Rengasamy Padmanabhan

Summary

Affiliation: Faculty of Medicine and Health Sciences
Country: United Arab Emirates

Publications

  1. ncbi Effect of maternal methionine pre-treatment on alcohol-induced exencephaly and axial skeletal dysmorphogenesis in mouse fetuses
    R Padmanabhan
    Department of Anatomy, Faculty of Medicine and Health Sciences, UAE University, PO Box 17666, Al Ain, United Arab Emirates
    Drug Alcohol Depend 65:263-81. 2002
  2. ncbi Abnormal folate metabolism and genetic polymorphism of the folate pathway in a child with Down syndrome and neural tube defect
    L I Al-Gazali
    Department of Paediatrics, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
    Am J Med Genet 103:128-32. 2001
  3. ncbi Effects of alpha-lipoic acid supplementation on maternal diabetes-induced growth retardation and congenital anomalies in rat fetuses
    M H M Al Ghafli
    Faculty of Science, UAE University, Al Ain, United Arab Emirates
    Mol Cell Biochem 261:123-35. 2004
  4. ncbi Mitochondrial dysmorphology in the neuroepithelium of rat embryos following a single dose of maternal hyperthermia during gestation
    Rengasamy Padmanabhan
    Department of Anatomy, Faculty of Medicine and Health Sciences, UAE University, P O Box 17666, Al Ain, United Arab Emirates
    Exp Brain Res 173:298-308. 2006
  5. ncbi Beneficial effect of supplemental lipoic acid on diabetes-induced pregnancy loss in the mouse
    Rengasamy Padmanabhan
    Department of Anatomy, Faculty of Medicine and Health Sciences, UAE University, PO Box 17666, Al Ain, United Arab Emirates
    Ann N Y Acad Sci 1084:118-31. 2006
  6. ncbi Experimental studies on cervical and lumbar ribs in mouse embryos
    Padmanabhan Rengasamy
    Department of Anatomy, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
    Congenit Anom (Kyoto) 44:156-71. 2004
  7. ncbi Histological, histochemical and electron microscopic changes of the placenta induced by maternal exposure to hyperthermia in the rat
    R Padmanabhan
    Department of Anatomy, Faculty of Medicine, UAE University, PO Box 17666, Al Ain, United Arab Emirates
    Int J Hyperthermia 21:29-44. 2005
  8. ncbi Effect of maternal diabetes and ethanol interactions on embryo development in the mouse
    R Padmanabhan
    Department of Anatomy, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
    Mol Cell Biochem 261:43-56. 2004
  9. ncbi Etiology, pathogenesis and prevention of neural tube defects
    Rengasamy Padmanabhan
    Department of Anatomy, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
    Congenit Anom (Kyoto) 46:55-67. 2006
  10. ncbi Experimental studies on reproductive toxicologic effects of lamotrigine in mice
    R Padmanabhan
    Department of Anatomy, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
    Birth Defects Res B Dev Reprod Toxicol 68:428-38. 2003

