Alan Thompson

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint Overview of primary progressive multiple sclerosis (PPMS): similarities and differences from other forms of MS, diagnostic criteria, pros and cons of progressive diagnosis
    Alan Thompson
    Department of Clinical Neurology, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Mult Scler 10:S2-7. 2004
  2. pmc The mesenchymal stem cells in multiple sclerosis (MSCIMS) trial protocol and baseline cohort characteristics: an open-label pre-test: post-test study with blinded outcome assessments
    Peter Connick
    Dept, of Clinical Neurosciences, University of Cambridge, UK
    Trials 12:62. 2011
  3. pmc A tool to measure the attributes of receiving IV therapy in a home versus hospital setting: the Multiple Sclerosis Relapse Management Scale (MSRMS)
    Afsane Riazi
    Department of Psychology, Royal Holloway, University of London, Surrey, TW20 0EX, UK
    Health Qual Life Outcomes 9:80. 2011
  4. pmc The cervical dystonia impact profile (CDIP-58): can a Rasch developed patient reported outcome measure satisfy traditional psychometric criteria?
    Stefan J Cano
    Neurological Outcome Measures Unit, Institute of Neurology, University College London, Queen Square, London, UK
    Health Qual Life Outcomes 6:58. 2008
  5. pmc Longitudinal proxy measurements in multiple sclerosis: patient-proxy agreement on the impact of MS on daily life over a period of two years
    Femke A H van der Linden
    Department of Neurology, VU University Medical Centre, Amsterdam, The Netherlands
    BMC Neurol 8:2. 2008
  6. pmc The size of the treatment effect: do patients and proxies agree?
    Femke A H van der Linden
    Department of Neurology, VU University Medical Centre, Amsterdam, The Netherlands
    BMC Neurol 9:12. 2009
  7. ncbi request reprint Multiple sclerosis: assessment of disability and disability scales
    A J Thompson
    Institute of Neurology, London, UK
    J Neurol 245:189-96. 1998
  8. ncbi request reprint Progress in neurorehabilitation in multiple sclerosis
    Alan J Thompson
    Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Curr Opin Neurol 15:267-70. 2002
  9. ncbi request reprint Neurorehabilitation in multiple sclerosis: foundations, facts and fiction
    Alan J Thompson
    Institute of Neurology, University College London and National Hospital for Neurology and Neurosurgery, University College London Hospital, London, UK
    Curr Opin Neurol 18:267-71. 2005
  10. ncbi request reprint The effectiveness of neurological rehabilitation in multiple sclerosis
    A J Thompson
    Institute of Neurology, London
    J Rehabil Res Dev 37:455-61. 2000

Collaborators

Detail Information

Publications142 found, 100 shown here

  1. ncbi request reprint Overview of primary progressive multiple sclerosis (PPMS): similarities and differences from other forms of MS, diagnostic criteria, pros and cons of progressive diagnosis
    Alan Thompson
    Department of Clinical Neurology, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Mult Scler 10:S2-7. 2004
    ..Following diagnosis, the need for information, specific to this form of MS, must be recognized and addressed...
  2. pmc The mesenchymal stem cells in multiple sclerosis (MSCIMS) trial protocol and baseline cohort characteristics: an open-label pre-test: post-test study with blinded outcome assessments
    Peter Connick
    Dept, of Clinical Neurosciences, University of Cambridge, UK
    Trials 12:62. 2011
    ..Illustrated by the MSCIMS trial protocol, we describe a novel methodology based on detailed assessment of the anterior visual pathway as a model of wider disease processes--the "sentinel lesion approach"...
  3. pmc A tool to measure the attributes of receiving IV therapy in a home versus hospital setting: the Multiple Sclerosis Relapse Management Scale (MSRMS)
    Afsane Riazi
    Department of Psychology, Royal Holloway, University of London, Surrey, TW20 0EX, UK
    Health Qual Life Outcomes 9:80. 2011
    ..We report the development of a rating scale to measure patient's experiences of relapse management that allowed this question to be answered confidently...
