Wellcome Trust Genome Campus

Summary

Organization: Wellcome Trust Genome Campus
Country: UK

Top Publications

  1. doi Critical roles of Bcl11b in T-cell development and maintenance of T-cell identity
    Pentao Liu
    Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK
    Immunol Rev 238:138-49. 2010
  2. pmc Haplotype-based search for SNPs associated with differential type 1 diabetes risk among chromosomes carrying a specific HLA DRB1-DQA1-DQB1 haplotype
    R McGinnis
    Wellcome Trust Sanger Institute, Cambridge, UK
    Diabetes Obes Metab 11:8-16. 2009
  3. pmc Population-specific risk of type 2 diabetes conferred by HNF4A P2 promoter variants: a lesson for replication studies
    Ines Barroso
    Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK
    Diabetes 57:3161-5. 2008
  4. pmc A common genomic framework for a diverse assembly of plasmids in the symbiotic nitrogen fixing bacteria
    Lisa C Crossman
    The Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom
    PLoS ONE 3:e2567. 2008
  5. pmc An evolutionary perspective on Y-chromosomal variation and male infertility
    Chris Tyler-Smith
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridgeshire, UK
    Int J Androl 31:376-82. 2008
  6. pmc Protein interactions in human genetic diseases
    Benjamin Schuster-Böckler
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SA, UK
    Genome Biol 9:R9. 2008
  7. pmc Backseat drivers take the wheel
    P Andrew Futreal
    Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK
    Cancer Cell 12:493-4. 2007
  8. ncbi The MEROPS batch BLAST: a tool to detect peptidases and their non-peptidase homologues in a genome
    Neil D Rawlings
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
    Biochimie 90:243-59. 2008
  9. pmc A linear plasmid truncation induces unidirectional flagellar phase change in H:z66 positive Salmonella Typhi
    Stephen Baker
    The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
    Mol Microbiol 66:1207-18. 2007
  10. ncbi Supramolecular signalling complexes in the nervous system
    M O Collins
    Proteomic Mass Spectrometry, The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom
    Subcell Biochem 43:185-207. 2007

Research Grants

Detail Information

Publications62

  1. doi Critical roles of Bcl11b in T-cell development and maintenance of T-cell identity
    Pentao Liu
    Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK
    Immunol Rev 238:138-49. 2010
    ..These reprogrammed cells have unique properties in proliferation, cytokine dependency and killing target cells, and may therefore provide a new cell source for some cell-based therapies...
  2. pmc Haplotype-based search for SNPs associated with differential type 1 diabetes risk among chromosomes carrying a specific HLA DRB1-DQA1-DQB1 haplotype
    R McGinnis
    Wellcome Trust Sanger Institute, Cambridge, UK
    Diabetes Obes Metab 11:8-16. 2009
    ....
  3. pmc Population-specific risk of type 2 diabetes conferred by HNF4A P2 promoter variants: a lesson for replication studies
    Ines Barroso
    Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK
    Diabetes 57:3161-5. 2008
    ..We aimed to investigate whether data from a large-scale mapping approach would replicate this association in novel Ashkenazi samples and in U.K. populations and whether these data would allow us to refine the association signal...
  4. pmc A common genomic framework for a diverse assembly of plasmids in the symbiotic nitrogen fixing bacteria
    Lisa C Crossman
    The Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom
    PLoS ONE 3:e2567. 2008
    ..The present analysis allows us to conclude that a heterogeneous and quickly diversifying group of plasmids co-exists in a common genomic framework...
  5. pmc An evolutionary perspective on Y-chromosomal variation and male infertility
    Chris Tyler-Smith
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridgeshire, UK
    Int J Androl 31:376-82. 2008
    ....
  6. pmc Protein interactions in human genetic diseases
    Benjamin Schuster-Böckler
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SA, UK
    Genome Biol 9:R9. 2008
    ..Combining predicted and hand-curated sets, we discuss how mutations affect protein interactions in general...
  7. pmc Backseat drivers take the wheel
    P Andrew Futreal
    Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK
    Cancer Cell 12:493-4. 2007
    ....
