Valerie Voon

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. pmc Decisional impulsivity and the associative-limbic subthalamic nucleus in obsessive-compulsive disorder: stimulation and connectivity
    Valerie Voon
    Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Brain . 2016
  2. pmc Waiting Impulsivity: The Influence of Acute Methylphenidate and Feedback
    Valerie Voon
    Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom Dr Voon, Ms Chang Webb, Ms Morris, Ms Cooper, Mr Sethi, Dr Baek, Dr Robbins, and Dr Harrison Behavioral and Clinical Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom Dr Voon, Ms Morris, and Dr Robbins Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, United Kingdom Dr Voon Department of Psychology, University of Cambridge, Cambridge, United Kingdom Ms Morris and Dr Robbins Department of Psychiatry, Brighton and Sussex Medical School, Brighton, United Kingdom Ms Cooper, Mr Sethi, and Dr Harrison Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL Dr Grant Sackler Centre for Consciousness Science, University of Sussex, Brighton, United Kingdom Dr Harrison Sussex Partnership NHS Trust, Brighton, United Kingdom Dr Harrison
    Int J Neuropsychopharmacol 19:. 2015
  3. doi request reprint Functional neurological disorders: imaging
    V Voon
    Department of Psychiatry, University of Cambridge, Cambridgeshire, United Kingdom Electronic address
    Neurophysiol Clin 44:339-42. 2014
  4. pmc Dopamine agonists and risk: impulse control disorders in Parkinson's disease
    Valerie Voon
    Behavioural and Clinical Neurosciences Institute, Department of Experimental Psychology, Downing Site, University of Cambridge, Cambridge CB2 3EB, UK
    Brain 134:1438-46. 2011
  5. pmc Impulse control disorders in Parkinson's disease: recent advances
    Valerie Voon
    Behavioural and Clinical Neurosciences Institute, University of Cambridge, Cambridge, UK
    Curr Opin Neurol 24:324-30. 2011
  6. ncbi request reprint Deep brain stimulation: preoperative issues
    Anthony E Lang
    Department of Neurology, Toronto Western Hospital, Toronto, Ontario, Canada
    Mov Disord 21:S171-96. 2006
  7. pmc Reflection impulsivity in binge drinking: behavioural and volumetric correlates
    Paula Banca
    Department of Psychiatry, University of Cambridge, UK
    Addict Biol 21:504-15. 2016
  8. pmc Fronto-striatal organization: Defining functional and microstructural substrates of behavioural flexibility
    Laurel S Morris
    Department of Psychology, University of Cambridge, Cambridge, United Kingdom Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom
    Cortex 74:118-33. 2016
  9. pmc Response inhibition in motor conversion disorder
    Valerie Voon
    Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
    Mov Disord 28:612-8. 2013
  10. pmc Biases in the Explore-Exploit Tradeoff in Addictions: The Role of Avoidance of Uncertainty
    Laurel S Morris
    Institute of Behavioural and Clinical Neuroscience, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 41:940-8. 2016

Collaborators

Detail Information

Publications54

  1. pmc Decisional impulsivity and the associative-limbic subthalamic nucleus in obsessive-compulsive disorder: stimulation and connectivity
    Valerie Voon
    Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Brain . 2016
    ....
  2. pmc Waiting Impulsivity: The Influence of Acute Methylphenidate and Feedback
    Valerie Voon
    Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom Dr Voon, Ms Chang Webb, Ms Morris, Ms Cooper, Mr Sethi, Dr Baek, Dr Robbins, and Dr Harrison Behavioral and Clinical Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom Dr Voon, Ms Morris, and Dr Robbins Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, United Kingdom Dr Voon Department of Psychology, University of Cambridge, Cambridge, United Kingdom Ms Morris and Dr Robbins Department of Psychiatry, Brighton and Sussex Medical School, Brighton, United Kingdom Ms Cooper, Mr Sethi, and Dr Harrison Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL Dr Grant Sackler Centre for Consciousness Science, University of Sussex, Brighton, United Kingdom Dr Harrison Sussex Partnership NHS Trust, Brighton, United Kingdom Dr Harrison
    Int J Neuropsychopharmacol 19:. 2015
    ..In study 2, we assessed the role of learning from feedback in disorders of addiction...
  3. doi request reprint Functional neurological disorders: imaging
    V Voon
    Department of Psychiatry, University of Cambridge, Cambridgeshire, United Kingdom Electronic address
    Neurophysiol Clin 44:339-42. 2014
    ..This review covers the neuroimaging literature focusing on functional motor symptoms including motor functioning and upstream influences including self-monitoring and internal representations, voluntariness and arousal and trauma. ..
