Genomes and Genes
Affiliation: Wellcome Trust Genome Campus
- Equatorial retention of the contractile actin ring by microtubules during cytokinesisMercedes Pardo
Cell Cycle Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
Science 300:1569-74. 2003..We propose that these microtubular structures contribute to a checkpoint control that retains the equatorial position of the ring when progression through cytokinesis is delayed...
- Molecular characterization of the Salmonella enterica serovar Typhi Vi-typing bacteriophage E1Derek Pickard
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, United Kingdom
J Bacteriol 190:2580-7. 2008..The genome of the Vi phage E1 is significantly related to other bacteriophages belonging to the same serovar Typhi phage-typing set, and we demonstrate a role for phage DNA modification in determining host specificity...
- Assignment of protein interactions from affinity purification/mass spectrometry dataMercedes Pardo
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SA Cambridgeshire, United Kingdom
J Proteome Res 11:1462-74. 2012..We aim to give awareness on the processing that takes place before an interaction list is reported and on the different types of list curation approaches suited to the different experiments...
- The nuclear rim protein Amo1 is required for proper microtubule cytoskeleton organisation in fission yeastMercedes Pardo
Cell Cycle Laboratory, Cancer Research UK, 44 Lincoln s Inn Fields, London, WC2A 3PX, UK
J Cell Sci 118:1705-14. 2005..Lack of Amo1 also causes a polarity defect. Amo1 is not required for the microtubule loading of several factors affecting microtubule dynamics, and does not seem to be required for nuclear pore function...
- An expanded Oct4 interaction network: implications for stem cell biology, development, and diseaseMercedes Pardo
Proteomic Mass Spectrometry, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK
Cell Stem Cell 6:382-95. 2010..The Oct4 interactome provides a resource for dissecting mechanisms of Oct4 function, enlightening the basis of pluripotency and development, and identifying potential additional reprogramming factors...
- Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formationCatherine H Wilson
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK
EMBO J 31:2486-97. 2012..Thus NRBP1 is a conserved regulator of cell fate, that plays an important role in tumour suppression...
- Prmt5 is essential for early mouse development and acts in the cytoplasm to maintain ES cell pluripotencyWee Wei Tee
Wellcome Trust, Cancer Research UK, Gurdon Institute of Cancer and Developmental Biology, University of Cambridge, Cambridge CB2 1QN, United Kingdom
Genes Dev 24:2772-7. 2010..Loss of Prmt5 or Mep50 results in derepression of differentiation genes, indicating the significance of the Prmt5/Mep50 complex for pluripotency, which may occur in conjunction with the leukemia inhibitory factor (LIF)/Stat3 pathway...
- Characterization of Two Distinct Nucleosome Remodeling and Deacetylase (NuRD) Complex Assemblies in Embryonic Stem CellsDaniel Bode
From the Proteomic Mass Spectrometry, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
Mol Cell Proteomics 15:878-91. 2016..The strategy described here can be more broadly applicable to investigate the topology of the multiple complexes an individual protein can participate in. ..