S A Buckner

Summary

Affiliation: Abbott Laboratories
Country: USA

Publications

  1. ncbi request reprint Pharmacological and molecular analysis of ATP-sensitive K(+) channels in the pig and human detrusor
    S A Buckner
    Neurological and Urological Diseases Research, Pharmaceutical Products Division, Abbott Laboratories, D47C, Bldg AP9, First Floor, 100 Abbott Park Road, Abbott Park, IL 60064 6118, USA
    Eur J Pharmacol 400:287-95. 2000
  2. ncbi request reprint A-315456: a selective alpha(1D)-adrenoceptor antagonist with minimal dopamine D(2) and 5-HT(1A) receptor affinity
    S A Buckner
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 6118, USA
    Eur J Pharmacol 433:123-7. 2001
  3. pmc Spontaneous phasic activity of the pig urinary bladder smooth muscle: characteristics and sensitivity to potassium channel modulators
    Steven A Buckner
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois, IL 60064, USA
    Br J Pharmacol 135:639-48. 2002
  4. ncbi request reprint Characterization of the ATP-sensitive potassium channels (KATP) expressed in guinea pig bladder smooth muscle cells
    M Gopalakrishnan
    Neurological and Urological Diseases Research, Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, Illinois, USA
    J Pharmacol Exp Ther 289:551-8. 1999
  5. ncbi request reprint Functional implication of spare ATP-sensitive K(+) channels in bladder smooth muscle cells
    C C Shieh
    Neurological and Urological Diseases Research, Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, Illinois 60064-6125, USA
    J Pharmacol Exp Ther 296:669-75. 2001
  6. ncbi request reprint Pharmacological properties of A-204176, a novel and selective alpha1A adrenergic agonist, in in vitro and in vivo models of urethral function
    A B O'Neill
    Neurological and Urological Diseases Research, Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, IL 60064, USA
    Life Sci 70:181-97. 2001
  7. pmc A-272651, a nonpeptidic blocker of large-conductance Ca2+-activated K+ channels, modulates bladder smooth muscle contractility and neuronal action potentials
    C C Shieh
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Br J Pharmacol 151:798-806. 2007
  8. ncbi request reprint Two novel and potent 3-[(o-methoxyphenyl)piperazinylethyl]-5-phenylthien
    W A Carroll
    Abbott Laboratories, Neurological and Urological Diseases Research, Abbott Park, IL 60064 6101, USA
    Bioorg Med Chem Lett 11:1119-21. 2001
  9. ncbi request reprint Structure-activity studies for a novel series of bicyclic substituted hexahydrobenz[e]isoindole alpha1A adrenoceptor antagonists as potential agents for the symptomatic treatment of benign prostatic hyperplasia
    M D Meyer
    Neurological and Urological Diseases Research, Pharmaceutical Products Division, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064, USA
    J Med Chem 44:1971-85. 2001
  10. pmc Characterization of a novel ATP-sensitive K+ channel opener, A-251179, on urinary bladder relaxation and cystometric parameters
    C C Shieh
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Br J Pharmacol 151:467-75. 2007

