Affiliation: Wellcome Trust Genome Campus
- Conformational change in substrate binding, catalysis and product release: an open and shut case?Alex Gutteridge
EBI, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK
FEBS Lett 567:67-73. 2004..In some enzymes there is significant movement of the binding residues, usually on surface loops...
- Conformational changes observed in enzyme crystal structures upon substrate bindingAlex Gutteridge
European Bioinformatics Institute, EMBL Outstation Hinxton, Wellcome Trust Genome Campus, CB10 1SD Hinxton Cambridge, UK
J Mol Biol 346:21-8. 2005..Knowing the extent of induced fit in enzymes is important for our understanding of the principles of enzyme catalysis and also for improving ligand docking and structural template searching...
- Understanding nature's catalytic toolkitAlex Gutteridge
EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK
Trends Biochem Sci 30:622-9. 2005....
- Using a neural network and spatial clustering to predict the location of active sites in enzymesAlex Gutteridge
EBI, Wellcome Trust Genome Campus, EMBL Outstation, Hinxton, Cambridgeshire CB10 1SD, UK
J Mol Biol 330:719-34. 2003..The method correctly identifies the putative active site in each case. In most cases the likely functional residues are identified correctly, as well as some potentially novel functional groups...
- Effective function annotation through catalytic residue conservationRichard A George
Inpharmatica, 60 Charlotte Street, London W1T 2NU, United Kingdom
Proc Natl Acad Sci U S A 102:12299-304. 2005....
- Prediction of drug-target interaction networks from the integration of chemical and genomic spacesYoshihiro Yamanishi
Bioinformatics Center, Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611 0011, Japan
Bioinformatics 24:i232-40. 2008..Therefore, there is a strong incentive to develop new methods capable of detecting these potential drug-target interactions efficiently...
- MIMOX: a web tool for phage display based epitope mappingJian Huang
Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji, Kyoto 611 0011, Japan
BMC Bioinformatics 7:451. 2006..Most of the existing tools have not been implemented as an online service until now however, making it less convenient for the community to access, utilize, and evaluate them...