Aarno Palotie

Summary

Affiliation: Wellcome Trust Genome Campus
Country: UK

Publications

  1. pmc The GENCODE exome: sequencing the complete human exome
    Alison J Coffey
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK
    Eur J Hum Genet 19:827-31. 2011
  2. pmc The functional spectrum of low-frequency coding variation
    Gabor T Marth
    Department of Biology, Boston College, 140 Commonwealth Avenue, Chestnut Hill, MA 02467, USA
    Genome Biol 12:R84. 2011
  3. pmc A genome-wide association scan on estrogen receptor-negative breast cancer
    Jingmei Li
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden
    Breast Cancer Res 12:R93. 2010
  4. pmc Primate-specific evolution of noncoding element insertion into PLA2G4C and human preterm birth
    Jevon Plunkett
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    BMC Med Genomics 3:62. 2010
  5. pmc High divergence in primate-specific duplicated regions: human and chimpanzee chorionic gonadotropin beta genes
    Pille Hallast
    Department of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu, Riia 23, 51010 Tartu, Estonia
    BMC Evol Biol 8:195. 2008
  6. pmc A comparison of the whole genome approach of MeDIP-seq to the targeted approach of the Infinium HumanMethylation450 BeadChip(®) for methylome profiling
    Christine Clark
    Department of Human Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
    PLoS ONE 7:e50233. 2012
  7. pmc Genome-wide meta-analysis of common variant differences between men and women
    Vesna Boraska
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Hum Mol Genet 21:4805-15. 2012
  8. pmc Genome-wide meta-analysis identifies new susceptibility loci for migraine
    Verneri Anttila
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK
    Nat Genet 45:912-7. 2013
  9. pmc An immune response network associated with blood lipid levels
    Michael Inouye
    Department of Human Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
    PLoS Genet 6:e1001113. 2010
  10. pmc A genetic study of Wilson's disease in the United Kingdom
    Alison J Coffey
    Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, UK
    Brain 136:1476-87. 2013

