Stephen J Yarwood

Summary

Country: UK

Publications

  1. pmc The role of c-Jun in controlling the EPAC1-dependent induction of the SOCS3 gene in HUVECs
    Jolanta Wiejak
    Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, G12 8QQ Scotland, United Kingdom
    FEBS Lett 588:1556-61. 2014
  2. pmc Interaction with receptor for activated C-kinase 1 (RACK1) sensitizes the phosphodiesterase PDE4D5 towards hydrolysis of cAMP and activation by protein kinase C
    Rebecca J Bird
    Institute of Molecular Cell and Systems Biology, University of Glasgow, Scotland, UK
    Biochem J 432:207-16. 2010
  3. pmc Flavanoids induce expression of the suppressor of cytokine signalling 3 (SOCS3) gene and suppress IL-6-activated signal transducer and activator of transcription 3 (STAT3) activation in vascular endothelial cells
    Jolanta Wiejak
    Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Scotland, UK
    Biochem J 454:283-93. 2013
  4. pmc The protein kinase C inhibitor, Ro-31-7459, is a potent activator of ERK and JNK MAP kinases in HUVECs and yet inhibits cyclic AMP-stimulated SOCS-3 gene induction through inactivation of the transcription factor c-Jun
    Jolanta Wiejak
    Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
    Cell Signal 24:1690-9. 2012
  5. pmc Activation of protein kinase Calpha by EPAC1 is required for the ERK- and CCAAT/enhancer-binding protein beta-dependent induction of the SOCS-3 gene by cyclic AMP in COS1 cells
    Gillian Borland
    Division of Molecular and Cellular Biology, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, United Kingdom
    J Biol Chem 284:17391-403. 2009
  6. ncbi request reprint MAP1A light chain 2 interacts with exchange protein activated by cyclic AMP 1 (EPAC1) to enhance Rap1 GTPase activity and cell adhesion
    Mona Gupta
    Molecular Pharmacology Group, Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Davidson Building, Glasgow G12 8QQ, Scotland, United Kingdom
    J Biol Chem 280:8109-16. 2005
  7. pmc Genomic analysis of the role of transcription factor C/EBPδ in the regulation of cell behaviour on nanometric grooves
    Jolanta Wiejak
    Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
    Biomaterials 34:1967-79. 2013
  8. ncbi request reprint Microtubule-associated protein 1B-light chain 1 enhances activation of Rap1 by exchange protein activated by cyclic AMP but not intracellular targeting
    Gillian Borland
    Molecular Pharmacology Group, Division of Biochemistry and Molecular Biology, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom
    Mol Pharmacol 69:374-84. 2006
  9. ncbi request reprint Extracellular signal-regulated kinase mitogen-activated protein kinase-dependent SOCS-3 gene induction requires c-Jun, signal transducer and activator of transcription 3, and specificity protein 3 transcription factors
    Jolanta Wiejak
    The Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
    Mol Pharmacol 81:657-68. 2012
  10. ncbi request reprint Selective inhibition of cytokine-activated extracellular signal-regulated kinase by cyclic AMP via Epac1-dependent induction of suppressor of cytokine signalling-3
    Hayley D Woolson
    Biochemistry and Cell Biology, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, UK
    Cell Signal 21:1706-15. 2009

Collaborators

  • Mona Gupta
  • William A Sands
  • Manuela Zaccolo
  • Penelope M Tsimbouri
  • George S Baillie
  • Jolanta Wiejak
  • Gillian Borland
  • Euan Parnell
  • Julia Dunlop
  • Timothy M Palmer
  • Matthew J Dalby
  • Rebecca J Bird
  • Catherine J Rundell
  • Suzanne Fuld
  • Shan Gao
  • Gillian R Milne
  • Maria M Magiera
  • Brian O Smith
  • Hayley D Woolson
  • Graham Hamilton
  • Pawel Herzyk
  • Simon P MacKay
  • Chloe Stoyle
  • Anna Terrin
  • Anna McIlroy
  • John D Pediani
  • Gillian Lappin
  • Claire Rutherford
  • Victoria S Thomson
  • Nilima Satish
  • Claire E Repellin
  • Isabelle Ernens
  • Stanley Affrossman
  • Heather J H Johnstone
  • Mathis O Riehle

