Marios C Yiannakas

Summary

Affiliation: University College London
Country: UK

Publications

  1. doi request reprint MRI acquisition and analysis protocol for in vivo intraorbital optic nerve segmentation at 3T
    Marios C Yiannakas
    Nuclear Magnetic Resonance Research Unit, University College London Institute of Neurology, London, United Kingdom
    Invest Ophthalmol Vis Sci 54:4235-40. 2013
  2. doi request reprint Feasibility of grey matter and white matter segmentation of the upper cervical cord in vivo: a pilot study with application to magnetisation transfer measurements
    M C Yiannakas
    NMR Research Unit, UCL Institute of Neurology, London, UK
    Neuroimage 63:1054-9. 2012
  3. pmc ADvanced IMage Algebra (ADIMA): a novel method for depicting multiple sclerosis lesion heterogeneity, as demonstrated by quantitative MRI
    Marios C Yiannakas
    Department of Neuroinflammation, University College London, Institute of Neurology, London, UK
    Mult Scler 19:732-41. 2013
  4. doi request reprint Cervical cord lesion load is associated with disability independently from atrophy in MS
    Hugh Kearney
    From the NMR Research Unit H K, D R A, R S S, M C Y, C A M W K, O C, D H M, Queen Square MS Centre, UCL Institute of Neurology, London the Department of Medical Statistics D R A, London School of Hygiene and Tropical Medicine and NIHR University College London Hospitals Biomedical Research Centre C A M W K, O C, D H M, UK
    Neurology 84:367-73. 2015
  5. pmc Evidence for early neurodegeneration in the cervical cord of patients with primary progressive multiple sclerosis
    Khaled Abdel-Aziz
    1 NMR Research Unit, UCL Institute of Neurology, London, UK 2 Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, UK
    Brain 138:1568-82. 2015
  6. pmc Age related changes in metabolite concentrations in the normal spinal cord
    Khaled Abdel-Aziz
    NMR Research Unit, UCL Institute of Neurology, London, United Kingdom Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom
    PLoS ONE 9:e105774. 2014
  7. doi request reprint Improved MRI quantification of spinal cord atrophy in multiple sclerosis
    Hugh Kearney
    NMR Research Unit, Queen Square MS Centre, UCL Institute of Neurology, London, UK
    J Magn Reson Imaging 39:617-23. 2014
  8. pmc Fully automated segmentation of the cervical cord from T1-weighted MRI using PropSeg: Application to multiple sclerosis
    Marios C Yiannakas
    NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, London, UK
    Neuroimage Clin 10:71-7. 2016
  9. doi request reprint Investigation of magnetization transfer ratio-derived pial and subpial abnormalities in the multiple sclerosis spinal cord
    Hugh Kearney
    1 NMR Research Unit, Queen Square MS Centre, UCL Institute of Neurology, London WC1N 3BG, UK
    Brain 137:2456-68. 2014
  10. doi request reprint In vivo magnetic resonance spectroscopy detection of combined glutamate-glutamine in healthy upper cervical cord at 3 T
    Bhavana S Solanky
    Queen Square MS Center, Department of Neuroinflammation, University College London Institute of Neurology, London, UK
    NMR Biomed 26:357-66. 2013

