Martin R Turner

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi request reprint Motor neuron disease: biomarker development for an expanding cerebral syndrome
    Martin R Turner
    Medical Research Council Senior Clinical Fellow, Nuffield Department of Clinical Neurosciences, University of Oxford, UK
    Clin Med (Lond) 16:s60-s65. 2016
  2. pmc What does imaging reveal about the pathology of amyotrophic lateral sclerosis?
    Martin R Turner
    Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK
    Curr Neurol Neurosci Rep 15:45. 2015
  3. pmc Multiple kernel learning captures a systems-level functional connectivity biomarker signature in amyotrophic lateral sclerosis
    Tomer Fekete
    Department of Biomedical Engineering, Stony Brook University, New York, New York, United States of America
    PLoS ONE 8:e85190. 2013
  4. pmc Progressive hemiparesis (Mills syndrome) with aphasia in amyotrophic lateral sclerosis
    Dirk Bäumer
    From Oxford University, John Radcliffe Hospital D B, R A L M, K T, M H, M R T Milton Keynes Hospital NHS Trust R B, Buckinghamshire and Oxford University, Warneford Hospital R A L M, UK
    Neurology 82:457-8. 2014
  5. pmc Myelin imaging in amyotrophic and primary lateral sclerosis
    Shannon Kolind
    Centre for Functional Magnetic Resonance Imaging of the Brain FMRIB, University of Oxford
    Amyotroph Lateral Scler Frontotemporal Degener 14:562-73. 2013
  6. pmc Mimics and chameleons in motor neurone disease
    Martin R Turner
    University of Oxford Nuffield Department of Clinical Neurosciences, Oxford, UK
    Pract Neurol 13:153-64. 2013
  7. pmc Mechanisms, models and biomarkers in amyotrophic lateral sclerosis
    Martin R Turner
    Nuffield Department of Clinical Neurosciences, University of Oxford, UK
    Amyotroph Lateral Scler Frontotemporal Degener 14:19-32. 2013
  8. doi request reprint Neuroimaging in amyotrophic lateral sclerosis
    Martin R Turner
    Nuffield Department of Clinical Neurosciences, Oxford University, UK
    Biomark Med 6:319-37. 2012
  9. doi request reprint Cardiovascular fitness as a risk factor for amyotrophic lateral sclerosis: indirect evidence from record linkage study
    Martin R Turner
    Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK
    J Neurol Neurosurg Psychiatry 83:395-8. 2012
  10. pmc Increased functional connectivity common to symptomatic amyotrophic lateral sclerosis and those at genetic risk
    Ricarda A L Menke
    Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK FMRIB Centre, John Radcliffe Hospital, University of Oxford, Oxford, UK
    J Neurol Neurosurg Psychiatry 87:580-8. 2016

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Motor neuron disease: biomarker development for an expanding cerebral syndrome
    Martin R Turner
    Medical Research Council Senior Clinical Fellow, Nuffield Department of Clinical Neurosciences, University of Oxford, UK
    Clin Med (Lond) 16:s60-s65. 2016
    ..With new genetic causes, most notably a hexanucleotide expansion in C9orf72 associated with both MND and FTD, the development of biomarkers against which to test therapeutic candidates is a priority...
  2. pmc What does imaging reveal about the pathology of amyotrophic lateral sclerosis?
    Martin R Turner
    Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK
    Curr Neurol Neurosci Rep 15:45. 2015
    ..Studies are being extended to the spinal cord, and the application of neuroimaging to unaffected carriers of highly penetrant genetic mutations linked to the development of ALS offers a unique window to the pre-symptomatic landscape. ..
  3. pmc Multiple kernel learning captures a systems-level functional connectivity biomarker signature in amyotrophic lateral sclerosis
    Tomer Fekete
    Department of Biomedical Engineering, Stony Brook University, New York, New York, United States of America
    PLoS ONE 8:e85190. 2013
    ..As the understanding of neurodegenerative disorders moves towards studying pre-symptomatic changes, there is potential for this type of approach to generate biomarkers for the testing of neuroprotective strategies. ..
