Anton J M Wagenmakers

Summary

Affiliation: University of Birmingham
Country: UK

Publications

  1. ncbi Preferential uptake of dietary Fatty acids in adipose tissue and muscle in the postprandial period
    Alex S T Bickerton
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, UK
    Diabetes 56:168-76. 2007
  2. pmc Metabolic manipulation in chronic heart failure: study protocol for a randomised controlled trial
    Roger M Beadle
    University of Aberdeen, School of Medicine and Dentistry, Polwarth Building, Foresterhill, Aberdeen, AB25 2ZD, UK
    Trials 12:140. 2011
  3. ncbi Integration of the metabolic and cardiovascular effects of exercise
    Anton J M Wagenmakers
    Exercise Metabolism and Biochemistry Group, School of Sport and Exercise Sciences, University of Birmingham, UK
    Essays Biochem 42:193-210. 2006
  4. pmc Insulin resistance in the offspring of parents with type 2 diabetes
    Anton J M Wagenmakers
    School of Sport and Exercise Sciences, University of Birmingham, Birmingham, United Kingdom
    PLoS Med 2:e289. 2005
  5. pmc Sprint interval and endurance training are equally effective in increasing muscle microvascular density and eNOS content in sedentary males
    Matthew Cocks
    Exercise Metabolism Research Group, School of Sport and Exercise Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    J Physiol 591:641-56. 2013
  6. doi Acute high-fat feeding does not prevent the improvement in glucose tolerance after resistance exercise in lean individuals
    Christopher S Shaw
    Exercise Metabolism Research Group, School of Sport and Exercise Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom
    Eur J Appl Physiol 111:2607-13. 2011
  7. doi The effect of exercise and nutrition on intramuscular fat metabolism and insulin sensitivity
    Christopher S Shaw
    School of Sport and Exercise Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT United Kingdom
    Annu Rev Nutr 30:13-34. 2010
  8. pmc Quantitative immunofluorescence microscopy of subcellular GLUT4 distribution in human skeletal muscle: effects of endurance and sprint interval training
    Helen Bradley
    School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK
    Physiol Rep 2:. 2014
  9. doi Immunofluorescence microscopy to assess enzymes controlling nitric oxide availability and microvascular blood flow in muscle
    Matthew Cocks
    Exercise Metabolism Research Group, School of Sport and Exercise Sciences, University of Birmingham, Edgbaston, Birmingham, UK
    Microcirculation 19:642-51. 2012
  10. doi Glucocorticoids fail to cause insulin resistance in human subcutaneous adipose tissue in vivo
    Jonathan M Hazlehurst
    Centre for Endocrinology, Diabetes, and Metabolism, School of Clinical and Experimental Medicine, Institute of Biomedical Research, University of Birmingham, Queen Elizabeth Hospital, Birmingham, United Kingdom
    J Clin Endocrinol Metab 98:1631-40. 2013