  8. ncbi The MEROPS batch BLAST: a tool to detect peptidases and their non-peptidase homologues in a genome
    Neil D Rawlings
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
    Biochimie 90:243-59. 2008
    ..A non-peptidase homologue can be distinguished by the absence or unacceptable replacement of any of these residues. An analysis of peptidase homologues in the genome of the bacterium Erythrobacter litoralis is presented as an example...
  9. pmc A linear plasmid truncation induces unidirectional flagellar phase change in H:z66 positive Salmonella Typhi
    Stephen Baker
    The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK
    Mol Microbiol 66:1207-18. 2007
    ..These data demonstrate that, like some Streptomyces linear elements, at least one of the terminal inverted repeats of pBSSB1 is non-essential, but that a palindromic repeat sequence may be necessary for replication...
  10. ncbi Supramolecular signalling complexes in the nervous system
    M O Collins
    Proteomic Mass Spectrometry, The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, United Kingdom
    Subcell Biochem 43:185-207. 2007
    ..In addition, we describe the characterisation of a number of multiprotein complexes associated with ion channels (NMDAR, P2X7 and Kir2) and GPCRs (5-HT2A/5-HT2C, D2 and mGluR5) and discuss common their common components and organisation...
  11. ncbi Modulation of steroidogenic gene expression and hormone production of H295R cells by pharmaceuticals and other environmentally active compounds
    Tannia Gracia
    Department of Zoology, National Food Safety and Toxicology Center, Center for Integrative Toxicology, Michigan State University, East Lansing, MI 48824, USA
    Toxicol Appl Pharmacol 225:142-53. 2007
    ..Dose-response results indicated that although two chemicals may share a common mechanism of action the concentration effects observed may be significantly different...
  12. pmc The Ras-association domain family (RASSF) members and their role in human tumourigenesis
    Louise van der Weyden
    Experimental Cancer Genetics Laboratory, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton Cambridge, UK
    Biochim Biophys Acta 1776:58-85. 2007
    ....
  13. pmc Prophage sequences defining hot spots of genome variation in Salmonella enterica serovar Typhimurium can be used to discriminate between field isolates
    Fiona J Cooke
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, United Kingdom
    J Clin Microbiol 45:2590-8. 2007
    ..These multiplex PCR assays, based on prophage-like elements and Salmonella genomic island 1, provide a simple method for identifying new variants of S. enterica serovar Typhimurium in the field...
  14. pmc The complete genome sequence and comparative genome analysis of the high pathogenicity Yersinia enterocolitica strain 8081
    Nicholas R Thomson
    The Pathogen Sequencing Unit, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
    PLoS Genet 2:e206. 2006
    ..Moreover, wider investigations looking at the patterns of gene loss and gain in the Yersinia have highlighted common themes in the genome evolution of other human enteropathogens...
  15. ncbi Sequencing the species pan-genome
    Stephen Bentley
    Stephen Bentley is at the Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
    Nat Rev Microbiol 7:258-9. 2009
    ....
  16. pmc The cancer genome
    Michael R Stratton
    Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
    Nature 458:719-24. 2009
    ..These studies will provide us with a detailed and comprehensive perspective on how individual cancers have developed...
  17. pmc HI: haplotype improver using paired-end short reads
    Quan Long
    The Wellcome Trust Sanger Institute, Hinxton, Cambs, UK
    Bioinformatics 25:2436-7. 2009
    ..We find that given a fixed coverage, longer reads (implying fewer of them) are preferable...
  18. pmc Use of purified Clostridium difficile spores to facilitate evaluation of health care disinfection regimens
    Trevor D Lawley
    Microbial Pathogenesis Laboratory, Wellcome Trust, Hinxton, Cambridgeshire CB10 1SA, United Kingdom
    Appl Environ Microbiol 76:6895-900. 2010
    ..Thus, pure C. difficile spores facilitate practical methods for evaluating the efficacy of C. difficile spore disinfection regimens and bringing scientific acumen to C. difficile infection control...