  4. pmc Dopamine agonists and risk: impulse control disorders in Parkinson's disease
    Valerie Voon
    Behavioural and Clinical Neurosciences Institute, Department of Experimental Psychology, Downing Site, University of Cambridge, Cambridge CB2 3EB, UK
    Brain 134:1438-46. 2011
    ..Our results provide a potential explanation of why dopamine agonists may lead to an unconscious bias towards risk in susceptible individuals...
  5. pmc Impulse control disorders in Parkinson's disease: recent advances
    Valerie Voon
    Behavioural and Clinical Neurosciences Institute, University of Cambridge, Cambridge, UK
    Curr Opin Neurol 24:324-30. 2011
    ..The aim is to review the recent advances in the epidemiology and pathophysiology of impulse control disorders (ICDs) in Parkinson's disease...
  6. ncbi request reprint Deep brain stimulation: preoperative issues
    Anthony E Lang
    Department of Neurology, Toronto Western Hospital, Toronto, Ontario, Canada
    Mov Disord 21:S171-96. 2006
    ..It outlines answers to a series of questions developed to address all aspects of deep brain stimulation preoperative decision-making...
  7. pmc Reflection impulsivity in binge drinking: behavioural and volumetric correlates
    Paula Banca
    Department of Psychiatry, University of Cambridge, UK
    Addict Biol 21:504-15. 2016
    ..These findings emphasize the role of possible therapeutic interventions targeting decision-making deficits. ..
  8. pmc Fronto-striatal organization: Defining functional and microstructural substrates of behavioural flexibility
    Laurel S Morris
    Department of Psychology, University of Cambridge, Cambridge, United Kingdom Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom
    Cortex 74:118-33. 2016
    ..This data highlights similarities between a computational account of MFc and conventional measures of habit learning. We highlight the intrinsic functional and structural architecture of parallel systems of behavioural control. ..
  9. pmc Response inhibition in motor conversion disorder
    Valerie Voon
    Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
    Mov Disord 28:612-8. 2013
    ..Our results point toward potential differences between conversion disorder subgroups. © 2013 Movement Disorder Society...
  10. pmc Biases in the Explore-Exploit Tradeoff in Addictions: The Role of Avoidance of Uncertainty
    Laurel S Morris
    Institute of Behavioural and Clinical Neuroscience, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 41:940-8. 2016
    ..For losses, exploration was associated with frontal polar and precuneus connectivity. We further implicate the relevance and dimensionality of constructs of compulsivity across disorders of both natural and drug rewards. ..
  11. pmc Acute Changes in Striatal Microstructure Predict the Development of Interferon-Alpha Induced Fatigue
    Nicholas G Dowell
    Brighton and Sussex Medical School, University of Sussex
    Biol Psychiatry 79:320-8. 2016
    ..Whether this reflects prolonged modulation of motivational processes underpinning fatigue or separate neurobiological mechanisms is currently unclear...
  12. pmc Enhanced attentional bias towards sexually explicit cues in individuals with and without compulsive sexual behaviours
    Daisy J Mechelmans
    Department of Psychiatry, Addenbrooke s Hospital, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 9:e105476. 2014
    ..These studies together provide support for an incentive motivation theory of addiction underlying the aberrant response towards sexual cues in CSB. ..
  13. pmc Neuronal correlates of risk-seeking attitudes to anticipated losses in binge drinkers
    Yulia Worbe
    Behavioural and Clinical Neurosciences Institute, University of Cambridge, Cambridge, United Kingdom
    Biol Psychiatry 76:717-24. 2014
    ..Previous studies suggest a decreased sensitivity to aversive conditioning in BD. Here, we asked whether BD might be characterized by enhanced risk seeking related to decreased sensitivity to the anticipation of negative outcomes...
  14. pmc Evidence accumulation in obsessive-compulsive disorder: the role of uncertainty and monetary reward on perceptual decision-making thresholds
    Paula Banca
    1 Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK 2 PhD Programme in Experimental Biology and Biomedicine, Center for Neuroscience and Cell Biology, University of Coimbra, Portugal 3 Institute for Biomedical Imaging and Life Sciences, University of Coimbra, Portugal
    Neuropsychopharmacology 40:1192-202. 2015
    ..It further emphasizes that OCD patients are sensitive to monetary incentives heightening speed in the speed-accuracy tradeoff, improving evidence accumulation. ..