Collaborators

Detail Information

Publications14

  1. doi request reprint MRI acquisition and analysis protocol for in vivo intraorbital optic nerve segmentation at 3T
    Marios C Yiannakas
    Nuclear Magnetic Resonance Research Unit, University College London Institute of Neurology, London, United Kingdom
    Invest Ophthalmol Vis Sci 54:4235-40. 2013
    ..To present a new acquisition and analysis protocol for reliable and reproducible segmentation of the entire intraorbital optic nerve (ION) mean cross-sectional area by means of magnetic resonance imaging (MRI) at 3 tesla (T)...
  2. doi request reprint Feasibility of grey matter and white matter segmentation of the upper cervical cord in vivo: a pilot study with application to magnetisation transfer measurements
    M C Yiannakas
    NMR Research Unit, UCL Institute of Neurology, London, UK
    Neuroimage 63:1054-9. 2012
    ....
  3. pmc ADvanced IMage Algebra (ADIMA): a novel method for depicting multiple sclerosis lesion heterogeneity, as demonstrated by quantitative MRI
    Marios C Yiannakas
    Department of Neuroinflammation, University College London, Institute of Neurology, London, UK
    Mult Scler 19:732-41. 2013
    ..This may partly reflect pathological heterogeneity in WMLs, which is not apparent on T2w scans...
  4. doi request reprint Cervical cord lesion load is associated with disability independently from atrophy in MS
    Hugh Kearney
    From the NMR Research Unit H K, D R A, R S S, M C Y, C A M W K, O C, D H M, Queen Square MS Centre, UCL Institute of Neurology, London the Department of Medical Statistics D R A, London School of Hygiene and Tropical Medicine and NIHR University College London Hospitals Biomedical Research Centre C A M W K, O C, D H M, UK
    Neurology 84:367-73. 2015
    ..To investigate whether spinal cord (SC) lesion load, when quantified on axial images with high in-plane resolution, is associated with disability in multiple sclerosis (MS)...
  5. pmc Evidence for early neurodegeneration in the cervical cord of patients with primary progressive multiple sclerosis
    Khaled Abdel-Aziz
    1 NMR Research Unit, UCL Institute of Neurology, London, UK 2 Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, UK
    Brain 138:1568-82. 2015
    ....
  6. pmc Age related changes in metabolite concentrations in the normal spinal cord
    Khaled Abdel-Aziz
    NMR Research Unit, UCL Institute of Neurology, London, United Kingdom Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom
    PLoS ONE 9:e105774. 2014
    ..002) was seen within our sample age range, starting in the early twenties. The findings suggest that neuroaxonal loss and/or metabolic neuronal dysfunction, and decline in glutamate-glutamine neurotransmitter pool progress with aging. ..
  7. doi request reprint Improved MRI quantification of spinal cord atrophy in multiple sclerosis
    Hugh Kearney
    NMR Research Unit, Queen Square MS Centre, UCL Institute of Neurology, London, UK
    J Magn Reson Imaging 39:617-23. 2014
    ..To identify an improved method for measuring spinal cord cross-sectional area (CSA) using magnetic resonance imaging (MRI) in multiple sclerosis (MS)...
  8. pmc Fully automated segmentation of the cervical cord from T1-weighted MRI using PropSeg: Application to multiple sclerosis
    Marios C Yiannakas
    NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, London, UK
    Neuroimage Clin 10:71-7. 2016
    ..PropSeg is a time-efficient and reliable segmentation method, which requires no manual intervention, and may facilitate large multi-centre neuroprotective trials in progressive MS. ..
  9. doi request reprint Investigation of magnetization transfer ratio-derived pial and subpial abnormalities in the multiple sclerosis spinal cord
    Hugh Kearney
    1 NMR Research Unit, Queen Square MS Centre, UCL Institute of Neurology, London WC1N 3BG, UK
    Brain 137:2456-68. 2014
    ..40, P < 0.01). Our in vivo imaging observations suggest that abnormalities in a region involving the pia mater and subpial cord occur early in the course of multiple sclerosis and are more marked in those with a progressive course...
  10. doi request reprint In vivo magnetic resonance spectroscopy detection of combined glutamate-glutamine in healthy upper cervical cord at 3 T
    Bhavana S Solanky
    Queen Square MS Center, Department of Neuroinflammation, University College London Institute of Neurology, London, UK
    NMR Biomed 26:357-66. 2013
    ..This study proposed a clinically feasible MRS method for Glx detection in the human cervical cord in vivo including sample sizes needed for conclusive clinical studies...
  11. pmc Grey and White Matter Magnetisation Transfer Ratio Measurements in the Lumbosacral Enlargement: A Pilot In Vivo Study at 3T
    Chinyere O Ugorji
    NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, London, United Kingdom
    PLoS ONE 10:e0134495. 2015
    ..The MTR acquisition and analysis protocol presented in this study can be used in future investigations of intrinsic spinal cord diseases that affect the LSE. ..
  12. doi request reprint A method for measuring the cross sectional area of the anterior portion of the optic nerve in vivo using a fast 3D MRI sequence
    Marios C Yiannakas
    Department of Neuroinflammation, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    J Magn Reson Imaging 31:1486-91. 2010
    ....
  13. pmc The use of the lumbosacral enlargement as an intrinsic imaging biomarker: feasibility of grey matter and white matter cross-sectional area measurements using MRI at 3T
    Marios C Yiannakas
    NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, London, United Kingdom
    PLoS ONE 9:e105544. 2014
    ..The method presented here can be potentially extended to study the LSE in the diseased state and could provide a solid foundation for subsequent multi-parametric MRI investigations. ..
  14. doi request reprint Phenytoin for neuroprotection in patients with acute optic neuritis: a randomised, placebo-controlled, phase 2 trial
    Rhian Raftopoulos
    National Hospital for Neurology and Neurosurgery, London, UK University College London Institute of Neurology, London, UK Queen Square Multiple Sclerosis Centre, London, UK
    Lancet Neurol 15:259-69. 2016
    ..Inhibition of voltage-gated sodium channels is neuroprotective in preclinical models. In this study we aimed to establish whether sodium-channel inhibition with phenytoin is neuroprotective in patient with acute optic neuritis...