Affiliation: University College London
- [123I]N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)nortropane single-photon emission computed tomography brain imaging in the diagnosis of dementia with Lewy bodiesZuzana Walker
UCL Mental Health Sciences Unit, University College London, United Kingdom
Alzheimers Dement 8:74-83. 2012..The technique is likely to be of particular utility in patients with dementia with an uncertain diagnosis...
- Evolution of clinical features in possible DLB depending on FP-CIT SPECT resultZuzana Walker
From University College London Z W North Essex Partnership University NHS Foundation Trust Z W, T S, T W, Braintree GE Healthcare E M, Buckinghamshire Newcastle University A T, Newcastle upon Tyne Glasgow Memory Clinic Ltd F I Brighton and Sussex Medical School N T, Brighton, UK Centre for Age Related Diseases D A, Stavanger University Hospital Department of Geriatric Psychiatry D A, Akershus University Hospital, Oslo, Norway Department of Neurobiology, D A Care Sciences and Society Division of Alzheimer s Disease Research Centre, Karolinska Institutet, Stockholm, Sweden Karl Landsteiner Institut für Gedächtnis und Alzheimerforschung Wien M R, Austria and University of Brescia A P, Italy
Neurology 87:1045-51. 2016..A further objective was to assess the evolution of core and suggestive features in patients with possible DLB over time depending on the (123)I-FP-CIT SPECT scan result...
- Imaging in neurodegenerative disorders: recent studiesZuzana Walker
University College London and North Essex Mental Health Partnership NHS Trust
Curr Opin Psychiatry 18:640-6. 2005..Advances in neuroimaging have expanded its already central role in neurodegenerative disorders...
- Lewy body dementiasZuzana Walker
Division of Psychiatry, University College London, London, UK North Essex Partnership University NHS Foundation Trust, Epping, UK Electronic address
Lancet 386:1683-97. 2015..We summarise the most pertinent progress from the past 10 years, outlining some of the challenges for the future, which will require refinement of diagnosis and clarification of the pathogenesis, leading to disease-modifying treatments. ..
- Comparison of cognitive decline between dementia with Lewy bodies and Alzheimer's disease: a cohort studyZuzana Walker
Research Department of Mental Health Sciences, University College London, Bloomsbury Campus, London, UK
BMJ Open 2:e000380. 2012..An understanding of the rate of decline of cognitive and non-cognitive symptoms in DLB may help patients and carers to plan for the future...
- Dopaminergic imaging: clinical utility now and in the futureZuzana Walker
University College London and North Essex Partnership NHS Foundation Trust, Mental Health Unit, St Margaret s Hospital, Epping, Essex, UK
Int Psychogeriatr 23:S32-40. 2011..This review summarizes present knowledge in this area and the implications for current and future clinical practice...
- Dementia with Lewy bodies: a comparison of clinical diagnosis, FP-CIT single photon emission computed tomography imaging and autopsyZuzana Walker
University College London and Royal Free Hospitals, London, UK
J Neurol Neurosurg Psychiatry 78:1176-81. 2007....
- Striatal dopamine transporter in dementia with Lewy bodies and Parkinson disease: a comparisonZ Walker
University College London, UK
Neurology 62:1568-72. 2004....
- Differentiation of dementia with Lewy bodies from Alzheimer's disease using a dopaminergic presynaptic ligandZ Walker
University College London, UK
J Neurol Neurosurg Psychiatry 73:134-40. 2002..In DLB there is 40-70% loss of striatal dopamine...
- Dementia with Lewy bodies versus Alzheimer's disease: role of dopamine transporter imagingDurval C Costa
University College, London, United Kingdom
Mov Disord 18:S34-8. 2003..Furthermore, it is important to consider and discuss the potential for ioflupane in the diagnostic workup of patients with DLB...
- Differentiation of frontotemporal dementia from dementia with Lewy bodies using FP-CIT SPECTShirlony Morgan
Older People and Healthy Aging Directorate, Central and North West London NHS Foundation Trust, Bently House, 15 21 Headstone Drive, Middlesex, London, HA3 5QX, UK
J Neurol Neurosurg Psychiatry 83:1063-70. 2012....
- Long-term clinical and cost-effectiveness of psychological intervention for family carers of people with dementia: a single-blind, randomised, controlled trialGill Livingston
Division of Psychiatry, University College London, London, UK Camden and Islington NHS Foundation Trust, St Pancras Hospital, London, UK Electronic address
Lancet Psychiatry 1:539-48. 2014..We aimed to assess the clinical effectiveness (long-term reduction of depression and anxiety symptoms in family carers) and cost-effectiveness of a psychological intervention called START (STrAtegies for RelaTives)...
- Oxidative stress and memory decline in adults with Down syndrome: longitudinal studyPanagiotis Zis
UCL Mental Health Sciences Unit, Charles Bell House, London, UK
J Alzheimers Dis 31:277-83. 2012..These findings may also have implications for prevention of cognitive decline in other groups which are at high risk of developing dementia, such as adults with familial AD or mild cognitive impairment...