Detail Information

Publications31

  1. ncbi request reprint Pharmacological and molecular analysis of ATP-sensitive K(+) channels in the pig and human detrusor
    S A Buckner
    Neurological and Urological Diseases Research, Pharmaceutical Products Division, Abbott Laboratories, D47C, Bldg AP9, First Floor, 100 Abbott Park Road, Abbott Park, IL 60064 6118, USA
    Eur J Pharmacol 400:287-95. 2000
    ....
  2. ncbi request reprint A-315456: a selective alpha(1D)-adrenoceptor antagonist with minimal dopamine D(2) and 5-HT(1A) receptor affinity
    S A Buckner
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 6118, USA
    Eur J Pharmacol 433:123-7. 2001
    ..These studies indicate that A-315456 is a potent and selective alpha(1D)-antagonist that may serve as a useful pharmacological ligand to probe the physiological role of the alpha(1D)-adrenoceptor subtype in normal and disease states...
  3. pmc Spontaneous phasic activity of the pig urinary bladder smooth muscle: characteristics and sensitivity to potassium channel modulators
    Steven A Buckner
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois, IL 60064, USA
    Br J Pharmacol 135:639-48. 2002
    ....
  4. ncbi request reprint Characterization of the ATP-sensitive potassium channels (KATP) expressed in guinea pig bladder smooth muscle cells
    M Gopalakrishnan
    Neurological and Urological Diseases Research, Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, Illinois, USA
    J Pharmacol Exp Ther 289:551-8. 1999
    ....
  5. ncbi request reprint Functional implication of spare ATP-sensitive K(+) channels in bladder smooth muscle cells
    C C Shieh
    Neurological and Urological Diseases Research, Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, Illinois 60064-6125, USA
    J Pharmacol Exp Ther 296:669-75. 2001
    ..These findings demonstrate that the reduction in membrane excitability by KCOs is associated with membrane hyperpolarization, and that a low amount of K(ATP) channel opening is sufficient to suppress bladder smooth muscle contraction...
  6. ncbi request reprint Pharmacological properties of A-204176, a novel and selective alpha1A adrenergic agonist, in in vitro and in vivo models of urethral function
    A B O'Neill
    Neurological and Urological Diseases Research, Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, IL 60064, USA
    Life Sci 70:181-97. 2001
    ..These data indicate that A-204176 may represent a useful pharmacological tool to investigate the functional role of the alpha1A adrenoceptor in the urethra and to elucidate the lack of uroselectivity observed in vivo...
  7. pmc A-272651, a nonpeptidic blocker of large-conductance Ca2+-activated K+ channels, modulates bladder smooth muscle contractility and neuronal action potentials
    C C Shieh
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Br J Pharmacol 151:798-806. 2007
    ..This study reports the characterization of a novel BK(Ca) channel blocker, 2,4-dimethoxy-N-naphthalen-2-yl-benzamide (A-272651)...
  8. ncbi request reprint Two novel and potent 3-[(o-methoxyphenyl)piperazinylethyl]-5-phenylthien
    W A Carroll
    Abbott Laboratories, Neurological and Urological Diseases Research, Abbott Park, IL 60064 6101, USA
    Bioorg Med Chem Lett 11:1119-21. 2001
    ..The synthesis and in vitro characterization of A-119637 and A-123189, two novel, selective and potent alpha1D antagonists, are described...
  9. ncbi request reprint Structure-activity studies for a novel series of bicyclic substituted hexahydrobenz[e]isoindole alpha1A adrenoceptor antagonists as potential agents for the symptomatic treatment of benign prostatic hyperplasia
    M D Meyer
    Neurological and Urological Diseases Research, Pharmaceutical Products Division, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064, USA
    J Med Chem 44:1971-85. 2001
    ..Compound 48 showed the highest degree of selectivity in the radioligand binding assays (56-fold), in the in vitro functional tests (80-fold), and for in vivo prostate selectivity (960-fold)...
  10. pmc Characterization of a novel ATP-sensitive K+ channel opener, A-251179, on urinary bladder relaxation and cystometric parameters
    C C Shieh
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Br J Pharmacol 151:467-75. 2007
    ..This study reports the characterization of 4-methyl-N-(2,2,2-trichloro-1-(3-pyridin-3-ylthioureido)ethyl)benzamide (A-251179) as a K(ATP) channel opener...
  11. ncbi request reprint Effects of substitution on 9-(3-bromo-4-fluorophenyl)-5,9-dihydro-3H,4H-2,6-dioxa-4- azacyclopenta[b]naphthalene-1,8-dione, a dihydropyridine ATP-sensitive potassium channel opener
