Brian D M Tom

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Antiangiogenic agents are effective inhibitors of endometriosis
    M Louise Hull
    Department of Pathology, Reproductive Molecular Research Group, Cambridge, United Kingdom CB2 1QP
    J Clin Endocrinol Metab 88:2889-99. 2003
  2. ncbi request reprint Conservation of unique cell-surface CD antigen mosaics in HIV-1-infected individuals
    Adrian Woolfson
    University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Hills Road, Box 111, Cambridge CB2 2SP, United Kingdom
    Blood 106:1003-7. 2005
  3. ncbi request reprint Fusing microarray experiments with multivariate regression
    Walter R Gilks
    MRC Biostatistics Unit, Cambridge, UK
    Bioinformatics 21:ii137-43. 2005
  4. pmc A corrected formulation for marginal inference derived from two-part mixed models for longitudinal semi-continuous data
    Brian Dm Tom
    Medical Research Council Biostatistics Unit, Institute of Public Health, Cambridge, UK
    Stat Methods Med Res 25:2014-2020. 2016
  5. ncbi request reprint Event-biased referral can distort estimation of hepatitis C virus progression rate to cirrhosis, and of prognostic influences
    Bo Fu
    MRC Biostatistics Unit, Robinson Way, Institute of Public Health, University Forvie Site Robinson Way, Cambridge, Cambridgeshire, UK
    J Clin Epidemiol 60:1140-8. 2007
  6. doi request reprint Intermittent observation of time-dependent explanatory variables: a multistate modelling approach
    Brian D M Tom
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 0SR, UK
    Stat Med 30:3520-31. 2011
  7. pmc Quality determination and the repair of poor quality spots in array experiments
    Brian D M Tom
    Medical Research Council, Institute of Public Health, Robinson Way, Cambridge CB2 2SR, UK
    BMC Bioinformatics 6:234. 2005
  8. pmc Bias in 2-part mixed models for longitudinal semicontinuous data
    Li Su
    Medical Research Council, Biostatistics Unit, Robinson Way, Cambridge CB2 0SR, UK
    Biostatistics 10:374-89. 2009
  9. pmc The versatility of multi-state models for the analysis of longitudinal data with unobservable features
    Vernon T Farewell
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge, CB2 0SR, UK
    Lifetime Data Anal 20:51-75. 2014
  10. ncbi request reprint Ectopic pregnancy diagnosis and the pseudo-sac
    Ahmed A Ahmed
    Medical Research Council, Biostatistics Unit, Institute of Public Health, University Forvite Site, Cambridge, United Kingdom
    Fertil Steril 81:1225-8. 2004