  4. pmc Progressive hemiparesis (Mills syndrome) with aphasia in amyotrophic lateral sclerosis
    Dirk Bäumer
    From Oxford University, John Radcliffe Hospital D B, R A L M, K T, M H, M R T Milton Keynes Hospital NHS Trust R B, Buckinghamshire and Oxford University, Warneford Hospital R A L M, UK
    Neurology 82:457-8. 2014
    ..Frank FTD is seen in up to 15% of patients with ALS, in whom it typically occurs before or soon after the development of motor symptoms, and is associated with a more rapid disease progression.(3.) ..
  5. pmc Myelin imaging in amyotrophic and primary lateral sclerosis
    Shannon Kolind
    Centre for Functional Magnetic Resonance Imaging of the Brain FMRIB, University of Oxford
    Amyotroph Lateral Scler Frontotemporal Degener 14:562-73. 2013
    ..PLS may be a more active cerebral pathological process than its rate of clinical deterioration suggests...
  6. pmc Mimics and chameleons in motor neurone disease
    Martin R Turner
    University of Oxford Nuffield Department of Clinical Neurosciences, Oxford, UK
    Pract Neurol 13:153-64. 2013
    ....
  7. pmc Mechanisms, models and biomarkers in amyotrophic lateral sclerosis
    Martin R Turner
    Nuffield Department of Clinical Neurosciences, University of Oxford, UK
    Amyotroph Lateral Scler Frontotemporal Degener 14:19-32. 2013
    ....
  8. doi request reprint Neuroimaging in amyotrophic lateral sclerosis
    Martin R Turner
    Nuffield Department of Clinical Neurosciences, Oxford University, UK
    Biomark Med 6:319-37. 2012
    ..This comprehensive review considers the full range of neuroimaging techniques applied to amyotrophic lateral sclerosis over the last 25 years, the biomarkers they have revealed and future developments...
  9. doi request reprint Cardiovascular fitness as a risk factor for amyotrophic lateral sclerosis: indirect evidence from record linkage study
    Martin R Turner
    Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK
    J Neurol Neurosurg Psychiatry 83:395-8. 2012
    ..Hospital admission for coronary heart disease (CHD) might serve as an objective marker of reduced cardiovascular fitness...
  10. pmc Increased functional connectivity common to symptomatic amyotrophic lateral sclerosis and those at genetic risk
    Ricarda A L Menke
    Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK FMRIB Centre, John Radcliffe Hospital, University of Oxford, Oxford, UK
    J Neurol Neurosurg Psychiatry 87:580-8. 2016
    ..To discern presymptomatic changes in brain structure or function using advanced MRI in carriers of mutations predisposing to amyotrophic lateral sclerosis (ALS)...
  11. pmc Autoimmune disease preceding amyotrophic lateral sclerosis: an epidemiologic study
    Martin R Turner
    From the Oxford University Nuffield Department of Clinical Neurosciences M R T, K T, John Radcliffe Hospital Oxford University Unit of Health Care Epidemiology R G, M J G, Department of Public Health and Oxford University Department of Physiology, Anatomy and Genetics S R, Oxford, UK
    Neurology 81:1222-5. 2013
    ..To study whether the risk of amyotrophic lateral sclerosis (ALS) is increased in people with prior autoimmune disease...
  12. pmc Eye-tracking in amyotrophic lateral sclerosis: A longitudinal study of saccadic and cognitive tasks
    Malcolm Proudfoot
    a Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK
    Amyotroph Lateral Scler Frontotemporal Degener 17:101-11. 2015
    ..PLS patients may have more cortical dysfunction than has been previously appreciated. ..
  13. pmc T₂-weighted MRI detects presymptomatic pathology in the SOD1 mouse model of ALS
    Matthew C Evans
    1 Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK 2 CR UK MRC Gray Institute for Radiation Oncology and Biology, Department of Oncology, University of Oxford, Oxford, UK
    J Cereb Blood Flow Metab 34:785-93. 2014
    ....