  19. doi High-throughput identification of transient extracellular protein interactions
    Gavin J Wright
    Cell Surface Signalling Laboratory, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
    Biochem Soc Trans 38:919-22. 2010
    ....
  20. pmc CODA: accurate detection of functional associations between proteins in eukaryotic genomes using domain fusion
    Adam J Reid
    Wellcome Trust Sanger Institute, Cambridge, United Kingdom
    PLoS ONE 5:e10908. 2010
    ..Here we introduce CODA (Co-Occurrence of Domains Analysis), a method to predict functional associations based on the gene fusion idiom...
  21. pmc Efficient construction of an assembly string graph using the FM-index
    Jared T Simpson
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, CB10 1SA, UK
    Bioinformatics 26:i367-73. 2010
    ....
  22. doi Microfluidics for the upstream pipeline of DNA sequencing--a worthy application?
    Paul Coupland
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK CB10 1SA
    Lab Chip 10:544-7. 2010
    ....
  23. doi Genetic variation of regulatory systems
    Antigone S Dimas
    Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva CH 1211, Switzerland
    Curr Opin Genet Dev 19:586-90. 2009
    ..In this short review we will address some of the key principles of the past and recent studies describing the degree and nature of regulatory variation with a focus on human populations...
  24. pmc Genetic factors in esophageal atresia, tracheo-esophageal fistula and the VACTERL association: roles for FOXF1 and the 16q24.1 FOX transcription factor gene cluster, and review of the literature
    Charles Shaw-Smith
    Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK
    Eur J Med Genet 53:6-13. 2010
    ..This article reviews these new data alongside other genetic causes of syndromic esophageal atresia, and also highlights information from relevant mouse models, particularly those for genes in the Sonic Hedgehog pathway...
  25. ncbi Specimens and culture media for the laboratory diagnosis of typhoid fever
    John Wain
    The Wellcome Trust Clinical Research Unit, Centre for Tropical Diseases, Ho Chi Minh City, Vietnam
    J Infect Dev Ctries 2:469-74. 2008
    ..However, current methods are not fully optimised and sourcing culture media and bottles for culture media may be problematic...
  26. pmc Comparative genomics of the fungal pathogens Candida dubliniensis and Candida albicans
    Andrew P Jackson
    Pathogen Genomics Group, Wellcome Trust Sanger Institute, Cambridge, United Kingdom
    Genome Res 19:2231-44. 2009
    ..albicans, C. dubliniensis has lost genomic capacity and key pathogenic functions. This could explain why C. albicans is a more potent pathogen in humans than C. dubliniensis...
  27. ncbi SPI-7: Salmonella's Vi-encoding Pathogenicity Island
    Helena M B Seth-Smith
    Pathogen Sequencing Unit, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, United Kingdom
    J Infect Dev Ctries 2:267-71. 2008
    ..The stability of SPI-7 is of interest with respect to typhoid fever and related vaccines...
  28. pmc Human Y chromosome base-substitution mutation rate measured by direct sequencing in a deep-rooting pedigree
    Yali Xue
    The Wellcome Trust Sanger Institute, Hinxton, Cambs CB10 1SA, UK
    Curr Biol 19:1453-7. 2009
    ..0 x 10(-8)), consistent with estimates of 2.3 x 10(-8)-6.3 x 10(-8) mutations/nucleotide/generation for the same Y-chromosomal region from published human-chimpanzee comparisons depending on the generation and split times assumed...
  29. pmc LookSeq: a browser-based viewer for deep sequencing data
    Heinrich Magnus Manske
    Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom
    Genome Res 19:2125-32. 2009
    ..LookSeq provides a simple graphical representation of paired sequence reads that is more revealing about potential insertions and deletions than are conventional methods...
  30. pmc The genome of the blood fluke Schistosoma mansoni
    Matthew Berriman
    Wellcome Trust Sanger Institute, Cambridge CB10 1SD, UK
    Nature 460:352-8. 2009
    ..The information generated provides an invaluable resource for the research community to develop much needed new control tools for the treatment and eradication of this important and neglected disease...