  4. pmc The cervical dystonia impact profile (CDIP-58): can a Rasch developed patient reported outcome measure satisfy traditional psychometric criteria?
    Stefan J Cano
    Neurological Outcome Measures Unit, Institute of Neurology, University College London, Queen Square, London, UK
    Health Qual Life Outcomes 6:58. 2008
    ....
  5. pmc Longitudinal proxy measurements in multiple sclerosis: patient-proxy agreement on the impact of MS on daily life over a period of two years
    Femke A H van der Linden
    Department of Neurology, VU University Medical Centre, Amsterdam, The Netherlands
    BMC Neurol 8:2. 2008
    ..g. partners) may replace self-ratings. The aim of this study was to examine the value of proxy ratings at separate points in time and to assess patient-proxy agreement on possible changes in disease impact of MS...
  6. pmc The size of the treatment effect: do patients and proxies agree?
    Femke A H van der Linden
    Department of Neurology, VU University Medical Centre, Amsterdam, The Netherlands
    BMC Neurol 9:12. 2009
    ..This may be of interest in situations when patients suffer from limitations that interfere with reliable self-assessment, such as cognitive impairment...
  7. ncbi request reprint Multiple sclerosis: assessment of disability and disability scales
    A J Thompson
    Institute of Neurology, London, UK
    J Neurol 245:189-96. 1998
    ..Current scales in this area are limited in either their scientific soundness and/or clinical usefulness, and it may be appropriate to consider the development of a new MS-specific measure of disease impact for use in clinical trials...
  8. ncbi request reprint Progress in neurorehabilitation in multiple sclerosis
    Alan J Thompson
    Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Curr Opin Neurol 15:267-70. 2002
    ..These advances need to be associated with improved models of care which provide comprehensive and accessible services throughout the course of the disease...
  9. ncbi request reprint Neurorehabilitation in multiple sclerosis: foundations, facts and fiction
    Alan J Thompson
    Institute of Neurology, University College London and National Hospital for Neurology and Neurosurgery, University College London Hospital, London, UK
    Curr Opin Neurol 18:267-71. 2005
    ..This review of recent work in the area of neurorehabilitation of multiple sclerosis patients surveys progress and underscores the need for further work to evaluate the effectiveness of treatments...
  10. ncbi request reprint The effectiveness of neurological rehabilitation in multiple sclerosis
    A J Thompson
    Institute of Neurology, London
    J Rehabil Res Dev 37:455-61. 2000
    ..These recent studies underline the fact that the evaluation of rehabilitation is feasible. Such studies are important, not simply to justify funding but to ensure continuing improvement of the way in which MS is managed...
  11. ncbi request reprint Symptomatic treatment in multiple sclerosis
    A J Thompson
    Institute of Neurology, London, UK
    Curr Opin Neurol 11:305-9. 1998
    ..It has also highlighted the paucity of evidence-based practice in this area and the need to develop agreed and comprehensive management strategies...
  12. doi request reprint Complementary roles of grey matter MTR and T2 lesions in predicting progression in early PPMS
    C Tur
    Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, UK
    J Neurol Neurosurg Psychiatry 82:423-8. 2011
    ....
  13. ncbi request reprint Metabolite changes in normal-appearing gray and white matter are linked with disability in early primary progressive multiple sclerosis
    J Sastre-Garriga
    Institute of Neurology, London, United Kingdom
    Arch Neurol 62:569-73. 2005
    ..Abnormalities in normal-appearing brain tissues may contribute to disability in primary progressive multiple sclerosis (PPMS), where few lesions are seen on conventional imaging...
  14. ncbi request reprint Long-term clinical outcome of primary progressive MS: predictive value of clinical and MRI data
    J Sastre-Garriga
    Institute of Neurology, UCL, Queen Square, London WC1N 3BG, UK
    Neurology 65:633-5. 2005
    ..Adding short-term change variables, baseline EDSS, changes in T2* lesion load and cord area, and number of new lesions were predictive. Clinical and MRI variables predict long-term outcome in PPMS...
