Affiliation: Wellcome Trust Genome Campus
- Comparative study of transcriptome profiles of mechanical- and skin-transformed Schistosoma mansoni schistosomulaAnna V Protasio
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
PLoS Negl Trop Dis 7:e2091. 2013..We report that these two very distinct schistosomula preparations differ only in the expression of 38 genes (out of ∼11,000), providing convincing evidence to resolve the skin vs. mechanical long-lasting controversy...
- The genomes of four tapeworm species reveal adaptations to parasitismIsheng J Tsai
Parasite Genomics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
Nature 496:57-63. 2013..We identify new potential drug targets, including some on which existing pharmaceuticals may act. The genomes provide a rich resource to underpin the development of urgently needed treatments and control...
- Germline transgenesis and insertional mutagenesis in Schistosoma mansoni mediated by murine leukemia virusGabriel Rinaldi
Department of Microbiology, Immunology and Tropical Medicine, School of Medicine and Health Sciences, The George Washington University, Washington, DC, United States of America
PLoS Pathog 8:e1002820. 2012..DATABASE ACCESSION: Sequence data from this study have been submitted to the European Nucleotide Archive (http://www.ebi.ac.uk/embl) under accession number ERP000379...
- A systematically improved high quality genome and transcriptome of the human blood fluke Schistosoma mansoniAnna V Protasio
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom
PLoS Negl Trop Dis 6:e1455. 2012..schistodb.net) databases. With further transcriptional profiling and genome sequencing increasingly accessible, the upgraded genome will form a fundamental dataset to underpin further advances in schistosome research...
- GeneDB--an annotation database for pathogensFlora J Logan-Klumpler
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
Nucleic Acids Res 40:D98-108. 2012..GeneDB is primarily a production and annotation database for the genomes of predominantly pathogenic organisms...
- The Ontology for Parasite Lifecycle (OPL): towards a consistent vocabulary of lifecycle stages in parasitic organismsPriti P Parikh
The Kno, E, sis Center, Department of Computer Science and Engineering, Wright State University, Dayton, OH, USA
J Biomed Semantics 3:5. 2012..abstract:..
- Characterization and gene expression analysis of the cir multi-gene family of Plasmodium chabaudi chabaudi (AS)Jennifer Lawton
Division of Parasitology, MRC National Institute for Medical Research, London, UK
BMC Genomics 13:125. 2012..In order to fully understand the role(s) of CIR proteins during P. chabaudi infection, a detailed characterization of the cir gene family was required...
- Using RNA-seq to determine the transcriptional landscape and the hypoxic response of the pathogenic yeast Candida parapsilosisAlessandro Guida
School of Medicine and Medical Science, Conway Institute, UniversityCollege Dublin, Belfield, Dublin 4, Ireland
BMC Genomics 12:628. 2011..The transcriptional response of C. parapsilosis to hypoxic (low oxygen) conditions, such as those encountered in the host, is also relatively unexplored...
- Diversity in parasitic nematode genomes: the microRNAs of Brugia pahangi and Haemonchus contortus are largely novelAlan D Winter
Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences University of Glasgow, Garscube Estate, Bearsden Road, Glasgow, G61 1QH, UK
BMC Genomics 13:4. 2012..Here we describe the the miRNA repertoire of two important parasitic nematodes as an essential first step in addressing this question...
- Improving draft assemblies by iterative mapping and assembly of short reads to eliminate gapsIsheng J Tsai
Parasite Genomics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
Genome Biol 11:R41. 2010..The continuity of a draft genome can thus be substantially improved, often without the need to generate new data...
- Assembly of the Candida albicans genome into sixteen supercontigs aligned on the eight chromosomesMarco van het Hoog
Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec, Canada
Genome Biol 8:R52. 2007..However, sequences of specific chromosomes were not determined...
- Transcriptome analysis of reproductive tissue and intrauterine developmental stages of the tsetse fly (Glossina morsitans morsitans)Geoffrey M Attardo
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA
BMC Genomics 11:160. 2010..3438 expressed sequence tags were sequenced and analyzed...
- Insights into the genome sequence of a free-living Kinetoplastid: Bodo saltans (Kinetoplastida: Euglenozoa)Andrew P Jackson
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, UK
BMC Genomics 9:594. 2008..Various coding regions were sequenced to provide a preliminary insight into the bodonid genome sequence, relative to trypanosomatid sequences...