  15. pmc Impaired decisional impulsivity in pathological videogamers
    Michael A Irvine
    Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 8:e75914. 2013
    ..Impulsivity is commonly impaired in disorders of behavioural and substance addiction, hence we sought to systematically investigate the different subtypes of decisional and motor impulsivity in a well-defined pathological gaming cohort...
  16. ncbi request reprint Deep brain stimulation: neuropsychological and neuropsychiatric issues
    Valerie Voon
    Department of Psychiatry, Toronto Western Hospital, Toronto, Canada
    Mov Disord 21:S305-27. 2006
    ..Outcome studies, methodological issues, pathophysiology, and preoperative and postoperative management of the cognitive and neuropsychiatric aspects and complications of DBS for PD are discussed...
  17. pmc Risk-taking in disorders of natural and drug rewards: neural correlates and effects of probability, valence, and magnitude
    Valerie Voon
    1 Department of Psychiatry, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK 2 Department of Psychiatry, Behavioural and Clinical Neurosciences Institute, University of Cambridge, Cambridge, UK 3 Cambridgeshire and Peterborough Foundation Trust, Cambridge, UK
    Neuropsychopharmacology 40:804-12. 2015
    ..The relationship to risk probability and valence may underlie the propensity toward pathological behaviors toward different types of rewards. ..
  18. pmc Novelty, conditioning and attentional bias to sexual rewards
    Paula Banca
    Department of Psychiatry, University of Cambridge, Cambridge, UK PhD Programme in Experimental Biology and Biomedicine, Center for Neuroscience and Cell Biology, University of Coimbra, Portugal Institute for Biomedical Imaging and Life Sciences, University of Coimbra, Portugal
    J Psychiatr Res 72:91-101. 2016
    ..These findings have wider relevance as the Internet provides a broad range of novel and potentially rewarding stimuli. ..
  19. doi request reprint Impulse control disorders in Parkinson disease: a multicenter case--control study
    Valerie Voon
    Behavioral and Clinical Neurosciences Institute, University of Cambridge, Cambridge, England
    Ann Neurol 69:986-96. 2011
    ..To assess factors associated with impulse control disorders (ICDs) in Parkinson disease (PD) using a multicenter case--control design...
  20. ncbi request reprint Punding prevalence in Parkinson's disease
    Janis M Miyasaki
    Movement Disorders Centre, Toronto Western Hospital, University Health Network, Krembil Neuroscience Centre, University of Toronto, Toronto, Canada
    Mov Disord 22:1179-81. 2007
    ..4%) in contrast with previous reports of 14%. Despite the low incidence, this behavior is disruptive and should be carefully elicited by physicians caring for Parkinson's disease patients...
  21. ncbi request reprint Psychiatric symptoms following surgery for Parkinson's disease with an emphasis on subthalamic stimulation
    Valerie Voon
    Department of Psychiatry, Toronto Western Hospital, UHN, Toronto, Canada
    Adv Neurol 96:130-47. 2005
    ..The paucity of the literature underscores the need for well-designed studies on psychiatric issues investigating both pathophysiology and clinical outcomes...
  22. doi request reprint Binge drinking differentially affects cortical and subcortical microstructure
    Laurel S Morris
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Addict Biol . 2017
    ..The findings illustrate novel microstructural abnormalities that may reflect an infnce of alcohol bingeing on critical neurodevelopmental processes in an at-risk young adult group...
  23. pmc Interferon-α acutely impairs whole-brain functional connectivity network architecture - A preliminary study
    Ottavia Dipasquale
    Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milan, Italy IRCCS, Fondazione Don Carlo Gnocchi, Milan, Italy Clinical Imaging Sciences Centre, Brighton and Sussex Medical School, Brighton, UK
    Brain Behav Immun 58:31-39. 2016
    ..Correlations with multiple indices of mood change support a role for global changes in brain functional connectivity architecture in coordinated behavioral responses to IFN-α...
  24. doi request reprint Specific Frontostriatal Circuits for Impaired Cognitive Flexibility and Goal-Directed Planning in Obsessive-Compulsive Disorder: Evidence From Resting-State Functional Connectivity
    Matilde M Vaghi
    Departments of Psychology, University of Cambridge, Cambridge Behavioural and Clinical Neurosciences Institute, University of Cambridge, Cambridge Electronic address
    Biol Psychiatry . 2016
    ..We tested this hypothesis in OCD patients and control subjects by relating measures of goal-directed planning and cognitive flexibility to underlying resting-state functional connectivity...