  15. ncbi request reprint Corticocortical coupling in chronic stroke: its relevance to recovery
    L H A Strens
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology and National Hospital for Neurology and Neurosurgery, London, UK
    Neurology 63:475-84. 2004
    ..Here, the authors investigate whether different cortical areas interact to form dynamic assemblies that may then compensate for disability...
  16. ncbi request reprint Gray and white matter volume changes in early RRMS: a 2-year longitudinal study
    M Tiberio
    NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, London WC1N 3BG, UK
    Neurology 64:1001-7. 2005
    ..Previous work has suggested that at this stage of the disease, gray matter (GM) atrophy progresses more rapidly than the white matter (WM) atrophy...
  17. ncbi request reprint From diffusion tractography to quantitative white matter tract measures: a reproducibility study
    O Ciccarelli
    NMR Research Unit, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Neuroimage 18:348-59. 2003
    ..In conclusion, these findings underline the importance of assessing the reliability of diffusion tractography before investigating white matter pathology...
  18. doi request reprint Lesion enhancement diminishes with time in primary progressive multiple sclerosis
    Z Khaleeli
    Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, London WC1N 3BG, UK
    Mult Scler 16:317-24. 2010
    ..02). In conclusion, a proportion of patients with PPMS may undergo an early inflammatory phase, which has some impact on subsequent mobility...
  19. doi request reprint Early MRI in optic neuritis: the risk for clinically definite multiple sclerosis
    J K Swanton
    Department of Neuroinflammation and NMR Research Unit, UCL Institute of Neurology, London, UK
    Mult Scler 16:156-65. 2010
    ..1, 2.4 and 4.9, respectively). No non-conventional measure predicted CDMS. It was concluded that new T2 lesions on an early follow-up scan were the strongest independent predictor of CDMS...
  20. ncbi request reprint Two-year follow-up study of primary and transitional progressive multiple sclerosis
    G T Ingle
    NMR Research Unit, Institute of Neurology, London, UK
    Mult Scler 8:108-14. 2002
    ..Measurable changes in MRI parameters can be detected in PPMS patients over a relatively short period of time. MRI quantification is likely to be useful in elucidating disease mechanisms in PPMS and in the execution of clinical trials...
  21. ncbi request reprint Diffusion tensor imaging of early relapsing-remitting multiple sclerosis with histogram analysis using automated segmentation and brain volume correction
    W Rashid
    MS NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Mult Scler 10:9-15. 2004
    ....
  22. pmc Recovery after spinal cord relapse in multiple sclerosis is predicted by radial diffusivity
    Patrick Freund
    Department of Brain Repair and Rehabilitation, NMR Unit, UCL Institute of Neurology, London, UK
    Mult Scler 16:1193-202. 2010
    ....
  23. ncbi request reprint Metabolite changes in early relapsing-remitting multiple sclerosis. A two year follow-up study
    M Tiberio
    NMR Research Group, Institute of Neurology, Queen Square, London, UK
    J Neurol 253:224-30. 2006
    ..Compared with other MR imaging measures, serial (1)H-MRSI may be relatively less sensitive to progressive pathological tissue changes in early RRMS...
  24. pmc Cord atrophy separates early primary progressive and relapsing remitting multiple sclerosis
    M Bieniek
    NMR Research Unit, Institute of Neurology, University College London, London, UK
    J Neurol Neurosurg Psychiatry 77:1036-9. 2006
    ..An improved understanding of the causes of early progressive disability in primary progressive multiple sclerosis (PPMS) could provide mechanistic targets for therapeutic intervention...
  25. ncbi request reprint Diffusion tractography based group mapping of major white-matter pathways in the human brain
    O Ciccarelli
    NMR Research Unit, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Neuroimage 19:1545-55. 2003
    ..In the future, group mapping could investigate in vivo white matter differences between normal subjects and patients affected by neurological and psychiatric diseases...