Detail Information

Publications21

  1. pmc The role of c-Jun in controlling the EPAC1-dependent induction of the SOCS3 gene in HUVECs
    Jolanta Wiejak
    Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, G12 8QQ Scotland, United Kingdom
    FEBS Lett 588:1556-61. 2014
    ..AP1 activation and SOCS3 induction by EPAC1 in HUVECs therefore occur independently of c-Jun phosphorylation on Ser63. ..
  2. pmc Interaction with receptor for activated C-kinase 1 (RACK1) sensitizes the phosphodiesterase PDE4D5 towards hydrolysis of cAMP and activation by protein kinase C
    Rebecca J Bird
    Institute of Molecular Cell and Systems Biology, University of Glasgow, Scotland, UK
    Biochem J 432:207-16. 2010
    ..Together these results reveal novel signalling cross-talk, whereby RACK1 mediates PKC-dependent activation of PDE4D5 in the particulate fraction of HEK-293 cells in response to elevations in intracellular cAMP...
  3. pmc Flavanoids induce expression of the suppressor of cytokine signalling 3 (SOCS3) gene and suppress IL-6-activated signal transducer and activator of transcription 3 (STAT3) activation in vascular endothelial cells
    Jolanta Wiejak
    Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Scotland, UK
    Biochem J 454:283-93. 2013
    ..These mechanisms could potentially be exploited to develop novel anti-atherogenic therapies...
  4. pmc The protein kinase C inhibitor, Ro-31-7459, is a potent activator of ERK and JNK MAP kinases in HUVECs and yet inhibits cyclic AMP-stimulated SOCS-3 gene induction through inactivation of the transcription factor c-Jun
    Jolanta Wiejak
    Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
    Cell Signal 24:1690-9. 2012
    ....
  5. pmc Activation of protein kinase Calpha by EPAC1 is required for the ERK- and CCAAT/enhancer-binding protein beta-dependent induction of the SOCS-3 gene by cyclic AMP in COS1 cells
    Gillian Borland
    Division of Molecular and Cellular Biology, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, United Kingdom
    J Biol Chem 284:17391-403. 2009
    ..Together, these results indicate that EPAC mediates novel regulatory cross-talk between the cyclic AMP and PKC signaling pathways leading to ERK- and C/EBPbeta-dependent induction of the SOCS-3 gene...
  6. ncbi request reprint MAP1A light chain 2 interacts with exchange protein activated by cyclic AMP 1 (EPAC1) to enhance Rap1 GTPase activity and cell adhesion
    Mona Gupta
    Molecular Pharmacology Group, Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Davidson Building, Glasgow G12 8QQ, Scotland, United Kingdom
    J Biol Chem 280:8109-16. 2005
    ..LC2 is therefore a biological enhancer of EPAC1 activity toward Rap1 and associated downstream signaling mechanisms...
  7. pmc Genomic analysis of the role of transcription factor C/EBPδ in the regulation of cell behaviour on nanometric grooves
    Jolanta Wiejak
    Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
    Biomaterials 34:1967-79. 2013
    ..C/EBPδ is therefore involved in the complex regulation of multiple genes, including cytoskeletal components and signalling mediators, which influence the nature of cell interactions with nanometric topology...
  8. ncbi request reprint Microtubule-associated protein 1B-light chain 1 enhances activation of Rap1 by exchange protein activated by cyclic AMP but not intracellular targeting
    Gillian Borland
    Molecular Pharmacology Group, Division of Biochemistry and Molecular Biology, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom
    Mol Pharmacol 69:374-84. 2006
    ..LC1 is therefore not involved in intracellular targeting of EPAC1, but it is rather a molecular chaperone of EPAC activity toward Rap1...
  9. ncbi request reprint Extracellular signal-regulated kinase mitogen-activated protein kinase-dependent SOCS-3 gene induction requires c-Jun, signal transducer and activator of transcription 3, and specificity protein 3 transcription factors
    Jolanta Wiejak
    The Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
    Mol Pharmacol 81:657-68. 2012
    ..Together these results describe novel, ERK-dependent regulation of transcriptional activity that requires codependent activation of multiple transcription factors within the same region of the SOCS-3 gene promoter...
  10. ncbi request reprint Selective inhibition of cytokine-activated extracellular signal-regulated kinase by cyclic AMP via Epac1-dependent induction of suppressor of cytokine signalling-3
    Hayley D Woolson
    Biochemistry and Cell Biology, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, UK
    Cell Signal 21:1706-15. 2009
    ..In addition, it reveals a novel Epac-dependent mechanism by which cAMP can specifically inhibit ERK in response to cytokine receptor activation...
  11. pmc Regulation of the inflammatory response of vascular endothelial cells by EPAC1
    Euan Parnell
    Institute of Molecular, Cell and Systems Biology, University of Glasgow, Glasgow, UK
    Br J Pharmacol 166:434-46. 2012
    ..LINKED ARTICLES This article is part of a themed section on Novel cAMP Signalling Paradigms. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2012.166.issue-2...