  25. pmc A Neurocomputational Account of How Inflammation Enhances Sensitivity to Punishments Versus Rewards
    Neil A Harrison
    Department of Psychiatry, Brighton and Sussex Medical School, Brighton Sackler Centre for Consciousness Science, University of Sussex Brighton Sussex Partnership National Health Service Foundation Trust, Brighton Electronic address
    Biol Psychiatry 80:73-81. 2016
    ..However, it remains unclear how these rapid shifts in behavior are mediated within the brain...
  26. pmc Quantitative Magnetization Transfer Imaging as a Biomarker for Effects of Systemic Inflammation on the Brain
    Neil A Harrison
    Brighton and Sussex Medical School, University of Sussex, Brighton Sackler Centre for Consciousness Science, University of Sussex, Falmer Sussex Partnership National Health Service Trust, Brighton Electronic address
    Biol Psychiatry 78:49-57. 2015
    ..However, efforts to identify patients most vulnerable to the central effects of inflammation are hindered by insensitivity of conventional structural magnetic resonance imaging...
  27. pmc Neural correlates of sexual cue reactivity in individuals with and without compulsive sexual behaviours
    Valerie Voon
    Department of Psychiatry, Addenbrooke s Hospital, University of Cambridge, Cambridge, United Kingdom Behavioural and Clinical Neurosciences Institute, University of Cambridge, Cambridge, United Kingdom Cambridgeshire and Peterborough Foundation Trust, Cambridge, United Kingdom
    PLoS ONE 9:e102419. 2014
    ..The greater engagement of corticostriatal limbic circuitry in CSB following exposure to sexual cues suggests neural mechanisms underlying CSB and potential biological targets for interventions. ..
  28. pmc Aberrant supplementary motor complex and limbic activity during motor preparation in motor conversion disorder
    Valerie Voon
    Behavioral and Clinical Neurosciences Institute, University of Cambridge, Cambridge, UK
    Mov Disord 26:2396-403. 2011
    ....
  29. pmc Measuring "waiting" impulsivity in substance addictions and binge eating disorder in a novel analogue of rodent serial reaction time task
    Valerie Voon
    Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, United Kingdom Electronic address
    Biol Psychiatry 75:148-55. 2014
    ..We developed a novel translation of the task, based on the rodent 5-choice serial reaction time task, testing premature responding in disorders of drug and natural food rewards...
  30. pmc Sexually dimorphic brain volume interaction in college-aged binge drinkers
    Timo L Kvamme
    Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom Cognitive Neuroscience Research Unit, Department of Communication and Psychology, Aalborg University, Aalborg, Denmark Center of Functionally Integrative Neuroscience, MindLab, Aarhus University, Aarhus C, Denmark
    Neuroimage Clin 10:310-7. 2016
    ..Here, we compared the brain volumetric differences between genders in college-aged binge drinkers and healthy volunteers...
  31. pmc The Role of Social Novelty in Risk Seeking and Exploratory Behavior: Implications for Addictions
    Simon Mitchell
    Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 11:e0158947. 2016
    ..Our findings link the observation that novelty preference and sensation seeking are important traits predicting the initiation and maintenance of risky behaviours, including substance and behavioural addictions. ..
  32. pmc Central autonomic network mediates cardiovascular responses to acute inflammation: relevance to increased cardiovascular risk in depression?
    Neil A Harrison
    Clinical Imaging Sciences Centre, Brighton and Sussex Medical School, University of Sussex Campus, Falmer, Brighton BN1 3AR, UK
    Brain Behav Immun 31:189-96. 2013
    ..Together our findings highlight mechanisms binding psychological and physiological well-being and their perturbation by peripheral inflammation...
  33. pmc Compulsive sexual behavior: Prefrontal and limbic volume and interactions
    Casper Schmidt
    Department of Psychiatry, University of Cambridge, Herchel Smith Buidling for Brain and Mind Sciences, Forvie Site, Robinson Way, Cambridge, CB2 0SZ, United Kingdom
    Hum Brain Mapp . 2016
    ..The underlying neurobiology is still poorly understood. The present study examines brain volumes and resting state functional connectivity in CSB compared with matched healthy volunteers (HV)...
  34. pmc Frequency of impulse control behaviours associated with dopaminergic therapy in restless legs syndrome
    Valerie Voon
    Behavioural and Clinical Neurosciences Institute, University of Cambridge, Cambridge, UK
    BMC Neurol 11:117. 2011
    ..With this study we sought to assess the cross-sectional prevalence of impulse control behaviours (ICBs) in restless legs syndrome (RLS) and to determine factors associated with ICBs in a population cohort in Germany...
