Affiliation: University of Oxford
- Survival of motor neuron gene downregulation by RNAi: towards a cell culture model of spinal muscular atrophyBarbara Trülzsch
Department of Human Anatomy and Genetics, Oxford University, South Parks Rd, Oxford OX1 3QX, UK
Brain Res Mol Brain Res 120:145-50. 2004..These results illustrate that double-stranded RNA can be an effective gene silencing approach even in a protein that is essential for survival and highly expressed, and it could therefore be a valuable tool to study SMN function...
- Neuromuscular defects in a Drosophila survival motor neuron gene mutantYick Bun Chan
MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
Hum Mol Genet 12:1367-76. 2003..This new Drosophila model for SMA thus proposes a functional role for SMN at the neuromuscular junction in the generation of neuromuscular defects...
- Ribozymes and siRNA for the treatment of diseases of the nervous systemMatthew J Wood
Department of Human Anatomy and Genetics, Oxford University, South Parks Road, Oxford, OX1 3QX, UK
Curr Opin Mol Ther 5:383-8. 2003..This review will assess the potential of these RNA-based therapeutic strategies and the challenges ahead in their application to the treatment of neurological disease...
- Applications of nucleic acid technology in the CNSBarbara Trülzsch
Department of Human Anatomy and Genetics, South Parks Road, Oxford, UK
J Neurochem 88:257-65. 2004..Recent advances in chemical modifications and delivery techniques are summarized. Applications in the CNS, including their use in primary neuronal cells, organotypic slice culture and the brain in vivo are further discussed...
- Therapeutic gene silencing in the nervous systemMatthew J A Wood
Department of Human Anatomy and Genetics, Oxford University, Oxford, UK
Hum Mol Genet 12:R279-84. 2003....