Affiliation: Wellcome Trust Genome Campus
- Uncover genetic interactions in Caenorhabditis elegans by RNA interferenceAngelo Fortunato
The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Cambridge, Hinxton, UK
Biosci Rep 25:299-307. 2005..In this review, we illustrate how RNAi has been used to analyse gene function in C. elegans as well as pointing to some future directions for using RNAi to examine genetic interactions in a systematic manner...
- Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathwaysBen Lehner
The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
Nat Genet 38:896-903. 2006..We propose that these genes function as general buffers of genetic variation and that these hub genes may act as modifier genes in multiple, mechanistically unrelated genetic diseases in humans...
- Loss of LIN-35, the Caenorhabditis elegans ortholog of the tumor suppressor p105Rb, results in enhanced RNA interferenceBen Lehner
The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
Genome Biol 7:R4. 2006..The effectiveness of RNAi varies from gene to gene, however, and neuronally expressed genes are largely refractive to RNAi in wild-type worms...
- Quantitative high-throughput analysis of synthetic genetic interactions in Caenorhabditis elegans by RNA interferenceAngelo Fortunato
The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK and Molecular Medicine, Department of Neuroscience, University of Siena, Via A Moro n 5, 53100 Siena, Italy
Genomics 93:392-6. 2009..Fifteen synthetic genetic interactions of efl-1/E2F with the genes of chromosome III were detected, measured and ranked by statistical relevance...