  35. pmc Impulse control disorders in Parkinson's disease: decreased striatal dopamine transporter levels
    Valerie Voon
    Department of Psychiatry, University of Cambridge, Cambridge, UK
    J Neurol Neurosurg Psychiatry 85:148-52. 2014
    ....
  36. pmc You turn me cold: evidence for temperature contagion
    Ella A Cooper
    Brighton and Sussex Medical School, University of Sussex, Brighton, United Kingdom
    PLoS ONE 9:e116126. 2014
    ..Here we investigate if observing cues indicating a change in another's body temperature results in a corresponding temperature change in the observer...
  37. pmc Peripheral inflammation acutely impairs human spatial memory via actions on medial temporal lobe glucose metabolism
    Neil A Harrison
    Department of Psychiatry, Brighton and Sussex Medical School, Falmer, United Kingdom Sackler Centre for Consciousness Science, University of Sussex, Falmer, United Kingdom Electronic address
    Biol Psychiatry 76:585-93. 2014
    ..They also demonstrated functional impairment of medial temporal lobe (MTL) structures by systemic inflammation. However, human data to support this position are limited...
  38. doi request reprint Amygdala and dlPFC abnormalities, with aberrant connectivity and habituation in response to emotional stimuli in females with BPD
    Robert B Dudas
    Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK Complex Cases Service, Cambridge shire and Peterborough Foundation NHS Trust, UK Behavioural and Clinical Neurosciences Institute, University of Cambridge, UK Psychiatric Liaison Service, Ipswich Hospital, Norfolk and Suffolk NHS Foundation Trust, UK Norwich Medical School, University of East Anglia, UK Electronic address
    J Affect Disord 208:460-466. 2017
    ..Little is known about the frontolimbic abnormalities thought to underlie borderline personality disorder (BPD). We endeavoured to study regional responses, as well as their connectivity and habituation during emotion processing...
  39. doi request reprint Psychiatric considerations in deep brain stimulation for Parkinson's disease
    Valerie Voon
    Department of Psychiatry, University of Cambridge, Cambridge, UK Electronic address
    Handb Clin Neurol 116:147-54. 2013
    ..This chapter reviews the evidence on psychiatric symptoms in the perioperative state including suicidal behaviors, depression, anxiety, mania, apathy, and impulse control disorders. ..
  40. pmc Psychiatric symptoms associated with focal hand dystonia
    Valerie Voon
    Behavioral and Clinical Neurosciences Institute, University of Cambridge, Cambridge, UK
    Mov Disord 25:2249-52. 2010
    ..95% of patients with FHD along with a family history of depression in (16 of 39) 41.02%. Overlapping mechanisms manifesting as FHD may also predispose to OC symptoms and likely implicates a common striatal dysfunction...
  41. pmc Gamma aminobutyric acidergic and neuronal structural markers in the nucleus accumbens core underlie trait-like impulsive behavior
    Daniele Caprioli
    Behavioural and Clinical Neuroscience Institute and Department of Psychology, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom Electronic address
    Biol Psychiatry 75:115-23. 2014
    ..However, the molecular and cellular substrates of impulsivity are poorly understood. Here, we investigated a specific form of motor impulsivity in rats, namely premature responding, on a five-choice serial reaction time task...
  42. pmc Distinct cortico-striatal connections with subthalamic nucleus underlie facets of compulsivity
    Laurel S Morris
    Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom Electronic address
    Cortex 88:143-150. 2016
    ..These findings are relevant to the development of potential biomarkers of treatment response in neurosurgical procedures targeting the STN for neurological and psychiatric disorders...
  43. pmc Effects of inflammation on hippocampus and substantia nigra responses to novelty in healthy human participants
    Neil A Harrison
    1 Clinical Imaging Sciences Centre, Brighton and Sussex Medical School, University of Sussex Campus, Brighton, UK 2 Sackler Centre for Consciousness Science, University of Sussex, Brighton, UK
    Neuropsychopharmacology 40:831-8. 2015
    ....
  44. doi request reprint Psychogenic movement disorders: past developments, current status, and future directions
    Anthony E Lang
    Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 26:1175-86. 2011
    ..Given the personal and societal impact of these problems, further advances in our understanding of their pathogenesis and the subsequent development of effective therapies are sorely needed...
