- Basement membranes and human diseaseTom Van Agtmael
University of Glasgow, UK
Cell Tissue Res 339:167-88. 2010..Despite this, exciting progress has recently been made with potential treatment options for some of these so far incurable diseases...
- Col4a1 mutation in mice causes defects in vascular function and low blood pressure associated with reduced red blood cell volumeTom Van Agtmael
Faculty of Biomedical and Life Sciences, University of Glasgow, University Avenue, Glasgow G12 8QQ, UK
Hum Mol Genet 19:1119-28. 2010..In summary, our results indicate that mutations in COL4A1 result in a complex vascular phenotype encompassing defects in maintenance of vascular tone, endothelial cell function and blood pressure regulation...
- ER stress and basement membrane defects combine to cause glomerular and tubular renal disease resulting from Col4a1 mutations in miceFrances E Jones
Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK
Dis Model Mech 9:165-76. 2016..These data show that both basement membrane defects and ER stress contribute to Col4a1 renal disease, which has important implications for the development of treatment strategies for collagenopathies. ..