  26. ncbi request reprint Measuring the impact of MS on walking ability: the 12-Item MS Walking Scale (MSWS-12)
    J C Hobart
    Institute of Neurology, University College London, UK
    Neurology 60:31-6. 2003
    ..To develop a patient-based measure of walking ability in MS...
  27. ncbi request reprint Progressive grey matter atrophy in clinically early relapsing-remitting multiple sclerosis
    D T Chard
    NMR Research Unit, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Mult Scler 10:387-91. 2004
    ..0021 per year in the NC subjects, difference P = 0.010). These results suggest that while both GM and WM atrophy are seen early in the clinical course of MS, they may not occur concurrently and may evolve at different rates...
  28. ncbi request reprint Serial magnetization transfer imaging in acute optic neuritis
    S J Hickman
    NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Brain 127:692-700. 2004
    ..Remyelination may have influenced subsequent MTR changes. The observations support using MTR to monitor symptomatic demyelinating lesions...
  29. pmc Abnormalities of cerebral perfusion in multiple sclerosis
    W Rashid
    MS NMR Research Unit, Department of Neuroinflammation, Brain Injury and Rehabilitation, Institute of Neurology, University College London, UK
    J Neurol Neurosurg Psychiatry 75:1288-93. 2004
    ..Studies in multiple sclerosis (MS) have identified areas of decreased perfusion in grey matter (GM) and white matter (WM), but the pattern in clinical subgroups is unclear...
  30. ncbi request reprint A longitudinal study of cognition in primary progressive multiple sclerosis
    S J Camp
    Department of Clinical Neurology, Institute of Neurology, London, UK
    Brain 128:2891-8. 2005
    ..266, P = 0.017; r = -0.303, P = 0.012). It is probable that multiple factors underlie this weak relation between the cognitive and MRI measures...
  31. ncbi request reprint Quantitative 1H MRS imaging 14 years after presenting with a clinically isolated syndrome suggestive of multiple sclerosis
    P Kapeller
    NMR Research Unit, Institute of Neurology, University College London, UK
    Mult Scler 8:207-10. 2002
    ..Elevated Ins in MS NAWM appeared functionally relevant It may indicate glial cell proliferation or gliosis...
  32. doi request reprint Diffusion-based tractography in neurological disorders: concepts, applications, and future developments
    Olga Ciccarelli
    Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, Queen Square, London, UK
    Lancet Neurol 7:715-27. 2008
    ..This Review will outline the limitations of tractography, describe its current clinical applications in the most common neurological diseases, and highlight future opportunities...
  33. pmc The patient's experience of being a human subject
    Susan Kerrison
    University College London, NHS Foundation Trust, Joint Biomedical Research Unit, Maples House, 149 Tottenham Court Road, London, UK
    J R Soc Med 101:416-22. 2008
    ..To explore the patient's experience of clinical research with a view to improving its conduct...
  34. doi request reprint Dissecting structure-function interactions in acute optic neuritis to investigate neuroplasticity
    Thomas Jenkins
    Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, Queen Square, London, United Kingdom
    Hum Brain Mapp 31:276-86. 2010
    ..Longitudinal studies will clarify whether different extra-striate cortical regions play a role in adaptive plasticity in the acute and chronic stages of injury...
  35. ncbi request reprint Clinically isolated syndromes suggestive of multiple sclerosis, part 2: non-conventional MRI, recovery processes, and management
    David Miller
    MS NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, London, UK
    Lancet Neurol 4:341-8. 2005
    ..Continued clinical and laboratory investigation of patients with a CIS should be encouraged...
  36. ncbi request reprint Clinically isolated syndromes suggestive of multiple sclerosis, part I: natural history, pathogenesis, diagnosis, and prognosis
    David Miller
    MS NMR Research Unit, Institute of Neurology, University College London, London, UK
    Lancet Neurol 4:281-8. 2005
    ..Development of more reliable prognostic markers will enable new treatments to be targeted for those who are most likely to benefit. We encourage continued clinical and laboratory assessment of patients with a CIS...