    Robert J Altenbach
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064 6123, USA
    J Med Chem 49:6869-87. 2006
    ..For compound 23b, this profile was mirrored in vivo where it was fully efficacious in inhibiting spontaneous myogenic bladder contractions but only partially able to reduce neurogenically mediated reflex bladder contractions...
  12. ncbi request reprint Pharmacological characterization of urinary bladder smooth muscle contractility following partial bladder outlet obstruction in pigs
    Ivan Milicic
    Neuroscience Research, Department R4MN, Building AP9, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA
    Eur J Pharmacol 532:107-14. 2006
    ..K(ATP) channel sensitivities remain essentially unimpaired in the obstructed bladder and could be effectively modulated by openers with potential for the treatment of overactive bladder secondary to outlet obstruction...
  13. ncbi request reprint Pharmacological characterization of the novel dihydropyridine potassium channel opener, (9R)-9-(3-iodo-4-methylphenyl)-5,9-dihydro-3H-furo[3,4-b]pyrano[4,3-e]pyridine-1,8(4H,7H)-dione (A-325100), and the regulation of cardiovascular function in conscious
    Ryan M Fryer
    Department of Integrative Pharmacology, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064 6119, USA
    J Cardiovasc Pharmacol 46:232-40. 2005
    ..Thus, these data demonstrate that the hemodynamic effects of vasoactive compounds, such as KCOs, can be effectively profiled in both the conscious and anesthetized dog...
  14. pmc In vitro and in vivo characterization of a novel naphthylamide ATP-sensitive K+ channel opener, A-151892
    Murali Gopalakrishnan
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA
    Br J Pharmacol 143:81-90. 2004
    ....
  15. ncbi request reprint Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist
    Robert J Altenbach
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 6123, USA
    J Med Chem 47:3220-35. 2004
    ..However, the data also support a prominent role of the alpha(1A)-AR subtype in the control of MAP...
  16. ncbi request reprint Synthesis and structure-activity relationships of a novel series of tricyclic dihydropyridine-based KATP openers that potently inhibit bladder contractions in vitro
    William A Carroll
    Neuroscience Research, R4PM, AP10, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 6101, USA
    J Med Chem 47:3180-92. 2004
    ..All compounds studied showed greater potency to inhibit spontaneous bladder contractions relative to their potencies to inhibit contractions elicited by electrical stimulation...
  17. ncbi request reprint Synthesis and structure-activity relationships of a novel series of 2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide K(ATP) channel openers: discovery of (-)-(9S)-9-(3-bromo-4-fluorophenyl)-2,3,5,6,7,9- hexahydrothieno[3,2-b]quinolin-8(4H)
    William A Carroll
    Abbott Laboratories, Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Park, IL 60064 6101, USA
    J Med Chem 47:3163-79. 2004
    ..Compound 14 showed approximately 5-fold greater selectivity than 1 in vivo and supports the concept that bladder-selective K(ATP) channel openers may have utility in the treatment of overactive bladder...
  18. ncbi request reprint Functional characterization of large conductance calcium-activated K+ channel openers in bladder and vascular smooth muscle
    John Malysz
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA
    Naunyn Schmiedebergs Arch Pharmacol 369:481-9. 2004
    ....
  19. ncbi request reprint Structure-activity studies for a novel series of tricyclic dihydropyridopyrazolones and dihydropyridoisoxazolones as K(ATP) channel openers
    Irene Drizin
    Neuroscience Research, GPRD, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 6101, USA
    Bioorg Med Chem 12:1895-904. 2004
    ..In vitro tests on the tissue from pig bladder strips provided further confirmation of K(ATP) activity of these compounds...
  20. ncbi request reprint Design and synthesis of novel cyanoguanidine ATP-sensitive potassium channel openers for the treatment of overactive bladder
    Arturo Perez-Medrano
    Abbott Laboratories, Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Park, IL 60064, USA
    Bioorg Med Chem Lett 14:397-400. 2004
    ..These agents are potent full agonists in relaxing electrically-stimulated pig bladder strips. The synthesis, SAR and biological properties of these agents are discussed...
  21. ncbi request reprint Preclinical pharmacology of fiduxosin, a novel alpha(1)-adrenoceptor antagonist with uroselective properties
