R Alan Wilson

Summary

Affiliation: University of York
Country: UK

Publications

  1. pmc Do schistosome vaccine trials in mice have an intrinsic flaw that generates spurious protection data?
    R Alan Wilson
    Centre for Immunology and Infection, Department of Biology, University of York, Heslington, York, YO10 5DD, UK
    Parasit Vectors 9:89. 2016
  2. pmc Protein variation in blood-dwelling schistosome worms generated by differential splicing of micro-exon gene transcripts
    Ricardo DeMarco
    Department of Biology, University of York, York YO10 5YW, United Kingdom
    Genome Res 20:1112-21. 2010
  3. pmc Elimination of Schistosoma mansoni Adult Worms by Rhesus Macaques: Basis for a Therapeutic Vaccine?
    R Alan Wilson
    Department of Biology, University of York, York, United Kingdom
    PLoS Negl Trop Dis 2:e290. 2008
  4. doi request reprint Abundance of tegument surface proteins in the human blood fluke Schistosoma mansoni determined by QconCAT proteomics
    William Castro-Borges
    Centre for Immunology and Infection, Department of Biology, University of York, Heslington, York, YO10 5DD, UK
    J Proteomics 74:1519-33. 2011
  5. ncbi request reprint 'Oming in on schistosomes: prospects and limitations for post-genomics
    R Alan Wilson
    Department of Biology, University of York, PO Box 373, York YO10 5YW, UK
    Trends Parasitol 23:14-20. 2007
  6. pmc Altered patterns of gene expression underlying the enhanced immunogenicity of radiation-attenuated schistosomes
    Gary P Dillon
    Department of Biology, University of York, York, United Kingdom
    PLoS Negl Trop Dis 2:e240. 2008
  7. doi request reprint The proteasome-ubiquitin pathway in the Schistosoma mansoni egg has development- and morphology-specific characteristics
    William Mathieson
    Department of Biology, University of York, York, UK
    Mol Biochem Parasitol 175:118-25. 2011
  8. ncbi request reprint Microarray analysis identifies genes preferentially expressed in the lung schistosomulum of Schistosoma mansoni
    Gary P Dillon
    Department of Biology, University of York, PO Box 373, York YO10 5YW, UK
    Int J Parasitol 36:1-8. 2006
  9. pmc Enzymatic shaving of the tegument surface of live schistosomes for proteomic analysis: a rational approach to select vaccine candidates
    William Castro-Borges
    Department of Biology, University of York, Heslington, York, United Kingdom
    PLoS Negl Trop Dis 5:e993. 2011
  10. doi request reprint A comparative proteomic study of the undeveloped and developed Schistosoma mansoni egg and its contents: the miracidium, hatch fluid and secretions
    William Mathieson
    Department of Biology, University of York, P O Box 373, York YO105YW, UK
    Int J Parasitol 40:617-28. 2010