  37. ncbi request reprint Magnetization transfer histograms in clinically isolated syndromes suggestive of multiple sclerosis
    K T M Fernando
    NMR Research Unit, Institute of Neurology, King s College, London, UK
    Brain 128:2911-25. 2005
    ..MTR abnormalities occur in the NAWM and NAGM at the earliest clinical stages of multiple sclerosis...
  38. pmc Quantification of optic nerve head topography in optic neuritis: a pilot study
    S A Trip
    NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Br J Ophthalmol 90:1128-31. 2006
    ..To investigate optic nerve head topography in patients with optic neuritis compared to controls using the Heidelberg retina tomograph-II (HRT-II) and to determine if detected changes are related to visual function and electrophysiology...
  39. ncbi request reprint Functional response to active and passive ankle movements with clinical correlations in patients with primary progressive multiple sclerosis
    O Ciccarelli
    Department of Headache, Brain Injury and Neurorehabilitation, Institute of Neurology, University College London, London, UK
    J Neurol 253:882-91. 2006
    ..This may inform future treatment strategies...
  40. ncbi request reprint Elevated white matter myo-inositol in clinically isolated syndromes suggestive of multiple sclerosis
    K T M Fernando
    Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Brain 127:1361-9. 2004
    ..The early increase in Ins may reflect a process of pathogenic importance in multiple sclerosis NAWM. Follow-up studies will investigate whether the increase in NAWM Ins is of prognostic importance for future relapses and disability...
  41. ncbi request reprint De-stabilizing and training effects of foot orthoses in multiple sclerosis
    G M Ramdharry
    MRC Human Movement Group, Sobell Department for Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, UK
    Mult Scler 12:219-26. 2006
    ..Improvement in body sway over time may be an overall training effect of the DFOs, as MS subjects adapt to the initial de-stabilization...
  42. doi request reprint Disability and T2 MRI lesions: a 20-year follow-up of patients with relapse onset of multiple sclerosis
    L K Fisniku
    NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, UK
    Brain 131:808-17. 2008
    ....
  43. ncbi request reprint Spinal cord spectroscopy and diffusion-based tractography to assess acute disability in multiple sclerosis
    O Ciccarelli
    Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, London, UK
    Brain 130:2220-31. 2007
    ..These measures were found to correlate with acute disability. Our findings suggest that it would be worthwhile performing longitudinal studies and extending these novel techniques to other neurological diseases affecting the spinal cord...
  44. pmc Is the frequency of abnormalities on magnetic resonance imaging in isolated optic neuritis related to the prevalence of multiple sclerosis? A global comparison
    J K Swanton
    NMR Research Unit, Institute of Neurology, University College London, Queen Square, London, UK
    J Neurol Neurosurg Psychiatry 77:1070-2. 2006
    ..These observations may support the hypothesis that optic neuritis is more likely to be associated with abnormalities on MRI and to be due to multiple sclerosis in geographical regions where multiple sclerosis is more common...
  45. ncbi request reprint Identifying brain regions for integrative sensorimotor processing with ankle movements
    O Ciccarelli
    Department of Headache, Brain Injury and Rehabilitation, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
    Exp Brain Res 166:31-42. 2005
    ..In future, similar fMRI studies using passive movements have potential to elucidate abnormalities of sensorimotor integration in central nervous system diseases that affect motor function...
  46. pmc Magnetisation transfer ratio in the normal appearing white matter predicts progression of disability over 1 year in early primary progressive multiple sclerosis
    Z Khaleeli
    Department of Brain Repair and Rehabilitation, Nuclear Magnetic Resonance Unit, Institute of Neurology, University College London, London, UK
    J Neurol Neurosurg Psychiatry 78:1076-82. 2007
    ..We investigated the predictive value of MTI and the longitudinal changes developing over 1 year in early PPMS...
  47. ncbi request reprint Magnetic resonance imaging predictors of disability in primary progressive multiple sclerosis: a 5-year study
    V L Stevenson
    Department of Clinical Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Mult Scler 10:398-401. 2004
    ....
