Stephen Ward

Summary

Affiliation: University of Bath
Country: UK

Publications

  1. ncbi request reprint T lymphocytes on the move: chemokines, PI 3-kinase and beyond
    Stephen G Ward
    Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Trends Immunol 27:80-7. 2006
  2. ncbi request reprint Evidence that phospholipase-C-dependent, calcium-independent mechanisms are required for directional migration of T-lymphocytes in response to the CCR4 ligands CCL17 and CCL22
    Darran G Cronshaw
    Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, Avon, UK BA2 7AY
    J Leukoc Biol 79:1369-80. 2006
  3. pmc Hydrogen Peroxide Triggers a Dual Signaling Axis To Selectively Suppress Activated Human T Lymphocyte Migration.
    Jennifer A Ball
    J Immunol 198:3679-3689. 2017
  4. pmc Pharmacological targeting of phosphoinositide lipid kinases and phosphatases in the immune system: success, disappointment, and new opportunities
    Matthew D Blunt
    Inflammatory Cell Biology Laboratory, Department of Pharmacy and Pharmacology, University of Bath Bath, UK
    Front Immunol 3:226. 2012
  5. doi request reprint Inhibition of PI3K signaling spurs new therapeutic opportunities in inflammatory/autoimmune diseases and hematological malignancies
    John G Foster
    Inflammatory Cell Biology Laboratory, Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, UK
    Pharmacol Rev 64:1027-54. 2012
  6. doi request reprint Millipede-like lymphocyte crawling: feeling the way with filopodia
    Stephen G Ward
    Inflammatory Cell Biology Laboratory, Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA27AY, UK
    Immunity 30:315-7. 2009
  7. doi request reprint Sat-Nav for T cells: Role of PI3K isoforms and lipid phosphatases in migration of T lymphocytes
    Stephen G Ward
    Department Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Immunol Lett 138:15-8. 2011
  8. doi request reprint Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation
    Stephen G Ward
    Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Biochem J 418:13-27. 2009
  9. ncbi request reprint Do phosphoinositide 3-kinases direct lymphocyte navigation?
    Stephen G Ward
    Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, UK, BA2 7AY
    Trends Immunol 25:67-74. 2004
  10. ncbi request reprint Isoform-specific phosphoinositide 3-kinase inhibitors as therapeutic agents
    Stephen G Ward
    Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Curr Opin Pharmacol 3:426-34. 2003