    Arthur A Hancock
    Neurological and Urological Diseases Research, Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, Illinois 60064 6125, USA
    J Pharmacol Exp Ther 300:478-86. 2002
    ....
  22. ncbi request reprint Functional characterization of adenosine receptors and coupling to ATP-sensitive K+ channels in Guinea pig urinary bladder smooth muscle
    Sujatha M Gopalakrishnan
    Advanced Technology, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064 6181, USA
    J Pharmacol Exp Ther 300:910-7. 2002
    ....
  23. ncbi request reprint Structure-Activity studies for a novel series of tricyclic dihydropyrimidines as K(ATP) channel openers (KCOs)
    Irene Drizin
    Neuroscience Research, GPRD, Abbott Laboratories, 100 Abbott Park Road, IL 60064 6101, USA
    Bioorg Med Chem Lett 12:1481-4. 2002
    ..A novel series of tricyclic dihydropyrimidines was synthesized and evaluated for activity as K(ATP) channel openers. The functional activity of several compounds, for example 6A (EC(50)=30nM) and its enantiomers exceeded cromakalim...
  24. ncbi request reprint ABT-866, a novel alpha(1A)-adrenoceptor agonist with antagonist properties at the alpha(1B)- and alpha(1D)-adrenoceptor subtypes
    Steven A Buckner
    Neuroscience Research, Global Pharmaceutical Research and Development, Department R4ND, Bldg AP9A, Third Floor, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064 6125, USA
    Eur J Pharmacol 449:159-65. 2002
    ....
  25. ncbi request reprint (-)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide (A-278637): a novel ATP-sensitive potassium channel opener efficacious in suppressing urinary bladder contractions. I. In vitro characterization
    Murali Gopalakrishnan
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Illinois 60064, USA
    J Pharmacol Exp Ther 303:379-86. 2002
    ..The pharmacological profile of A-278637 represents an attractive basis for further investigations of selective K(ATP) channel openers for the treatment of overactive bladder via myogenic etiology...
  26. ncbi request reprint N-[3-(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1),(1) a novel alpha(1)-adrenoceptor ligand with an enhanced in vitro and in vivo profile relative to phenylpropanolamine and midodrine
    Robert J Altenbach
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064, USA
    J Med Chem 45:4395-7. 2002
    ..4) and alpha(1D) (rat aorta, pA(2) = 6.2) antagonism. An in vivo dog model showed 1 to be more selective for the urethra over the vasculature than A-61603 (2), ST-1059 (3, the active metabolite of midodrine), and phenylpropanolamine (4)...
  27. pmc Pharmacological characterization of a 1,4-dihydropyridine analogue, 9-(3,4-dichlorophenyl)-3,3,6,6-tetramethyl-3,4,6,7,9,10-hexahydro-1,8(2H,5H)-acridinedione (A-184209) as a novelK(ATP) channel inhibitor
    Murali Gopalakrishnan
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois, IL 60064, U S A
    Br J Pharmacol 138:393-9. 2003
    ....
  28. ncbi request reprint Structure-activity relationship of a novel class of naphthyl amide KATP channel openers
    Sean C Turner
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, IL 60064, USA
    Bioorg Med Chem Lett 13:1741-4. 2003
    ..2/SUR2B cells and pig bladder strips. Additionally, A-151892 was found to selectively inhibit unstable bladder contractions in vivo in an obstructed rat model of myogenic bladder function..
  29. ncbi request reprint The discovery of a new class of large-conductance Ca2+-activated K+ channel opener targeted for overactive bladder: synthesis and structure-activity relationships of 2-amino-4-azaindoles
    Sean C Turner
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA
    Bioorg Med Chem Lett 13:2003-7. 2003
    ..The preliminary SAR data indicate the importance of steric bulk around the 2-amino substituent...
  30. ncbi request reprint [125I]A-312110, a novel high-affinity 1,4-dihydropyridine ATP-sensitive K+ channel opener: characterization and pharmacology of binding
    Rachel Davis-Taber
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois, USA
    Mol Pharmacol 64:143-53. 2003
    ....
  31. ncbi request reprint Structure-activity studies of novel cyanoguanidine ATP-sensitive potassium channel openers for the treatment of overactive bladder
    Arturo Perez-Medrano
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064 6104, USA
    J Med Chem 50:6265-73. 2007
    ..Preliminary pharmacokinetic studies in dog demonstrated excellent oral bioavailability and a t1/2 of 15 h. The synthesis, SAR studies, and biological properties of these agents are discussed...