Keith G Harding

Summary

Affiliation: Wound Healing Research Unit
Country: UK

Publications

  1. ncbi Wound chronicity and fibroblast senescence--implications for treatment
    Keith G Harding
    Wound Healing Research Unit, Department of Surgery, Cardiff University, Cardiff, UK
    Int Wound J 2:364-8. 2005
  2. ncbi A prospective study of the microbiology of chronic venous leg ulcers to reevaluate the clinical predictive value of tissue biopsies and swabs
    Charlotte E Davies
    Wound Biology Group, Cardiff Institute of Tissue Engineering and Repair, Cardiff, UK
    Wound Repair Regen 15:17-22. 2007
  3. pmc Nonlinear modeling of venous leg ulcer healing rates
    Matthew Cardinal
    Advanced BioHealing, La Jolla, CA, USA
    BMC Dermatol 9:2. 2009
  4. ncbi Hepatocyte growth factor regulation: an integral part of why wounds become chronic
    Kevin Conway
    Wound Healing Research Unit, Department of Surgery, Wales College of Medicine, Cardiff University, Cardiff, United Kingdom
    Wound Repair Regen 15:683-92. 2007
  5. doi Activated leukocyte cell adhesion molecule impacts on clinical wound healing and inhibits HaCaT migration
    Andrew J Sanders
    Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Cardiff, UK
    Int Wound J 8:500-7. 2011
  6. doi Role of HuR in keratinocyte migration and wound healing
    David C Bosanquet
    Department of Surgery, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XW, UK
    Mol Med Rep 5:529-34. 2012
  7. pmc ABC of wound healing. Non-surgical and drug treatments
    Stuart Enoch
    Wound Healing Research Unit, Cardiff University
    BMJ 332:900-3. 2006
  8. pmc Recent advances and emerging treatments
    Stuart Enoch
    Royal College of Surgeons of England, Wound Healing Research Unit, Cardiff University
    BMJ 332:962-5. 2006
  9. pmc Pressure ulcers
    Joseph E Grey
    Royal College of Surgeons of England, Wound Healing Research Unit, Cardiff University
    BMJ 332:472-5. 2006
  10. ncbi The role of vascular endothelial growth inhibitor in wound healing
    Kevin P Conway
    Metastasis and Angiogenesis Research Group, Department of Surgery, Cardiff University, College of Medicine, Cardiff, UK
    Int Wound J 4:55-64. 2007

Collaborators

Detail Information

Publications54

  1. ncbi Wound chronicity and fibroblast senescence--implications for treatment
    Keith G Harding
    Wound Healing Research Unit, Department of Surgery, Cardiff University, Cardiff, UK
    Int Wound J 2:364-8. 2005
    ..Recognition of the role of fibroblast senescence in wound chronicity may allow for identification of those wounds that will respond positively to these products...
  2. ncbi A prospective study of the microbiology of chronic venous leg ulcers to reevaluate the clinical predictive value of tissue biopsies and swabs
    Charlotte E Davies
    Wound Biology Group, Cardiff Institute of Tissue Engineering and Repair, Cardiff, UK
    Wound Repair Regen 15:17-22. 2007
    ..Furthermore, independent predictors of healing, such as wound surface microbial diversity and density, could identify patients likely to have an unfavorable outcome and to whom resources should be targeted...
  3. pmc Nonlinear modeling of venous leg ulcer healing rates
    Matthew Cardinal
    Advanced BioHealing, La Jolla, CA, USA
    BMC Dermatol 9:2. 2009
    ..The purpose of this manuscript was to determine whether the change in wound surface area over time could be described through nonlinear mathematics...
  4. ncbi Hepatocyte growth factor regulation: an integral part of why wounds become chronic
    Kevin Conway
    Wound Healing Research Unit, Department of Surgery, Wales College of Medicine, Cardiff University, Cardiff, United Kingdom
    Wound Repair Regen 15:683-92. 2007
    ..This aberrant expression may have a value in predicting the process of healing and nonhealing wounds and constitute important targets of future therapies...
  5. doi Activated leukocyte cell adhesion molecule impacts on clinical wound healing and inhibits HaCaT migration
    Andrew J Sanders
    Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Cardiff, UK
    Int Wound J 8:500-7. 2011
    ..The data also suggests that higher levels of ALCAM may impair healing in chronic wounds. The impact of ALCAM in wound healing may thus be somewhat due to its impact on cell migration and growth...
