William P Unsworth

Summary

Affiliation: University of York
Country: UK

Publications

  1. doi request reprint 'Upenamide: trials and tribulations
    William P Unsworth
    Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK
    Org Biomol Chem 11:7250-61. 2013
  2. doi request reprint Total synthesis of spirobacillene A
    William P Unsworth
    Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK
    Org Lett 15:3306-9. 2013
  3. doi request reprint An expedient protecting-group-free total synthesis of (±)-dievodiamine
    William P Unsworth
    Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK
    Org Lett 15:3302-5. 2013
  4. doi request reprint Direct imine acylation: synthesis of the proposed structures of 'upenamide
    William P Unsworth
    Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK
    Org Lett 15:262-5. 2013
  5. doi request reprint A one-pot C-H insertion/olefination sequence for the formation of α-alkylidene-γ-butyrolactones
    Matthew G Lloyd
    Department of Chemistry, University of York, Heslington, York, YO10 5DD, U K
    Org Lett 16:2772-5. 2014
  6. doi request reprint Direct imine acylation: rapid access to diverse heterocyclic scaffolds
    William P Unsworth
    Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK
    Org Lett 15:258-61. 2013
  7. doi request reprint Synthesis of Spirocyclic Indolenines
    Michael J James
    Department of Chemistry, University of York, York, YO10 5DD, UK
    Chemistry 22:2856-81. 2016
  8. doi request reprint Rhodium(II)-catalysed tandem aziridination and ring-opening: stereoselective synthesis of functionalised tetrahydrofurans
    William P Unsworth
    Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK
    Chem Commun (Camb) 50:11393-6. 2014
  9. doi request reprint A selective C-H insertion/olefination protocol for the synthesis of α-methylene-γ-butyrolactone natural products
    Matthew G Lloyd
    Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK
    Org Biomol Chem 14:1641-5. 2016
  10. doi request reprint Stereospecificity in the Au-catalysed cyclisation of monoallylic diols. Synthesis of (+)-isoaltholactone
    William P Unsworth
    Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK
    Chem Commun (Camb) 47:7659-61. 2011

Collaborators

  • Richard J K Taylor
  • Jeremy Robertson
  • Michael J James
  • Matthew G Lloyd
  • Peter O'Brien
  • Christiana Kitsiou
  • Jonathan D Osler
  • Mariantonietta D'Acunto
  • Eleanor K Daly
  • Hannah R Felstead
  • Paula Jackson
  • Rosa E Clubley
  • Kleopas Y Palate
  • Anthony C Wyton
  • Jordan J Hindes
  • Thomas C Wilson
  • Peter Hearnshaw
  • Phillip I'Anson
  • Thomas J Procter

Detail Information

Publications13

  1. doi request reprint 'Upenamide: trials and tribulations
    William P Unsworth
    Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK
    Org Biomol Chem 11:7250-61. 2013
    ..The evolution of the synthetic route and the development of associated methodologies are described. ..
  2. doi request reprint Total synthesis of spirobacillene A
    William P Unsworth
    Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK
    Org Lett 15:3306-9. 2013
    ..A Lewis acid mediated spirocyclization of an anisole derivative onto a tethered ynone was used as a key step, drawing inspiration from a potential biosynthesis of the natural product. ..
  3. doi request reprint An expedient protecting-group-free total synthesis of (±)-dievodiamine
    William P Unsworth
    Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK
    Org Lett 15:3302-5. 2013
    ..Key steps include organometallic addition into a DHED adduct and the Stille coupling of two advanced intermediates to complete the synthesis. ..
  4. doi request reprint Direct imine acylation: synthesis of the proposed structures of 'upenamide
    William P Unsworth
    Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK
    Org Lett 15:262-5. 2013
    ..The key step utilizes direct imine acylation (DIA) with a protected β-hydroxy acid to construct the key tricyclic ABC ring system. The macrocyclization was completed in the final step using a Stille cross-coupling reaction...
  5. doi request reprint A one-pot C-H insertion/olefination sequence for the formation of α-alkylidene-γ-butyrolactones
    Matthew G Lloyd
    Department of Chemistry, University of York, Heslington, York, YO10 5DD, U K
    Org Lett 16:2772-5. 2014
    ..The utility of the process is demonstrated by the synthesis of a known Staphylococcus aureus (MRSA) virulence inhibitor. ..
  6. doi request reprint Direct imine acylation: rapid access to diverse heterocyclic scaffolds
    William P Unsworth
    Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK
    Org Lett 15:258-61. 2013
    ..Preliminary mechanistic studies, using ReactIR, are also reported...
  7. doi request reprint Synthesis of Spirocyclic Indolenines
    Michael J James
    Department of Chemistry, University of York, York, YO10 5DD, UK
    Chemistry 22:2856-81. 2016
    ..The historical background, common synthetic challenges, current state-of-the-art and future perspectives of this field are examined. ..
  8. doi request reprint Rhodium(II)-catalysed tandem aziridination and ring-opening: stereoselective synthesis of functionalised tetrahydrofurans
    William P Unsworth
    Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK
    Chem Commun (Camb) 50:11393-6. 2014
    ..Aziridines formed upon treatment of allylic carbamates and homoallylic sulfamates with Rh(II) carboxylate catalysts under oxidative conditions are trapped by suitably-disposed hydroxyl groups to give functionalised tetrahydrofurans...
  9. doi request reprint A selective C-H insertion/olefination protocol for the synthesis of α-methylene-γ-butyrolactone natural products
    Matthew G Lloyd
    Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK
    Org Biomol Chem 14:1641-5. 2016
    ..The method has been successfully applied in the total synthesis of eudesmanolide natural product frameworks, including α-cyclocostunolide. ..
  10. doi request reprint Stereospecificity in the Au-catalysed cyclisation of monoallylic diols. Synthesis of (+)-isoaltholactone
    William P Unsworth
    Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK
    Chem Commun (Camb) 47:7659-61. 2011
    ..Analogous cyclisations show that the stereochemical outcome is dictated by the stereochemistry of the diol substrate...
  11. doi request reprint Silver(I)-Catalyzed Dearomatization of Alkyne-Tethered Indoles: Divergent Synthesis of Spirocyclic Indolenines and Carbazoles
    Michael J James
    Department of Chemistry, University of York, Heslington, York, YO10 5DD, U K
    Org Lett 17:4372-5. 2015
    ..Either product can be obtained upon treatment with different Ag(I) catalysts at rt. An unexpected hydration reaction to afford (±)-actinopolymorphol B is also reported. ..
  12. doi request reprint The Synthesis of Structurally Diverse Macrocycles By Successive Ring Expansion
    Christiana Kitsiou
    University of York, York, YO24 4PP UK
    Angew Chem Int Ed Engl 54:15794-8. 2015
    ....
  13. doi request reprint The Cope rearrangement of gem-dimethyl substituted divinylcyclopropanes
    Jonathan D Osler
    Department of Chemistry, University of York, York, YO10 5DD, UK
    Org Biomol Chem 11:7587-94. 2013
    ....