Timothy J Underwood

Summary

Affiliation: University of Southampton
Country: UK

Publications

  1. pmc The Development, Application and Analysis of an Enhanced Recovery Programme for Major Oesophagogastric Resection
    Timothy J Underwood
    Department of Surgery, University Hospital Southampton, Tremona Road, Southampton, Hampshire, SO16 6YD, UK
    J Gastrointest Surg . 2017
  2. pmc Perforated diverticulitis presenting as necrotising fasciitis of the leg
    Timothy J Underwood
    Poole Hospital NHS Foundation Trust, Longfleet Road, Poole, BH15 2JB, UK
    World J Emerg Surg 3:10. 2008
  3. doi request reprint A comparison of primary oesophageal squamous epithelial cells with HET-1A in organotypic culture
    Timothy J Underwood
    Cancer Sciences Division, University of Southampton, Somers Cancer Research Building, MP824, Southampton General Hospital, Southampton SO16 6YD, UK
    Biol Cell 102:635-44. 2010
  4. pmc The relevance of the Siewert classification in the era of multimodal therapy for adenocarcinoma of the gastro-oesophageal junction
    Nathan J Curtis
    Department of Surgery, University Hospital Southampton NHS Foundation Trust, Southampton, Hampshire, UK Cancer Sciences Unit, Faculty of Medicine, University of Southampton, University Hospital Southampton NHS Foundation Trust, Southampton, UK
    J Surg Oncol 109:202-7. 2014
  5. doi request reprint The role of systemic inflammatory and nutritional blood-borne markers in predicting response to neoadjuvant chemotherapy and survival in oesophagogastric cancer
    Fergus Noble
    Department of Surgery, University Hospital Southampton NHS Foundation Trust, Tremona Road, Southampton, Hampshire, SO16 6YD, UK
    Med Oncol 30:596. 2013
  6. pmc Tumour infiltrating lymphocytes correlate with improved survival in patients with oesophageal adenocarcinoma
    Fergus Noble
    Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Somers Cancer Research Building MP824, Southampton General Hospital, Tremona Road, Southampton, UK
    Cancer Immunol Immunother 65:651-62. 2016
  7. pmc Induction of fibroblast senescence generates a non-fibrogenic myofibroblast phenotype that differentially impacts on cancer prognosis
    Massimiliano Mellone
    Cancer Sciences Unit, Faculty of Medicine, University of Southampton, SO166YD, UK
    Aging (Albany NY) . 2016
  8. doi request reprint Risk assessment using a novel score to predict anastomotic leak and major complications after oesophageal resection
    Fergus Noble
    Department of Surgery, University Hospital Southampton NHS Foundation Trust, Tremona Road, Southampton, Hampshire, SO16 6YD, United Kingdom
    J Gastrointest Surg 16:1083-95. 2012
  9. pmc Authentication and characterisation of a new oesophageal adenocarcinoma cell line: MFD-1
    Edwin Garcia
    Faculty of Medicine, University of Southampton, Southampton General Hospital, Mailpoint 801, South Academic Block, Tremona Road, Southampton, SO16 6YD, United Kingdom
    Sci Rep 6:32417. 2016
  10. pmc Cancer-associated fibroblasts predict poor outcome and promote periostin-dependent invasion in oesophageal adenocarcinoma
    Timothy J Underwood
    Cancer Sciences Unit, Somers Cancer Research Building, University of Southampton, UK
    J Pathol 235:466-77. 2015

Collaborators

  • Adrian C Bateman
  • Peter A Brennan
  • Jesus Gil
  • Rebecca C Fitzgerald
  • J J Kelly
  • F Noble
  • Eric Smith
  • Edwin Garcia
  • Massimiliano Mellone
  • Gareth J Thomas
  • Nathan J Curtis
  • Christopher Woelk
  • Edward Britton
  • Nicol├ís Herranz
  • Clarisa Choh
  • Christopher J Hanley
  • Jonathan C Strefford
  • Toby Mellows
  • Daniel W Lambert
  • Michael J White
  • Mathieu Derouet
  • Andrew Cowie
  • Matthew Rose-Zerilli
  • Karwan A Moutasim
  • Yeng Ang
  • Annette Hayden
  • James Clarke
  • Stephen S Prime
  • Charles Birts
  • Steve Thirdborough
  • Karen Pickard
  • John N Primrose
  • Giulia Venturi
  • Kirsty Ford
  • Patrick Duriez
  • Christian H Ottensmeier
  • Tasnuva D Kabir
  • Steve Frampton
  • Emma V King
  • Joanne Tod
  • Jeongmin Woo
  • Kevin W Eliceiri
  • Pandurangan Vijayanand
  • Andrew D Sharrocks
  • Veronika Jenei
  • Kue Peng Lim
  • James P Byrne
  • Ian S Bailey

