G Sebastiaan Winkler

Summary

Affiliation: University of Nottingham
Country: UK

Publications

  1. doi request reprint The mammalian anti-proliferative BTG/Tob protein family
    G Sebastiaan Winkler
    School of Pharmacy, Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, United Kingdom
    J Cell Physiol 222:66-72. 2010
  2. pmc The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex
    Rachel Doidge
    School of Pharmacy, Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, United Kingdom
    PLoS ONE 7:e51331. 2012
  3. pmc The Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subunits of the human Ccr4-Not complex contribute to the prevention of cell death and senescence
    Saloni Mittal
    School of Pharmacy and Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD, United Kingdom
    Mol Biol Cell 22:748-58. 2011
  4. pmc Discovery, synthesis and biochemical profiling of purine-2,6-dione derivatives as inhibitors of the human poly(A)-selective ribonuclease Caf1
    Gopal P Jadhav
    School of Pharmacy, Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, UK
    Bioorg Med Chem Lett 25:4219-24. 2015
  5. doi request reprint Deadenylation of cytoplasmic mRNA by the mammalian Ccr4-Not complex
    Rachel Doidge
    School of Pharmacy, University of Nottingham, University Park, Nottingham, UK
    Biochem Soc Trans 40:896-901. 2012
  6. pmc A fluorescence-based assay suitable for quantitative analysis of deadenylase enzyme activity
    Maryati Maryati
    School of Pharmacy and Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, UK
    Nucleic Acids Res 42:e30. 2014
  7. pmc The enzyme activities of Caf1 and Ccr4 are both required for deadenylation by the human Ccr4-Not nuclease module
    Maryati Maryati
    School of Pharmacy, University of Nottingham, East Drive, University Park, Nottingham NG7 2RD, U K
    Biochem J 469:169-76. 2015
  8. pmc Differential effects of garcinol and curcumin on histone and p53 modifications in tumour cells
    Hilary M Collins
    Gene Regulation Group, Centre for Biomolecular Sciences, School of Pharmacy, University of Nottingham, University Park, NG7 2RD, Nottingham United Kingdom
    BMC Cancer 13:37. 2013
  9. pmc The Ccr4-NOT deadenylase subunits CNOT7 and CNOT8 have overlapping roles and modulate cell proliferation
    Akhmed Aslam
    The School of Pharmacy, Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom
    Mol Biol Cell 20:3840-50. 2009
  10. pmc Heterogeneity and complexity within the nuclease module of the Ccr4-Not complex
    G Sebastiaan Winkler
    School of Pharmacy, Centre for Biomolecular Sciences, University of Nottingham, University Park Nottingham, UK
    Front Genet 4:296. 2013

Collaborators

  • Akhmed Aslam
  • Peter M Fischer
  • David M Heery
  • Maryati Maryati
  • Rachel Doidge
  • Saloni Mittal
  • Gopal P Jadhav
  • Blessing Airhihen
  • Ishwinder Kaur
  • Hilary M Collins
  • Loyin Olotu-Umoren
  • Blessing Oveh
  • Lubna Hashmi
  • Kempegowda Mantelingu
  • Marie Messmer
  • Baigong Yue
  • Magdy K Abdelghany
  • Sian E Deeves
  • Karin B Kindle
  • Tapas K Kundu
  • Rachel Medica

Detail Information

Publications10

  1. doi request reprint The mammalian anti-proliferative BTG/Tob protein family
    G Sebastiaan Winkler
    School of Pharmacy, Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, United Kingdom
    J Cell Physiol 222:66-72. 2010
    ....
  2. pmc The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex
    Rachel Doidge
    School of Pharmacy, Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, United Kingdom
    PLoS ONE 7:e51331. 2012
    ....
  3. pmc The Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subunits of the human Ccr4-Not complex contribute to the prevention of cell death and senescence
    Saloni Mittal
    School of Pharmacy and Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD, United Kingdom
    Mol Biol Cell 22:748-58. 2011
    ....
  4. pmc Discovery, synthesis and biochemical profiling of purine-2,6-dione derivatives as inhibitors of the human poly(A)-selective ribonuclease Caf1
    Gopal P Jadhav
    School of Pharmacy, Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, UK
    Bioorg Med Chem Lett 25:4219-24. 2015
    ..Two Mg(2+) ions present in the active sites of these ribonucleases are required for RNA cleavage. Here, we report the discovery, synthesis and biochemical profiling of purine-2,6-dione derivatives as (sub)micromolar inhibitors of Caf1. ..
  5. doi request reprint Deadenylation of cytoplasmic mRNA by the mammalian Ccr4-Not complex
    Rachel Doidge
    School of Pharmacy, University of Nottingham, University Park, Nottingham, UK
    Biochem Soc Trans 40:896-901. 2012
    ..Here, the role of the human Ccr4-Not complex in cytoplasmic deadenylation of mRNA is discussed, including the mechanism of its recruitment to mRNA and the role of the BTG/Tob proteins...
  6. pmc A fluorescence-based assay suitable for quantitative analysis of deadenylase enzyme activity
    Maryati Maryati
    School of Pharmacy and Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, UK
    Nucleic Acids Res 42:e30. 2014
    ....
  7. pmc The enzyme activities of Caf1 and Ccr4 are both required for deadenylation by the human Ccr4-Not nuclease module
    Maryati Maryati
    School of Pharmacy, University of Nottingham, East Drive, University Park, Nottingham NG7 2RD, U K
    Biochem J 469:169-76. 2015
    ..These results indicate that Caf1 and Ccr4 cooperate in mRNA deadenylation and suggest that the enzyme activities of Caf1 and Ccr4 are regulated via allosteric interactions within the nuclease module. ..
  8. pmc Differential effects of garcinol and curcumin on histone and p53 modifications in tumour cells
    Hilary M Collins
    Gene Regulation Group, Centre for Biomolecular Sciences, School of Pharmacy, University of Nottingham, University Park, NG7 2RD, Nottingham United Kingdom
    BMC Cancer 13:37. 2013
    ..In this study we assessed the effects of the phytocompounds garcinol and curcumin on histone and p53 modification in cancer cells, focussing on the breast tumour cell line MCF7...
  9. pmc The Ccr4-NOT deadenylase subunits CNOT7 and CNOT8 have overlapping roles and modulate cell proliferation
    Akhmed Aslam
    The School of Pharmacy, Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom
    Mol Biol Cell 20:3840-50. 2009
    ....
  10. pmc Heterogeneity and complexity within the nuclease module of the Ccr4-Not complex
    G Sebastiaan Winkler
    School of Pharmacy, Centre for Biomolecular Sciences, University of Nottingham, University Park Nottingham, UK
    Front Genet 4:296. 2013
    ..Finally, novel approaches to study the catalytic roles of the Caf1 and Ccr4 subunits will be discussed. ..