- An insight into the sialome of Glossina morsitans morsitansJuliana Alves-Silva
Vector Group, Liverpool School of Tropical Medicine, Liverpool, L3 5QA, UK
BMC Genomics 11:213. 2010..Adult tsetse flies feed exclusively on vertebrate blood and are important vectors of human and animal diseases. Thus far, only limited information exists regarding the Glossina sialome, or any other fly belonging to the Hippoboscidae...
- GOtcha: a new method for prediction of protein function assessed by the annotation of seven genomesDavid M A Martin
Post Genomics and Molecular Interactions Centre, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK
BMC Bioinformatics 5:178. 2004..GOtcha predicts GO term associations with term-specific probability (P-score) measures of confidence. Term-specific probabilities are a novel feature of GOtcha and allow the identification of conflicts or uncertainty in annotation...
- Viewing and annotating sequence data with ArtemisMatt Berriman
The Wellcome Trust Sanger Institute, Genome Campus, Hinxton CB10 1SA, UK
Brief Bioinform 4:124-32. 2003....
- The genome of the blood fluke Schistosoma mansoniMatthew Berriman
Wellcome Trust Sanger Institute, Cambridge CB10 1SD, UK
Nature 460:352-8. 2009..The information generated provides an invaluable resource for the research community to develop much needed new control tools for the treatment and eradication of this important and neglected disease...
- Data mining parasite genomesM Berriman
Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton, CB10 ISA, UK
Parasitology 128:S23-31. 2004..If these roles are accurately reflected in genome annotation, they can be used by researchers to frame queries and interrogate the data further...
- The genome of the African trypanosome Trypanosoma bruceiMatthew Berriman
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
Science 309:416-22. 2005..brucei and the greatest in L. major. Horizontal transfer of genes of bacterial origin has contributed to some of the metabolic differences in these parasites, and a number of novel potential drug targets have been identified...
- The genome of the simian and human malaria parasite Plasmodium knowlesiA Pain
Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
Nature 455:799-803. 2008..One of these families, the KIRs, contains sequences that collectively match over one-half of the host CD99 extracellular domain, which may represent an unusual form of molecular mimicry...
- Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13N Hall
The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
Nature 419:527-31. 2002..We identify a highly conserved sequence element found in the intergenic region of internal var genes that is not associated with their telomeric counterparts...
- The Gene Ontology (GO) database and informatics resourceM A Harris
GO EBI, Hinxton, UK
Nucleic Acids Res 32:D258-61. 2004..The GO Web resource also provides access to extensive documentation about the GO project and links to applications that use GO data for functional analyses...
- A case for a Glossina genome projectSerap Aksoy
Yale University School of Medicine, 60 College Street, 606 LEPH, New Haven, CT 06520, USA
Trends Parasitol 21:107-11. 2005..An international consortium is now in place to further efforts to lead to a full genome project...
- Composite genome map and recombination parameters derived from three archetypal lineages of Toxoplasma gondiiAsis Khan
Department of Molecular Microbiology, Center for Infectious Diseases, Washington University School of Medicine St Louis, MO 63110, USA
Nucleic Acids Res 33:2980-92. 2005..The resulting genome map provides a framework for analysis of complex traits such as virulence and transmission, and for comparative population genetic studies...
- Continuing tsetse and Trypanosoma genome sequencing projectsChristiane Hertz-Fowler
Trends Parasitol 20:308-9; author reply 309-10. 2004
- Genome-wide discovery and verification of novel structured RNAs in Plasmodium falciparumTobias Mourier
Ancient DNA and Evolution Group, Department of Biology, University of Copenhagen, Copenhagen DK 2100, Denmark
Genome Res 18:281-92. 2008..reichenowi. The high confirmation rate within a single parasite life cycle stage suggests that many more of the predictions may be expressed in other stages of the organism's life cycle...
- The genome of the protist parasite Entamoeba histolyticaBrendan Loftus
TIGR, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
Nature 433:865-8. 2005..Analysis of the genome provides new insights into the workings and genome evolution of a major human pathogen...
- Evolution of noncoding and silent coding sites in the Plasmodium falciparum and Plasmodium reichenowi genomesDaniel E Neafsey
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA
Mol Biol Evol 22:1621-6. 2005..Divergence rates of different classes of silent sites in these Plasmodium genomes are determined by a combination of mutational and selective pressures...