Collaborators

Detail Information

Publications40

  1. ncbi Preferential uptake of dietary Fatty acids in adipose tissue and muscle in the postprandial period
    Alex S T Bickerton
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, UK
    Diabetes 56:168-76. 2007
    ..With this integrative physiological approach, we have revealed hidden complexities in pathways of fatty acid uptake in adipose tissue and skeletal muscle...
  2. pmc Metabolic manipulation in chronic heart failure: study protocol for a randomised controlled trial
    Roger M Beadle
    University of Aberdeen, School of Medicine and Dentistry, Polwarth Building, Foresterhill, Aberdeen, AB25 2ZD, UK
    Trials 12:140. 2011
    ..We aim to determine the effect of perhexiline on cardiac energetics and alterations in substrate utilisation in patients with non-ischaemic dilated cardiomyopathy...
  3. ncbi Integration of the metabolic and cardiovascular effects of exercise
    Anton J M Wagenmakers
    Exercise Metabolism and Biochemistry Group, School of Sport and Exercise Sciences, University of Birmingham, UK
    Essays Biochem 42:193-210. 2006
    ....
  4. pmc Insulin resistance in the offspring of parents with type 2 diabetes
    Anton J M Wagenmakers
    School of Sport and Exercise Sciences, University of Birmingham, Birmingham, United Kingdom
    PLoS Med 2:e289. 2005
  5. pmc Sprint interval and endurance training are equally effective in increasing muscle microvascular density and eNOS content in sedentary males
    Matthew Cocks
    Exercise Metabolism Research Group, School of Sport and Exercise Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    J Physiol 591:641-56. 2013
    ..Both training modes reduced aortic stiffness and increased whole body insulin sensitivity (P < 0.05). In conclusion, in sedentary males SIT and ET are effective in improving muscle microvascular density and eNOS protein content...
  6. doi Acute high-fat feeding does not prevent the improvement in glucose tolerance after resistance exercise in lean individuals
    Christopher S Shaw
    Exercise Metabolism Research Group, School of Sport and Exercise Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom
    Eur J Appl Physiol 111:2607-13. 2011
    ....
  7. doi The effect of exercise and nutrition on intramuscular fat metabolism and insulin sensitivity
    Christopher S Shaw
    School of Sport and Exercise Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT United Kingdom
    Annu Rev Nutr 30:13-34. 2010
    ..This review provides a summary of current knowledge on the effects of acute and chronic exercise as well as energy intake and macronutrient composition of the diet upon the metabolism of IMTG and the implications for metabolic health...
  8. pmc Quantitative immunofluorescence microscopy of subcellular GLUT4 distribution in human skeletal muscle: effects of endurance and sprint interval training
    Helen Bradley
    School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK
    Physiol Rep 2:. 2014
    ..The increase in peripheral localisation and protein content of GLUT4 following ET and SIT is likely to contribute to the improvements in glucose homeostasis observed after both training modes...
  9. doi Immunofluorescence microscopy to assess enzymes controlling nitric oxide availability and microvascular blood flow in muscle
    Matthew Cocks
    Exercise Metabolism Research Group, School of Sport and Exercise Sciences, University of Birmingham, Edgbaston, Birmingham, UK
    Microcirculation 19:642-51. 2012
    ..Here, we describe the development of a method to quantify the protein content and phosphorylation of endothelial NO synthase (eNOS content and eNOS ser(1177) phosphorylation) and NAD(P)H oxidase expression...
  10. doi Glucocorticoids fail to cause insulin resistance in human subcutaneous adipose tissue in vivo
    Jonathan M Hazlehurst
    Centre for Endocrinology, Diabetes, and Metabolism, School of Clinical and Experimental Medicine, Institute of Biomedical Research, University of Birmingham, Queen Elizabeth Hospital, Birmingham, United Kingdom
    J Clin Endocrinol Metab 98:1631-40. 2013
    ..We have previously demonstrated that glucocorticoids cause insulin sensitization in human adipose tissue in vitro and induce insulin resistance in skeletal muscle...
  11. doi Immunofluorescent visualisation of focal adhesion kinase in human skeletal muscle and its associated microvasculature
    Oliver J Wilson
    Exercise Metabolism Research Group, School of Sport and Exercise Sciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Histochem Cell Biol 138:617-26. 2012
    ..This technique will be an important tool for investigating the role of FAK in the intracellular signalling of human skeletal muscle and the endothelium of its associated microvasculature...
  12. ncbi Network distribution of mitochondria and lipid droplets in human muscle fibres
    Christopher S Shaw
    Exercise Metabolism Research Group, School of Sport and Exercise Sciences, The University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
    Histochem Cell Biol 129:65-72. 2008
    ..The density of mitochondria was the highest in the subsarcolemmal region. Anti-COX staining was combined with oil red O demonstrating that in type I fibres lipid droplets are mainly located in the space between the mitochondria...
  13. doi Paxillin and focal adhesion kinase colocalise in human skeletal muscle and its associated microvasculature
    Oliver J Wilson
    Exercise Metabolism Research Group, School of Sport and Exercise Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
