Weiguang Wang

Summary

Affiliation: University of Glasgow
Country: UK

Publications

  1. ncbi Disulfiram-mediated inhibition of NF-kappaB activity enhances cytotoxicity of 5-fluorouracil in human colorectal cancer cell lines
    Weiguang Wang
    Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, United Kingdom
    Int J Cancer 104:504-11. 2003
  2. ncbi Cerivastatin enhances the cytotoxicity of 5-fluorouracil on chemosensitive and resistant colorectal cancer cell lines
    Weiguang Wang
    Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, AB25 2ZD, Aberdeen, UK
    FEBS Lett 531:415-20. 2002
  3. pmc Constitutive nuclear factor-kappa B mRNA, protein overexpression and enhanced DNA-binding activity in thymidylate synthase inhibitor-resistant tumour cells
    W Wang
    Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, UK
    Br J Cancer 88:624-9. 2003
  4. ncbi Mechanistic and predictive profiling of 5-Fluorouracil resistance in human cancer cells
    Weiguang Wang
    Department of Medical Oncology, Beatson Institute for Cancer Research, Glasgow, United Kingdom
    Cancer Res 64:8167-76. 2004
  5. ncbi Pharmacogenomic dissection of resistance to thymidylate synthase inhibitors
    W Wang
    Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
    Cancer Res 61:5505-10. 2001
  6. pmc APRIL is a novel clinical chemo-resistance biomarker in colorectal adenocarcinoma identified by gene expression profiling
    Russell D Petty
    University of Aberdeen, UK
    BMC Cancer 9:434. 2009
  7. ncbi Mechanisms of acquired chemoresistance to 5-fluorouracil and tomudex: thymidylate synthase dependent and independent networks
    Weiguang Wang
    Research Institute in Healthcare Science, School of Applied Sciences, University of Wolverhampton, Wolverhampton, WV1 1SB, UK
    Cancer Chemother Pharmacol 59:839-45. 2007
  8. ncbi Cell cycle perturbation and acquired 5-fluorouracil chemoresistance
    Xiaoxia Guo
    Research Institute in Healthcare Science, University of Wolverhampton, Wolverhampton, UK
    Anticancer Res 28:9-14. 2008
  9. ncbi The interaction between endogenous calcineurin and the plasma membrane calcium-dependent ATPase is isoform specific in breast cancer cells
    Marylouisa Holton
    Molecular Pharmacology Group, Research Institute in Healthcare Sciences, School of Applied Sciences, University of Wolverhampton, Wulfruna Street, Wolverhampton WV1 1SB, UK
    FEBS Lett 581:4115-9. 2007

Collaborators

Detail Information

Publications9

  1. ncbi Disulfiram-mediated inhibition of NF-kappaB activity enhances cytotoxicity of 5-fluorouracil in human colorectal cancer cell lines
    Weiguang Wang
    Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, United Kingdom
    Int J Cancer 104:504-11. 2003
    ..As DS has extensive preclinical and clinical experience, translating its anticancer usage from in vitro study to clinical trials is relatively straightforward...
  2. ncbi Cerivastatin enhances the cytotoxicity of 5-fluorouracil on chemosensitive and resistant colorectal cancer cell lines
    Weiguang Wang
    Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, AB25 2ZD, Aberdeen, UK
    FEBS Lett 531:415-20. 2002
    ..Cerivastatin inhibited nuclear factor kappaB DNA binding activity. The enhancing effect of cerivastatin on 5FU was partially mevalonate pathway independent. Cerivastatin may allow successful 5FU therapy in chemoresistant patients...
  3. pmc Constitutive nuclear factor-kappa B mRNA, protein overexpression and enhanced DNA-binding activity in thymidylate synthase inhibitor-resistant tumour cells
    W Wang
    Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, UK
    Br J Cancer 88:624-9. 2003
    ..NF-kappa B can antagonise anticancer drug-induced apoptosis. High NF-kappa B expression and nuclear activity in TS inhibitor-resistant cancer cells may play an important role in the chemoresistance...
  4. ncbi Mechanistic and predictive profiling of 5-Fluorouracil resistance in human cancer cells
    Weiguang Wang
    Department of Medical Oncology, Beatson Institute for Cancer Research, Glasgow, United Kingdom
    Cancer Res 64:8167-76. 2004
    ..This phenotype may protect resistant cells from cell death induced by incorporation of 5-FU into DNA chains, by allowing time to repair 5-FU-induced damage. Our findings may provide novel targets for tackling 5-FU resistance...
  5. ncbi Pharmacogenomic dissection of resistance to thymidylate synthase inhibitors
    W Wang
    Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
    Cancer Res 61:5505-10. 2001
    ..These data provide encouragement that comprehensive transcript analysis will aid the quest for more enlightened therapeutics...
  6. pmc APRIL is a novel clinical chemo-resistance biomarker in colorectal adenocarcinoma identified by gene expression profiling
    Russell D Petty
    University of Aberdeen, UK
    BMC Cancer 9:434. 2009
    ..The aim was to identify novel 5FU resistance mechanisms and qualify these as candidate biomarkers and therapeutic targets...
  7. ncbi Mechanisms of acquired chemoresistance to 5-fluorouracil and tomudex: thymidylate synthase dependent and independent networks
    Weiguang Wang
    Research Institute in Healthcare Science, School of Applied Sciences, University of Wolverhampton, Wolverhampton, WV1 1SB, UK
    Cancer Chemother Pharmacol 59:839-45. 2007
    ..Thymidylate synthase (TS) over-expression is widely accepted as a major molecular mechanism responsible for 5-fluorouracil (5-FU) and tomudex (TDX) resistance. In this study, the importance of TS in 5-FU and TDX resistance was evaluated...
  8. ncbi Cell cycle perturbation and acquired 5-fluorouracil chemoresistance
    Xiaoxia Guo
    Research Institute in Healthcare Science, University of Wolverhampton, Wolverhampton, UK
    Anticancer Res 28:9-14. 2008
    ..The cell cycle perturbation may be involved in acquired 5-FU resistance...
  9. ncbi The interaction between endogenous calcineurin and the plasma membrane calcium-dependent ATPase is isoform specific in breast cancer cells
    Marylouisa Holton
    Molecular Pharmacology Group, Research Institute in Healthcare Sciences, School of Applied Sciences, University of Wolverhampton, Wulfruna Street, Wolverhampton WV1 1SB, UK
    FEBS Lett 581:4115-9. 2007
    ..The domain of PMCA2 involved in the interaction is equivalent to that reported for PMCA4b. PMCA2-calcineurin interaction results in inhibition of the calcineurin/nuclear factor of activated T-cells signalling pathway...