Collaborators

Detail Information

Publications18

  1. pmc The GENCODE exome: sequencing the complete human exome
    Alison J Coffey
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK
    Eur J Hum Genet 19:827-31. 2011
    ..9 Mb and performed well in sequence capture experiments. In the sample set used in this study, we identified over 5000 SNP variants more in the GENCODE exome target (24%) than in the CCDS-based exome sequencing...
  2. pmc The functional spectrum of low-frequency coding variation
    Gabor T Marth
    Department of Biology, Boston College, 140 Commonwealth Avenue, Chestnut Hill, MA 02467, USA
    Genome Biol 12:R84. 2011
    ....
  3. pmc A genome-wide association scan on estrogen receptor-negative breast cancer
    Jingmei Li
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden
    Breast Cancer Res 12:R93. 2010
    ..ER status of breast cancer is important clinically, and is used both as a prognostic indicator and treatment predictor. In this study, we focused on identifying genetic markers associated with ER-negative breast cancer risk...
  4. pmc Primate-specific evolution of noncoding element insertion into PLA2G4C and human preterm birth
    Jevon Plunkett
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    BMC Med Genomics 3:62. 2010
    ..We hypothesize that higher primate-specific gene evolution may lead to these differences and target genes involved in human preterm birth, an area of global health significance...
  5. pmc High divergence in primate-specific duplicated regions: human and chimpanzee chorionic gonadotropin beta genes
    Pille Hallast
    Department of Biotechnology, Institute of Molecular and Cell Biology, University of Tartu, Riia 23, 51010 Tartu, Estonia
    BMC Evol Biol 8:195. 2008
    ..The placental CGB genes that are essential for implantation have evolved from an ancestral pituitary LHB gene by duplications in the primate lineage...
  6. pmc A comparison of the whole genome approach of MeDIP-seq to the targeted approach of the Infinium HumanMethylation450 BeadChip(®) for methylome profiling
    Christine Clark
    Department of Human Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
    PLoS ONE 7:e50233. 2012
    ..In our study MeDIP-seq allowed the detection of 15,709 differentially methylated regions, nearly twice as many as the array-based method (8070), which may result in a more comprehensive study of the methylome...
  7. pmc Genome-wide meta-analysis of common variant differences between men and women
    Vesna Boraska
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Hum Mol Genet 21:4805-15. 2012
    ..The absence of sex-specific differences is useful in guiding genetic association study design, for example when using mixed controls for sex-biased traits...
  8. pmc Genome-wide meta-analysis identifies new susceptibility loci for migraine
    Verneri Anttila
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK
    Nat Genet 45:912-7. 2013
    ..Three of these loci were identified in disease subgroup analyses. Brain tissue expression quantitative trait locus analysis suggests potential functional candidate genes at four loci: APOA1BP, TBC1D7, FUT9, STAT6 and ATP5B...
  9. pmc An immune response network associated with blood lipid levels
    Michael Inouye
    Department of Human Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
    PLoS Genet 6:e1001113. 2010
    ....
  10. pmc A genetic study of Wilson's disease in the United Kingdom
    Alison J Coffey
    Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, UK
    Brain 136:1476-87. 2013
    ....
  11. pmc An evaluation of different target enrichment methods in pooled sequencing designs for complex disease association studies
    Aaron G Day-Williams
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, United Kingdom
    PLoS ONE 6:e26279. 2011
    ....
  12. doi request reprint Probing the brain of comorbidity
    Aarno Palotie
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Sci Transl Med 5:183fs15. 2013
    ..Inherited sleep disorders might provide insights for migraine pathophysiology (Brennan et al., this issue)...
  13. pmc A map of human genome variation from population-scale sequencing
    Richard M Durbin
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK
    Nature 467:1061-73. 2010
    ..These methods and public data will support the next phase of human genetic research...
  14. pmc Genome-wide association study to identify common variants associated with brachial circumference: a meta-analysis of 14 cohorts
    Vesna Boraska
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
    PLoS ONE 7:e31369. 2012
    ..Large-scale collaborations will be necessary to achieve higher power to detect loci underlying BC...
  15. pmc Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1
    Verneri Anttila
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK
    Nat Genet 42:869-73. 2010
    ..96 × 10⁻⁵, permuted threshold for genome-wide significance 7.7 × 10⁻⁵. To our knowledge, our data establish rs1835740 as the first genetic risk factor for migraine...
  16. pmc The variant call format and VCFtools
    Petr Danecek
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK
    Bioinformatics 27:2156-8. 2011
    ..VCFtools is a software suite that implements various utilities for processing VCF files, including validation, merging, comparing and also provides a general Perl API...
  17. pmc Towards an understanding of genetic predisposition to migraine
    Verneri Anttila
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, UK
    Genome Med 3:17. 2011
    ..This putative mechanism, regulating the expression of the primary glutamate transporter in the brain, EAAT2/GLT-1, has interesting implications bridging the gap between Mendelian and common forms in this key group of disorders...
  18. doi request reprint Pain in 1,000 women treated for breast cancer: a prospective study of pain sensitivity and postoperative pain
    Mari A Kaunisto
    Senior Researcher, Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland and Folkhälsan Institute of Genetics, Folkhälsan Research Center Associate Professor, Student, Clinical Psychologist, Department of Anaesthesia and Intensive Care Medicine, Consultant in Oncology, Department of Oncology, Associate Professor, Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland Student, Professor, Institute for Molecular Medicine Finland, University of Helsinki Professor, Institute for Molecular Medicine Finland, University of Helsinki and Department of Human Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom Professor, Department of Anaesthesia, Intensive Care Medicine, Emergency Medicine and Pain Medicine, Helsinki University Central Hospital, Helsinki and Institute of Clinical Medicine, University of Helsinki
    Anesthesiology 119:1410-21. 2013
    ....