Affiliation: University of Glasgow
- Disulfiram-mediated inhibition of NF-kappaB activity enhances cytotoxicity of 5-fluorouracil in human colorectal cancer cell linesWeiguang Wang
Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, United Kingdom
Int J Cancer 104:504-11. 2003..As DS has extensive preclinical and clinical experience, translating its anticancer usage from in vitro study to clinical trials is relatively straightforward...
- Cerivastatin enhances the cytotoxicity of 5-fluorouracil on chemosensitive and resistant colorectal cancer cell linesWeiguang Wang
Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, AB25 2ZD, Aberdeen, UK
FEBS Lett 531:415-20. 2002..Cerivastatin inhibited nuclear factor kappaB DNA binding activity. The enhancing effect of cerivastatin on 5FU was partially mevalonate pathway independent. Cerivastatin may allow successful 5FU therapy in chemoresistant patients...
- Constitutive nuclear factor-kappa B mRNA, protein overexpression and enhanced DNA-binding activity in thymidylate synthase inhibitor-resistant tumour cellsW Wang
Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, UK
Br J Cancer 88:624-9. 2003..NF-kappa B can antagonise anticancer drug-induced apoptosis. High NF-kappa B expression and nuclear activity in TS inhibitor-resistant cancer cells may play an important role in the chemoresistance...
- Mechanistic and predictive profiling of 5-Fluorouracil resistance in human cancer cellsWeiguang Wang
Department of Medical Oncology, Beatson Institute for Cancer Research, Glasgow, United Kingdom
Cancer Res 64:8167-76. 2004..This phenotype may protect resistant cells from cell death induced by incorporation of 5-FU into DNA chains, by allowing time to repair 5-FU-induced damage. Our findings may provide novel targets for tackling 5-FU resistance...
- Pharmacogenomic dissection of resistance to thymidylate synthase inhibitorsW Wang
Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
Cancer Res 61:5505-10. 2001..These data provide encouragement that comprehensive transcript analysis will aid the quest for more enlightened therapeutics...
- APRIL is a novel clinical chemo-resistance biomarker in colorectal adenocarcinoma identified by gene expression profilingRussell D Petty
University of Aberdeen, UK
BMC Cancer 9:434. 2009..The aim was to identify novel 5FU resistance mechanisms and qualify these as candidate biomarkers and therapeutic targets...
- Mechanisms of acquired chemoresistance to 5-fluorouracil and tomudex: thymidylate synthase dependent and independent networksWeiguang Wang
Research Institute in Healthcare Science, School of Applied Sciences, University of Wolverhampton, Wolverhampton, WV1 1SB, UK
Cancer Chemother Pharmacol 59:839-45. 2007..Thymidylate synthase (TS) over-expression is widely accepted as a major molecular mechanism responsible for 5-fluorouracil (5-FU) and tomudex (TDX) resistance. In this study, the importance of TS in 5-FU and TDX resistance was evaluated...
- Cell cycle perturbation and acquired 5-fluorouracil chemoresistanceXiaoxia Guo
Research Institute in Healthcare Science, University of Wolverhampton, Wolverhampton, UK
Anticancer Res 28:9-14. 2008..The cell cycle perturbation may be involved in acquired 5-FU resistance...
- The interaction between endogenous calcineurin and the plasma membrane calcium-dependent ATPase is isoform specific in breast cancer cellsMarylouisa Holton
Molecular Pharmacology Group, Research Institute in Healthcare Sciences, School of Applied Sciences, University of Wolverhampton, Wulfruna Street, Wolverhampton WV1 1SB, UK
FEBS Lett 581:4115-9. 2007..The domain of PMCA2 involved in the interaction is equivalent to that reported for PMCA4b. PMCA2-calcineurin interaction results in inhibition of the calcineurin/nuclear factor of activated T-cells signalling pathway...