Collaborators

Detail Information

Publications27

  1. pmc Do schistosome vaccine trials in mice have an intrinsic flaw that generates spurious protection data?
    R Alan Wilson
    Centre for Immunology and Infection, Department of Biology, University of York, Heslington, York, YO10 5DD, UK
    Parasit Vectors 9:89. 2016
    ..japonicum in the mouse model; this schistosome species seems a more robust parasite, even harder to eliminate by acquired immune responses. We propose a number of ways in which our conclusions may be tested...
  2. pmc Protein variation in blood-dwelling schistosome worms generated by differential splicing of micro-exon gene transcripts
    Ricardo DeMarco
    Department of Biology, University of York, York YO10 5YW, United Kingdom
    Genome Res 20:1112-21. 2010
    ..We believe that our data open a new chapter in the study of immune evasion by schistosomes, and their ability to generate variant proteins could represent a significant obstacle to vaccine development...
  3. pmc Elimination of Schistosoma mansoni Adult Worms by Rhesus Macaques: Basis for a Therapeutic Vaccine?
    R Alan Wilson
    Department of Biology, University of York, York, United Kingdom
    PLoS Negl Trop Dis 2:e290. 2008
    ..Among animal models of schistosomiasis, the rhesus macaque is unique in that an infection establishes but egg excretion rapidly diminishes, potentially due to loss of adult worms from the portal system via shunts or death by immune attack...
  4. doi request reprint Abundance of tegument surface proteins in the human blood fluke Schistosoma mansoni determined by QconCAT proteomics
    William Castro-Borges
    Centre for Immunology and Infection, Department of Biology, University of York, Heslington, York, YO10 5DD, UK
    J Proteomics 74:1519-33. 2011
    ..Two host IgGs were identified but in amounts much lower than their targets. The findings are interpreted in relation to the models of protective immunity...
  5. ncbi request reprint 'Oming in on schistosomes: prospects and limitations for post-genomics
    R Alan Wilson
    Department of Biology, University of York, PO Box 373, York YO10 5YW, UK
    Trends Parasitol 23:14-20. 2007
    ..Most importantly, the limitations (which are mostly technical) that need to be addressed before the full potential of the genome database(s) can be realized are emphasized...
  6. pmc Altered patterns of gene expression underlying the enhanced immunogenicity of radiation-attenuated schistosomes
    Gary P Dillon
    Department of Biology, University of York, York, United Kingdom
    PLoS Negl Trop Dis 2:e240. 2008
    ..However, the underlying molecular mechanisms responsible for the altered phenotype of the irradiated parasite that primes for protection have yet to be identified...
  7. doi request reprint The proteasome-ubiquitin pathway in the Schistosoma mansoni egg has development- and morphology-specific characteristics
    William Mathieson
    Department of Biology, University of York, York, UK
    Mol Biochem Parasitol 175:118-25. 2011
    ..The envelope is involved in the defence of the miracidium and produces the proteins that the egg secretes, presumably to facilitate its escape from the host, so the UPP probably has a multi-faceted role in the egg's biology...
  8. ncbi request reprint Microarray analysis identifies genes preferentially expressed in the lung schistosomulum of Schistosoma mansoni
    Gary P Dillon
    Department of Biology, University of York, PO Box 373, York YO10 5YW, UK
    Int J Parasitol 36:1-8. 2006
    ..Two promising secreted molecules have homology to antigens with vaccine and/or immunomodulatory potential in other helminths...
  9. pmc Enzymatic shaving of the tegument surface of live schistosomes for proteomic analysis: a rational approach to select vaccine candidates
    William Castro-Borges
    Department of Biology, University of York, Heslington, York, United Kingdom
    PLoS Negl Trop Dis 5:e993. 2011
    ..Biotinylation of live worms using membrane-impermeant probes revealed that only a small subset of the proteins was accessible to the reagents. Their position within the multilayered architecture of the surface has not been ascertained...
  10. doi request reprint A comparative proteomic study of the undeveloped and developed Schistosoma mansoni egg and its contents: the miracidium, hatch fluid and secretions
    William Mathieson
    Department of Biology, University of York, P O Box 373, York YO105YW, UK
    Int J Parasitol 40:617-28. 2010
    ....
  11. pmc Gene expression patterns in larval Schistosoma mansoni associated with infection of the mammalian host
    Sophia J Parker-Manuel
    University of York, Heslington, United Kingdom
    PLoS Negl Trop Dis 5:e1274. 2011
    ..Patterns of gene expression underlying this transition have been characterised...
  12. doi request reprint Insights into blood feeding by schistosomes from a proteomic analysis of worm vomitus
    Stephanie L Hall
    Centre for Immunology and Infection, Department of Biology, University of York, York YO10 5DD, UK
    Mol Biochem Parasitol 179:18-29. 2011
    ....
  13. pmc Immune effector mechanisms against schistosomiasis: looking for a chink in the parasite's armour
    R Alan Wilson
    Department of Biology, University of York, PO Box 373, York YO10 5YW, UK
    Trends Parasitol 25:423-31. 2009
