A Michael Wallace
Affiliation: University of Glasgow
- Ovarian function and metabolic factors in women with oligomenorrhea treated with metformin in a randomized double blind placebo-controlled trialRichard Fleming
University Department of Obstetrics and Gynecology, Royal Infirmary, Glasgow, G31 2ER, United Kingdom
J Clin Endocrinol Metab 87:569-74. 2002..These data support a beneficial effect of metformin in improving ovarian function in women with oligomenorrhea and polycystic ovaries...
- Adiponectin and coronary heart disease: a prospective study and meta-analysisNaveed Sattar
University Department of Vascular Biochemistry, Glasgow, Scotland
Circulation 114:623-9. 2006..We report new data from a prospective study in the context of a meta-analysis of previously published prospective studies...
- The co-ordinated cytokine/hormone response to acute injury incorporates leptinA M Wallace
Clinical Biochemistry, Royal Infirmary, Glasgow, UK
Cytokine 12:1042-5. 2000..e. stimulatory in acute and suppressive in chronic situations. They also imply a physiological role for leptin in acute injury...
- Effect of weight loss and the inflammatory response on leptin concentrations in gastrointestinal cancer patientsA M Wallace
University Department of Clinical Biochemistry, Royal Infirmary, Glasgow, United Kingdom
Clin Cancer Res 4:2977-9. 1998..001). Circulating leptin concentrations in the cancer patients were not altered by the presence of an inflammatory response. These results suggest that cancer anorexia/cachexia is not due to a simple dysregulation of leptin production...
- Short-term effects of prednisolone and dexamethasone on circulating concentrations of leptin and sex hormone-binding globulin in children being treated for acute lymphoblastic leukaemiaA M Wallace
Department of Clinical Biochemistry, Royal Infirmary, Glasgow, UK
Clin Endocrinol (Oxf) 58:770-6. 2003..This randomization process provided a suitable opportunity to compare the effects of these two administered steroid on surrogate markers of adipocyte activity (leptin) and hyperinsulinaemia/insulin resistance (SHBG)...
- Circulating concentrations of "free" leptin in relation to fat mass and appetite in gastrointestinal cancer patientsA Michael Wallace
University Department of Pathological Biochemistry, Royal Infirmary, Glasgow G4 0SF, UK
Nutr Cancer 44:157-60. 2002..Furthermore, the increase in circulating leptin concentrations after megestrol acetate treatment is not associated with any alteration in leptin binding...
- A longitudinal study of leptin and appetite, resting energy expenditure and body fat mass in weight-stable cancer patientsRoma Maguire
University Department of Surgery, Royal Infirmary, Glasgow, Scotland, UK
Cytokine 20:174-7. 2002..Therefore, it would appear that leptin concentrations reflect changes in fat mass in male weight-stable patients with cancer and their role in the regulation of energy metabolism appears more complex than previously proposed...
- Production of gender-specific morning salivary cortisol reference intervals using internationally accepted proceduresRajan S Patel
Department of Otolaryngology, North Glasgow Hospitals University NHS Trust, Alexandra Parade, Glasgow, UK
Clin Chem Lab Med 42:1424-9. 2004..This may be partly explained by the lack of robust reference data in the literature...
- The relationship between the insulin-like growth factor-1 axis, weight loss, an inflammation-based score and survival in patients with inoperable non-small cell lung cancerClaire L Meek
University Department of Surgery, Faculty of Medicine University of Glasgow, Royal Infirmary, Alexandra Parade, Glasgow G31 2ER, UK
Clin Nutr 29:206-9. 2010..The aim of the present study was to examine the relationship between IGF-1 and IGFBP-3, performance status, mGPS and survival in patients with inoperable NSCLC...
- Leptin and coronary heart disease: prospective study and systematic reviewNaveed Sattar
BHF Glasgow Cardiovascular Research Centre, Faculty of Medicine, University of Glasgow, Glasgow, Scotland, UK
J Am Coll Cardiol 53:167-75. 2009..This study sought to better determine the link between leptin and coronary heart disease (CHD)...
- Strikingly low circulating CRP concentrations in ultramarathon runners independent of markers of adiposity: how low can you go?Maciej Tomaszewski
British Heart Foundation Glasgow Cardiovascular Research Centre, Division of Cardiovascular and Medical Sciences, University of Glasgow, UK
Arterioscler Thromb Vasc Biol 23:1640-4. 2003....
- Maternal obesity is associated with dysregulation of metabolic, vascular, and inflammatory pathwaysJane E Ramsay
University Department of Obstetrics and Gynaecology, Glasgow Royal Infirmary, Scotland, G31 2ER, United Kingdom
J Clin Endocrinol Metab 87:4231-7. 2002..Clearly, these data provide further rationale to examine the potential benefits of preconceptual weight loss and antenatal exercise...
