Daniel Zehnder

Summary

Affiliation: University of Warwick
Country: UK

Publications

  1. pmc Reduction of the vitamin D hormonal system in kidney disease is associated with increased renal inflammation
    Daniel Zehnder
    Department of Nephrology, University Hospital Coventry and Warwickshire NHS Trust, Coventry, UK mail
    Kidney Int 74:1343-53. 2008
  2. ncbi request reprint Cross-sectional analysis of abnormalities of mineral homeostasis, vitamin D and parathyroid hormone in a cohort of pre-dialysis patients. The chronic renal impairment in Birmingham (CRIB) study
    Daniel Zehnder
    Department of Nephrology, University Hospital Coventry and Warwickshire NHS Trust, Coventry, UK
    Nephron Clin Pract 107:c109-16. 2007
  3. doi request reprint Double filtration plasmapheresis in antibody-incompatible kidney transplantation
    Rob Higgins
    Transplant Unit, University Hospitals Coventry and Warwickshire, Coventry, UK
    Ther Apher Dial 14:392-9. 2010
  4. doi request reprint The histological development of acute antibody-mediated rejection in HLA antibody-incompatible renal transplantation
    Rob Higgins
    Transplant Unit, University Hospitals Coventry and Warwickshire, Coventry, West Midlands, UK
    Nephrol Dial Transplant 25:1306-12. 2010
  5. doi request reprint Human leukocyte antigen-specific antibodies and gamma-interferon stimulate human microvascular and glomerular endothelial cells to produce complement factor C4
    Rizwan Hamer
    Renal Unit, University Hospitals Coventry and Warwickshire, Coventry, West Midlands, UK
    Transplantation 93:867-73. 2012
  6. doi request reprint New choices for patients needing kidney transplantation across antibody barriers
    Rob Higgins
    Transplant Unit, University Hospitals Coventry and Warwickshire, Coventry, West Midlands, UK
    J Ren Care 34:85-93. 2008
  7. doi request reprint Soluble CD30 and Cd27 levels in patients undergoing HLA antibody-incompatible renal transplantation
    Rizwan Hamer
    Transplant Unit, University Hospitals Coventry and Warwickshire, Coventry, West Midlands, UK
    Transpl Immunol 23:161-5. 2010
  8. pmc Behaviour of non-donor specific antibodies during rapid re-synthesis of donor specific HLA antibodies after antibody incompatible renal transplantation
    Nithya S Krishnan
    Department of Nephrology, University Hospitals Coventry and Warwickshire National Health Service Trust, Coventry, United Kingdom
    PLoS ONE 8:e68663. 2013
  9. doi request reprint Extracellular calcium-sensing receptor mediated signalling is involved in human vascular smooth muscle cell proliferation and apoptosis
    Guerman Molostvov
    The Clinical Sciences Research Institute, Warwick Medical School, Coventry, UK
    Cell Physiol Biochem 22:413-22. 2008
  10. pmc Subclass analysis of donor HLA-specific IgG in antibody-incompatible renal transplantation reveals a significant association of IgG4 with rejection and graft failure
    Natasha Khovanova
    School of Engineering, University of Warwick, Coventry, UK
    Transpl Int 28:1405-15. 2015

