Peter Wardman

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. doi request reprint Kinetics of reaction of nitrogen dioxide with dihydrorhodamine and the reaction of the dihydrorhodamine radical with oxygen: implications for quantifying peroxynitrite formation in cells
    Lisa K Folkes
    University of Oxford, Gray Institute for Radiation Oncology and Biology, Old Road Campus Research Building, Roosevelt Drive, Oxford OX37DQ, UK
    Arch Biochem Biophys 484:122-6. 2009
  2. ncbi request reprint Radiation chemistry comes before radiation biology
    Peter O'Neill
    University of Oxford, Gray Institute for Radiation Oncology and Biology, Oxford, UK
    Int J Radiat Biol 85:9-25. 2009
  3. doi request reprint Kinetics of reduction of tyrosine phenoxyl radicals by glutathione
    Lisa K Folkes
    University of Oxford, Gray Institute for Radiation, Oncology and Biology, Old Road Campus Research Building, Roosevelt Drive, Oxford OX37DQ, UK
    Arch Biochem Biophys 506:242-9. 2011
  4. pmc Hierarchy of lesion processing governs the repair, double-strand break formation and mutability of three-lesion clustered DNA damage
    Laura J Eccles
    CRUK MRC Gray Institute for Radiation Oncology and Biology, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, UK
    Nucleic Acids Res 38:1123-34. 2010
  5. pmc Processing of thymine glycol in a clustered DNA damage site: mutagenic or cytotoxic
    Sophie Bellon
    DNA Damage Group, Gray Institute for Radiation Oncology and Biology, University of Oxford, Oxford OX3 7DQ, UK
    Nucleic Acids Res 37:4430-40. 2009
  6. pmc Delayed repair of radiation induced clustered DNA damage: friend or foe?
    Laura J Eccles
    DNA Damage Group, Gray Institute for Radiation Oncology and Biology, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK
    Mutat Res 711:134-41. 2011
  7. ncbi request reprint Thiyl radicals react with nitric oxide to form S-nitrosothiols with rate constants near the diffusion-controlled limit
    Edyta Madej
    Gray Cancer Institute, University of Oxford, Northwood, Middlesex HA6 2JR, UK
    Free Radic Biol Med 44:2013-8. 2008
  8. ncbi request reprint Oxidative metabolism of combretastatin A-1 produces quinone intermediates with the potential to bind to nucleophiles and to enhance oxidative stress via free radicals
    Lisa K Folkes
    University of Oxford, Gray Cancer Institute, Mount Vernon Hospital, Middlesex, UK
    Chem Res Toxicol 20:1885-94. 2007
  9. ncbi request reprint Fluorescent and luminescent probes for measurement of oxidative and nitrosative species in cells and tissues: progress, pitfalls, and prospects
    Peter Wardman
    University of Oxford, Gray Cancer Institute, Mount Vernon Hospital, Northwood, Middlesex HA6 2JR, UK
    Free Radic Biol Med 43:995-1022. 2007
  10. ncbi request reprint The oxidizing power of the glutathione thiyl radical as measured by its electrode potential at physiological pH
    Edyta Madej
    University of Oxford, Gray Cancer Institute, Mount Vernon Hospital, Northwood, Middlesex, UK
    Arch Biochem Biophys 462:94-102. 2007

Collaborators

  • Sara Goldstein
  • Martine E Lomax
  • R Radi
  • Lisa K Folkes
  • Peter O'Neill
  • Edyta Madej
  • Laura J Eccles
  • Sophie Bellon
  • Madia Trujillo
  • Silvina Bartesaghi
  • Kantilal B Patel
  • Siobhan Cunniffe
  • Naoya Shikazono
  • Marta Wrona
  • Gidon Czapski
  • Martin Christlieb
  • Michael R L Stratford