  12. pmc Exchange protein directly activated by cAMP (EPAC) interacts with the light chain (LC) 2 of MAP1A
    Maria M Magiera
    Molecular Pharmacology Group, Division of Biochemistry and Molecular Biology, Faculty of Biomedical and Life Sciences, University of Glasgow, Davidson Building, Glasgow G12 8QQ, Scotland, UK
    Biochem J 382:803-10. 2004
    ..Together with our two-hybrid results, this suggests that the cAMP-binding domain of EPAC1 mediates interaction with LC2...
  13. ncbi request reprint Novel control of cAMP-regulated transcription in vascular endothelial cells
    Gillian R Milne
    Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
    Biochem Soc Trans 40:1-5. 2012
    ..These novel 'protective' mechanisms of cAMP action will inform the development of the next generation of pharmaceuticals specifically designed to combat endothelial inflammation associated with cardiovascular disease...
  14. ncbi request reprint Identification of CCAAT/enhancer-binding proteins as exchange protein activated by cAMP-activated transcription factors that mediate the induction of the SOCS-3 gene
    Stephen J Yarwood
    Molecular Pharmacology Group, Division of Biochemistry and Molecular Biology, Faculty of Biomedical and Life Sciences, University of Glasgow, Davidson Bldg, Glasgow G12 8QQ, United Kingdom
    J Biol Chem 283:6843-53. 2008
    ..In summary, our findings constitute the first description of an EPAC-C/EBP pathway that can control cAMP-mediated changes in gene expression independently of protein kinase A...
  15. ncbi request reprint Elevation of cyclic AMP in Jurkat T-cells provokes distinct transcriptional responses through the protein kinase A (PKA) and exchange protein activated by cyclic AMP (EPAC) pathways
    Suzanne Fuld
    Molecular Pharmacology Group, Division of Biochemistry and Molecular Biology, Faculty of Biomedical and Life Sciences, University of Glasgow, Davidson Building, Glasgow G12 8QQ, Scotland, UK
    Exp Cell Res 309:161-73. 2005
    ..The control of gene expression by cyclic AMP in Jurkat T-cells therefore requires input from the EPAC signalling cascade...
  16. ncbi request reprint Analysis of focal adhesions and cytoskeleton by custom microarray
    Matthew J Dalby
    Center for Cell Engineering, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK
    Methods Mol Biol 370:121-34. 2007
    ..Comparative analysis of the immunofluorescence and array data should allow the researcher to build up a global picture of changes to both direct and indirect mechanotransduction through the cytoskeleton from focal adhesions...
  17. ncbi request reprint Exchange protein directly activated by cyclic AMP-1-regulated recruitment of CCAAT/enhancer-binding proteins to the suppressor of cytokine signaling-3 promoter
    William A Sands
    Institute for Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, UK
    Methods Mol Biol 809:201-14. 2012
    ..We also describe the RNA interference strategies with which we identified a role for Epac1 and SOCS-3 in being responsible for mediating the inhibitory effect of cAMP elevation on IL-6 signaling...
  18. pmc EPAC proteins transduce diverse cellular actions of cAMP
    Gillian Borland
    Division of Molecular and Cellular Biology, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK
    Br J Pharmacol 158:70-86. 2009
    ..Further elucidation of these important signalling mechanisms will no doubt support the development of the next generation of anti-inflammatory drugs...
  19. ncbi request reprint Protease inhibitors prevent the protein kinase A-dependent loss of Rap1 GTPase from the particulate fraction of COS1 cells
    Catherine J Rundell
    Molecular Pharmacology Group, Division of Biochemistry and Molecular Biology, Faculty of Biomedical and Life Sciences, University of Glasgow, Davidson Building, Glasgow G12 8QQ, Scotland, UK
    Biochem Biophys Res Commun 315:1077-81. 2004
    ..Peptide inhibitors of the proteasome, cathespin, and calpain II also inhibited the decrease in Rap1 levels, indicating that proteolytic degradation may contribute to maintaining Rap1 levels in the nuclear/perinuclear fraction of cells...
  20. ncbi request reprint Fibroblast signaling events in response to nanotopography: a gene array study
    Matthew J Dalby
    Centre for Cell Engineering, Institute of Biomedical and Life Sciences, University of Glasgow, G12 8QQ Glasgow, UK
    IEEE Trans Nanobioscience 1:12-7. 2002
    ..The use of microarray has expanded the range of observations possible using established microscopical and biochemical techniques...
  21. ncbi request reprint Interactions between Epac1 and ezrin in the control of endothelial barrier function
    Euan Parnell
    Institute of Molecular, Cell and Systems Biology, University of Glasgow, Glasgow G12 8QQ, Scotland, U K
    Biochem Soc Trans 42:274-8. 2014
    ..The actin/cytoskeleton linker ezrin will be described in terms of the growing body of evidence placing it downstream of cAMP signalling as a mediator of altered cellular morphology. ..