Nianshu Zhang

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. pmc The transcription activity of Gis1 is negatively modulated by proteasome-mediated limited proteolysis
    Nianshu Zhang
    Cambridge Systems Biology Centre and Department of Biochemistry, University of Cambridge, Sanger Building, 80 Tennis Court Road, Cambridge CB2 1GA, United Kingdom
    J Biol Chem 285:6465-76. 2010
  2. doi request reprint Contributions of Saccharomyces cerevisiae to understanding mammalian gene function and therapy
    Nianshu Zhang
    Department of Biochemistry, Cambridge Systems Biology Centre, University of Cambridge, Cambridge, UK
    Methods Mol Biol 759:501-23. 2011
  3. pmc Synergistic effects of TOR and proteasome pathways on the yeast transcriptome and cell growth
    Nianshu Zhang
    Cambridge Systems Biology Centre and Department of Biochemistry, University of Cambridge, Sanger Building, 80 Tennis Court Road, Cambridge CB2 1GA, UK
    Open Biol 3:120137. 2013
  4. doi request reprint Gis1 is required for transcriptional reprogramming of carbon metabolism and the stress response during transition into stationary phase in yeast
    Nianshu Zhang
    Cambridge Systems Biology Centre and Department of Biochemistry, University of Cambridge, Sanger Building, 80 Tennis Court Road, Cambridge CB2 1GA, UK
    Microbiology 155:1690-8. 2009
  5. pmc Chronological Lifespan in Yeast Is Dependent on the Accumulation of Storage Carbohydrates Mediated by Yak1, Mck1 and Rim15 Kinases
    Lu Cao
    Cambridge Systems Biology Centre and Department of Biochemistry, University of Cambridge, Sanger Building, United Kingdom
    PLoS Genet 12:e1006458. 2016
  6. doi request reprint JmjN interacts with JmjC to ensure selective proteolysis of Gis1 by the proteasome
    Zhenzhen Quan
    Cambridge Systems Biology Centre and Department of Biochemistry, University of Cambridge, Sanger Building, 80 Tennis Court Road, Cambridge CB2 1GA, UK
    Microbiology 157:2694-701. 2011
  7. pmc The genetic control of growth rate: a systems biology study in yeast
    Pinar Pir
    Cambridge Systems Biology Centre and Department of Biochemistry, University of Cambridge, Sanger Building, 80 Tennis Court Road, Cambridge CB2 1GA, UK
    BMC Syst Biol 6:4. 2012
  8. pmc The Yeast GSK-3 Homologue Mck1 Is a Key Controller of Quiescence Entry and Chronological Lifespan
    Zhenzhen Quan
    Cambridge Systems Biology Centre and Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom
    PLoS Genet 11:e1005282. 2015

Collaborators

Detail Information

Publications8

  1. pmc The transcription activity of Gis1 is negatively modulated by proteasome-mediated limited proteolysis
    Nianshu Zhang
    Cambridge Systems Biology Centre and Department of Biochemistry, University of Cambridge, Sanger Building, 80 Tennis Court Road, Cambridge CB2 1GA, United Kingdom
    J Biol Chem 285:6465-76. 2010
    ..Furthermore, we have revealed that the kinase activity of Rim15 is essential for this regulation...
  2. doi request reprint Contributions of Saccharomyces cerevisiae to understanding mammalian gene function and therapy
    Nianshu Zhang
    Department of Biochemistry, Cambridge Systems Biology Centre, University of Cambridge, Cambridge, UK
    Methods Mol Biol 759:501-23. 2011
    ..Here we focused on using these technologies in revealing functions of genes from mammals, in identifying targets of novel and known drugs and in screening drugs targeting specific proteins and/or protein-protein interactions...
  3. pmc Synergistic effects of TOR and proteasome pathways on the yeast transcriptome and cell growth
    Nianshu Zhang
    Cambridge Systems Biology Centre and Department of Biochemistry, University of Cambridge, Sanger Building, 80 Tennis Court Road, Cambridge CB2 1GA, UK
    Open Biol 3:120137. 2013
    ..These data suggest that the proteasome and the TOR signalling pathway synergistically regulate a significant portion of the genome to coordinate cell growth and starvation response...
  4. doi request reprint Gis1 is required for transcriptional reprogramming of carbon metabolism and the stress response during transition into stationary phase in yeast
    Nianshu Zhang
    Cambridge Systems Biology Centre and Department of Biochemistry, University of Cambridge, Sanger Building, 80 Tennis Court Road, Cambridge CB2 1GA, UK
    Microbiology 155:1690-8. 2009
    ..In agreement with this, Rim15p is shown to act in parallel with Hog1p to defend cells against osmotic stress...
  5. pmc Chronological Lifespan in Yeast Is Dependent on the Accumulation of Storage Carbohydrates Mediated by Yak1, Mck1 and Rim15 Kinases
    Lu Cao
    Cambridge Systems Biology Centre and Department of Biochemistry, University of Cambridge, Sanger Building, United Kingdom
    PLoS Genet 12:e1006458. 2016
    ....
  6. doi request reprint JmjN interacts with JmjC to ensure selective proteolysis of Gis1 by the proteasome
    Zhenzhen Quan
    Cambridge Systems Biology Centre and Department of Biochemistry, University of Cambridge, Sanger Building, 80 Tennis Court Road, Cambridge CB2 1GA, UK
    Microbiology 157:2694-701. 2011
    ..Together, these data suggest that JmjN and JmjC interact physically to form a structural unit that ensures the stability and appropriate transcription activity of Gis1...
  7. pmc The genetic control of growth rate: a systems biology study in yeast
    Pinar Pir
    Cambridge Systems Biology Centre and Department of Biochemistry, University of Cambridge, Sanger Building, 80 Tennis Court Road, Cambridge CB2 1GA, UK
    BMC Syst Biol 6:4. 2012
    ..It has not been determined whether the set of HFC genes is the same at all growth rates or whether it is the same in conditions of nutrient limitation or excess...
  8. pmc The Yeast GSK-3 Homologue Mck1 Is a Key Controller of Quiescence Entry and Chronological Lifespan
    Zhenzhen Quan
    Cambridge Systems Biology Centre and Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom
    PLoS Genet 11:e1005282. 2015
    ..One involves the negative regulation of the effectors of G0 entry such as Mck1 and Rim15, while the other likely to involve its functions in promoting respiratory growth, a phenotype also contributed by Mck1 and Rim15. ..