Detail Information

Publications17

  1. ncbi request reprint Antiangiogenic agents are effective inhibitors of endometriosis
    M Louise Hull
    Department of Pathology, Reproductive Molecular Research Group, Cambridge, United Kingdom CB2 1QP
    J Clin Endocrinol Metab 88:2889-99. 2003
    ..These findings suggest that antiangiogenic agents may provide a novel therapeutic approach for the treatment of endometriosis...
  2. ncbi request reprint Conservation of unique cell-surface CD antigen mosaics in HIV-1-infected individuals
    Adrian Woolfson
    University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Hills Road, Box 111, Cambridge CB2 2SP, United Kingdom
    Blood 106:1003-7. 2005
    ..Their invariant nature indicates an irreversible component to retroviral infection and suggests the utility of CD antigen expression patterns in other disease settings...
  3. ncbi request reprint Fusing microarray experiments with multivariate regression
    Walter R Gilks
    MRC Biostatistics Unit, Cambridge, UK
    Bioinformatics 21:ii137-43. 2005
    ..Also, the variability in the quality of experimentation should be taken into account...
  4. pmc A corrected formulation for marginal inference derived from two-part mixed models for longitudinal semi-continuous data
    Brian Dm Tom
    Medical Research Council Biostatistics Unit, Institute of Public Health, Cambridge, UK
    Stat Methods Med Res 25:2014-2020. 2016
    ..We present a corrected formulation and additionally explore the use of the two-part model for inferences on the overall marginal mean, which may be of more practical relevance in our application and more generally...
  5. ncbi request reprint Event-biased referral can distort estimation of hepatitis C virus progression rate to cirrhosis, and of prognostic influences
    Bo Fu
    MRC Biostatistics Unit, Robinson Way, Institute of Public Health, University Forvie Site Robinson Way, Cambridge, Cambridgeshire, UK
    J Clin Epidemiol 60:1140-8. 2007
    ....
  6. doi request reprint Intermittent observation of time-dependent explanatory variables: a multistate modelling approach
    Brian D M Tom
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 0SR, UK
    Stat Med 30:3520-31. 2011
    ..We examine the bias in estimating effects associated with other variables via simulation for different modelling choices. We present an analysis of a motivating data set on physical functional disability in psoriatic arthritis patients...
  7. pmc Quality determination and the repair of poor quality spots in array experiments
    Brian D M Tom
    Medical Research Council, Institute of Public Health, Robinson Way, Cambridge CB2 2SR, UK
    BMC Bioinformatics 6:234. 2005
    ..Furthermore, biases may be introduced into analyses through missing information on some genes. Thus methods for appropriately replacing (imputing) missing data and/or weighting poor quality spots are required...
  8. pmc Bias in 2-part mixed models for longitudinal semicontinuous data
    Li Su
    Medical Research Council, Biostatistics Unit, Robinson Way, Cambridge CB2 0SR, UK
    Biostatistics 10:374-89. 2009
    ..Some practical issues on variance component estimation revealed through this data analysis are considered...
  9. pmc The versatility of multi-state models for the analysis of longitudinal data with unobservable features
    Vernon T Farewell
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge, CB2 0SR, UK
    Lifetime Data Anal 20:51-75. 2014
    ..In addition, joint modelling of multiple processes is illustrated with application to potentially informative loss to follow-up, mis-measured or missclassified data and causal inference. ..
  10. ncbi request reprint Ectopic pregnancy diagnosis and the pseudo-sac
    Ahmed A Ahmed
    Medical Research Council, Biostatistics Unit, Institute of Public Health, University Forvite Site, Cambridge, United Kingdom
    Fertil Steril 81:1225-8. 2004
    ..To evaluate the impact of an ultrasound finding of a pseudo-sac (PS), a uterine sac without a double decidual ring or a yolk sac, on the management of cases with possible ectopic pregnancy...
  11. pmc Mixture distributions in multi-state modelling: some considerations in a study of psoriatic arthritis
    Aidan G O'Keeffe
    MRC Biostatistics Unit, Cambridge, U K
    Stat Med 32:600-19. 2013
    ..Furthermore, we fit a mover-stayer model that allows a dependence of the probability of a patient being a stayer on a patient-level explanatory variable...
  12. pmc Trivariate mover-stayer counting process models for investigating joint damage in psoriatic arthritis
    Sean Yiu
    MRC Biostatistics Unit, Cambridge, CB2 0SR, U K
    Stat Med 35:5701-5716. 2016
    ..A particularly attractive feature of the proposed models is that only an optimisation routine is required in their model fitting procedures. © 2016 The Authors. Statistics in Medicine Published by John Wiley & Sons Ltd...
  13. doi request reprint Validation of the Toronto Psoriatic Arthritis Screen Version 2 (ToPAS 2)
    Brian D M Tom
    From the MRC Biostatistics Unit, UK Institute of Public Health, Cambridge, UK the Psoriatic Arthritis Program, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital Division of Dermatology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada B D Tom, PhD, MRC Biostatistics Unit, UK Institute of Public Health V Chandran, MBBS, MD, DM, PhD, Psoriatic Arthritis Program, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital V T Farewell, PhD, MRC Biostatistics Unit, UK Institute of Public Health C F Rosen, MD, FRCPC, Division of Dermatology, Toronto Western Hospital, University of Toronto D D Gladman, MD, FRCPC, Psoriatic Arthritis Program, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital
    J Rheumatol 42:841-6. 2015
    ..Subsequently, a second version of ToPAS was developed, ToPAS 2, which incorporated the suggested refinements. We aimed to validate ToPAS 2 as a screening instrument for PsA...
  14. ncbi request reprint Variation in thresholds for reporting mobility disability between national population subgroups and studies
    David Melzer
    Department of Public Health and Primary Care, University of Cambridge, Cambridge CB2 2SR, UK
    J Gerontol A Biol Sci Med Sci 59:1295-303. 2004
    ..We also aimed to compare reported and tested performance across two national population studies...
  15. ncbi request reprint Is there disparity between risk and incidence of cardiovascular disease after liver transplant?
    David A J Neal
    Department of Medicine, University of Cambridge, School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, UK
    Transplantation 77:93-9. 2004
    ....
  16. ncbi request reprint Endothelial cells preparing to die by apoptosis initiate a program of transcriptome and glycome regulation
    Nicola A Johnson
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    FASEB J 18:188-90. 2004
    ..We propose that the transcriptome and glycome regulation presented here synergize with previously described protein-based changes to guide the apoptotic program...
  17. ncbi request reprint Performance tests and disability: developing an objective index of mobility-related limitation in older populations
    Tzuo Yun Lan
    Department of Public Health and Primary Care, University of Cambridge, United Kingdom
    J Gerontol A Biol Sci Med Sci 57:M294-301. 2002
    ..This study aimed to identify an index of mobility-related limitations composed of physiological measures that are most closely associated with reported mobility disability in elders...