    Histochem Cell Biol 142:245-56. 2014
    ..Colocalisation of FAK and paxillin supports their suggested role in hormonal and mechano-sensitive signalling...
  14. doi Adipophilin distribution and colocalization with lipid droplets in skeletal muscle
    Christopher S Shaw
    Exercise Metabolism Research Group, School of Sport and Exercise Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
    Histochem Cell Biol 131:575-81. 2009
    ..In conclusion, this study indicates that the IMCL pool is heterogeneous, as the majority but not all IMCL contain adipophilin...
  15. doi Effect of muscle metaboreflex activation on central hemodynamics and cardiac function in humans
    Clare L McNulty
    a School of Sport, Exercise and Rehabilitation Sciences, College of Life and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, England
    Appl Physiol Nutr Metab 39:861-70. 2014
    ....
  16. ncbi Effect of acute exercise on glucose tolerance following post-exercise feeding
    Michelle C Venables
    Human Performance Laboratory, School of Sport and Exercise Sciences, The University of Birmingham, Edgbaston, Birmingham, UK
    Eur J Appl Physiol 100:711-7. 2007
    ....
  17. ncbi Heat stress increases muscle glycogen use but reduces the oxidation of ingested carbohydrates during exercise
    Roy L P G Jentjens
    Human Performance Laboratory, School of Sport and Exercise Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    J Appl Physiol 92:1562-72. 2002
    ..087 and P = 0.082, respectively). These results demonstrate that the oxidation rate of ingested CHO is reduced and muscle glycogen utilization is increased during exercise in the heat compared with a cool environment...
  18. ncbi Co-ingestion of leucine with protein does not further augment post-exercise muscle protein synthesis rates in elderly men
    Rene Koopman
    Department of Movement Sciences, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, 6200 MD Maastricht, The Netherlands
    Br J Nutr 99:571-80. 2008
    ..Co-ingestion of leucine with carbohydrate and protein following physical activity does not further elevate muscle protein fractional synthetic rate in elderly men when ample protein is ingested...
  19. ncbi Creatine supplementation increases glycogen storage but not GLUT-4 expression in human skeletal muscle
    Luc J C van Loon
    Nutrition Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Clin Sci (Lond) 106:99-106. 2004
    ..In addition, neither muscle GS-1 nor Gln-1 mRNA expression was affected. We conclude that creatine ingestion itself stimulates muscle glycogen storage, but does not affect muscle GLUT-4 expression...
  20. ncbi Combined ingestion of protein and free leucine with carbohydrate increases postexercise muscle protein synthesis in vivo in male subjects
    Rene Koopman
    Department of Human Biology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 288:E645-53. 2005
    ..0820 +/- 0.0104%/h). We conclude that coingestion of protein and leucine stimulates muscle protein synthesis and optimizes whole body protein balance compared with the intake of carbohydrate only...
  21. ncbi Effects of creatine loading and prolonged creatine supplementation on body composition, fuel selection, sprint and endurance performance in humans
    Luc J C van Loon
    Nutrition and Toxicology Research Institute Maastricht NUTRIM, Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    Clin Sci (Lond) 104:153-62. 2003
    ..In addition, our findings suggest that prolonged creatine ingestion induces an increase in fat-free mass...
  22. ncbi Nutritional interventions to promote post-exercise muscle protein synthesis
    Rene Koopman
    Department of Movement Sciences, Maastricht University, Maastricht, The Netherlands
    Sports Med 37:895-906. 2007
    ..Exercise interventions combined with specific nutritional modulation provide an effective strategy to counteract or reduce the loss of skeletal muscle mass with aging...
  23. ncbi Substrate source use in older, trained males after decades of endurance training
    Hanneke Boon
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Med Sci Sports Exerc 39:2160-70. 2007
    ..The purpose of this study was to compare substrate source use in older, long-term exercising, endurance-trained males with sedentary controls...
  24. ncbi Protein hydrolysate/leucine co-ingestion reduces the prevalence of hyperglycemia in type 2 diabetic patients
    Ralph J F Manders
    Department of Human Biology, Maastricht University, P O Box 616, 6200 MD Maastricht, Netherlands
    Diabetes Care 29:2721-2. 2006
  25. ncbi The fate of [U-(13)C]palmitate extracted by skeletal muscle in subjects with type 2 diabetes and control subjects
    Ellen E Blaak
    Department of Human Biology, Nutrition Research Center, Maastricht University, Maastricht, The Netherlands
    Diabetes 51:784-9. 2002
    ....
  26. ncbi The effect of a 3-month low-intensity endurance training program on fat oxidation and acetyl-CoA carboxylase-2 expression
    Patrick Schrauwen
    Department of Human Biology, Nutrition, Toxicology and Environmental Research Institute NUTRIM, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Diabetes 51:2220-6. 2002
    ..07). In conclusion, a minimal amount of physical activity tends to increase fat oxidation and leads to marked changes in the expression of genes encoding for key enzymes in fat metabolism...
  27. ncbi Impaired performance of skeletal muscle in alpha-glucosidase knockout mice
    Reinout P Hesselink
    Department of Movement Sciences, Cardiovascular Research Institute, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Muscle Nerve 25:873-83. 2002