Collaborators

Detail Information

Publications41

  1. ncbi request reprint T lymphocytes on the move: chemokines, PI 3-kinase and beyond
    Stephen G Ward
    Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Trends Immunol 27:80-7. 2006
    ..These aspects of T-cell migration are the subject of this review...
  2. ncbi request reprint Evidence that phospholipase-C-dependent, calcium-independent mechanisms are required for directional migration of T-lymphocytes in response to the CCR4 ligands CCL17 and CCL22
    Darran G Cronshaw
    Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, Avon, UK BA2 7AY
    J Leukoc Biol 79:1369-80. 2006
    ....
  3. pmc Hydrogen Peroxide Triggers a Dual Signaling Axis To Selectively Suppress Activated Human T Lymphocyte Migration.
    Jennifer A Ball
    J Immunol 198:3679-3689. 2017
    ..We hypothesize that although H2O2 serves as an early recruitment trigger for innate immune cells, it appears to operate as an inhibitor of T lymphocyte immune adaptive responses that are not required until later in the repair process...
  4. pmc Pharmacological targeting of phosphoinositide lipid kinases and phosphatases in the immune system: success, disappointment, and new opportunities
    Matthew D Blunt
    Inflammatory Cell Biology Laboratory, Department of Pharmacy and Pharmacology, University of Bath Bath, UK
    Front Immunol 3:226. 2012
    ..Finally, we consider the current state of development of small molecule compounds that potently and selectively modulate SHIP activity and which offer novel opportunities to manipulate PI3K mediated signaling in the immune system...
  5. doi request reprint Inhibition of PI3K signaling spurs new therapeutic opportunities in inflammatory/autoimmune diseases and hematological malignancies
    John G Foster
    Inflammatory Cell Biology Laboratory, Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, UK
    Pharmacol Rev 64:1027-54. 2012
    ..We also consider whether manipulating other proximal elements of the PI3K signaling cascade (such as class II and III PI3Ks or lipid phosphatases) are likely to be successful in fighting off different immune diseases...
  6. doi request reprint Millipede-like lymphocyte crawling: feeling the way with filopodia
    Stephen G Ward
    Inflammatory Cell Biology Laboratory, Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA27AY, UK
    Immunity 30:315-7. 2009
    ..These filopodia facilitate a novel millipede-like mode of lymphocyte locomotion over endothelial cells prior to extravasation...
  7. doi request reprint Sat-Nav for T cells: Role of PI3K isoforms and lipid phosphatases in migration of T lymphocytes
    Stephen G Ward
    Department Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Immunol Lett 138:15-8. 2011
    ..This review assesses the evidence for and against PI3K-dependent mechanisms of T lymphocyte migration and whether pharmacological targeting of PI3K isoforms is likely to offer potential benefit for T cell mediated pathologies...
  8. doi request reprint Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation
    Stephen G Ward
    Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Biochem J 418:13-27. 2009
    ....
  9. ncbi request reprint Do phosphoinositide 3-kinases direct lymphocyte navigation?
    Stephen G Ward
    Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, UK, BA2 7AY
    Trends Immunol 25:67-74. 2004
    ....
  10. ncbi request reprint Isoform-specific phosphoinositide 3-kinase inhibitors as therapeutic agents
    Stephen G Ward
    Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Curr Opin Pharmacol 3:426-34. 2003
    ..There is now cautious optimism that isoform-selective PI3K inhibitors will provide new avenues for therapeutic applications in a range of diseases...
  11. ncbi request reprint Spotlight on new anti-inflammatory drug targets in the immune system
    Stephen G Ward
    Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Curr Opin Pharmacol 3:391-5. 2003
  12. ncbi request reprint Therapeutic potential of phosphoinositide 3-kinase inhibitors
    Stephen Ward
    Department of Pharmacy and Pharmacology, Bath University, Claverton Down, Bath, BA2 7AY, United Kingdom
    Chem Biol 10:207-13. 2003
    ....
  13. pmc New drug targets in inflammation: efforts to expand the anti-inflammatory armoury
    S G Ward
    Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, UK
    Br J Pharmacol 153:S5-6. 2008
    ..The speakers from this meeting were invited to generate reviews on the basis of their presentations and these reviews contribute to this themed issue and are summarized in this short article...
  14. ncbi request reprint Optimal chemotactic responses of leukemic T cells to stromal cell-derived factor-1 requires the activation of both class IA and IB phosphoinositide 3-kinases
    Adam P Curnock
    Department of Pharmacy and Pharmacology, Bath University, Bath, United Kingdom
    J Immunol 170:4021-30. 2003
    ..Together, these results demonstrate that optimal chemotactic response of leukemic T cells to SDF-1 requires the activation of both class IA and class IB PI 3-kinases...