  14. doi request reprint Biomarkers in amyotrophic lateral sclerosis
    Martin R Turner
    Department of Clinical Neurology, University of Oxford, Oxford, UK
    Lancet Neurol 8:94-109. 2009
    ..Such biomarkers might also resolve complexities of phenotypic heterogeneity in clinical trials. In this Review, we discuss the development of biomarkers in ALS and consider potential future directions for research...
  15. pmc Pattern of spread and prognosis in lower limb-onset ALS
    Martin R Turner
    Oxford University Department of Clinical Neurology, Oxford, UK
    Amyotroph Lateral Scler 11:369-73. 2010
    ..The time interval to this initial spread is a powerful factor in predicting overall survival, and could be used to facilitate decision-making and effective care planning...
  16. doi request reprint Young-onset amyotrophic lateral sclerosis: historical and other observations
    Martin R Turner
    Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK
    Brain 135:2883-91. 2012
    ..The timing of initiating pathological processes in relation to the emergence of symptoms is discussed, including the potential role of very early development and the interaction of epigenetic and environmental factors...
  17. pmc Widespread grey matter pathology dominates the longitudinal cerebral MRI and clinical landscape of amyotrophic lateral sclerosis
    Ricarda A L Menke
    1 Oxford Centre for Functional Magnetic Resonance of the Brain, University of Oxford, UK2 Nuffield Department of Clinical Neurosciences, University of Oxford, UK
    Brain 137:2546-55. 2014
    ..Amyotrophic lateral sclerosis may be characterized initially by a predominantly white matter tract pathological signature, evolving as a widespread cortical network degeneration...
  18. pmc CNS-targeted glucocorticoid reduces pathology in mouse model of amyotrophic lateral sclerosis
    Matthew C Evans
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
    Acta Neuropathol Commun 2:66. 2014
    ..At the end of the experimental period (116 days) mice were imaged using T2-weighted MRI for brainstem pathology; brain and spinal cord tissue were then collected for histological analysis...
  19. doi request reprint Oculomotor dysfunction in amyotrophic lateral sclerosis: a comprehensive review
    Rakesh Sharma
    Oxford University Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, United Kingdom
    Arch Neurol 68:857-61. 2011
    ..The study of oculomotor dysfunction holds significant promise as an additional source of much needed prognostic, monitoring, and mechanistic biomarkers for ALS...
  20. pmc Advances in motor neurone disease
    Dirk Bäumer
    Nuffield Department of Clinical Neurosciences, Oxford University, John Radcliffe Hospital, Oxford OX3 9DU, UK
    J R Soc Med 107:14-21. 2014
    ..A major gap remains in understanding how such fundamental processes appear to function without obvious deficit in the decades prior to symptom emergence, and the study of pre-symptomatic gene carriers is an important new initiative. ..
  21. doi request reprint Epilepsy and the subsequent risk of cerebral tumour: record linkage retrospective cohort study
    Tasneem Khan
    University of Oxford Medical School, John Radcliffe Hospital, Oxford, UK
    J Neurol Neurosurg Psychiatry 82:1041-5. 2011
    ..Studies suggest that seizures may precede the detection of cerebral tumour by several years. Aim To quantify the risk of cerebral tumour after new onset seizures, with particular interest in long term risk...
  22. doi request reprint Trends in death certification for multiple sclerosis, motor neuron disease, Parkinson's disease and epilepsy in English populations 1979-2006
    Michael J Goldacre
    Unit of Health Care Epidemiology, Department of Public Health, University of Oxford, Old Road Campus, Oxford OX3 7LF, UK
    J Neurol 257:706-15. 2010
    ..A substantial percentage of neurological deaths are missed. Time trends may be misleading. All certified causes for each disease, as well as the underlying cause, should be analysed...
  23. doi request reprint Head and other physical trauma requiring hospitalisation is not a significant risk factor in the development of ALS
    Martin R Turner
    Oxford University Department of Clinical Neurology, John Radcliffe Hospital, Oxford, OX3 9DU, UK
    J Neurol Sci 288:45-8. 2010
    ..The high risk of head injury observed in the immediate post-diagnosis period may be amenable to primary prevention...