  6. doi Role of HuR in keratinocyte migration and wound healing
    David C Bosanquet
    Department of Surgery, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XW, UK
    Mol Med Rep 5:529-34. 2012
    ..It also slows cellular growth rate via its effect on both cell cycle progression and rates of apoptosis...
  7. pmc ABC of wound healing. Non-surgical and drug treatments
    Stuart Enoch
    Wound Healing Research Unit, Cardiff University
    BMJ 332:900-3. 2006
  8. pmc Recent advances and emerging treatments
    Stuart Enoch
    Royal College of Surgeons of England, Wound Healing Research Unit, Cardiff University
    BMJ 332:962-5. 2006
  9. pmc Pressure ulcers
    Joseph E Grey
    Royal College of Surgeons of England, Wound Healing Research Unit, Cardiff University
    BMJ 332:472-5. 2006
  10. ncbi The role of vascular endothelial growth inhibitor in wound healing
    Kevin P Conway
    Metastasis and Angiogenesis Research Group, Department of Surgery, Cardiff University, College of Medicine, Cardiff, UK
    Int Wound J 4:55-64. 2007
    ..The aberrant expression of VEGI in different wound types appears to be linked to the outcome of the healing in these wounds. The altered expression of VEGI in chronic wounds constitutes an important target of future therapies...
  11. ncbi Early diagnosis is vital in the management of squamous cell carcinomas associated with chronic non healing ulcers: a case series and review of the literature
    Stuart Enoch
    Clinical Research Fellow, Wound Healing Research Unit, University of Wales College of Medicine, Cardiff CF14 4NX, UK
    Int Wound J 1:165-75. 2004
    ..Therefore, a low threshold to biopsy static non healing ulcers or ulcers in unusual sites should be adopted even in those not manifesting any evidence of malignancy...
  12. doi Dressing-related pain in patients with chronic wounds: an international patient perspective
    Patricia E Price
    Department of Wound Healing, School of Medicine, Cardiff University, Cardiff, UK
    Int Wound J 5:159-71. 2008
    ..This study adds substantially to our knowledge of how patients experience wound pain and gives us the opportunity to explore cultural differences in more detail...
  13. doi Surface bacteriology of venous leg ulcers and healing outcome
    Keith Moore
    Department of Wound Healing, Cardiff University, School of Medicine, Cardiff, UK
    J Clin Pathol 63:830-4. 2010
    ..The aim of this study was to characterise the bacteriological flora of VLUs by routine culture to determine whether the data generated had prognostic value...
  14. pmc Expression of the SOCS family in human chronic wound tissues: Potential implications for SOCS in chronic wound healing
    Yi Feng
    Cardiff China Medical Research Collaborative, Cardiff University School of Medicine, Cardiff University, Cardiff CF14 4XN, UK
    Int J Mol Med . 2016
    ..Thus, the results show that the expression of SOCS transcript indicated that SOCS members may act as a prognostic biomarker of chronic wounds...
  15. doi A 25-year wound care journey within the evolution of wound care
    Keith G Harding
    Department of Dermatology and Wound Healing, School of Medicine, Cardiff University, Cardiff, UK
    Adv Skin Wound Care 25:66-70. 2012
    ..Much progress has been achieved in wound care in the past 25 years, but much work still remains if the profession is to be truly recognized as a clinical specialty...
  16. doi Early use of negative pressure therapy in combination with silver dressings in a difficult breast abscess
    Alastair J Richards
    Department of Dermatology and Wound Healing, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    Int Wound J 8:608-11. 2011
    ..Full epithelisation of the wound was achieved and there was no recurrence of the infection for the duration of the treatment...
  17. doi Expression of WAVEs, the WASP (Wiskott-Aldrich syndrome protein) family of verprolin homologous proteins in human wound tissues and the biological influence on human keratinocytes
    Wen G Jiang
    Department of Surgery, Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Cardiff, UK
    Wound Repair Regen 18:594-604. 2010
    ..The WAVE proteins have a significant predicative and therapeutic value in wound healing...