  48. ncbi request reprint Localized grey matter damage in early primary progressive multiple sclerosis contributes to disability
    Z Khaleeli
    Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Neuroimage 37:253-61. 2007
    ..In conclusion, localized grey matter damage occurs in early PPMS, and MTR change is more widespread than atrophy. Damage demonstrated by reduced MTR is clinically eloquent...
  49. ncbi request reprint Optic nerve magnetization transfer imaging and measures of axonal loss and demyelination in optic neuritis
    S A Trip
    NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, London, UK
    Mult Scler 13:875-9. 2007
    ..Because axonal loss following optic neuritis also results in myelin loss, the relative contributions of the two pathological conditions to the MTR measures cannot be estimated from this study...
  50. ncbi request reprint Probabilistic diffusion tractography: a potential tool to assess the rate of disease progression in amyotrophic lateral sclerosis
    O Ciccarelli
    Department of Headache, Brain Injury and Neurorehabilitation, Institute of Neurology, University College London UK
    Brain 129:1859-71. 2006
    ..The development of such connectivity measures raises their potential as markers of disease progression in ALS, and provides guidance for their use in other neurological diseases...
  51. ncbi request reprint Normal-appearing grey and white matter T1 abnormality in early relapsing-remitting multiple sclerosis: a longitudinal study
    G R Davies
    NMR Research Unit, Institute of Neurology, University College London, Queen Square, London, UK
    Mult Scler 13:169-77. 2007
    ..To investigate the presence and evolution of T(1) relaxation time abnormalities in normal-appearing white matter (NAWM) and grey matter (GM), early in the course of relapsing-remitting multiple sclerosis (MS)...
  52. ncbi request reprint Reproducibility of magnetic resonance imaging measurements of spinal cord atrophy: the role of quality assurance
    S M Leary
    NMR Research Unit, Institute of Neurology, London, United Kingdom
    Magn Reson Imaging 17:773-6. 1999
    ..Quality assurance is an essential and practical component of all serial MRI studies, without which the clinical implications of change cannot be reliably evaluated...
  53. ncbi request reprint Interferon beta-1a in primary progressive MS: an exploratory, randomized, controlled trial
    S M Leary
    NMR Research Unit, Institute of Neurology, University College London, UK
    Neurology 60:44-51. 2003
    ..Patients with primary progressive MS have atypical clinical and MRI characteristics and have been excluded from most therapeutic trials. The authors report a randomized, controlled trial restricted to primary progressive MS...
  54. doi request reprint MRI only conversion to multiple sclerosis following a clinically isolated syndrome
    D T Chard
    Department of Neuroinflammation, UCL Institute of Neurology, University College London, Queen Square, London, UK
    J Neurol Neurosurg Psychiatry 82:176-9. 2011
    ..This study investigated the frequency of radiological without clinical conversion to MS after long term follow-up as this has not previously been defined...
  55. doi request reprint Hippocampal atrophy in relapsing-remitting and primary progressive MS: a comparative study
    V M Anderson
    Department of Neuroinflammation, UCL Institute of Neurology, Queen Square, London, UK
    Mult Scler 16:1083-90. 2010
    ..In multiple sclerosis (MS), demyelination and neuroaxonal damage are seen in the hippocampus, and MRI has revealed hippocampal atrophy...
  56. pmc Cognitive dysfunction after isolated brain stem insult. An underdiagnosed cause of long term morbidity
    P Garrard
    Institute of Cognitive Neuroscience, London, UK
    J Neurol Neurosurg Psychiatry 73:191-4. 2002
    ..The practical importance of recognising cognitive dysfunction in this group of patients, and the theoretical significance of the disruption of specific cognitive domains by lesions to distributed neural circuits, are discussed...
  57. ncbi request reprint Serum inflammatory markers and clinical/MRI markers of disease progression in multiple sclerosis
    G Giovannoni
    Department of Neurochemistry, University of London, UK
    J Neurol 248:487-95. 2001
    ..These findings, although preliminary, pose interesting questions on the role of nitric oxide in the pathogenesis of MS. Inducible NO production in the early stages of the disease may be beneficial...
