David H Wyllie

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. pmc Are there better methods of monitoring MRSA control than bacteraemia surveillance? An observational database study
    Sarah Walker
    Oxford Radcliffe Hospitals NHS Trust, John Radcliffe Hospital, Oxford, United Kingdom
    PLoS ONE 3:e2378. 2008
  2. pmc Relation between lymphopenia and bacteraemia in UK adults with medical emergencies
    D H Wyllie
    Nuffield Departments of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    J Clin Pathol 57:950-5. 2004
  3. pmc Bacteraemia prediction in emergency medical admissions: role of C reactive protein
    D H Wyllie
    Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    J Clin Pathol 58:352-6. 2005
  4. pmc MRSA bacteraemia in patients on arrival in hospital: a cohort study in Oxfordshire 1997-2003
    David H Wyllie
    Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU
    BMJ 331:992. 2005
  5. pmc Mortality after Staphylococcus aureus bacteraemia in two hospitals in Oxfordshire, 1997-2003: cohort study
    David H Wyllie
    Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU
    BMJ 333:281. 2006
  6. ncbi request reprint Hospital exposure in a UK population, and its association with bacteraemia
    D H Wyllie
    Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford, UK
    J Hosp Infect 67:301-7. 2007
  7. pmc Relationship between bacterial strain type, host biomarkers, and mortality in Clostridium difficile infection
    A Sarah Walker
    NIHR Biomedical Research Centre, Oxford, UK
    Clin Infect Dis 56:1589-600. 2013
  8. pmc Surveillance of infection severity: a registry study of laboratory diagnosed Clostridium difficile
    Iryna Schlackow
    NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom
    PLoS Med 9:e1001279. 2012
  9. pmc Characterisation of Clostridium difficile hospital ward-based transmission using extensive epidemiological data and molecular typing
    A Sarah Walker
    National Institute for Health Research Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom
    PLoS Med 9:e1001172. 2012
  10. pmc Diverse sources of C. difficile infection identified on whole-genome sequencing
    David W Eyre
    Nuffield Department of Clinical Medicine, University of Oxford, the National Institute for Health Research NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom
    N Engl J Med 369:1195-205. 2013

Collaborators

  • Derrick W Crook
  • Mark H Wilcox
  • Kate E Dingle
  • John M Finney
  • Timothy M Walker
  • Daniel J Wilson
  • Roland Diel
  • Silke Feuerriegel
  • Laura Dunn
  • Xavier Didelot
  • Nicole Stoesser
  • Sarah A Walker
  • A Sarah Walker
  • Tim E A Peto
  • David W Eyre
  • Antonina A Votintseva
  • David Griffiths
  • Iryna Schlackow
  • Yuko Yamaguchi
  • Lily O'Connor
  • Elizabeth R Allen
  • Amy Flaxman
  • Claudia Lindemann
  • Louise J Pankhurst
  • Kyle Knox
  • Phelim Bradley
  • Paolo Piazza
  • Tanya Golubchik
  • Rory Bowden
  • Pauline M van Diemen
  • Alison Vaughan
  • Rosalind M Harding
  • Sarah Oakley
  • Ali Vaughan
  • Adrian V S Hill
  • Christine S Rollier
  • Arturo Reyes-Sandoval
  • Elizabeth Soilleux
  • Pauline van Diemen
  • Frances Gunner
  • Elizabeth Allen
  • Christine Rollier
  • Joanne L Fallowfield
  • Michael Lindsay
  • Jurgen Schneider
  • Fergal Hill
  • Matthew K O'Shea
  • Marcus R Morgan
  • Nazir Ismail
  • N Claire Gordon
  • Bill Huang
  • E Grace Smith
  • Shaheed V Omar
  • T Phuong Quan
  • Stefan Niemann
  • Thomas A Kohl
  • Gil McVean
  • Deborah Gascoyne-Binzi
  • Luke Anson
  • Simon Heys
  • Luke W Anson
  • David Buck
  • Carlos Del Ojo Elias
  • Zamin Iqbal
  • Mariateresa de Cesare
  • Sarah Earle
  • Heather Godwin
  • Rowena Fung
  • Ruth R Miller
  • Camilla L C Ip
  • Gavin K Paterson
  • Brian Shine
  • Madeleine L Cule
  • Elizabeth M Batty
  • Martin J Gill
  • Karolis Bauza
  • Anita Milicic
  • Emily K Forbes