  18. ncbi The influence of diabetes and lower limb arterial disease on cutaneous foot perfusion
    Dean T Williams
    Wound Healing Research Unit, Department of Surgery, University of Wales College of Medicine, Cardiff, United Kingdom
    J Vasc Surg 44:770-5. 2006
    ..We evaluated the relative influences of noncritical lower limb arterial disease and peripheral neuropathy on cutaneous foot perfusion in diabetes...
  19. pmc Wound dressings
    Vanessa Jones
    Wound Healing Research Unit, Cardiff University
    BMJ 332:777-80. 2006
  20. doi Acute generalised exanthematous pustulosis following intravitreal Ranibizumab
    David C Bosanquet
    Department of Dermatology and Wound Healing, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Int Wound J 8:317-9. 2011
    ..We present a case of AGEP following intravitreal injection of Ranibizumab, a monoclonal antibody vascular endothelial growth factor inhibitor...
  21. doi Human skin cancer stem cells: a tale of mice and men
    Chantal S Colmont
    Department of Dermatology and Wound Healing, School of Medicine Cardiff University, Cardiff, UK
    Exp Dermatol 21:576-80. 2012
    ..In this review, we describe the evidence for the existence of tumor-initiating cells, with emphasis on skin cancer, limiting our discussions to primary human cancer studies where possible...
  22. ncbi Wound problems due to zinc deficiency
    Girish K Patel
    Department of Dermatology and Wound Healing Research Unit, University of Wales College of Medicine, Heath Park, Cardiff, UK
    Int Wound J 1:150-1. 2004
    ..Further surgery was then undertaken, surgery had been postponed until normalisation of zinc levels due the association between zinc deficiency and poor postoperative wound healing...
  23. ncbi Surgical treatment of hidradenitis suppurativa: case series and review of the literature
    Shahzad Ather
    Wound Healing Research Unit, School of Medicine, Cardiff University, Cardiff CF14 4UJ, Wales, UK
    Int Wound J 3:159-69. 2006
    ..All the patients had endured a long period of medical treatment and subsequently required surgery for a long-term relief of symptoms. This has undoubtedly led to psychological symptoms and a decrease in quality of life...
  24. doi Ulcerated tophaceous gout
    Girish K Patel
    Department of Dermatology and Wound Healing, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Int Wound J 7:423-7. 2010
    ..We describe four cases of ulceration associated with gout tophi to highlight the clinical presentation, complications and a management strategy...
  25. ncbi Dystrophic calcification as a cause for non healing leg ulcers
    Stuart Enoch
    Wound Healing Research Unit, Cardiff University, Medicentre, Cardiff, UK
    Int Wound J 2:142-7. 2005
    ..We also report their clinical prognosis using a series of patients with venous ulcers complicated by DC leading to difficulties in healing...
  26. ncbi Effect of sharp debridement using curette on recalcitrant nonhealing venous leg ulcers: a concurrently controlled, prospective cohort study
    Dean Williams
    Wound Healing Research Unit, University of Wales College of Medicine, Cardiff University, Cardiff, United Kingdom
    Wound Repair Regen 13:131-7. 2005
    ..Infection rates and antimicrobial usage were similar. We conclude that sharp debridement is effective in stimulating healing of recalcitrant CVLU. It is safe, well tolerated, and can be performed in an outpatient setting...
  27. pmc Wound assessment
    Joseph E Grey
    Royal College of Surgeons of England, Wound Healing Research Unit, Cardiff University
    BMJ 332:285-8. 2006
  28. ncbi Efficacy and safety of the freeze-dried cultured human keratinocyte lysate, LyphoDerm 0.9%, in the treatment of hard-to-heal venous leg ulcers
    Keith G Harding
    Department of Surgery, Wound Healing Research Unit, University of Wales, College of Medicine, Cardiff, United Kingdom
    Wound Repair Regen 13:138-47. 2005
    ....
  29. ncbi An analysis of replicative senescence in dermal fibroblasts derived from chronic leg wounds predicts that telomerase therapy would fail to reverse their disease-specific cellular and proteolytic phenotype
    Phil Stephens
    Department of Oral Surgery, Medicine, and Pathology, University of Wales College of Medicine, Cardiff, UK
    Exp Cell Res 283:22-35. 2003
    ....