  31. ncbi Microdeletion encompassing MAPT at chromosome 17q21.3 is associated with developmental delay and learning disability
    Charles Shaw-Smith
    University of Cambridge Department of Medical Genetics, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Nat Genet 38:1032-7. 2006
    ..The orientation of LCRs flanking the deleted segment in inversion heterozygotes is likely to facilitate the generation of this microdeletion by means of non-allelic homologous recombination...
  32. pmc Homozygous mutation of focal adhesion kinase in embryonic stem cell derived neurons: normal electrophysiological and morphological properties in vitro
    P Charlesworth
    Centre for Neuroscience Research, University of Edinburgh, Edinburgh, UK
    BMC Neurosci 7:47. 2006
    ..Here we report a study of focal adhesion kinase (FAK), which has been implicated in synapse formation and regulation of ion channels, using the ESN system to circumvent the embryonic lethality of homozygous FAK mutant mice...
  33. pmc The DNA sequence and analysis of human chromosome 13
    A Dunham
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK
    Nature 428:522-8. 2004
    ..Chromosome 13 has one of the lowest gene densities (6.5 genes per Mb) among human chromosomes, and contains a central region of 38 Mb where the gene density drops to only 3.1 genes per Mb...
  34. ncbi The HapMap project and its application to genetic studies of drug response
    P Deloukas
    Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK
    Pharmacogenomics J 4:88-90. 2004
  35. ncbi Synapse signalling complexes and networks: machines underlying cognition
    Seth G N Grant
    Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, CB1D 1SA, UK
    Bioessays 25:1229-35. 2003
    ..Supplementary material for this article can be found on the BioEssays website http://www.interscience.wiley.com/jpages/0265-9247/suppmat/index.html...
  36. ncbi All walks of life
    Nicholas R Thomson
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Trends Microbiol 11:159-60. 2003
  37. pmc Domain architectures of sigma54-dependent transcriptional activators
    David J Studholme
    Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom
    J Bacteriol 185:1757-67. 2003
  38. pmc Rfam: an RNA family database
    Sam Griffiths-Jones
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Nucleic Acids Res 31:439-41. 2003
    ..wustl.edu/). The first release of Rfam (1.0) contains 25 families, which annotate over 50 000 non-coding RNA genes in the taxonomic divisions of the EMBL nucleotide database...
  39. ncbi Distribution of basement membrane pores in bronchus revealed by microscopy following epithelial removal
    William J Howat
    Respiratory, Cell and Molecular Biology, Division of Infection Inflammation and Repair, School of Medicine, University of Southampton, MP888, Level D, Centre Block, Southampton General Hospital, SO16 6YD, Southampton, UK
    J Struct Biol 139:137-45. 2002
    ..We suggest that basement membrane pores can be generated by the passage of infiltrating cells into the epithelium providing a network suitable for intraepithelial surveillance...
  40. ncbi Comparative analysis of comparative genomic hybridization microarray technologies: report of a workshop sponsored by the Wellcome Trust
    N P Carter
    Wellcome Trust Sanger Institute, Hinxton, United Kingdom
    Cytometry 49:43-8. 2002
    ..Array-comparative genomic hybridization (CGH), although providing much higher resolution compared with conventional CGH, has not yet become a widely applied method for the analysis of genomic gains and losses...
  41. ncbi The DNA sequence and comparative analysis of human chromosome 20
    P Deloukas
    The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
    Nature 414:865-71. 2001
    ....
  42. pmc The Pfam protein families database
    Alex Bateman
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Nucleic Acids Res 30:276-80. 2002
    ..New search tools, including taxonomy search and domain query, greatly add to the functionality and usability of the Pfam resource...
  43. ncbi It ain't over till it's ova: germline sex determination in C. elegans
    P E Kuwabara
    The Sanger Centre, Wellcome Trust Genome Campus, Hinxton, UK
    Bioessays 23:596-604. 2001
    ....
