H A Van Den Berg

Summary

Affiliation: University of Warwick
Country: UK

Publications

  1. ncbi request reprint Optimal allocation of building blocks between nutrient uptake systems in a microbe
    Hugo A van den Berg
    Mathematics Institute, University of Warwick, Coventry, United Kingdom
    J Math Biol 44:276-96. 2002
  2. ncbi request reprint Specific T-cell activation in an unspecific T-cell repertoire
    Hugo A van den Berg
    Mathematics Institue, University of Warwick
    Sci Prog 94:245-64. 2011
  3. doi request reprint Homeostatic regulation in physiological systems: A versatile Ansatz
    Hugo A van den Berg
    University of Warwick, Coventry, CV4 7AL UK Electronic address
    Math Biosci 268:92-101. 2015
  4. doi request reprint Modulation of T-cell receptor functional sensitivity via the opposing actions of protein tyrosine kinases and phosphatases: a mathematical model
    Barbara Szomolay
    University of Warwick, Coventry CV4 7AL, UK
    Integr Biol (Camb) 6:1183-95. 2014
  5. ncbi request reprint How microbes can achieve balanced growth in a fluctuating environment
    H A Van Den Berg
    Mathematics Institute, University of Warwick, Coventry, United Kingdom
    Acta Biotheor 49:1-21. 2001
  6. ncbi request reprint Quantifying the strength of ligand antagonism in TCR triggering
    H A Van Den Berg
    Mathematics Institute, University of Warwick, Coventry CV4 7AL, U K
    Bull Math Biol 64:781-808. 2002
  7. ncbi request reprint Antigen presentation on MHC molecules as a diversity filter that enhances immune efficacy
    Hugo A van den Berg
    Mathematics Institute, University of Warwick, Coventry, CV4 7AL, UK
    J Theor Biol 224:249-67. 2003
  8. ncbi request reprint Dynamics of T cell activation threshold tuning
    Hugo A van den Berg
    Interdisciplinary Programme for Cellular Regulation Mathematics Institute, University of Warwick, Coventry CV4 7AL, UK
    J Theor Biol 228:397-416. 2004
  9. ncbi request reprint Expansion and contraction of the cytotoxic T lymphocyte response--an optimal control approach
    Hugo Antonius van den Berg
    Interdisciplinary Programme for Cellular Regulation, Mathematics Institute, University of Warwick, Coventry CV4 7AL, UK
    Bull Math Biol 66:1345-69. 2004
  10. ncbi request reprint Foreignness as a matter of degree: the relative immunogenicity of peptide/MHC ligands
    Hugo A van den Berg
    Interdisciplinary Programme for Cellular Regulation, Mathematics Institute, University of Warwick, Coventry CV4 7AL, UK
    J Theor Biol 231:535-48. 2004