Detail Information

Publications10

  1. pmc The Development, Application and Analysis of an Enhanced Recovery Programme for Major Oesophagogastric Resection
    Timothy J Underwood
    Department of Surgery, University Hospital Southampton, Tremona Road, Southampton, Hampshire, SO16 6YD, UK
    J Gastrointest Surg . 2017
    ..The aim of this study was to compare short-term outcomes for patients undergoing oesophagogastric surgery in an enhanced recovery programme (EROS)...
  2. pmc Perforated diverticulitis presenting as necrotising fasciitis of the leg
    Timothy J Underwood
    Poole Hospital NHS Foundation Trust, Longfleet Road, Poole, BH15 2JB, UK
    World J Emerg Surg 3:10. 2008
    ..We describe for the first time, to our knowledge, a case of retroperitoneal diverticula perforation presenting as necrotising fasciitis of the leg necessitating hind-quarter amputation...
  3. doi request reprint A comparison of primary oesophageal squamous epithelial cells with HET-1A in organotypic culture
    Timothy J Underwood
    Cancer Sciences Division, University of Southampton, Somers Cancer Research Building, MP824, Southampton General Hospital, Southampton SO16 6YD, UK
    Biol Cell 102:635-44. 2010
    ....
  4. pmc The relevance of the Siewert classification in the era of multimodal therapy for adenocarcinoma of the gastro-oesophageal junction
    Nathan J Curtis
    Department of Surgery, University Hospital Southampton NHS Foundation Trust, Southampton, Hampshire, UK Cancer Sciences Unit, Faculty of Medicine, University of Southampton, University Hospital Southampton NHS Foundation Trust, Southampton, UK
    J Surg Oncol 109:202-7. 2014
    ....
  5. doi request reprint The role of systemic inflammatory and nutritional blood-borne markers in predicting response to neoadjuvant chemotherapy and survival in oesophagogastric cancer
    Fergus Noble
    Department of Surgery, University Hospital Southampton NHS Foundation Trust, Tremona Road, Southampton, Hampshire, SO16 6YD, UK
    Med Oncol 30:596. 2013
    ..Prospective studies evaluating the role of immunonutritional modulation to improve response to chemotherapy and long-term outcome are required...
  6. pmc Tumour infiltrating lymphocytes correlate with improved survival in patients with oesophageal adenocarcinoma
    Fergus Noble
    Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Somers Cancer Research Building MP824, Southampton General Hospital, Tremona Road, Southampton, UK
    Cancer Immunol Immunother 65:651-62. 2016
    ..The ability of lymphocytes to recognise tumour antigens provides a mechanism for a host immune attack against cancer providing a potential treatment strategy...
  7. pmc Induction of fibroblast senescence generates a non-fibrogenic myofibroblast phenotype that differentially impacts on cancer prognosis
    Massimiliano Mellone
    Cancer Sciences Unit, Faculty of Medicine, University of Southampton, SO166YD, UK
    Aging (Albany NY) . 2016
    ..These results show that non-fibrogenic, SMA-positive myofibroblasts can be directly generated through induction of fibroblast senescence and suggest that senescence and myofibroblast differentiation are closely linked processes...
  8. doi request reprint Risk assessment using a novel score to predict anastomotic leak and major complications after oesophageal resection
    Fergus Noble
    Department of Surgery, University Hospital Southampton NHS Foundation Trust, Tremona Road, Southampton, Hampshire, SO16 6YD, United Kingdom
    J Gastrointest Surg 16:1083-95. 2012
    ..Oesophagectomy is associated with significant morbidity and mortality. A simple score to define a patient's risk of developing major complications would be beneficial...
  9. pmc Authentication and characterisation of a new oesophageal adenocarcinoma cell line: MFD-1
    Edwin Garcia
    Faculty of Medicine, University of Southampton, Southampton General Hospital, Mailpoint 801, South Academic Block, Tremona Road, Southampton, SO16 6YD, United Kingdom
    Sci Rep 6:32417. 2016
    ..We have described the first such system to arise from the oesophageal International Cancer Genome Consortium project. ..
  10. pmc Cancer-associated fibroblasts predict poor outcome and promote periostin-dependent invasion in oesophageal adenocarcinoma
    Timothy J Underwood
    Cancer Sciences Unit, Somers Cancer Research Building, University of Southampton, UK
    J Pathol 235:466-77. 2015
    ..Most EACs contain a myofibroblastic CAF-rich stroma; this may explain the aggressive, highly infiltrative nature of the disease, and suggests that stromal targeting may produce therapeutic benefit in EAC patients...