Detail Information

Publications22

  1. pmc Are there better methods of monitoring MRSA control than bacteraemia surveillance? An observational database study
    Sarah Walker
    Oxford Radcliffe Hospitals NHS Trust, John Radcliffe Hospital, Oxford, United Kingdom
    PLoS ONE 3:e2378. 2008
    ..Using bacteraemia as an outcome, trends at hospital level are difficult to discern, due to random variation. We investigated rates of nosocomial bacteraemic and non-bacteraemic MRSA infection as surveillance outcomes...
  2. pmc Relation between lymphopenia and bacteraemia in UK adults with medical emergencies
    D H Wyllie
    Nuffield Departments of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    J Clin Pathol 57:950-5. 2004
    ..To determine the relevance of lymphopenia to the diagnosis of bacteraemia in patients admitted with medical emergencies, relative to peripheral blood white cell count and neutrophilia...
  3. pmc Bacteraemia prediction in emergency medical admissions: role of C reactive protein
    D H Wyllie
    Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    J Clin Pathol 58:352-6. 2005
    ..To define the contribution made by C reactive protein (CRP) measurement to bacteraemia prediction in adults with medical emergencies in the UK...
  4. pmc MRSA bacteraemia in patients on arrival in hospital: a cohort study in Oxfordshire 1997-2003
    David H Wyllie
    Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU
    BMJ 331:992. 2005
    ..To describe the incidence and determinants of methicillin resistant and methicillin sensitive Staphylococcus aureus (MRSA and MSSA) bacteraemia in patients presenting to acute hospitals...
  5. pmc Mortality after Staphylococcus aureus bacteraemia in two hospitals in Oxfordshire, 1997-2003: cohort study
    David H Wyllie
    Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU
    BMJ 333:281. 2006
    ..To determine the incidence of methicillin resistant and methicillin sensitive Staphylococcus aureus (MRSA and MSSA) bacteraemia in inpatients and associated mortality within 30 days after diagnosis...
  6. ncbi request reprint Hospital exposure in a UK population, and its association with bacteraemia
    D H Wyllie
    Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford, UK
    J Hosp Infect 67:301-7. 2007
    ..This quantitative analysis confirms that prior hospital admission is a major risk factor for bacteraemia on hospital admission; it is unclear whether acquisition of pathogens in hospital, co-morbidity or other factors explain this...
  7. pmc Relationship between bacterial strain type, host biomarkers, and mortality in Clostridium difficile infection
    A Sarah Walker
    NIHR Biomedical Research Centre, Oxford, UK
    Clin Infect Dis 56:1589-600. 2013
    ..Despite substantial interest in biomarkers, their impact on clinical outcomes and variation with bacterial strain has rarely been explored using integrated databases...
  8. pmc Surveillance of infection severity: a registry study of laboratory diagnosed Clostridium difficile
    Iryna Schlackow
    NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom
    PLoS Med 9:e1001279. 2012
    ..Consequently, innovative techniques monitoring infection severity are of potential clinical value...
  9. pmc Characterisation of Clostridium difficile hospital ward-based transmission using extensive epidemiological data and molecular typing
    A Sarah Walker
    National Institute for Health Research Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom
    PLoS Med 9:e1001172. 2012
    ..This study aimed to investigate ward-based transmission of C. difficile, by subdividing outbreaks into distinct lineages defined by multi-locus sequence typing (MLST)...
  10. pmc Diverse sources of C. difficile infection identified on whole-genome sequencing
    David W Eyre
    Nuffield Department of Clinical Medicine, University of Oxford, the National Institute for Health Research NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom
    N Engl J Med 369:1195-205. 2013
    ..However, endemic spread has hampered identification of precise sources of infection and the assessment of the efficacy of interventions...
  11. doi request reprint Increasing incidence of Escherichia coli bacteraemia is driven by an increase in antibiotic-resistant isolates: electronic database study in Oxfordshire 1999-2011
    Iryna Schlackow
    NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK
    J Antimicrob Chemother 67:1514-24. 2012
