Anton Wutz

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. pmc The histone deacetylase inhibitor sodium valproate causes limited transcriptional change in mouse embryonic stem cells but selectively overrides Polycomb-mediated Hoxb silencing
    Elsa Boudadi
    Chromatin and Gene Expression Group, College of Medical and Dental Sciences, Institute of Biomedical Research, University of Birmingham, Birmingham B15 2TT, UK
    Epigenetics Chromatin 6:11. 2013
  2. doi Epigenetic regulation of stem cells : the role of chromatin in cell differentiation
    Anton Wutz
    Wellcome Trust Centre for Stem Cell Research, Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QR, UK
    Adv Exp Med Biol 786:307-28. 2013
  3. doi Response: the diversity of proteins linking xist to gene silencing
    Anton Wutz
    Wellcome Trust Medical Research Council Stem Cell Institute, Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK Electronic address
    Dev Cell 23:680. 2012
  4. doi Epigenetic alterations in human pluripotent stem cells: a tale of two cultures
    Anton Wutz
    Wellcome Trust Centre for Stem Cell Research, Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
    Cell Stem Cell 11:9-15. 2012
  5. doi Gene silencing in X-chromosome inactivation: advances in understanding facultative heterochromatin formation
    Anton Wutz
    Wellcome Trust Centre for Stem Cell Research, Cambridge, UK
    Nat Rev Genet 12:542-53. 2011
  6. pmc Establishment of epigenetic patterns in development
    Martin Leeb
    Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK
    Chromosoma 121:251-62. 2012
  7. pmc Reactivation of the inactive X chromosome in development and reprogramming
    Tatsuya Ohhata
    Wellcome Trust and MRC Stem Cell Institute, Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, UK
    Cell Mol Life Sci 70:2443-61. 2013
  8. pmc Histone H3 Lysine 36 Trimethylation Is Established over the Xist Promoter by Antisense Tsix Transcription and Contributes to Repressing Xist Expression
    Tatsuya Ohhata
    Department of Molecular Biology, Hamamatsu University School of Medicine, Hamamatsu, Japan WT and MRC Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom
    Mol Cell Biol 35:3909-20. 2015
  9. pmc Lineage-specific function of the noncoding Tsix RNA for Xist repression and Xi reactivation in mice
    Tatsuya Ohhata
    The Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Cambridge CB2 1QR, United Kingdom
    Genes Dev 25:1702-15. 2011
  10. pmc Germline potential of parthenogenetic haploid mouse embryonic stem cells
    Martin Leeb
    Centre for Stem Cell Research, Wellcome Trust and Medical Research Council Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
    Development 139:3301-5. 2012