  30. doi Potential roles of suppressor of cytokine signaling in wound healing
    Yi Feng
    Cardiff China Medical Research Collaborative and Wound Healing Research Unit, Cardiff University School of Medicine, Cardiff University, Cardiff, UK
    Regen Med 11:193-209. 2016
    ..This review demonstrates the possible links between SOCS proteins and wound healing, and also highlights the potential importance of this family in a variety of other aspects of regenerative medicine. ..
  31. ncbi New treatments for diabetic neuropathic foot ulceration: views from a wound healing unit
    Dean T Williams
    Wound Healing Research Unit, Department of Surgery, University of Wales College of Medicine, Cardiff Medicentre, Heath Park, UK
    Curr Diab Rep 3:468-74. 2003
    ..This would aid in formulating personalized therapies, tailoring treatments to optimize the ulcer healing environment...
  32. ncbi Bacteria and wound healing
    Ruth Edwards
    Wound Healing Research Unit, University of Wales College of Medicine, Cardiff, UK
    Curr Opin Infect Dis 17:91-6. 2004
    ..Wound infection is detrimental to wound healing, but the diagnosis and management of wound infection is controversial, and varies between clinicians...
  33. ncbi An evaluation of the efficacy of methods used in screening for lower-limb arterial disease in diabetes
    Dean T Williams
    Wound Healing Research Unit, Department of Surgery, University of Wales College of Medicine, Cardiff, UK
    Diabetes Care 28:2206-10. 2005
    ..We evaluated the efficacy of several commonly used screening methods in different subject populations...
  34. pmc Nicorandil ulcer: moves beyond the mucosa
    Girish K Patel
    Department of Dermatology and Wound Healing, School of Medicine, Cardiff University, Cardiff, UK
    Ann R Coll Surg Engl 92:451-2. 2010
    ..The management of wounds is a specialty in its infancy. Success requires more than the use of dressings. All wounds require a diagnosis, a point well illustrated by the management of these cases which depended solely on stopping nicorandil...
  35. ncbi Numerous keratinocyte subtypes involved in wound re-epithelialization
    Girish K Patel
    Department of Dermatology, School of Medicine, Cardiff University, Cardiff, UK
    J Invest Dermatol 126:497-502. 2006
    ..Keratinocytes populated the wound bed below the scab by migration, which was supported by keratinocyte proliferation in the surrounding epidermis both at and adjacent to the wound edge...
  36. ncbi The molecular and clinical impact of hepatocyte growth factor, its receptor, activators, and inhibitors in wound healing
    Kevin Conway
    Metastasis and Angiogenesis Research Group, Wales College of Medicine, Cardiff University, Cardiff, United Kingdom
    Wound Repair Regen 14:2-10. 2006
    ..The current article discusses recent progress in understanding the multiple roles played by this growth factor in tissue repair...
  37. doi Wound bed preparation: TIME for an update
    Rhiannon L Harries
    Royal College of Surgeons Welsh Wound Initiative Research Fellow, Wound Healing Research Unit, School of Medicine, Cardiff University, Cardiff, UK
    Int Wound J 13:8-14. 2016
    ....
  38. doi Safety and performance evaluation of a next-generation antimicrobial dressing in patients with chronic venous leg ulcers
    Keith G Harding
    Wound Healing Research Unit WHRU, Cardiff University School of Medicine, Cardiff, UK
    Int Wound J 13:442-8. 2016
    ..These data indicate that AQUACELâ„¢ Ag+ dressing has an acceptable safety profile in the management of venous leg ulcers that may be impeded by biofilm. ..
  39. doi A randomized controlled trial of larval therapy for the debridement of leg ulcers: results of a multicenter, randomized, controlled, open, observer blind, parallel group study
    Elizabeth Mudge
    Wound Healing Research Unit, Cardiff University School of Medicine, Cardiff, United Kingdom
    Wound Repair Regen 22:43-51. 2014
    ..001). This study provided good evidence to show that larval therapy, in the form of a BioFOAM dressing, debrided VLU and MLU considerably more quickly than a hydrogel, although the possibility of resloughing should be closely monitored. ..
