Bruno Manta

Summary

Country: Uruguay

Publications

  1. doi request reprint Trypanothione: a unique bis-glutathionyl derivative in trypanosomatids
    Bruno Manta
    Institut Pasteur de Montevideo, Montevideo, Uruguay
    Biochim Biophys Acta 1830:3199-216. 2013
  2. doi request reprint Factors affecting protein thiol reactivity and specificity in peroxide reduction
    Gerardo Ferrer-Sueta
    Laboratorio de Fisicoquímica Biológica, Instituto de Química Biológica, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay
    Chem Res Toxicol 24:434-50. 2011
  3. pmc Iron-sulfur cluster binding by mitochondrial monothiol glutaredoxin-1 of Trypanosoma brucei: molecular basis of iron-sulfur cluster coordination and relevance for parasite infectivity
    Bruno Manta
    Laboratory Redox Biology of Trypanosomes, Institut Pasteur de Montevideo, Montevideo, Uruguay
    Antioxid Redox Signal 19:665-82. 2013
  4. pmc Nitration transforms a sensitive peroxiredoxin 2 into a more active and robust peroxidase
    Lía M Randall
    From the Laboratorio de Fisicoquímica Biológica, Instituto de Quimica Biologica, Facultad de Ciencias, Universidad de la Republica, 11400 Montevideo, Uruguay, the Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la Republica, Montevideo 11100, Uruguay
    J Biol Chem 289:15536-43. 2014
  5. doi request reprint Thiol and sulfenic acid oxidation of AhpE, the one-cysteine peroxiredoxin from Mycobacterium tuberculosis: kinetics, acidity constants, and conformational dynamics
    Martín Hugo
    Departamento de Bioqumica, Facultad de Medicina, Center for Free Radical and Biomedical Research, Universidad de la Republica, Montevideo, Uruguay
    Biochemistry 48:9416-26. 2009
  6. doi request reprint Structural changes upon peroxynitrite-mediated nitration of peroxiredoxin 2; nitrated Prx2 resembles its disulfide-oxidized form
    Lía Randall
    Laboratorio de Fisicoquímica Biológica, Instituto de Quimica Biologica, Facultad de Ciencias, Universidad de la Republica, Montevideo, Uruguay Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la Republica, Montevideo, Uruguay
    Arch Biochem Biophys 590:101-8. 2016
  7. doi request reprint Deconstructing the catalytic efficiency of peroxiredoxin-5 peroxidatic cysteine
    Stephanie Portillo-Ledesma
    Laboratorio de Fisicoquímica Biológica, Laboratorio de Química Teórica y Computacional and Laboratorio de Enzimología, Instituto de Quimica Biologica, Facultad de Ciencias, Universidad de la Republica, Montevideo, Uruguay
    Biochemistry 53:6113-25. 2014

Collaborators

Detail Information

Publications7

  1. doi request reprint Trypanothione: a unique bis-glutathionyl derivative in trypanosomatids
    Bruno Manta
    Institut Pasteur de Montevideo, Montevideo, Uruguay
    Biochim Biophys Acta 1830:3199-216. 2013
    ..Notably, the trypanothione system is capable to sustain several cellular functions mediated by thiol-dependent (redox) processes...
  2. doi request reprint Factors affecting protein thiol reactivity and specificity in peroxide reduction
    Gerardo Ferrer-Sueta
    Laboratorio de Fisicoquímica Biológica, Instituto de Química Biológica, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay
    Chem Res Toxicol 24:434-50. 2011
    ..The extraordinary thiol reactivity and specificity toward H(2)O(2) combined with their ubiquity and abundance place peroxiredoxins, along with glutathione peroxidases, as obligate hydroperoxide cellular sensors...
  3. pmc Iron-sulfur cluster binding by mitochondrial monothiol glutaredoxin-1 of Trypanosoma brucei: molecular basis of iron-sulfur cluster coordination and relevance for parasite infectivity
    Bruno Manta
    Laboratory Redox Biology of Trypanosomes, Institut Pasteur de Montevideo, Montevideo, Uruguay
    Antioxid Redox Signal 19:665-82. 2013
    ..We here report on the functional and structural analysis of 1-C-Grx1 in relation to its ISC-binding properties...
  4. pmc Nitration transforms a sensitive peroxiredoxin 2 into a more active and robust peroxidase
    Lía M Randall
    From the Laboratorio de Fisicoquímica Biológica, Instituto de Quimica Biologica, Facultad de Ciencias, Universidad de la Republica, 11400 Montevideo, Uruguay, the Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la Republica, Montevideo 11100, Uruguay
    J Biol Chem 289:15536-43. 2014
    ..Thus, tyrosine nitration appears as another mechanism to modulate these enzymes in the complex network of redox signaling. ..
  5. doi request reprint Thiol and sulfenic acid oxidation of AhpE, the one-cysteine peroxiredoxin from Mycobacterium tuberculosis: kinetics, acidity constants, and conformational dynamics
    Martín Hugo
    Departamento de Bioqumica, Facultad de Medicina, Center for Free Radical and Biomedical Research, Universidad de la Republica, Montevideo, Uruguay
    Biochemistry 48:9416-26. 2009
    ..Taken together, our results indicate that MtAhpE is a relevant component in the antioxidant repertoire of M. tuberculosis probably involved in peroxide and specially peroxynitrite detoxification...
  6. doi request reprint Structural changes upon peroxynitrite-mediated nitration of peroxiredoxin 2; nitrated Prx2 resembles its disulfide-oxidized form
    Lía Randall
    Laboratorio de Fisicoquímica Biológica, Instituto de Quimica Biologica, Facultad de Ciencias, Universidad de la Republica, Montevideo, Uruguay Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la Republica, Montevideo, Uruguay
    Arch Biochem Biophys 590:101-8. 2016
    ..These results provide structural basis for the kinetic analysis previously reported, the observed increase in activity and the resistance to overoxidation of the peroxynitrite-treated enzyme. ..
  7. doi request reprint Deconstructing the catalytic efficiency of peroxiredoxin-5 peroxidatic cysteine
    Stephanie Portillo-Ledesma
    Laboratorio de Fisicoquímica Biológica, Laboratorio de Química Teórica y Computacional and Laboratorio de Enzimología, Instituto de Quimica Biologica, Facultad de Ciencias, Universidad de la Republica, Montevideo, Uruguay
    Biochemistry 53:6113-25. 2014
    ..In both effects, T44 has a central role. These effects occur in a precise temporal sequence that ensures that the selective nucleophilicity of C47 is available only for peroxide substrates. ..