  44. ncbi Artemis: sequence visualization and annotation
    K Rutherford
    The Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
    Bioinformatics 16:944-5. 2000
    ..Sequences and annotation can be read and written directly in EMBL, GenBank and GFF format. AVAILABITLTY: Artemis is available under the GNU General Public License from http://www.sanger.ac.uk/Software/Artemis..
  45. ncbi Sequence organisation of the class II region of the human MHC
    S Beck
    Sanger Centre, Cambridge, UK
    Immunol Rev 167:201-10. 1999
    ....
  46. pmc Enhanced protein domain discovery using taxonomy
    Lachlan Coin
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    BMC Bioinformatics 5:56. 2004
    ..This information has not yet been incorporated into statistical methods for finding domains in sequences of amino acids...
  47. pmc DNA sequence and analysis of human chromosome 9
    S J Humphray
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Nature 429:369-74. 2004
    ..We have also detected recently duplicated genes that exhibit different rates of sequence divergence, presumably reflecting natural selection...
  48. pmc Fibronectin binding to the Salmonella enterica serotype Typhimurium ShdA autotransporter protein is inhibited by a monoclonal antibody recognizing the A3 repeat
    Robert A Kingsley
    Department of Medical Microbiology and Immunology, College of Medicine, College Station, TX 77843, USA
    J Bacteriol 186:4931-9. 2004
    ..Furthermore, a monoclonal antibody that specifically recognized an epitope in a recombinant protein containing the A3 repeat inhibited binding of ShdA to fibronectin...
  49. pmc Comparative genomics and concerted evolution of beta-tubulin paralogs in Leishmania spp
    Andrew P Jackson
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK
    BMC Genomics 7:137. 2006
    ..infantum and L. braziliensis. Untranscribed regions and coding sequences for each isoform were compared within and between species in relation to the known diversity of beta-tubulin transcripts in Leishmania spp...
  50. ncbi The biology of intron gain and loss
    Daniel C Jeffares
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, CB10 1SA
    Trends Genet 22:16-22. 2006
    ..In this article, we discuss the growing evidence that these differences are subject to selection acting on introns depending on the biology of the organism and the gene involved...
  51. ncbi Defining a genomic radius for long-range enhancer action: duplicated conserved non-coding elements hold the key
    Tanya Vavouri
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, CB10 1SA
    Trends Genet 22:5-10. 2006
    ..This enables us to provide the first systematic estimate of the genomic range for distal cis-regulatory interactions in the human genome: half of CNEs are >250 kb away from their associated gene...
  52. pmc Prenatal detection of unbalanced chromosomal rearrangements by array CGH
    L Rickman
    University of Cambridge, Department of Medical Genetics, Addenbrooke s Hospital, Hills Road, Cambridge, UK
    J Med Genet 43:353-61. 2006
    ..We have developed a genomic microarray of approximately 600 large insert clones designed to detect aneuploidy, known microdeletion syndromes, and large unbalanced chromosomal rearrangements...
  53. pmc Detection of Vi-negative Salmonella enterica serovar typhi in the peripheral blood of patients with typhoid fever in the Faisalabad region of Pakistan
    Stephen Baker
    The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, UK
    J Clin Microbiol 43:4418-25. 2005
    ..The method described here can be used to monitor the incidence of Vi-negative serovar Typhi in regions where the Vi vaccine is used...
  54. ncbi Tissue microarrays: fast-tracking protein expression at the cellular level
    Anthony Warford
    Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK
    Expert Rev Proteomics 1:283-92. 2004
    ..They are also leading a revolution in cellular pathology as high-throughput technology is introduced to maximize the information provided...
  55. ncbi Visualizing profile-profile alignment: pairwise HMM logos
    Benjamin Schuster-Böckler
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Bioinformatics 21:2912-3. 2005
    ..The method illustrates the similarities of pairs of protein family profiles in an intuitive way. Two HMM logos, one for each profile, are drawn one upon the other. The aligned states are then highlighted and connected...
