Vihandha O Wickramasinghe

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. pmc Functional and structural characterization of the mammalian TREX-2 complex that links transcription with nuclear messenger RNA export
    Divyang Jani
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Nucleic Acids Res 40:4562-73. 2012
  2. pmc GANP enhances the efficiency of mRNA nuclear export in mammalian cells
    Vihandha O Wickramasinghe
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge, UK
    Nucleus 1:393-6. 2010
  3. pmc MCM3AP is transcribed from a promoter within an intron of the overlapping gene for GANP
    Vihandha O Wickramasinghe
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 0XZ, UK
    J Mol Biol 406:355-61. 2011
  4. pmc mRNA export from mammalian cell nuclei is dependent on GANP
    Vihandha O Wickramasinghe
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 0XZ, UK
    Curr Biol 20:25-31. 2010
  5. pmc Selective nuclear export of specific classes of mRNA from mammalian nuclei is promoted by GANP
    Vihandha O Wickramasinghe
    MRC Cancer Unit, University of Cambridge, Hutchison MRC Research Centre, Box 197, Biomedical Campus, Cambridge CB2 0XZ, UK, The Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge CB10 1SA, UK, Wellcome Trust, Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge CB2 1QN, UK, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK and Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
    Nucleic Acids Res 42:5059-71. 2014
  6. doi request reprint Human inositol polyphosphate multikinase regulates transcript-selective nuclear mRNA export to preserve genome integrity
    Vihandha O Wickramasinghe
    The Medical Research Council Cancer Unit, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 0XZ, UK
    Mol Cell 51:737-50. 2013
  7. pmc Regulation of constitutive and alternative mRNA splicing across the human transcriptome by PRPF8 is determined by 5' splice site strength
    Vihandha O Wickramasinghe
    The Medical Research Council Cancer Unit, University of Cambridge, Cambridge Biomedical Campus, Box 197, Cambridge, CB2 0XZ, UK
    Genome Biol 16:201. 2015
  8. doi request reprint RNA Processing and Genome Stability: Cause and Consequence
    Vihandha O Wickramasinghe
    Medical Research Council Cancer Unit, University of Cambridge, Hills Road, Cambridge CB2 0XZ, UK Electronic address
    Mol Cell 61:496-505. 2016
  9. doi request reprint Control of mammalian gene expression by selective mRNA export
    Vihandha O Wickramasinghe
    Medical Research Centre MRC Cancer Unit, Hutchison MRC Research Centre, Box 197, Biomedical Campus, Cambridge CB2 0XZ, UK
    Nat Rev Mol Cell Biol 16:431-42. 2015

Detail Information

Publications9

  1. pmc Functional and structural characterization of the mammalian TREX-2 complex that links transcription with nuclear messenger RNA export
    Divyang Jani
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Nucleic Acids Res 40:4562-73. 2012
    ..Thus, we implicate TREX-2 as an integral component of the mammalian mRNA export machinery where it links transcription and nuclear export by facilitating the transfer of mature mRNPs from the nuclear interior to NPCs...
  2. pmc GANP enhances the efficiency of mRNA nuclear export in mammalian cells
    Vihandha O Wickramasinghe
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Cambridge, UK
    Nucleus 1:393-6. 2010
    ..Here, we discuss the model for GANP function presented in our recent paper and its implications for the mechanism of mRNA export in mammalian cells...
  3. pmc MCM3AP is transcribed from a promoter within an intron of the overlapping gene for GANP
    Vihandha O Wickramasinghe
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 0XZ, UK
    J Mol Biol 406:355-61. 2011
    ..Therefore, to avoid further confusion, they should now be referred to as separate but overlapping genes...
  4. pmc mRNA export from mammalian cell nuclei is dependent on GANP
    Vihandha O Wickramasinghe
    MRC Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 0XZ, UK
    Curr Biol 20:25-31. 2010
    ..These results establish GANP as an integral component of the mammalian mRNA export machinery and suggest a model whereby GANP facilitates the transfer of NXF1-containing mRNPs to NPCs...
  5. pmc Selective nuclear export of specific classes of mRNA from mammalian nuclei is promoted by GANP
    Vihandha O Wickramasinghe
    MRC Cancer Unit, University of Cambridge, Hutchison MRC Research Centre, Box 197, Biomedical Campus, Cambridge CB2 0XZ, UK, The Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge CB10 1SA, UK, Wellcome Trust, Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge CB2 1QN, UK, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK and Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
    Nucleic Acids Res 42:5059-71. 2014
    ..We propose that GANP promotes the nuclear export of specific classes of mRNAs that may facilitate rapid changes in gene expression. ..
  6. doi request reprint Human inositol polyphosphate multikinase regulates transcript-selective nuclear mRNA export to preserve genome integrity
    Vihandha O Wickramasinghe
    The Medical Research Council Cancer Unit, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 0XZ, UK
    Mol Cell 51:737-50. 2013
    ..Our findings implicate IPMK in a transcript-selective mRNA export pathway controlled by phosphoinositide turnover that preserves genome integrity in humans. ..
  7. pmc Regulation of constitutive and alternative mRNA splicing across the human transcriptome by PRPF8 is determined by 5' splice site strength
    Vihandha O Wickramasinghe
    The Medical Research Council Cancer Unit, University of Cambridge, Cambridge Biomedical Campus, Box 197, Cambridge, CB2 0XZ, UK
    Genome Biol 16:201. 2015
    ..PRPF8 deficiency is linked to human diseases like retinitis pigmentosa or myeloid neoplasia, but its genome-wide effects on constitutive and alternative splicing remain unclear...
  8. doi request reprint RNA Processing and Genome Stability: Cause and Consequence
    Vihandha O Wickramasinghe
    Medical Research Council Cancer Unit, University of Cambridge, Hills Road, Cambridge CB2 0XZ, UK Electronic address
    Mol Cell 61:496-505. 2016
    ....
  9. doi request reprint Control of mammalian gene expression by selective mRNA export
    Vihandha O Wickramasinghe
    Medical Research Centre MRC Cancer Unit, Hutchison MRC Research Centre, Box 197, Biomedical Campus, Cambridge CB2 0XZ, UK
    Nat Rev Mol Cell Biol 16:431-42. 2015
    ..Such findings show that mRNA export is an unexpected, yet potentially important, mechanism for the control of gene expression and of the mammalian transcriptome. ..