  45. pmc Serotonin depletion induces 'waiting impulsivity' on the human four-choice serial reaction time task: cross-species translational significance
    Yulia Worbe
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 39:1519-26. 2014
    ....
  46. pmc Enhanced avoidance habits in obsessive-compulsive disorder
    Claire M Gillan
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge Department of Psychology, University of Cambridge, Cambridge Electronic address
    Biol Psychiatry 75:631-8. 2014
    ..To explore how habits, as a putative model of compulsivity, might relate to obsessions and anxiety, we recorded measures of contingency knowledge, explicit fear, and physiological arousal...
  47. doi request reprint Deficits in Limb Praxis in Patients With Obsessive-Compulsive Disorder
    Elisabeth Rounis
    From the Division of Clinical Neurology, Nuffield Dept of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, UK ER the Dept of Psychiatry, University of Cambridge, Addenbrooks Hospital, Cambridge, UK PB, VV and Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK VV
    J Neuropsychiatry Clin Neurosci 28:232-5. 2016
    ..Patients showed significantly lower scores in this task. Further studies are needed to elucidate the nature of patients' deficits in praxis. This might reveal similar mechanisms underlying OCD and some types of movement disorders. ..
  48. pmc Dissociated Accumbens and Hippocampal Structural Abnormalities across Obesity and Alcohol Dependence
    Tom B Mole
    Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK Dr Mole, Mr Mak, Ms Chien, and Dr Voon Behavioural and Clinical Neurosciences Institute, University of Cambridge, UK Dr Voon
    Int J Neuropsychopharmacol 19:. 2016
    ..We specifically hypothesized that these 2 established regions in addiction neurocircuitry are associated with distinctive in vivo structural abnormalities in obesity and alcohol dependence...
  49. doi request reprint Translatable and Back-Translatable Measurement of Impulsivity and Compulsivity: Convergent and Divergent Processes
    Valerie Voon
    Behavioral and Clinical Neuroscience Institute, University of Cambridge, Cambridge, CB2 3EB, UK
    Curr Top Behav Neurosci 28:53-91. 2016
    ..We emphasize the relevance of these constructs for understanding dimensional psychiatry. ..
  50. pmc Imbalance in habitual versus goal directed neural systems during symptom provocation in obsessive-compulsive disorder
    Paula Banca
    1 Institute for Biomedical Imaging and Life Sciences, Faculty of Medicine, University of Coimbra, Portugal 2 PhD Programme in Experimental Biology and Biomedicine, Centre for Neuroscience and Cell Biology, University of Coimbra, Portugal 3 Department of Psychiatry, University of Cambridge, Cambridge, UK
    Brain 138:798-811. 2015
    ..Our results complement current models of symptom generation in obsessive-compulsive disorder and may enable the development of future therapeutic approaches that aim to alleviate this imbalance. ..
  51. pmc Increased ventral striatal volume in college-aged binge drinkers
    Nicholas A Howell
    Toronto Western Research Institute, Division of Brain Imaging and Behaviour Systems Neuroscience, Toronto Western Hospital, University Health Network, Toronto, Canada Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 8:e74164. 2013
    ..To address this, we compared the grey matter volumes of college-age binge drinkers and healthy controls, focusing on the ventral striatum, hippocampus and amygdala...
  52. ncbi request reprint Antidepressant treatment outcomes of psychogenic movement disorder
    Valerie Voon
    Department of Psychiatry, Toronto Western Hospital, Toronto, Ontario, Canada
    J Clin Psychiatry 66:1529-34. 2005
    ..Psychogenic movement disorder (PMD) is a subtype of conversion disorder. We describe the outcomes of a series of PMD patients following antidepressant treatment...
  53. ncbi request reprint Pharmacological characterization of psychosis-like behavior in the MPTP-lesioned nonhuman primate model of Parkinson's disease
    Naomi P Visanji
    Toronto Western Research Institute, Toronto Western Hospital, Toronto, Ontario, Canada
    Mov Disord 21:1879-91. 2006
    ..The response of different components of the psychotomimetic behavior suggested the involvement of both dopaminergic and nondopaminergic mechanisms in their expression...
  54. ncbi request reprint Psychiatric symptoms in patients with Parkinson disease presenting for deep brain stimulation surgery
    Valerie Voon
    Department of Psychiatry, Toronto Western Hospital, University Health Network, University of Toronto, Ontario, Canada
    J Neurosurg 103:246-51. 2005
    ..In the present study, preoperative psychiatric symptoms were systematically assessed in patients with PD presenting for routine preoperative psychiatric assessment...