  56. ncbi The nuclear rim protein Amo1 is required for proper microtubule cytoskeleton organisation in fission yeast
    Mercedes Pardo
    Cell Cycle Laboratory, Cancer Research UK, 44 Lincoln s Inn Fields, London, WC2A 3PX, UK
    J Cell Sci 118:1705-14. 2005
    ..Lack of Amo1 also causes a polarity defect. Amo1 is not required for the microtubule loading of several factors affecting microtubule dynamics, and does not seem to be required for nuclear pore function...
  57. pmc NestedMICA: sensitive inference of over-represented motifs in nucleic acid sequence
    Thomas A Down
    Wellcome Trust Sanger Institute, Hinxton Cambridge, CB10 1SA, UK
    Nucleic Acids Res 33:1445-53. 2005
    ..When tested on a real set of regulatory sequences, NestedMICA produced motifs which were good predictors for all five abundant classes of annotated binding sites...
  58. pmc Production of soluble mammalian proteins in Escherichia coli: identification of protein features that correlate with successful expression
    Michael R Dyson
    The Atlas of Gene Expression Project, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
    BMC Biotechnol 4:32. 2004
    ..Expression of an additional set of 95 mammalian proteins was also performed to test the conclusions of this study...
  59. ncbi Towards full employment: using RNAi to find roles for the redundant
    Andrew Fraser
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Oncogene 23:8346-52. 2004
    ..elegans. In particular, I discuss the use of genome-wide RNAi screens in C. elegans to identify synthetic lethal interactions and compare this with synthetic lethal interaction analysis in Saccharomyces cerevisiae...
  60. ncbi The notochord
    Derek L Stemple
    Vertebrate Development and Genetics Team 31, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Curr Biol 14:R873-4. 2004
  61. ncbi Predominant African-derived mtDNA in Caribbean and Brazilian Creole cattle is also found in Spanish cattle (Bos taurus)
    M M Miretti
    Departamento de Tecnologia, Faculdade de Ciencias Agrarias e Veterinarias, Universidade Estadual Paulista, via de acesso Professor P D Castellane km 5, 14884 900, Jaboticabal, SP, Brazil
    J Hered 95:450-3. 2004
    ..The presence of taurine AA and T3 haplotypes in Brazilian Nellore may indicate introgression by local European-derived cattle. Data presented in this work will contribute to the understanding of the origin of Guadeloupe Creole cattle...
  62. pmc Using neural networks for prediction of the subcellular location of proteins
    A Reinhardt
    The Sanger Centre, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
    Nucleic Acids Res 26:2230-6. 1998
    ..With the subcellular location restricting a protein's possible function, this method should be a useful tool for the systematic analysis of genome data and is available via a server on the world wide web...

Research Grants13

  1. Integrated human genome annotation: generation of a reference gene set
    Timothy Hubbard; Fiscal Year: 2007
    ..From this foundation, more accurate descriptions of the genetic causes of disease can be discovered. ..
  2. Methods for Efficient Detection of Mutations in Zebrafish
    Derek L Stemple; Fiscal Year: 2010
    ..These mutations will provide models of human genetic disease that may be used to identify new drugs and therapies. ..
  3. A Xenopus tropicalis mutant resource
    Derek L Stemple; Fiscal Year: 2010
    ....
  4. A Xenopus tropicalis mutant resource
    DEREK STEMPLE; Fiscal Year: 2007
    ....
  5. Genetic Screens in Xenopus tropicalis
    DEREK STEMPLE; Fiscal Year: 2004
    ..tropicalis infrastructure development. Functional characterization of EST sequences will help integrate genetic and physical mapping efforts already underway. ..
  6. Detecting Human Functional Sequences with Microarrays
    Ian Dunham; Fiscal Year: 2006
    ..All data will be deposited with the ENCODE consortium as soon as it is shown to be reliable by replication and preliminary analysis. ..
  7. Methods for high-resolution analysis of genetic effects on gene expression
    MARK IAN MCCARTHY; Fiscal Year: 2010
    ..It is the understanding of the basic molecular functions in health and disease that will provide the utmost resolution of information for the improvement of human health. ..