  40. ncbi Managing patients unable to tolerate therapeutic compression
    Sue Bale
    Nursing Research, Wound Healing Research Unit, University of Wales College of Medicine, Cardiff
    Br J Nurs 12:S4-13. 2003
    ..6 cm(2) (SD = 7.4), and median of 2.3 cm(2) (range 28.5). The authors found three layers of graduated Tubigrip useful for managing patients who cannot tolerate therapeutic forms of compression...
  41. ncbi Potential role of anaerobic cocci in impaired human wound healing
    Ivan B Wall
    Wound Healing Research Unit, Department of Surgery, University of Wales College of Medicine, Cardiff, United Kingdom
    Wound Repair Regen 10:346-53. 2002
    ..This article discusses the mechanisms by which these microorganisms may interfere with the inflammation, repair, and remodeling phases of the wound healing process...
  42. pmc Uncommon causes of ulceration
    Girish K Patel
    Cardiff University and Cardiff and Vale NHS Trust
    BMJ 332:594-6. 2006
  43. pmc Venous and arterial leg ulcers
    Joseph E Grey
    Royal College of Surgeons of England, Cardiff University
    BMJ 332:347-50. 2006
  44. ncbi Diabetic foot ulcers
    William J Jeffcoate
    Department of Diabetes and Endocrinology, City Hospital, Nottingham, UK
    Lancet 361:1545-51. 2003
    ..Furthermore, the pathological processes are poorly understood and poorly taught and communication between the many specialties involved is disjointed and insensitive to the needs of patients...
  45. ncbi Chronic ulcers, calcification and calcified fibrous tumours: phenotypic manifestations of a congenital disorder of heterotopic ossification
    Susanne Kupitz
    Department of Medicine, New Cross Hospital, Wolverhampton, England, UK
    Int Wound J 4:273-80. 2007
    ....
  46. ncbi Prediction and monitoring the therapeutic response of chronic dermal wounds
    Keith Moore
    WoundSci, Usk, Monmouthshire, UK
    Int Wound J 3:89-96. 2006
    ..Retrospective analysis of large patient groups indicates that approximately 75% correct prediction of healing outcome can be achieved...
  47. ncbi Wound healing and treatments for people with diabetic foot ulcers
    William J Jeffcoate
    Diabetes Metab Res Rev 20:S78-89. 2004
    ..There are many applications and dressings that may be chosen to promote healing, but, whichever is selected, wound management has to be integrated into an effective programme of multidisciplinary care...
  48. ncbi Comparison of oxidative stress biomarker profiles between acute and chronic wound environments
    Ryan Moseley
    Wound Biology Group, and Cardiff Institute of Tissue Engineering and Repair, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XY, Wales, UK
    Wound Repair Regen 12:419-29. 2004
    ..This study highlights the roles of ROS/antioxidants in skin wound healing, their possible involvement in chronic wounds and the potential value of ROS-induced biomarkers in wound healing prognosis...
  49. ncbi Guidelines for the treatment of venous ulcers
    Martin C Robson
    University of South Florida, Tampa, FL, USA
    Wound Repair Regen 14:649-62. 2006
  50. ncbi Venous leg ulcers - the search for a prognostic indicator
    Keith Moore
    WoundSci, PO Box 32, Usk, Monmouthshire NP15 1YU, UK
    Int Wound J 4:163-72. 2007
    ....
  51. ncbi To oxygenate or not to oxygenate--that is the question!
    Douglas Queen
    Int Wound J 4:1. 2007
  52. doi Guidelines for the prevention of venous ulcers
    Martin C Robson
    University of South Florida, Tampa, Florida, USA
    Wound Repair Regen 16:147-50. 2008
  53. ncbi Differential expression of matrix metalloproteinases during impaired wound healing of the diabetes mouse
    Steven J Wall
    School of Biological Sciences, University of East Anglia, Norwich, U K
    J Invest Dermatol 119:91-8. 2002
    ....
  54. pmc Use of 16S ribosomal DNA PCR and denaturing gradient gel electrophoresis for analysis of the microfloras of healing and nonhealing chronic venous leg ulcers
    Charlotte E Davies
    Wound Biology Group, Department of Oral Surgery, Medicine, and Pathology, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XY, United Kingdom
    J Clin Microbiol 42:3549-57. 2004
    ..Hence, the present study shows that DGGE could give valuable additional information about chronic wound microflora that is not apparent from cultural analysis alone...