- Comparison of simple acid-ethanol precipitation with gel exclusion chromatography for measuring leptin binding in serum of normal subjects and cancer patientsNigel B Jamieson
University Department of Surgery, Royal Infirmary, Glasgow, G31 2ER, UK
Ann Clin Biochem 40:185-7. 2003..Serum samples collected from healthy subjects and cancer patients were used in this comparison...
- Aldosterone synthase gene variation and adrenocortical response to sodium status, angiotensin II and ACTH in normal male subjectsBrian Kennon
MRC Blood Pressure Group, Division of Cardiovascular and Medical Sciences, University of Glasgow, Western Infirmary, Glasgow, UK
Clin Endocrinol (Oxf) 61:174-81. 2004..The mechanism by which these variants predispose to cardiovascular disease and the precise intermediate phenotype associated with them remains speculative...
- Systemic inflammatory response, prostate-specific antigen and survival in patients with metastatic prostate cancerPeter A McArdle
University Department of Surgery, Royal Infirmary, Glasgow, UK
Urol Int 77:127-9. 2006....
- The changing role of the clinical laboratory in the investigation of polycystic ovarian syndromeA Michael Wallace
Department of Clinical Biochemistry and Vascular Biochemistry, Glasgow Royal Infirmary, Glasgow, UK
Clin Biochem Rev 28:79-92. 2007..We provide some explanation for confusion over the selection of the best hormone measurements for diagnosis. Finally, we outline the best current and future laboratory support for this common condition in young women...
- Morning salivary cortisol versus short Synacthen test as a test of adrenal suppressionRajan S Patel
Department of Otolaryngology, North Glasgow Hospitals University, NHS Trust, Glasgow, UK
Ann Clin Biochem 41:408-10. 2004....
- The relation between acute changes in the systemic inflammatory response and plasma 25-hydroxyvitamin D concentrations after elective knee arthroplastyDavid Reid
Department of Anaesthesia, Faculty of Medicine, University of Glasgow, Royal Infirmary, Glasgow, United Kingdom
Am J Clin Nutr 93:1006-11. 2011..However, other lipid-soluble vitamins decrease during the systemic inflammatory response, and this response may confound the interpretation of plasma 25(OH)D...
- Divergent metabolic and vascular phenotypes in pre-eclampsia and intrauterine growth restriction: relevance of adiposityJane E Ramsay
University Department of Obstetrics and Gynaecology, Glasgow Royal Infirmary, Scotland, UK
J Hypertens 22:2177-83. 2004..Pre-eclampsia (PE) and intrauterine growth restriction (IUGR) may both arise secondary to inadequate trophoblast invasion. Maternal vascular disease is evident only in PE. Little mechanistic evidence exists to explain this dichotomy...
- Plasma leptin: associations with metabolic, inflammatory and haemostatic risk factors for cardiovascular diseaseS Goya Wannamethee
Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK
Atherosclerosis 191:418-26. 2007..We have examined the relationship between leptin and vascular risk factors including insulin resistance, metabolic, inflammatory and haemostatic risk factors...
- Benefits of salmon eating on traditional and novel vascular risk factors in young, non-obese healthy subjectsJose J Lara
Department of Human Nutrition, Division of Developmental Medicine, University of Glasgow, Glasgow Royal Infirmary, Glasgow G31 2ER, Scotland, UK
Atherosclerosis 193:213-21. 2007..The present clinical study tested the hypothesis that oil-rich fish consumption improves CHD risk factors...
- The relationship between leptin concentrations, the systemic inflammatory response and illness severity in surgical patients admitted to ITUTara Quasim
University Department of Surgery, Glasgow Royal Infirmary, Glasgow G31 2ER, Scotland, UK
Clin Nutr 23:233-8. 2004..The aim of the present study was to examine these relationships in critically ill surgical patients admitted to the intensive therapy unit (ITU)...
- Evidence for tissue selectivity of the synthetic androgen 7 alpha-methyl-19-nortestosterone in hypogonadal menRichard A Anderson
Medical Research Council Human Reproductive Sciences Unit, University of Edinburgh, Edinburgh, United Kingdom EH16 4SB
J Clin Endocrinol Metab 88:2784-93. 2003..In addition, our data are consistent with the importance of adequate estrogenicity as part of the necessary spectrum of activity of an androgen for replacement therapy in men...
- Studies on the origin of circulating 18-hydroxycortisol and 18-oxocortisol in normal human subjectsE Marie Freel
Medical Research Council Blood Pressure Group, Western Infirmary, Glasgow G11 6NT, Scotland, United Kingdom
J Clin Endocrinol Metab 89:4628-33. 2004..Although 18OHF can be synthesized using circulating cortisol as substrate, our data suggest this is normally produced in the zona fasciculata by 11beta-hydroxylase from locally available cortisol...