Collaborators

Detail Information

Publications17

  1. pmc The histone deacetylase inhibitor sodium valproate causes limited transcriptional change in mouse embryonic stem cells but selectively overrides Polycomb-mediated Hoxb silencing
    Elsa Boudadi
    Chromatin and Gene Expression Group, College of Medical and Dental Sciences, Institute of Biomedical Research, University of Birmingham, Birmingham B15 2TT, UK
    Epigenetics Chromatin 6:11. 2013
    ..Here we have explored the ability of the clinically important HDACi valproic acid (VPA) to alter histone modification and gene expression, both globally and at specific genes, in mouse embryonic stem (ES) cells...
  2. doi Epigenetic regulation of stem cells : the role of chromatin in cell differentiation
    Anton Wutz
    Wellcome Trust Centre for Stem Cell Research, Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QR, UK
    Adv Exp Med Biol 786:307-28. 2013
    ..Identification of these mechanism is an important aim for future research to obtain a more complete framework for understanding stem cell differentiation during tissue homeostasis...
  3. doi Response: the diversity of proteins linking xist to gene silencing
    Anton Wutz
    Wellcome Trust Medical Research Council Stem Cell Institute, Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK Electronic address
    Dev Cell 23:680. 2012
    ..Here, Wutz and Agrelo respond, discussing ways to reconcile the available data. Both groups agree that multiple redundant factors may contribute in parallel...
  4. doi Epigenetic alterations in human pluripotent stem cells: a tale of two cultures
    Anton Wutz
    Wellcome Trust Centre for Stem Cell Research, Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
    Cell Stem Cell 11:9-15. 2012
    ....
  5. doi Gene silencing in X-chromosome inactivation: advances in understanding facultative heterochromatin formation
    Anton Wutz
    Wellcome Trust Centre for Stem Cell Research, Cambridge, UK
    Nat Rev Genet 12:542-53. 2011
    ..The emerging picture is complex and suggests that chromosome-wide silencing can be partitioned into several steps, the molecular components of which are starting to be defined...
  6. pmc Establishment of epigenetic patterns in development
    Martin Leeb
    Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK
    Chromosoma 121:251-62. 2012
    ..Insights into this epigenetic "memory" of the first lineage decisions help to provide a better understanding of the function of epigenetic regulation in adult stem cell differentiation...
  7. pmc Reactivation of the inactive X chromosome in development and reprogramming
    Tatsuya Ohhata
    Wellcome Trust and MRC Stem Cell Institute, Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, UK
    Cell Mol Life Sci 70:2443-61. 2013
    ..Here, we review recent advances in the understanding of Xi reactivation during development and reprogramming and illustrate potential clinical applications. ..
  8. pmc Histone H3 Lysine 36 Trimethylation Is Established over the Xist Promoter by Antisense Tsix Transcription and Contributes to Repressing Xist Expression
    Tatsuya Ohhata
    Department of Molecular Biology, Hamamatsu University School of Medicine, Hamamatsu, Japan WT and MRC Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom
    Mol Cell Biol 35:3909-20. 2015
    ..Furthermore, we found that reduction of H3K36me3 does not facilitate an increase in H3K27me3 over the Xist promoter, indicating that additional mechanisms exist by which Tsix blocks PRC2 recruitment to the Xist promoter. ..
  9. pmc Lineage-specific function of the noncoding Tsix RNA for Xist repression and Xi reactivation in mice
    Tatsuya Ohhata
    The Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Cambridge CB2 1QR, United Kingdom
    Genes Dev 25:1702-15. 2011
    ..This finding shows that reversible XCI is not exclusive to pluripotent cells, and that in some lineages cell differentiation is not accompanied by a stabilization of the Xi...
  10. pmc Germline potential of parthenogenetic haploid mouse embryonic stem cells
    Martin Leeb
    Centre for Stem Cell Research, Wellcome Trust and Medical Research Council Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
    Development 139:3301-5. 2012
    ..By contrast, we find that a haploid karyotype is maintained when differentiation to an extra-embryonic fate is forced by induction of Gata6...
  11. pmc Breathing-in epigenetic change with vitamin C
    Asun Monfort
    Wellcome Trust, Medical Research Council Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
    EMBO Rep 14:337-46. 2013
    ..The available data suggest a link between dioxygenase function and stem cell differentiation, which is exposed to environmental influence and is relevant for human disease...
  12. doi Mechanistic insights into chromosome-wide silencing in X inactivation
    Susanne Arthold
    Wellcome Trust Centre for Stem Cell Research, Tennis Court Road, Cambridge CB2 1QR, UK
    Hum Genet 130:295-305. 2011
    ..In this review, we summarize the present knowledge of the mechanism of chromosome-wide silencing and give an outlook on future directions...
  13. pmc Haploid genomes illustrate epigenetic constraints and gene dosage effects in mammals
    Martin Leeb
    Wellcome Trust Medical Research Council Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
    Epigenetics Chromatin 6:41. 2013
    ..Here we review the recent literature on haploid genomes and dosage effects and try to embed recent findings in an evolutionary perspective. ..
  14. doi Establishment and Use of Mouse Haploid ES Cells
    Martin Leeb
    Wellcome Trust Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom
    Curr Protoc Mouse Biol 5:155-85. 2015
    ..Here we provide detailed protocols for the establishment, culture, and manipulation of parthenogenetic and androgenetic haploid embryonic stem cells from mouse embryos...
  15. pmc Derivation of haploid embryonic stem cells from mouse embryos
    Martin Leeb
    Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
    Nature 479:131-4. 2011
    ..Here we describe haploid mouse embryonic stem cells and show their application in forward genetic screening...
  16. pmc RYBP-PRC1 complexes mediate H2A ubiquitylation at polycomb target sites independently of PRC2 and H3K27me3
    Ligia Tavares
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Cell 148:664-78. 2012
    ..We discuss the implications of these findings for understanding recruitment and function of Polycomb repressors...
  17. doi RNA-mediated silencing mechanisms in mammalian cells
    Anton Wutz
    Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Cambridge, United Kingdom
    Prog Mol Biol Transl Sci 101:351-76. 2011
    ..Well-studied examples of noncoding RNAs include Xist, Air, Kcnq1ot1, HOTAIR, and Tsix. Here, a concise review of noncoding RNA function in mammals is given, and the present understanding and future directions of the field are summarized...