  58. ncbi request reprint Integrated care pathways: outcome from inpatient rehabilitation following nontraumatic spinal cord lesion
    E D Playford
    Institute of Neurology, University College, London, UK
    Clin Rehabil 16:269-75. 2002
    ..This study describes the use of an ICP to audit the rehabilitation of patients with nontraumatic spinal cord injury admitted between 1997 and 1999...
  59. ncbi request reprint Relationship of triple dose contrast enhanced lesions with clinical measures and brain atrophy in early relapsing-remitting multiple sclerosis: a two-year longitudinal study
    W Rashid
    Department of Neuroinflammation, MS NMR Research Unit, Institute of Neurology, University College London, Queen Square, London, UK
    Mult Scler 13:178-85. 2007
    ..041), but there was no consistent correlation with clinical and MRI outcomes at two years. More prolonged follow-up is warranted to clarify the relationship between early inflammatory lesions and long-term clinical course...
  60. ncbi request reprint Brain atrophy in clinically early relapsing-remitting multiple sclerosis
    D T Chard
    NMR Research Unit, Department of Clinical Neurology, Institute of Neurology, University College London, UK
    Brain 125:327-37. 2002
    ..The lack of correlation between lesion load measures and WMF suggests that pathological changes in white matter may occur by mechanisms which are at least partly independent from overt lesion genesis in early multiple sclerosis...
  61. ncbi request reprint Fatigue is not associated with raised inflammatory markers in multiple sclerosis
    G Giovannoni
    Department of Neurochemistry, Institute of Neurology, London, United Kingdom
    Neurology 57:676-81. 2001
    ..The pathogenesis of fatigue in patients with MS is poorly understood...
  62. ncbi request reprint Evidence-based measurement: which disability scale for neurologic rehabilitation?
    J C Hobart
    Institute of Neurology, University College London, London, United Kingdom
    Neurology 57:639-44. 2001
    ....
  63. ncbi request reprint T1 hypointensity of the spinal cord in multiple sclerosis
    N A Losseff
    NMR Research Unit, Institute of Neurology, London, UK
    J Neurol 248:517-21. 2001
    ..A lower T1 signal intensity in the spinal cord may be more pathologically specific than T2 hyperintensity and may represent underlying axonal loss, although gliosis and predominant white matter atrophy are alternative possibilities...
  64. pmc The five item Barthel index
    J C Hobart
    Department of Clinical Neurology and Neurorehabilitation, Neurological Outcome Measures Unit, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    J Neurol Neurosurg Psychiatry 71:225-30. 2001
    ....
  65. ncbi request reprint Magnetisation transfer ratio histogram analysis of primary progressive and other multiple sclerosis subgroups
    J Dehmeshki
    NMR Research Unit, Department of Cilnical Neurology, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    J Neurol Sci 185:11-7. 2001
    ..The improved correlation with disability obtained by PC analysis suggests a useful role of this method for following clinically relevant pathological changes depicted in the MTR histogram...
  66. ncbi request reprint A (1)H magnetic resonance spectroscopy study of aging in parietal white matter: implications for trials in multiple sclerosis
    S M Leary
    NMR Research Unit, Institute of Neurology, Queen Square, London, UK
    Magn Reson Imaging 18:455-9. 2000
    ..This emphasizes the need to perform absolute quantification of metabolite concentrations rather than ratios and the importance of age-matching in (1)H MRS studies of multiple sclerosis...
  67. pmc Spinal cord repair in MS: does mitochondrial metabolism play a role?
    O Ciccarelli
    Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Neurology 74:721-7. 2010
    ....
  68. doi request reprint Texture analysis of magnetization transfer maps from patients with clinically isolated syndrome and multiple sclerosis
    D J Tozer
    UCL Institute of Neurology, London, UK
    J Magn Reson Imaging 30:506-13. 2009
    ..To investigate the behavior of texture parameters derived from the gray level co-occurrence matrix from gray matter (GM) and white matter (WM) (with lesions removed) segments of magnetization transfer ratio maps from controls and patients...