  24. pmc Whole-brain magnetic resonance spectroscopic imaging measures are related to disability in ALS
    Charlotte J Stagg
    Centre for Functional Magnetic Resonance of the Brain, University of Oxford, UK
    Neurology 80:610-5. 2013
    ....
  25. doi request reprint Extracellular vesicles in neurodegenerative disease - pathogenesis to biomarkers
    Alexander G Thompson
    Nuffield Department of Clinical Neurosciences, University of Oxford, Level 6, West Wing, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Nat Rev Neurol 12:346-57. 2016
    ..This Review examines the current knowledge of the biology and function of EVs, discusses the evidence for their involvement in the pathogenesis of neurodegenerative diseases, and considers their potential as biomarkers of disease. ..
  26. pmc Altered cortical beta-band oscillations reflect motor system degeneration in amyotrophic lateral sclerosis
    Malcolm Proudfoot
    Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom
    Hum Brain Mapp 38:237-254. 2017
    ..Hum Brain Mapp 38:237-254, 2017. © 2016 Wiley Periodicals, Inc...
  27. pmc Cerebrovascular injury as a risk factor for amyotrophic lateral sclerosis
    Martin R Turner
    Nuffield Department of Clinical Neurosciences, Oxford University, John Radcliffe Hospital, Oxford, UK
    J Neurol Neurosurg Psychiatry 87:244-6. 2016
    ..To use an unbiased method to test a previously reported association between cerebral arteriovenous malformation (AVM) embolisation and the subsequent development of amyotrophic lateral sclerosis (ALS)...
  28. doi request reprint Does interneuronal dysfunction contribute to neurodegeneration in amyotrophic lateral sclerosis?
    Martin R Turner
    Oxford University Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK
    Amyotroph Lateral Scler 13:245-50. 2012
    ..An excitotoxic final common pathway might then result from unopposed glutamatergic activity. If correct, therapies aimed specifically at supporting interneuronal function may provide a novel therapeutic strategy...
  29. doi request reprint Magnetic resonance imaging of pathological processes in rodent models of amyotrophic lateral sclerosis
    Matthew C Evans
    Oxford University Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK
    Amyotroph Lateral Scler 13:288-301. 2012
    ..These are potentially important steps towards the ultimate goal of human therapeutic translation...
  30. pmc Lockhart Clarke's contribution to the description of amyotrophic lateral sclerosis
    Martin R Turner
    Department of Clinical Neurology, West Wing Level 3, John Radcliffe Hospital, Oxford University, Oxford OX3 9DU, UK
    Brain 133:3470-9. 2010
    ..These 'past masters' still have much to teach us...
  31. doi request reprint The diagnostic pathway and prognosis in bulbar-onset amyotrophic lateral sclerosis
    Martin R Turner
    Oxford University Department of Clinical Neurology, John Radcliffe Hospital, Oxford, UK
    J Neurol Sci 294:81-5. 2010
    ..Diagnostic delay is a common occurrence in ALS, and many BO patients report having attended other specialist clinics prior to diagnosis...
  32. pmc Neuroimaging Endpoints in Amyotrophic Lateral Sclerosis
    Ricarda A L Menke
    Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK
    Neurotherapeutics 14:11-23. 2017
    ..Further multicenter research is now needed to establish their validity as therapeutic outcome measures...
  33. doi request reprint A risk stratifying tool to facilitate safe late-stage percutaneous endoscopic gastrostomy in ALS
    Alexander G Thompson
    a Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK
    Amyotroph Lateral Scler Frontotemporal Degener . 2017
    ..The safety of percutaneous endoscopic gastrostomy (PEG) insertion in amyotrophic lateral sclerosis (ALS) patients with significant respiratory compromise has been questioned...
  34. pmc The longitudinal cerebrospinal fluid metabolomic profile of amyotrophic lateral sclerosis
    Elizabeth Gray
    a Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford, UK
    Amyotroph Lateral Scler Frontotemporal Degener 16:456-63. 2015
    ..Endogenous ethanol in the CSF may be an unrecognized novel marker of neuronal tissue injury in ALS. ..