    ..In addition, ways need to be found of keeping the immune system on permanent alert, either to achieve adequate inhibition of protein function in adults, or because a trickle of incoming parasites does not amplify the secondary response...
  14. ncbi request reprint The 20S proteasome of Schistosoma mansoni: a proteomic analysis
    William Castro-Borges
    Department of Biology, University of York, Heslington, York, UK
    Proteomics 7:1065-75. 2007
    ....
  15. pmc Previous or ongoing schistosome infections do not compromise the efficacy of the attenuated cercaria vaccine
    Thomas M Kariuki
    Department of Biology, P O Box 373, University of York, York YO10 5YW, United Kingdom
    Infect Immun 74:3979-86. 2006
    ..Nevertheless, the well-documented immunomodulation of immune responses that follows egg deposition did not appear to impede the protective mechanisms elicited by vaccination with attenuated cercariae...
  16. ncbi request reprint Schistosome albumin is of host, not parasite, origin
    Ricardo DeMarco
    Department of Biology, University of York, P O Box 373, York YO10 5YW, UK
    Int J Parasitol 37:1201-8. 2007
    ..By analogy, we suggest that other reported examples of horizontal gene transfer to schistosomes might similarly be explained by complementary/genomic DNA contamination...
  17. ncbi request reprint Proteomic analysis of the schistosome tegument and its surface membranes
    Simon Braschi
    Department of Biology, University of York, York, United Kingdom
    Mem Inst Oswaldo Cruz 101:205-12. 2006
    ....
  18. ncbi request reprint Identification of novel proteases and immunomodulators in the secretions of schistosome cercariae that facilitate host entry
    Rachel S Curwen
    Department of Biology, University of York, York YO10 5YW, UK
    Mol Cell Proteomics 5:835-44. 2006
    ..All the novel constituents merit investigation as vaccine candidates, and the potential immunomodulators merit investigation as therapeutic agents...
  19. ncbi request reprint The Schistosoma mansoni soluble proteome: a comparison across four life-cycle stages
    Rachel S Curwen
    Department of Biology, University of York, Heslington, York YO10 5DD, UK
    Mol Biochem Parasitol 138:57-66. 2004
    ..Equally, it is difficult to reconcile the abundance and immunogenicity of such cytosolic proteins with their status as vaccine candidates, as it is unlikely they will be accessible to the immune system in an intact parasite...
  20. ncbi request reprint Schistosome vaccines: a critical appraisal
    R Alan Wilson
    Department of Biology, University of York, York, UK
    Mem Inst Oswaldo Cruz 101:13-20. 2006
    ..Only then will we know if schistosomes have an Achilles' heel...
  21. doi request reprint Exploring the Fasciola hepatica tegument proteome
    R Alan Wilson
    Centre for Immunology and Infection, Department of Biology, University of York, Heslington, York YO10 5DD, United Kingdom
    Int J Parasitol 41:1347-59. 2011
    ..This study demonstrates that components of the tegumental surface of F. hepatica can be defined using proteomic approaches, but also indicates the need to prevent vomiting if tegument secretions are to be characterised...
  22. doi request reprint The cell biology of schistosomes: a window on the evolution of the early metazoa
    R Alan Wilson
    Centre for Immunology and Infection, Department of Biology, University of York, York YO10 5DD, UK
    Protoplasma 249:503-18. 2012
    ..The biggest jump in the evolution of cellular capabilities appears to be in the transition from a diploblast to triploblast level of organisation associated with development of a mobile and plastic body form...
  23. pmc The Schistosome Esophagus Is a 'Hotspot' for Microexon and Lysosomal Hydrolase Gene Expression: Implications for Blood Processing
    R Alan Wilson
    Centre for Immunology and Infection, Department of Biology, University of York, Heslington, York, United Kingdom
    PLoS Negl Trop Dis 9:e0004272. 2015
    ..Erythrocytes are lysed in the lumen, leucocytes are tethered and killed and platelets are eliminated. We know little about the proteins secreted from the two glands that mediate these biological processes...
  24. ncbi request reprint From genomes to vaccines via the proteome
    R Alan Wilson
    Department of Biology, University of York, PO Box 373, York, YO10 5YW, UK
    Mem Inst Oswaldo Cruz 99:45-50. 2004
    ..The next step is to discover which target proteins represent the weak points in the worm's defences...
  25. ncbi request reprint Proteins exposed at the adult schistosome surface revealed by biotinylation
    Simon Braschi
    Department of Biology, University of York, York YO10 5DD, United Kingdom
    Mol Cell Proteomics 5:347-56. 2006
    ..Collectively the labeled parasite proteins merit investigation as potential vaccine candidates...
  26. doi request reprint Virulence factors of schistosomes
    R Alan Wilson
    Centre for Immunology and Infection, Department of Biology, University of York, Heslington, York YO10 5DD, UK
    Microbes Infect 14:1442-50. 2012
    ....
  27. ncbi request reprint IL-10 is crucial for the transition from acute to chronic disease state during infection of mice with Schistosoma mansoni
    Clare H Sadler
    Department of Biology, University of York, York, GB
    Eur J Immunol 33:880-8. 2003
    ..It is a crucial agent in the down-modulation of immune responses and immunopathology that defines the transition from acute to chronic disease...