Detail Information

Publications10

  1. doi request reprint Kinetics of reaction of nitrogen dioxide with dihydrorhodamine and the reaction of the dihydrorhodamine radical with oxygen: implications for quantifying peroxynitrite formation in cells
    Lisa K Folkes
    University of Oxford, Gray Institute for Radiation Oncology and Biology, Old Road Campus Research Building, Roosevelt Drive, Oxford OX37DQ, UK
    Arch Biochem Biophys 484:122-6. 2009
    ..may be scavenged intracellularly by RhH2...
  2. ncbi request reprint Radiation chemistry comes before radiation biology
    Peter O'Neill
    University of Oxford, Gray Institute for Radiation Oncology and Biology, Oxford, UK
    Int J Radiat Biol 85:9-25. 2009
    ..The illustrations of the broader applications of radiation chemistry in this article focus on their relevance to radiation biology and demonstrate the importance of synergy in the radiation sciences...
  3. doi request reprint Kinetics of reduction of tyrosine phenoxyl radicals by glutathione
    Lisa K Folkes
    University of Oxford, Gray Institute for Radiation, Oncology and Biology, Old Road Campus Research Building, Roosevelt Drive, Oxford OX37DQ, UK
    Arch Biochem Biophys 506:242-9. 2011
    ..Loss of thiyl radicals, facilitating repair of TyrO·, can arise either via conjugation of thiyl with thiol/thiolate or oxygen, or unimolecular transformation, the latter important at low concentrations of thiols and oxygen...
  4. pmc Hierarchy of lesion processing governs the repair, double-strand break formation and mutability of three-lesion clustered DNA damage
    Laura J Eccles
    CRUK MRC Gray Institute for Radiation Oncology and Biology, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, UK
    Nucleic Acids Res 38:1123-34. 2010
    ..The inaccurate repair of such clusters has biological significance due to the ultimate risk of tumourigenesis or as potential cytotoxic lesions in tumour cells...
  5. pmc Processing of thymine glycol in a clustered DNA damage site: mutagenic or cytotoxic
    Sophie Bellon
    DNA Damage Group, Gray Institute for Radiation Oncology and Biology, University of Oxford, Oxford OX3 7DQ, UK
    Nucleic Acids Res 37:4430-40. 2009
    ....
  6. pmc Delayed repair of radiation induced clustered DNA damage: friend or foe?
    Laura J Eccles
    DNA Damage Group, Gray Institute for Radiation Oncology and Biology, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK
    Mutat Res 711:134-41. 2011
    ..The delayed repair of non-DSB clustered damaged sites in humans can be seen as a "friend", leading to cell killing in tumour cells or as a "foe", resulting in the formation of mutations and genetic instability in normal tissue...
  7. ncbi request reprint Thiyl radicals react with nitric oxide to form S-nitrosothiols with rate constants near the diffusion-controlled limit
    Edyta Madej
    Gray Cancer Institute, University of Oxford, Northwood, Middlesex HA6 2JR, UK
    Free Radic Biol Med 44:2013-8. 2008
    ..These rate constants imply that formation of S-nitrosothiols in biological systems from the combination of thiyl radicals with nitric oxide is much more likely than claimed by Hofstetter et al...
  8. ncbi request reprint Oxidative metabolism of combretastatin A-1 produces quinone intermediates with the potential to bind to nucleophiles and to enhance oxidative stress via free radicals
    Lisa K Folkes
    University of Oxford, Gray Cancer Institute, Mount Vernon Hospital, Middlesex, UK
    Chem Res Toxicol 20:1885-94. 2007
    ..The observation of the GSH conjugate Q1H2-SG in vivo provides a new marker for oxidative metabolism of relevance to current clinical trials of CA1-bis(phosphate) (OXi4503)...
  9. ncbi request reprint Fluorescent and luminescent probes for measurement of oxidative and nitrosative species in cells and tissues: progress, pitfalls, and prospects
    Peter Wardman
    University of Oxford, Gray Cancer Institute, Mount Vernon Hospital, Northwood, Middlesex HA6 2JR, UK
    Free Radic Biol Med 43:995-1022. 2007
    ..Rational use of probes requires understanding and quantitation of the mechanistic pathways involved, and of environmental factors such as oxygen and pH. We can build on this framework of knowledge in evaluating new probes...
  10. ncbi request reprint The oxidizing power of the glutathione thiyl radical as measured by its electrode potential at physiological pH
    Edyta Madej
    University of Oxford, Gray Cancer Institute, Mount Vernon Hospital, Northwood, Middlesex, UK
    Arch Biochem Biophys 462:94-102. 2007
    ....