- Prediction of survival in Alzheimer's disease--the LASER-AD longitudinal studyMatt Paradise
Department of Mental Health Sciences, University College London, UK
Int J Geriatr Psychiatry 24:739-47. 2009..Our objective was to identify determinants of survival in a cohort of people with mild to moderate AD and test these on a separate validation cohort...
- START (STrAtegies for RelaTives) study: a pragmatic randomised controlled trial to determine the clinical effectiveness and cost-effectiveness of a manual-based coping strategy programme in promoting the mental health of carers of people with dementiaGill Livingston
Division of Psychiatry, University College London, London, UK
Health Technol Assess 18:1-242. 2014..This impacts on the person with dementia, families and society, predicting care breakdown. There are currently no clinically effective and cost-effective NHS family carer interventions...
- Memory complaints with and without memory impairment: the impact of leukoaraiosis on cognitionMelissa Lamar
Institute of Psychiatry, King s College London, London, United Kingdom
J Int Neuropsychol Soc 17:1104-12. 2011....
- Clinical usefulness of dopamine transporter SPECT imaging with 123I-FP-CIT in patients with possible dementia with Lewy bodies: randomised studyZuzana Walker
Zuzana Walker, MD, FRCPsych, Division of Psychiatry, University College London, London, and North Essex Partnership University NHS Foundation Trust, Essex, UK Emilio Moreno, MD, PhD, GE Healthcare, Amersham, UK Alan Thomas, PhD, FRCPsych, Biological Research Building, Newcastle University, Newcastle, UK Fraser Inglis, FRCP, Glasgow Memory Clinic, Glasgow, UK Naji Tabet, MD, MRCPsych, Postgraduate Medicine, Brighton and Sussex Medical School, Brighton, UK Michael Rainer, MD, Karl Landsteiner Institut für Gedächtnis und Alzheimerforschung, Vienna, Austria Gilberto Pizzolato deceased, MD, previously at Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy Alessandro Padovani, USA
Br J Psychiatry 206:145-52. 2015..Dementia with Lewy bodies (DLB) is underrecognised in clinical settings...
- Subjective cognitive impairment: increased prefrontal cortex activation compared to controls during an encoding taskJoanne E Rodda
University College London, Department of Mental Health Sciences, UK
Int J Geriatr Psychiatry 24:865-74. 2009....
- Secrets and lies: the dilemma of disclosing the diagnosis to an adult with dementiaMartin Fahy
Department of Psychiatry and Behavioural Sciences, Archway Campus, Highgate Hill, University College London, London N19 5NF, UK
Age Ageing 32:439-41. 2003..Clinicians should strive for earlier diagnosis and to address carer concerns, disclose the diagnosis and thus avoid the need for secrets and lies...
- An fMRI study of verbal episodic memory encoding in amnestic mild cognitive impairmentThomas M Dannhauser
Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
Cortex 44:869-80. 2008..We propose that verbal episodic memory impairment in aMCI is related to PFC dysfunction which affects semantic processing at encoding...
- Memory decline in Down syndrome and its relationship to iPF2alpha, a urinary marker of oxidative stressPanagiotis Zis
University College London, Division of Psychiatry, London, United Kingdom
PLoS ONE 9:e97709. 2014..We aimed to investigate whether changes in lipid peroxidation is associated with cognitive decline in individuals with Down syndrome over a 4-year period...
- Clinical effectiveness of a manual based coping strategy programme (START, STrAtegies for RelaTives) in promoting the mental health of carers of family members with dementia: pragmatic randomised controlled trialGill Livingston
Mental Health Science, University College London, London W1W 7EJ, UK
BMJ 347:f6276. 2013..To assess whether a manual based coping strategy compared with treatment as usual reduces depression and anxiety symptoms in carers of family members with dementia...
- Islington study of dementia subtypes in the communityTim Stevens
Department of Psychiatry and Behavioural Sciences, Royal Free and University College Medical School, London, UK
Br J Psychiatry 180:270-6. 2002..Epidemiological studies of dementia subtypes have revealed widely varying distribution rates. There are almost no published community prevalence data for dementia with Lewy bodies (DLB) or the frontal lobe dementias (FLD)...
- Dopamine transporter single photon emission computerized tomography in the diagnosis of dementia with Lewy bodiesRodney W H Walker
Department of Neurology, Barts and The London NHS Trust, London, United Kingdom
Mov Disord 24:S754-9. 2009..This communication outlines the evidence for this and discusses some of the advantages, potential disadvantages, and areas of uncertainty with regard to the use of dopamine transporter SPECT in DLB diagnosis...
- Relationship of exercise and other risk factors to depression of Alzheimer's disease: the LASER-AD studyCiaran Regan
Department of Psychiatry and Behavioural Sciences, University College London, London, UK
Int J Geriatr Psychiatry 20:261-8. 2005..It is associated with increased disability, cost of care and carer burden. Exercise is known to be associated with a lower prevalence of depression across the age range but little is known about its relationship to depression in AD...
