Barbara Trülzsch

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi request reprint Survival of motor neuron gene downregulation by RNAi: towards a cell culture model of spinal muscular atrophy
    Barbara Trülzsch
    Department of Human Anatomy and Genetics, Oxford University, South Parks Rd, Oxford OX1 3QX, UK
    Brain Res Mol Brain Res 120:145-50. 2004
  2. ncbi request reprint Neuromuscular defects in a Drosophila survival motor neuron gene mutant
    Yick Bun Chan
    MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
    Hum Mol Genet 12:1367-76. 2003
  3. ncbi request reprint Ribozymes and siRNA for the treatment of diseases of the nervous system
    Matthew J Wood
    Department of Human Anatomy and Genetics, Oxford University, South Parks Road, Oxford, OX1 3QX, UK
    Curr Opin Mol Ther 5:383-8. 2003
  4. ncbi request reprint Applications of nucleic acid technology in the CNS
    Barbara Trülzsch
    Department of Human Anatomy and Genetics, South Parks Road, Oxford, UK
    J Neurochem 88:257-65. 2004
  5. ncbi request reprint Therapeutic gene silencing in the nervous system
    Matthew J A Wood
    Department of Human Anatomy and Genetics, Oxford University, Oxford, UK
    Hum Mol Genet 12:R279-84. 2003

Collaborators

Detail Information

Publications5

  1. ncbi request reprint Survival of motor neuron gene downregulation by RNAi: towards a cell culture model of spinal muscular atrophy
    Barbara Trülzsch
    Department of Human Anatomy and Genetics, Oxford University, South Parks Rd, Oxford OX1 3QX, UK
    Brain Res Mol Brain Res 120:145-50. 2004
    ..These results illustrate that double-stranded RNA can be an effective gene silencing approach even in a protein that is essential for survival and highly expressed, and it could therefore be a valuable tool to study SMN function...
  2. ncbi request reprint Neuromuscular defects in a Drosophila survival motor neuron gene mutant
    Yick Bun Chan
    MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
    Hum Mol Genet 12:1367-76. 2003
    ..This new Drosophila model for SMA thus proposes a functional role for SMN at the neuromuscular junction in the generation of neuromuscular defects...
  3. ncbi request reprint Ribozymes and siRNA for the treatment of diseases of the nervous system
    Matthew J Wood
    Department of Human Anatomy and Genetics, Oxford University, South Parks Road, Oxford, OX1 3QX, UK
    Curr Opin Mol Ther 5:383-8. 2003
    ..This review will assess the potential of these RNA-based therapeutic strategies and the challenges ahead in their application to the treatment of neurological disease...
  4. ncbi request reprint Applications of nucleic acid technology in the CNS
    Barbara Trülzsch
    Department of Human Anatomy and Genetics, South Parks Road, Oxford, UK
    J Neurochem 88:257-65. 2004
    ..Recent advances in chemical modifications and delivery techniques are summarized. Applications in the CNS, including their use in primary neuronal cells, organotypic slice culture and the brain in vivo are further discussed...
  5. ncbi request reprint Therapeutic gene silencing in the nervous system
    Matthew J A Wood
    Department of Human Anatomy and Genetics, Oxford University, Oxford, UK
    Hum Mol Genet 12:R279-84. 2003
    ....