    ..To investigate trends in Escherichia coli resistance, bacteraemia rates and post-bacteraemia outcomes over time...
  12. pmc Clostridium difficile mixed infection and reinfection
    David W Eyre
    NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom
    J Clin Microbiol 50:142-4. 2012
    ..Of 109 sample pairs taken on the same day, 3 (3%) had different genotypes. Considering samples 0 to 7 days apart as the same CDI, 7% of cases had mixed infections with >1 genotype...
  13. pmc Decline of meticillin-resistant Staphylococcus aureus in Oxfordshire hospitals is strain-specific and preceded infection-control intensification
    David H Wyllie
    Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK
    BMJ Open 1:e000160. 2011
    ..A major, mainly meticillin-sensitive, S aureus burden remains...
  14. pmc CD8+ T effector memory cells protect against liver-stage malaria
    Arturo Reyes-Sandoval
    The Jenner Institute, University of Oxford, Oxford OX3 7DQ, United Kingdom
    J Immunol 187:1347-57. 2011
    ..Thus, we identify persistent CD8 T(EM) populations as essential for vaccine-induced pre-erythrocytic protection against malaria, a finding that has important implications for vaccine design...
  15. pmc MRI Based Localisation and Quantification of Abscesses following Experimental S. aureus Intravenous Challenge: Application to Vaccine Evaluation
    Elizabeth R Allen
    Jenner Institute, Centre for Cellular and Molecular Physiology, University of Oxford, Oxford, United Kingdom
    PLoS ONE 11:e0154705. 2016
    ..To develop and validate a sensitive and specific method of abscess enumeration and quantification in a preclinical model of Staphylococcus aureus infection...
  16. pmc Risk factors for dermatitis in submariners during a submerged patrol: an observational cohort study
    Amy Flaxman
    Jenner Institute, Centre for Cellular and Molecular Physiology, University of Oxford, Oxford, UK
    BMJ Open 6:e010975. 2016
    ..The aim of this pilot study was to determine risk factors, including Staphylococcus aureus nasal carriage, for dermatitis in submariners during a submarine patrol...
  17. pmc Prevalence of Staphylococcus aureus protein A (spa) mutants in the community and hospitals in Oxfordshire
    Antonina A Votintseva
    Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Level 7, Room 7724, Oxford OX3 9DU, United Kingdom
    BMC Microbiol 14:63. 2014
    ..A weakness of current spa-typing primers is that rearrangements in the IgG-binding region of the gene cause 1-2% of strains to be designated as "non-typeable"...
  18. doi request reprint Irradiated wild-type and Spa mutant Staphylococcus aureus induce anti-S. aureus immune responses in mice which do not protect against subsequent intravenous challenge
    Pauline M van Diemen
    Jenner Institute, University of Oxford, Oxford, UK
    Pathog Dis 68:20-6. 2013
    ..Additionally, these data suggest a limited role for irradiated wild-type or spa mutant S. aureus as vaccines...
  19. pmc Rapid antibiotic-resistance predictions from genome sequence data for Staphylococcus aureus and Mycobacterium tuberculosis
    Phelim Bradley
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK
    Nat Commun 6:10063. 2015
    ..We give evidence that minor alleles improve detection of extremely drug-resistant strains, and demonstrate feasibility of the use of emerging single-molecule nanopore sequencing techniques for these purposes. ..
  20. pmc Mycobacterial DNA extraction for whole-genome sequencing from early positive liquid (MGIT) cultures
    Antonina A Votintseva
    Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    J Clin Microbiol 53:1137-43. 2015
    ..The DNA extraction protocol, therefore, will facilitate fast and accurate identification of mycobacterial species and resistance using a range of bioinformatics tools. ..
  21. pmc An efficient record linkage scheme using graphical analysis for identifier error detection
    John M Finney
    NIHR Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK
    BMC Med Inform Decis Mak 11:7. 2011
    ..It is now common to be required to link very large numbers of records, often containing various combinations of theoretically unique identifiers, such as NHS numbers, which are both incomplete and error-prone...
  22. ncbi request reprint Spread of multiresistance and extended-spectrum beta-lactamases amongst urinary Escherichia coli in Oxford, UK
    David H Wyllie
    J Antimicrob Chemother 56:986-8. 2005