Detail Information

Publications16

  1. ncbi request reprint Optimal allocation of building blocks between nutrient uptake systems in a microbe
    Hugo A van den Berg
    Mathematics Institute, University of Warwick, Coventry, United Kingdom
    J Math Biol 44:276-96. 2002
    ..We show that allocation converges rapidly to balanced growth under this control regime...
  2. ncbi request reprint Specific T-cell activation in an unspecific T-cell repertoire
    Hugo A van den Berg
    Mathematics Institue, University of Warwick
    Sci Prog 94:245-64. 2011
    ..This paradigm of continual modulation affords the TCR repertoire, despite its limited numerical diversity, the flexibility to respond to almost any antigenic challenge while avoiding autoimmunity...
  3. doi request reprint Homeostatic regulation in physiological systems: A versatile Ansatz
    Hugo A van den Berg
    University of Warwick, Coventry, CV4 7AL UK Electronic address
    Math Biosci 268:92-101. 2015
    ..We discuss the method in relation to optimal control theory as well as more conventional modelling approaches. ..
  4. doi request reprint Modulation of T-cell receptor functional sensitivity via the opposing actions of protein tyrosine kinases and phosphatases: a mathematical model
    Barbara Szomolay
    University of Warwick, Coventry CV4 7AL, UK
    Integr Biol (Camb) 6:1183-95. 2014
    ..Moreover, we propose that in vivo, the T-cell gauges ligand quality by monitoring changes in TCR triggering rate concomitant with shifts in this balance, for instance as the immunological synapse matures. ..
  5. ncbi request reprint How microbes can achieve balanced growth in a fluctuating environment
    H A Van Den Berg
    Mathematics Institute, University of Warwick, Coventry, United Kingdom
    Acta Biotheor 49:1-21. 2001
    ..Moreover, it is shown that a feedback mechanism, which monitors internal stores, is able to achieve this allocation...
  6. ncbi request reprint Quantifying the strength of ligand antagonism in TCR triggering
    H A Van Den Berg
    Mathematics Institute, University of Warwick, Coventry CV4 7AL, U K
    Bull Math Biol 64:781-808. 2002
    ..A method for experimental differentiation between passive and active antagonistic effects is proposed which exploits the differences between TCR and MHC limitation...
  7. ncbi request reprint Antigen presentation on MHC molecules as a diversity filter that enhances immune efficacy
    Hugo A van den Berg
    Mathematics Institute, University of Warwick, Coventry, CV4 7AL, UK
    J Theor Biol 224:249-67. 2003
    ..Thus we deduce that an important role of MHC presentation is to act as a filter that limits the diversity of antigen presentation...
  8. ncbi request reprint Dynamics of T cell activation threshold tuning
    Hugo A van den Berg
    Interdisciplinary Programme for Cellular Regulation Mathematics Institute, University of Warwick, Coventry CV4 7AL, UK
    J Theor Biol 228:397-416. 2004
    ..Our analysis indicates that central tolerance enhances the efficiency of peripheral tolerance, casting new light on the role of negative selection in the thymus...
  9. ncbi request reprint Expansion and contraction of the cytotoxic T lymphocyte response--an optimal control approach
    Hugo Antonius van den Berg
    Interdisciplinary Programme for Cellular Regulation, Mathematics Institute, University of Warwick, Coventry CV4 7AL, UK
    Bull Math Biol 66:1345-69. 2004
    ..Finally, we show that the stereotypical nature of CTL kinetics relies upon stringent regulation of the rates at which CTLs proliferate and die...
  10. ncbi request reprint Foreignness as a matter of degree: the relative immunogenicity of peptide/MHC ligands
    Hugo A van den Berg
    Interdisciplinary Programme for Cellular Regulation, Mathematics Institute, University of Warwick, Coventry CV4 7AL, UK
    J Theor Biol 231:535-48. 2004
    ..Our theory provides a quantitative tool to analyse the immunogenicity of tumour-associated neoantigens and the aetiology of autoimmune disease...
  11. ncbi request reprint Quantitative theories of T-cell responsiveness
    Hugo A van den Berg
    Warwick Systems Biology Centre, Mathematics Institute, University of Warwick, Coventry, UK
    Immunol Rev 216:81-92. 2007
    ..Theoretical models relate molecular kinetic parameters and cellular properties to systemic level statistics such as avidity spectra. Such bridge equations are crucial for rational clinical manipulation of T cells at the molecular level...
  12. ncbi request reprint Coreceptor CD8-driven modulation of T cell antigen receptor specificity
    Hugo A van den Berg
    Warwick Systems Biology Centre, Coventry House, University of Warwick, Coventry CV4 7AL, UK
    J Theor Biol 249:395-408. 2007
    ..The functional diversity of the TCR repertoire would therefore be greatly augmented by coreceptor-mediated ligand focussing...
  13. doi request reprint Eradication-resolution dynamics with stochastic flare-ups
    Hugo A van den Berg
    Mathematics Institute, University of Warwick, Coventry CV4 7AL, UK
    J Theor Biol 264:962-70. 2010
    ....
  14. ncbi request reprint A reliable and safe T cell repertoire based on low-affinity T cell receptors
    H A Van Den Berg
    Mathematics Institute, University of Warwick, Coventry CV4 7AL, UK
    J Theor Biol 209:465-86. 2001
    ..We introduce "activation curves" as a useful tool to study the repertoire's statistical activation properties...