Ludwigshafen, Germany
J Neurosci 30:10369-79. 2010..Our findings demonstrate that selective reduction of Abeta oligomers by immunotherapy is sufficient to normalize cognitive behavior and synaptic deficits in APP transgenic mice...
- Abeta-globulomers are formed independently of the fibril pathwayGerald P Gellermann
Neuroscience Discovery Research, Abbott GmbH and Co KG, Knollstrasse, d 67061 Ludwigshafen, Germany
Neurobiol Dis 30:212-20. 2008..We hypothesize that a conformational switch of A beta is decisive for either fibril formation or alternatively and independently A beta-globulomer formation...
- Amyloid beta oligomers (A beta(1-42) globulomer) suppress spontaneous synaptic activity by inhibition of P/Q-type calcium currentsVolker Nimmrich
Neuroscience Discovery, Global Pharmaceutical Research and Development, Abbott, d 67061 Ludwigshafen, Germany
J Neurosci 28:788-97. 2008..Selective enhancement of the P/Q calcium current may provide a promising strategy in the treatment of Alzheimer's disease...