  15. ncbi request reprint Differential expression of cannabinoid receptors in the human colon: cannabinoids promote epithelial wound healing
    Karen Wright
    Department of Pharmacy and Pharmacology, University of Bath, UK
    Gastroenterology 129:437-53. 2005
    ....
  16. ncbi request reprint Signalling to suit function: tailoring phosphoinositide 3-kinase during T-cell activation
    Richard V Parry
    Inflammatory Cell Biology Laboratory, Department of Pharmacy and Pharmacology, University of Bath, Bath, UK
    Trends Immunol 28:161-8. 2007
    ..This article examines how differential positive or negative regulation of the PI3K-Akt signalling pathway by CD28 family receptors enables functional differences between the receptors...
  17. doi request reprint Cdx genes, inflammation and the pathogenesis of Barrett's metaplasia
    Benjamin J Colleypriest
    Centre for Regenerative Medicine, Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Trends Mol Med 15:313-22. 2009
    ..This review highlights the relationship between inflammation, metaplasia and carcinogenesis...
  18. ncbi request reprint Phosphoinositide lipid phosphatases: natural regulators of phosphoinositide 3-kinase signaling in T lymphocytes
    Stephanie J Harris
    Inflammatory Cell Biology Laboratory, Department of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom
    J Biol Chem 283:2465-9. 2008
    ..We discuss their role in regulating T lymphocyte signaling as well their potential as future therapeutic targets...
  19. ncbi request reprint PI3K isoforms as drug targets in inflammatory diseases: lessons from pharmacological and genetic strategies
    Stephanie J Harris
    Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, BA2 7AY, UK
    Curr Opin Investig Drugs 10:1151-62. 2009
    ..More specifically, the contribution of the gamma and delta isoforms of PI3K to the immune processes that underpin inflammatory responses, as well as their potential as therapeutic targets, are evaluated...
  20. doi request reprint Protein arginine methylation: a new handle on T lymphocytes?
    Richard V Parry
    Inflammatory Cell Biology Laboratory, Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, United Kingdom
    Trends Immunol 31:164-9. 2010
    ....
  21. doi request reprint Analysis of CXCR3 and atypical variant expression and signalling in human T lymphocytes
    Anna Korniejewska
    Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, Slough, UK
    Methods Mol Biol 616:125-47. 2010
    ....
  22. ncbi request reprint Activation of phosphoinositide 3-kinases by the CCR4 ligand macrophage-derived chemokine is a dispensable signal for T lymphocyte chemotaxis
    Darran G Cronshaw
    Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom
    J Immunol 172:7761-70. 2004
    ..These data demonstrate that although there is PI(3,4,5)P(3) accumulation downstream of CCR4, phosphoinositide 3-kinase activity is a dispensable signal for CCR4-stimulated chemotaxis of Th2 cells and the CEM T cell line...
  23. ncbi request reprint Assessing the role of multiple phosphoinositide 3-kinases in chemokine signaling: use of dominant negative mutants controlled by a tetracycline-regulated gene expression system
    Adam P Curnock
    Department of Pharmacy and Pharmacology, University of Bath, Bath, U K
    Methods Mol Biol 239:211-22. 2004
  24. ncbi request reprint PI3Kgamma is the dominant isoform involved in migratory responses of human T lymphocytes: effects of ex vivo maintenance and limitations of non-viral delivery of siRNA
    Laura D Smith
    Inflammatory Cell Biology Laboratory, Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, Avon, BA2 7AY, UK
    Cell Signal 19:2528-39. 2007
    ..However, the role of PI3K in cell migration is context-dependent and diminishes during ex vivo maintenance...
  25. ncbi request reprint Development and characterisation of tetracycline-regulated phosphoinositide 3-kinase mutants: assessing the role of multiple phosphoinositide 3-kinases in chemokine signaling
    Adam P Curnock
    Department of Pharmacy and Pharmacology, Bath University, Claverton Down, Bath, Avon BA2 7AY, UK
    J Immunol Methods 273:29-41. 2003
    ....
  26. doi request reprint Fine tuning T lymphocytes: a role for the lipid phosphatase SHIP-1
    Richard V Parry
    Inflammatory Cell Biology Laboratory, Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK
    Biochim Biophys Acta 1804:592-7. 2010
    ..Here we discuss the role of SHIP-1 in regulating T lymphocyte and immune function, as well as its potential as a therapeutic target...
  27. doi request reprint Evidence for PI-3K-dependent migration of Th17-polarized cells in response to CCR2 and CCR6 agonists
    Adam Webb
    Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, BA2 7AY, UK
    J Leukoc Biol 84:1202-12. 2008
    ....
  28. ncbi request reprint Leukocyte navigation mechanisms as targets in airway diseases
    David A Medina-Tato
    Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, BA2 7AY, UK
    Drug Discov Today 11:866-79. 2006