- Dementia with Lewy bodies: clinical characteristics and diagnostic criteriaZuzana Walker
Royal Free and University College Medical School, University College London, London, England
J Geriatr Psychiatry Neurol 15:188-94. 2002..Nevertheless, at least one in five patients with DLB will continue to be misclassified...
- Family carers' distress and abusive behaviour: longitudinal studyClaudia Cooper
Department of Mental Health Sciences, UCL, 67 73 Riding House Street, 2nd Floor, Charles Bell House, London W1W7EJ, UK
Br J Psychiatry 196:480-5. 2010..A third of family carers of people with dementia report abusive behaviour towards the person for whom they are caring. This is the first longitudinal study to investigate such behaviour...
- Abuse of people with dementia by family carers: representative cross sectional surveyClaudia Cooper
Department of Mental Health Sciences, University College London, W1W 7EJ
BMJ 338:b155. 2009..To determine the prevalence of abusive behaviours by family carers of people with dementia...
- Endogenous antioxidant activities in relation to concurrent vitamins A, C, and E intake in dementiaNaji Tabet
Department of Old Age Psychiatry, Maudsley Hospital, London, UK
Int Psychogeriatr 14:7-15. 2002..The data underscore the importance of concurrent quantitative assessment of nutritional intake when measuring endogenous antioxidant activities and support a role for antioxidant supplementation in the treatment of dementia disorders...
- Microglia, amyloid, and glucose metabolism in Parkinson's disease with and without dementiaPaul Edison
Centre of Neuroscience, Department of Medicine, Imperial College London, London, UK
Neuropsychopharmacology 38:938-49. 2013..Significant microglial activation may be a factor in driving the disease process in PDD. Given this, agents that affect microglial activation could have an influence on disease progression...
- Attitudes of UK psychiatrists to the diagnosis of MCI in clinical practiceJoanne Rodda
University College London, London, UK
Int Psychogeriatr 25:286-91. 2013..Our aim was to investigate current practice as well as familiarity with and attitudes toward the concept of MCI amongst UK old age psychiatrists...
- Are cholinesterase inhibitors effective in the management of the behavioral and psychological symptoms of dementia in Alzheimer's disease? A systematic review of randomized, placebo-controlled trials of donepezil, rivastigmine and galantamineJoanne Rodda
Department of Mental Health Sciences, University College London, UK
Int Psychogeriatr 21:813-24. 2009....
- What to tell dementia caregivers--the rule of threesClaudia Wald
Central and North West London Mental Health NHS Trust, St Charles Hospital, London, UK
Int J Geriatr Psychiatry 18:313-7. 2003..To determine and prioritise what information dementia caregivers wish to know at the time of diagnosis and later on in the illness, and in what form this information should be presented...
- Autopsy validation of 123I-FP-CIT dopaminergic neuroimaging for the diagnosis of DLBAlan J Thomas
From the Institute of Neuroscience A J T, J A, S J C, I M, D B, D J L, Newcastle University, Campus for Ageing and Vitality, Newcastle Upon Tyne Department of Psychiatry J T O, University of Cambridge School of Clinical Medicine Department of Neurology R W, Barts Health NHS Trust, Royal London Hospital North Essex Partnership University NHS Foundation Trust L L, Z W, Epping and Division of Psychiatry Z W, University College London, UK
Neurology . 2016....
- Factors that predict cognitive decline in patients with subjective cognitive impairmentJose Andres Saez Fonseca
Department of Psychology, University of Roehampton, Roehampton Lane, London, SW15 5PU, UK
Int Psychogeriatr 27:1671-7. 2015....
- A complex multimodal activity intervention to reduce the risk of dementia in mild cognitive impairment--ThinkingFit: pilot and feasibility study for a randomized controlled trialThomas M Dannhauser
University College London, London, UK
BMC Psychiatry 14:129. 2014..Before this can be investigated conclusively, complex multimodal activity programmes are required that (1) combine multiple health promoting activities, (2) engage people with MCI, and (3) result in sufficient adherence rates...
- Oxidative stress and cognitive ability in adults with Down syndromeAndre Strydom
Department of Mental Health Sciences, RFUCMS, UCL, Hampstead Campus, Rowland Hill Street, London, NW3 2PF, UK
Prog Neuropsychopharmacol Biol Psychiatry 33:76-80. 2009..Compensatory rises in the activity of glutathione peroxidase (GPx) was expected to be associated with better ability, so that a high ratio between SOD1 and GPx was hypothesised to be the best predictor of poorer cognitive performance...
- A double-blind randomized placebo-controlled withdrawal trial comparing memantine and antipsychotics for the long-term treatment of function and neuropsychiatric symptoms in people with Alzheimer's disease (MAIN-AD)Clive Ballard
Wolfson Centre for Age Related Diseases, King s College London, London, UK Electronic address
J Am Med Dir Assoc 16:316-22. 2015..There is emerging evidence to support the potential benefits of memantine, currently licensed for moderate to severe AD, in the prophylaxis of neuropsychiatric symptoms...