Collaborators

Detail Information

Publications23

  1. pmc Reduction of the vitamin D hormonal system in kidney disease is associated with increased renal inflammation
    Daniel Zehnder
    Department of Nephrology, University Hospital Coventry and Warwickshire NHS Trust, Coventry, UK mail
    Kidney Int 74:1343-53. 2008
    ..Our study indicates that renal inflammation is associated with decreased serum vitamin D metabolites and involves activation of the paracrine/autocrine vitamin D system...
  2. ncbi request reprint Cross-sectional analysis of abnormalities of mineral homeostasis, vitamin D and parathyroid hormone in a cohort of pre-dialysis patients. The chronic renal impairment in Birmingham (CRIB) study
    Daniel Zehnder
    Department of Nephrology, University Hospital Coventry and Warwickshire NHS Trust, Coventry, UK
    Nephron Clin Pract 107:c109-16. 2007
    ..However, it is unclear at what stage of chronic kidney disease (CKD) these abnormalities develop...
  3. doi request reprint Double filtration plasmapheresis in antibody-incompatible kidney transplantation
    Rob Higgins
    Transplant Unit, University Hospitals Coventry and Warwickshire, Coventry, UK
    Ther Apher Dial 14:392-9. 2010
    ..Despite this, most patients were transplanted with a positive crossmatch, and DFPP post-transplant was unable to control rising antibody levels...
  4. doi request reprint The histological development of acute antibody-mediated rejection in HLA antibody-incompatible renal transplantation
    Rob Higgins
    Transplant Unit, University Hospitals Coventry and Warwickshire, Coventry, West Midlands, UK
    Nephrol Dial Transplant 25:1306-12. 2010
    ..The aim of this study was to examine the development of acute antibody-mediated rejection in HLA antibody-incompatible renal transplantation in relation to the Banff 07 histological classification...
  5. doi request reprint Human leukocyte antigen-specific antibodies and gamma-interferon stimulate human microvascular and glomerular endothelial cells to produce complement factor C4
    Rizwan Hamer
    Renal Unit, University Hospitals Coventry and Warwickshire, Coventry, West Midlands, UK
    Transplantation 93:867-73. 2012
    ..However, the possible importance of local complement synthesis is less clear. The aim of this study was to determine whether human vascular endothelium could produce C4 in response to stimulation in vitro...
  6. doi request reprint New choices for patients needing kidney transplantation across antibody barriers
    Rob Higgins
    Transplant Unit, University Hospitals Coventry and Warwickshire, Coventry, West Midlands, UK
    J Ren Care 34:85-93. 2008
    ..It is likely that both schemes will complement each other and both are available in the United Kingdom...
  7. doi request reprint Soluble CD30 and Cd27 levels in patients undergoing HLA antibody-incompatible renal transplantation
    Rizwan Hamer
    Transplant Unit, University Hospitals Coventry and Warwickshire, Coventry, West Midlands, UK
    Transpl Immunol 23:161-5. 2010
    ..High sCD30 levels measured at 4-6 weeks post-transplantation was associated with poorer graft function at one year...
  8. pmc Behaviour of non-donor specific antibodies during rapid re-synthesis of donor specific HLA antibodies after antibody incompatible renal transplantation
    Nithya S Krishnan
    Department of Nephrology, University Hospitals Coventry and Warwickshire National Health Service Trust, Coventry, United Kingdom
    PLoS ONE 8:e68663. 2013
    ..However it is not known whether the converse occurs, and whether changes on non-donor specific antibodies are associated with any outcomes following HLA antibody incompatible renal transplantation...
  9. doi request reprint Extracellular calcium-sensing receptor mediated signalling is involved in human vascular smooth muscle cell proliferation and apoptosis
    Guerman Molostvov
    The Clinical Sciences Research Institute, Warwick Medical School, Coventry, UK
    Cell Physiol Biochem 22:413-22. 2008
    ..05). In conclusion, stimulation of CaSR leads to activation of MEK1/ERK1,2 and PLC pathways and up-regulation of cell proliferation. CaSR-mediated PLC activation is important for SMC survival and protection against apoptosis...
  10. pmc Subclass analysis of donor HLA-specific IgG in antibody-incompatible renal transplantation reveals a significant association of IgG4 with rejection and graft failure
    Natasha Khovanova
    School of Engineering, University of Warwick, Coventry, UK
    Transpl Int 28:1405-15. 2015
    ..Thus, pretreatment IgG4 DSA may be used as a biomarker to predict and risk stratify cases with higher levels of pan-IgG DSA in HLA antibody-incompatible transplantation. Further investigations are needed to confirm our results. ..
  11. doi request reprint Rapid resolution of severe sustained low blood pressure in haemodialysis patients after successful renal transplantation
    Lindsay Muscroft
    Warwick Medical School, University of Warwick, Coventry, UK
    Nephrol Dial Transplant 27:4223-7. 2012
    ..The pathophysiology of this syndrome is poorly understood...
  12. doi request reprint The role of capillary density, macrophage infiltration and interstitial scarring in the pathogenesis of human chronic kidney disease
    Kevin S Eardley
    Department of Nephrology, Royal Shrewsbury Hospital, Shrewsbury, UK
    Kidney Int 74:495-504. 2008