  35. pmc Controversies and priorities in amyotrophic lateral sclerosis
    Martin R Turner
    Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK
    Lancet Neurol 12:310-22. 2013
    ....
  36. doi request reprint Integration of structural and functional magnetic resonance imaging in amyotrophic lateral sclerosis
    Gwenaelle Douaud
    Oxford Centre for Functional Magnetic Resonance of the Brain FMRIB, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK
    Brain 134:3470-9. 2011
    ....
  37. doi request reprint The borderland of neuromyelitis optica
    Lucy A E Matthews
    Specialist Registrar in Neurology, Department of Clinical Neurology, John Radcliffe Hospital, Oxford, UK
    Pract Neurol 9:335-40. 2009
    ..We describe two cases of optic neuritis-only NMO, and explore the current understanding of the diagnosis and spectrum of NMO disorders...
  38. pmc The expanding syndrome of amyotrophic lateral sclerosis: a clinical and molecular odyssey
    Martin R Turner
    Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK
    J Neurol Neurosurg Psychiatry 86:667-73. 2015
    ..Nonetheless, there is a common clinical core to ALS, as clear today as it was to Charcot and others. We stress the continuing relevance of clinical observations amid the increasing molecular complexity of ALS. ..
  39. pmc Ensuring continued progress in biomarkers for amyotrophic lateral sclerosis
    Martin R Turner
    Oxford University, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, West Wing Level 3, Oxford, OX3 9DU, UK
    Muscle Nerve 51:14-8. 2015
    ..Appropriate application of multimodal approaches, international collaboration, presymptomatic studies, and biomarker integration into future therapeutic trials are among the essential priorities going forward...
  40. pmc An eye-tracking version of the trail-making test
    Stephen L Hicks
    Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom
    PLoS ONE 8:e84061. 2013
    ..There was good correlation for speed between both versions of Part B (R(2)=0.73), suggesting that this is a viable method to objectively assess cognitive impairment in disorders where patients are unable to speak or write. ..
  41. doi request reprint Cancer in patients with motor neuron disease, multiple sclerosis and Parkinson's disease: record linkage studies
    Alessandro F Fois
    Unit of Health Care Epidemiology, Department of Public Health, University of Oxford, Old Road Campus, Old Road, Oxford, UK
    J Neurol Neurosurg Psychiatry 81:215-21. 2010
    ..To determine the risk of cancer before and after the diagnosis of motor neuron disease (MND), multiple sclerosis (MS) and Parkinson's disease (PD)...
  42. pmc The internet for self-diagnosis and prognostication in ALS
    Zhongbo Chen
    Oxford University Medical School, John Radcliffe Hospital, Oxford, UK
    Amyotroph Lateral Scler 11:565-7. 2010
    ..Results in relation to 'cure' were misleading and may promulgate false hopes. There is a need to guide those with ALS (and particularly their children) to sources of reliable web-based information in addition to open discussion...
  43. doi request reprint Functional vitamin B12 deficiency
    Martin R Turner
    Department of Neurology, John Radcliffe Hospital, University of Oxford, Oxford, UK
    Pract Neurol 9:37-41. 2009
    ..Such patients may respond to repeated high-dose injections of B12...
  44. ncbi request reprint Volumetric cortical loss in sporadic and familial amyotrophic lateral sclerosis
    Martin R Turner
    Department of Neurology, John Radcliffe Hospital, Oxford, UK
    Amyotroph Lateral Scler 8:343-7. 2007
    ..This study provides further evidence for a different pattern of cortical neuronal vulnerability in homD90A versus SALS patients that may provide insight as to their slower rate of disease progression...
  45. ncbi request reprint A case of celiac disease mimicking amyotrophic lateral sclerosis
    Martin R Turner
    Department of Neurology, John Radcliffe Hospital, Oxford, UK
    Nat Clin Pract Neurol 3:581-4. 2007
    ..The thigh muscle in the affected leg showed signs of wasting. The patient had a remote family history of celiac disease...