    ..In this article, the process of leukocyte accumulation is summarized, together with the preclinical and clinical evidence supporting the utility of the individual components of this process as targets for disease therapy...
  29. pmc Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases
    Adam P Curnock
    Department of Pharmacy and Pharmacology, Bath University, Claverton Down, Bath, Avon BA2 7AY, UK
    Immunology 105:125-36. 2002
    ..This review considers the role of individual PI3Ks (e.g. the p85/p110 heterodimer, PI3Kgamma and PI3KC2alpha) as well their downstream effector targets in mediating chemokine-stimulated cell migration...
  30. ncbi request reprint Ligation of CD28 stimulates the formation of a multimeric signaling complex involving grb-2-associated binder 2 (gab2), SRC homology phosphatase-2, and phosphatidylinositol 3-kinase: evidence that negative regulation of CD28 signaling requires the gab2 pl
    Richard V Parry
    Lymphocyte Activation Group, Department of Pharmacy and Pharmacology, University of Bath, Bath, UK
    J Immunol 176:594-602. 2006
    ..Furthermore, the inhibitory capacity of Gab2 is strictly dependent upon the integrity of its PH domain, suggesting phosphoinositide-mediated membrane recruitment is important to Gab2 function in T cells...
  31. ncbi request reprint Evidence that SHIP-1 contributes to phosphatidylinositol 3,4,5-trisphosphate metabolism in T lymphocytes and can regulate novel phosphoinositide 3-kinase effectors
    Robin W Freeburn
    Department of Pharmacy and Pharmacology, Bath University, Claverton Down, Bath, BA2 7AY, UK
    J Immunol 169:5441-50. 2002
    ..This study provides the first evidence that SHIP-1 can influence the constitutive levels of PI(3,4,5)P(3) and the activity of downstream phosphoinositide 3-kinase effectors in T lymphocytes...
  32. ncbi request reprint Temporal variation in CB2R levels following T lymphocyte activation: evidence that cannabinoids modulate CXCL12-induced chemotaxis
    Karen Coopman
    Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, BA2 7AY, U K
    Int Immunopharmacol 7:360-71. 2007
    ..Interestingly, both 2-AG and JWH-133 inhibited CXCL12-induced chemotaxis, suggesting a modulatory role for cannabinoids in activated T lymphocytes...
  33. doi request reprint How does inflammation cause Barrett's metaplasia?
    Benjamin J Colleypriest
    Centre for Regenerative Medicine, Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, UK
    Curr Opin Pharmacol 9:721-6. 2009
    ..Understanding the role of oesophageal inflammation will provide important insight into the development of Barrett's metaplasia and oesophageal cancer...
  34. ncbi request reprint Heterologous regulation of chemokine receptor signaling by the lipid phosphatase SHIP in lymphocytes
    Clare M Wain
    Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, Avon, BA2 7AY, UK
    Cell Signal 17:1194-202. 2005
    ..Thus, it appears that heterologous activation of SHIP by non-G-protein-coupled receptor-mediated routes can impinge on PI3K-dependent signaling pathways activated by independently ligated G-protein-coupled chemokine receptors...
  35. ncbi request reprint Differential modulation of COX-2 expression in A549 airway epithelial cells by structurally distinct PPAR(gamma) agonists: evidence for disparate functional effects which are independent of NF-(kappa)B and PPAR(gamma)
    Kajal M Patel
    Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Cell Signal 17:1098-110. 2005
    ..Moreover, we have identified unique biochemical and functional actions of troglitazone that are not shared by 15d-PGJ2, which may influence the therapeutic potential of this compound in inflammatory settings...
  36. pmc Phosphoinositide 3-kinase signalling in lung disease: leucocytes and beyond
    David A Medina-Tato
    Department of Pharmacy and Pharmacology, University of Bath, Bath, UK
    Immunology 121:448-61. 2007
    ..In this review, we will evaluate the evidence for the roles of specific PI3K isoforms in the lung and airways, and discuss their potential as targets for novel drug therapies...
  37. ncbi request reprint The chemokines CXCL9, CXCL10, and CXCL11 differentially stimulate G alpha i-independent signaling and actin responses in human intestinal myofibroblasts
    Andreas Kouroumalis
    Department of Pharmacy and Pharmacology, University of Bath, United Kingdom
    J Immunol 175:5403-11. 2005
    ....
  38. ncbi request reprint The PI3K inhibitor arsenal: choose your weapon!
    Tom Crabbe
    UCB Celltech, Slough, UK
    Trends Biochem Sci 32:450-6. 2007
    ..However, challenges remain for the efforts to pharmacologically target this enzyme family in a successful manner...
  39. ncbi request reprint PI3K comes of age
    Stephen G Ward
    Nat Immunol 4:2. 2003
  40. pmc Phosphatidylinositol 3-kinase mediates activation of ATM by high NaCl and by ionizing radiation: Role in osmoprotective transcriptional regulation
    Carlos E Irarrazabal
    National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 1603, USA
    Proc Natl Acad Sci U S A 103:8882-7. 2006
    ....
  41. ncbi request reprint Toll-like receptors in the spotlight
    Luke A J O'Neill
    Nat Immunol 4:299. 2003