    ..The increase in muscular desmin content is most likely reflecting adaptations to altered intracellular force transmission...
  28. ncbi The primary target of nutritional support: body composition or muscle function?
    Anton J M Wagenmakers
    Department of Human Biology and Stable Isotope Research Center, NUTRIM, Maastricht University and University Hospital, Maastricht, The Netherlands
    Nestle Nutr Workshop Ser Clin Perform Programme 7:219-34; discussion 234-8. 2002
  29. ncbi Amino acid ingestion strongly enhances insulin secretion in patients with long-term type 2 diabetes
    Luc J C van Loon
    Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University, Maastricht, The Netherlands
    Diabetes Care 26:625-30. 2003
    ..In this study, we aimed to investigate the insulinotropic capacity of this mixture in long-term type 2 diabetic patients...
  30. ncbi Lysosomal dysfunction in muscle with special reference to glycogen storage disease type II
    Reinout P Hesselink
    Department of Movement Sciences, Cardiovascular Research Institute Maastricht, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Biochim Biophys Acta 1637:164-70. 2003
    ....
  31. ncbi The use of the [1,2-13C]acetate recovery factor in metabolic research
    Luc J C van Loon
    Nutrition Research Institute Maastricht NUTRIM, Department of Human Biology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Eur J Appl Physiol 89:377-83. 2003
    ..Therefore, theoretical acetate recovery factors taken from previous literature are not generally applicable...
  32. ncbi Influence of prolonged endurance cycling and recovery diet on intramuscular triglyceride content in trained males
    Luc J C van Loon
    Department of Human Biology, Nutrition Research Institute Maastricht, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 285:E804-11. 2003
    ..Data obtained by quantitative fluorescence microscopy correspond well with MRS results, implying that both are valid methods to quantify IMTG content...
  33. pmc Intramyocellular lipids form an important substrate source during moderate intensity exercise in endurance-trained males in a fasted state
    Luc J C van Loon
    Nutrition Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    J Physiol 553:611-25. 2003
    ....
  34. ncbi Combined ingestion of protein and carbohydrate improves protein balance during ultra-endurance exercise
    Rene Koopman
    Department of Human Biology, Maastricht University, PO Box 616, 6200 MD, The Netherlands
    Am J Physiol Endocrinol Metab 287:E712-20. 2004
    ..Combined ingestion of protein and carbohydrate improves net protein balance at rest as well as during exercise and postexercise recovery...
  35. ncbi Age-related decline in muscle strength and power output in acid 1-4 alpha-glucosidase knockout mice
    Reinout P Hesselink
    Department of Movement Sciences, Nutrition and Toxicology Research Institute, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Muscle Nerve 31:374-81. 2005
    ..Mechanical effects of glycogen inclusions could not fully explain this decrease. Additional factors must therefore play a role...
  36. ncbi Inhibition of adipose tissue lipolysis increases intramuscular lipid and glycogen use in vivo in humans
    Luc J C van Loon
    Department of Movement Sciences, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 289:E482-93. 2005
    ..This study confirms the hypothesis that plasma FFA availability regulates both intramuscular lipid and glycogen use in vivo in humans...
  37. ncbi Co-ingestion of a protein hydrolysate and amino acid mixture with carbohydrate improves plasma glucose disposal in patients with type 2 diabetes
    Ralph J F Manders
    Departments of Human Biology and Internal Medicine, Maastricht University Hospital, Maastricht, Netherlands
    Am J Clin Nutr 82:76-83. 2005
    ..Although insulin secretion after carbohydrate ingestion is severely impaired in patients with type 2 diabetes, amino acid and protein co-ingestion can substantially increase plasma insulin responses...
  38. ncbi Age-related morphological changes in skeletal muscle cells of acid alpha-glucosidase knockout mice
    Reinout P Hesselink
    Department of Movement Sciences, Cardiovascular Research Institute Maastricht, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Muscle Nerve 33:505-13. 2006
    ..These collective findings, on the one hand, may explain the decrease in tissue quality and, on the other, may represent markers for efficacy of therapeutic interventions to restore muscle function in patients suffering from GSDII...
  39. ncbi Co-ingestion of protein and leucine stimulates muscle protein synthesis rates to the same extent in young and elderly lean men
    Rene Koopman
    Department of Human Biology, Maastricht University, Maastricht, Netherlands
    Am J Clin Nutr 84:623-32. 2006
    ..The progressive loss of skeletal muscle mass with aging is attributed to a disruption in the regulation of skeletal muscle protein turnover...
  40. ncbi Effect of exercise training at different intensities on fat metabolism of obese men
    Dorien P C van Aggel-Leijssen
    Department of Human Biology, Nutrition, Toxicology, and Environmental Research Institute, Maastricht University, 6200 MD Maastricht, The Netherlands
    J Appl Physiol 92:1300-9. 2002
    ..It was concluded that low-intensity exercise training in obese subjects seemed to increase fat oxidation during exercise but not at rest. No effect of high-intensity exercise training on fat oxidation could be shown...