Collaborators

Detail Information

Publications21

  1. ncbi Effect of maternal methionine pre-treatment on alcohol-induced exencephaly and axial skeletal dysmorphogenesis in mouse fetuses
    R Padmanabhan
    Department of Anatomy, Faculty of Medicine and Health Sciences, UAE University, PO Box 17666, Al Ain, United Arab Emirates
    Drug Alcohol Depend 65:263-81. 2002
    ....
  2. ncbi Abnormal folate metabolism and genetic polymorphism of the folate pathway in a child with Down syndrome and neural tube defect
    L I Al-Gazali
    Department of Paediatrics, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
    Am J Med Genet 103:128-32. 2001
    ..The presence of both trisomy 21 and postclosure NTD in the same child supports the need for an extended periconceptional period of maternal folate supplementation to achieve greater preventive effects for both NTD and trisomy 21...
  3. ncbi Effects of alpha-lipoic acid supplementation on maternal diabetes-induced growth retardation and congenital anomalies in rat fetuses
    M H M Al Ghafli
    Faculty of Science, UAE University, Al Ain, United Arab Emirates
    Mol Cell Biochem 261:123-35. 2004
    ..They also highlight the possible role of antioxidants in the normal processes of embryo survival, growth and development...
  4. ncbi Mitochondrial dysmorphology in the neuroepithelium of rat embryos following a single dose of maternal hyperthermia during gestation
    Rengasamy Padmanabhan
    Department of Anatomy, Faculty of Medicine and Health Sciences, UAE University, P O Box 17666, Al Ain, United Arab Emirates
    Exp Brain Res 173:298-308. 2006
    ..The results of this study indicate that the embryonic response to maternal heat shock is tissue-specific and morphologically distinct in this species...
  5. ncbi Beneficial effect of supplemental lipoic acid on diabetes-induced pregnancy loss in the mouse
    Rengasamy Padmanabhan
    Department of Anatomy, Faculty of Medicine and Health Sciences, UAE University, PO Box 17666, Al Ain, United Arab Emirates
    Ann N Y Acad Sci 1084:118-31. 2006
    ..Rates of intrauterine growth restriction and major congenital malformations were also augmented thus indicating that the interaction between DM and LA has deleterious effects on postimplantation embryos...
  6. ncbi Experimental studies on cervical and lumbar ribs in mouse embryos
    Padmanabhan Rengasamy
    Department of Anatomy, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
    Congenit Anom (Kyoto) 44:156-71. 2004
    ....
  7. ncbi Histological, histochemical and electron microscopic changes of the placenta induced by maternal exposure to hyperthermia in the rat
    R Padmanabhan
    Department of Anatomy, Faculty of Medicine, UAE University, PO Box 17666, Al Ain, United Arab Emirates
    Int J Hyperthermia 21:29-44. 2005
    ..These data suggest that placental pathology possibly contributes to fetal growth retardation in maternally heat-stressed rat fetuses...
  8. ncbi Effect of maternal diabetes and ethanol interactions on embryo development in the mouse
    R Padmanabhan
    Department of Anatomy, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
    Mol Cell Biochem 261:43-56. 2004
    ..These data suggest that the interaction effects are possibly related to alterations in fundamental developmental processes of early embryos...
  9. ncbi Etiology, pathogenesis and prevention of neural tube defects
    Rengasamy Padmanabhan
    Department of Anatomy, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
    Congenit Anom (Kyoto) 46:55-67. 2006
    ..Future studies must address issues of gene-gene, gene-nutrient and gene-environment interactions in the pathogenesis of NTD...
  10. ncbi Experimental studies on reproductive toxicologic effects of lamotrigine in mice
    R Padmanabhan
    Department of Anatomy, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
    Birth Defects Res B Dev Reprod Toxicol 68:428-38. 2003
    ..With only a few cases of prenatal exposure to LTG in the record, however, it has not been possible to establish a recognizable pattern of malformations in the infants of LTG-treated mothers...
  11. ncbi Amelioration of sodium valproate-induced neural tube defects in mouse fetuses by maternal folic acid supplementation during gestation
    R Padmanabhan
    Department of Anatomy, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
    Congenit Anom (Kyoto) 43:29-40. 2003
    ..These data suggest that plasma levels of FA and B12 have to be kept substantially elevated and maintained high throughout organogenesis period to protect embryos against VPA-induced NTD in this mouse model...
  12. doi Intrauterine growth restriction and skeletal variations in mouse fetuses induced by vigabatrin administered at preimplantation stages of development
    Rengasamy Padmanabhan
    Department of Anatomy, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
    Congenit Anom (Kyoto) 48:29-39. 2008
    ..Future studies must address the mechanisms of VGB-induced IUGR and minor malformations...
  13. ncbi Caudal dysgenesis in staged human embryos: Carnegie stages 16-23
    R Padmanabhan
    Department of Anatomy, Faculty of Medicine, UAE University, Al Ain, United Arab Emirates
    Am J Med Genet 87:115-27. 1999
    ..The data suggest that these polytopic field defects arise very early in development possibly as result of disturbances to fundamental developmental events that share common molecular and cellular mechanisms...
  14. ncbi Effect of maternal exposure to homocystine on sodium valproate-induced neural tube defects in the mouse embryos
    R Padmanabhan
    Department of Anatomy, Faculty of Medicine and Health Sciences, UAE University, PO Box 17666, Al Ain, United Arab Emirates
    Eur J Nutr 45:311-9. 2006
    ..Maternal treatment with valproic acid (VPA) during pregnancy induces NTD in susceptible fetuses. Elevated levels of homocysteine are observed in pregnancies with NTD. The mechanism by which homocysteine might cause NTD is unknown...
  15. ncbi Effect of maternal administration of vigabatrin during late gestation on fetoplacental amino acid profile in the mouse
    Yousef M Abdulrazzaq
    Department of Paediatrics, Faculty of Medicine and Health Sciences, UAE University, P O Box Number 17666, Al Ain, United Arab Emirates
    Reprod Toxicol 20:549-60. 2005
    ..This increase did not help restore growth suggesting that early fetal period is particularly vulnerable to VGB-induced intrauterine growth retardation in the mouse...
  16. ncbi Intrauterine growth retardation in experimental diabetes: possible role of the placenta
    R Padmanabhan
    Department of Anatomy, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
    Arch Physiol Biochem 109:260-71. 2001
    ..The consistent association of placental pathology with fetal growth retardation is suggestive of an alteration in placental function possibly contributing to IUGR in STZ-induced diabetes in rats...
  17. ncbi Placental transfer of vigabatrin (gamma-vinyl GABA) and its effect on concentration of amino acids in the embryo of TO mice
    Y M Abdulrazzaq
    Department of Paediatrics, FMHS, United Arab Emirates University, PO Box 17666, Al Ain, United Arab Emirates
    Teratology 63:127-33. 2001
    ..The objectives of this study were to determine the placental transfer of VGB and to evaluate the effect of VGB on maternal, placental, and fetal concentrations of amino acids...
  18. doi Toxicokinetics of aflatoxin in pregnant mice
    Salim A Bastaki
    Department of Paediatrics, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates
    Int J Toxicol 29:425-31. 2010
    ..The absorption was 5.0 microg/min and elimination was 3.0 microg/min. The toxicokinetics of AFB1 have been delineated. Aflatoxins are easily and rapidly absorbed both from the gastrointestinal tract (GI) tract and through the peritoneum...
  19. ncbi Further delineation of Hennekam syndrome
    L I Al-Gazali
    Department of Paediatrics and Anatomy, Faculty of Medicine and Health Sciences, UAE University, Al Ain, UAE
    Clin Dysmorphol 12:227-32. 2003
    ....
  20. ncbi Folic acid awareness and intake survey in the United Arab Emirates
    Yousef M Abdulrazzaq
    Department of Paediatrics, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates
    Reprod Toxicol 17:171-6. 2003
    ..The aim of this study was to determine the level of knowledge and use of periconceptional folic acid supplementation in a sample of postpartum women recruited from three hospitals...
  21. ncbi Pattern of central nervous system anomalies in a population with a high rate of consanguineous marriages
    L I Al-Gazali
    Department of Paediatrics, Faculty of Medicine and Health Sciences, UAE University, Al Ain Hospital, United Arab Emirates
    Clin Genet 55:95-102. 1999
    ..The study indicates that CNS anomalies are fairly common in the UAE, particularly, the recessive syndromic types. Careful and detailed analysis of such anomalies is required so that accurate genetic advice can be given...