    ..As renal scarring evolves, alternative pathways relating to progressive tissue ischemia secondary to obliteration of the interstitial capillary bed predominate...
  13. ncbi request reprint Expression and role of the calcium-sensing receptor in the blood vessel wall
    Guerman Molostvov
    The Clinical Sciences Research Institute, Warwick Medical School and Department of Biological Sciences, The University of Warwick, Coventry, UK
    Curr Pharm Biotechnol 10:282-8. 2009
    ..Further detailed analysis will clarify the role the vascular CaSR plays as a therapeutic target for complex disease conditions such as hypertension, tissue hypoperfusion, atherosclerosis and vascular calcification...
  14. pmc Increased glycation and oxidative damage to apolipoprotein B100 of LDL cholesterol in patients with type 2 diabetes and effect of metformin
    Naila Rabbani
    Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, University Hospital, Coventry, UK
    Diabetes 59:1038-45. 2010
    ..The aim of this study was to investigate whether apolipoprotein B100 of LDL suffers increased damage by glycation, oxidation, and nitration in patients with type 2 diabetes, including patients receiving metformin therapy...
  15. pmc Exaggerated blood pressure response to dynamic exercise despite chronic refractory hypotension: results of a human case study
    Alice Rogan
    Departments of Renal Medicine and Transplantation, University Hospital Coventry and Warwickshire NHS Trust, Clifford Bridge Road, Coventry, CV2 2DX, UK
    BMC Nephrol 16:81. 2015
    ..We present a case with severe chronic hypotension who underwent exercise testing before and after renal transplantation, with marked differences in blood pressure response to exercise...
  16. ncbi request reprint Elevated relative mortality risk with mild-to-moderate chronic kidney disease decreases with age
    Neil T Raymond
    Health Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry, CV4 7AL, UK
    Nephrol Dial Transplant 22:3214-20. 2007
    ..The aim of this study was to examine all-cause mortality risk in relation to chronic kidney disease (CKD) stages defined by estimated glomerular filtration rate (eGFR)...
  17. doi request reprint Reduced Cardiovascular Reserve in Chronic Kidney Failure: A Matched Cohort Study
    Stephen M S Ting
    Division of Nephrology, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, United Kingdom Division of Metabolic and Vascular Health, The University of Warwick, Coventry, United Kingdom Electronic address
    Am J Kidney Dis 66:274-84. 2015
    ..No studies have examined whether this is related to impaired cardiovascular compliance as a consequence of loss of adaptive structural alterations, resulting from chronic uremia or hypertension...
  18. ncbi request reprint Extracellular calcium-sensing receptor is functionally expressed in human artery
    Guerman Molostvov
    Clinical Sciences Research Institute, University of Warwick, Coventry, UK
    Am J Physiol Renal Physiol 293:F946-55. 2007
    ..Expression was significantly lower in arteries from ESRD patients. In conclusion, these data not only demonstrate the presence of a functional CaSR in human artery but show a correlation between CaSR expression and progression of CKD...
  19. pmc Reduced functional measure of cardiovascular reserve predicts admission to critical care unit following kidney transplantation
    Stephen M S Ting
    Department of Renal Medicine and Transplantation, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, United Kingdom
    PLoS ONE 8:e64335. 2013
    ..We sought to determine if functional measures of cardiovascular reserve, in particular the anaerobic threshold (VO₂AT) could identify these patients...
  20. doi request reprint Vascular Klotho deficiency potentiates the development of human artery calcification and mediates resistance to fibroblast growth factor 23
    Kenneth Lim
    Brigham and Women s Hospital, Harvard Medical School, Room 120, 41 Ave Louis Pasteur, Boston, MA 02115, USA
    Circulation 125:2243-55. 2012
    ..FGF-23 levels rise in chronic kidney disease (CKD) despite progression of accelerated vascular calcification. There are currently conflicting data on whether FGF-23 may exhibit direct vasculoprotective effects in CKD...
  21. ncbi request reprint Blood levels of donor-specific human leukocyte antigen antibodies after renal transplantation: resolution of rejection in the presence of circulating donor-specific antibody
    Rob Higgins
    Transplant Unit, University Hospitals Coventry and Warwickshire, Coventry, West Midlands, UK
    Transplantation 84:876-84. 2007
    ....
  22. ncbi request reprint Vitamin D and barrier function: a novel role for extra-renal 1 alpha-hydroxylase
    Martin Hewison
    Division of Medical Sciences, Institute of Clinical Research, The University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2TH, UK
    Mol Cell Endocrinol 215:31-8. 2004
    ....
  23. ncbi request reprint Vitamin D-mediated hypercalcemia in lymphoma: evidence for hormone production by tumor-adjacent macrophages
    Martin Hewison
    Division of Medical Sciences, University of Birmingham, Birmingham, United Kingdom
    J Bone Miner Res 18:579-82. 2003
    ..Based on this case study, we propose that the abnormal synthesis of 1,25(OH)2D3 associated with some lymphomas is because of paracrine regulation of tumor-associated macrophages...