  69. pmc The longitudinal relation between brain lesion load and atrophy in multiple sclerosis: a 14 year follow up study
    D T Chard
    NMR Research Unit, Institute of Neurology, University College London, Queen Square, London WC1, UK
    J Neurol Neurosurg Psychiatry 74:1551-4. 2003
    ..The temporal relation between these processes remains unclear...
  70. ncbi request reprint Magnetic resonance studies of abnormalities in the normal appearing white matter and grey matter in multiple sclerosis
    D H Miller
    NMR Research Unit, Institute of Neurology and National Hospital for Neurology and Neurosurgery, London, UK
    J Neurol 250:1407-19. 2003
    ..In future, new imaging modalities are needed that provide a more specific measure of histopathological and cellular aspects of the disease process in vivo...
  71. doi request reprint Early MRI in optic neuritis: the risk for disability
    J K Swanton
    NMR Unit, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Neurology 72:542-50. 2009
    ..MRI findings influence the risk of patients with optic neuritis (ON) developing clinically definite (CD) multiple sclerosis (MS) but their influence on future disability is less clear...
  72. ncbi request reprint Talking the talk on walking the walk: a 12-item generic walking scale suitable for neurological conditions?
    A Holland
    Neurorehabilitation Group, Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    J Neurol 253:1594-602. 2006
    ....
  73. ncbi request reprint Self-efficacy predicts self-reported health status in multiple sclerosis
    A Riazi
    Neurological Outcome Measures Unit, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Mult Scler 10:61-6. 2004
    ..The findings suggest that self-efficacy predicts improvement in health status and that self-efficacy would be an important domain to measure and manage actively in education and rehabilitation programs...
  74. pmc Neural correlates of motor recovery after stroke: a longitudinal fMRI study
    N S Ward
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London, UK
    Brain 126:2476-96. 2003
    ..These results further our understanding of the recovery process by demonstrating for the first time a clear temporal relationship between recovery and task-related activation of the motor system after stroke...
  75. pmc Magnetization transfer ratio abnormalities reflect clinically relevant grey matter damage in multiple sclerosis
    L K Fisniku
    NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, London, UK
    Mult Scler 15:668-77. 2009
    ..In multiple sclerosis, grey matter (GM) damage appears more clinically relevant than either white matter damage or lesion load...
  76. doi request reprint MRI measures show significant cerebellar gray matter volume loss in multiple sclerosis and are associated with cerebellar dysfunction
    V M Anderson
    Nuclear Magnetic Resonance Research Unit, Institute of Neurology, University College London, Queen Square, London, UK
    Mult Scler 15:811-7. 2009
    ..Regional atrophy measures may offer useful information about the causes of specific clinical deficits in multiple sclerosis (MS)...
  77. pmc Neural correlates of outcome after stroke: a cross-sectional fMRI study
    N S Ward
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London, UK
    Brain 126:1430-48. 2003
    ..These results further our understanding of the recovery process by demonstrating for the first time a clear relationship between task-related activation of the motor system and outcome after stroke...
  78. pmc MRI investigation of the sensorimotor cortex and the corticospinal tract after acute spinal cord injury: a prospective longitudinal study
    Patrick Freund
    Spinal Cord Injury Center Balgrist, University Hospital Zurich, University of Zurich, Zurich, Switzerland
    Lancet Neurol 12:873-81. 2013
    ..We aimed to use MRI to assess neuronal degeneration above the level of the lesion after acute spinal cord injury...
  79. ncbi request reprint Multiple sclerosis in the UK: service use, costs, quality of life and disability
    Paul McCrone
    Institute of Psychiatry, King s College London, London, UK
    Pharmacoeconomics 26:847-60. 2008
    ..Few studies have examined the impact of QOL, disability and demographic characteristics on treatment costs...
  80. pmc Tracking changes following spinal cord injury: insights from neuroimaging
    Patrick Freund
    Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, UCL, London, UK
    Neuroscientist 19:116-28. 2013
    ..e., functional retraining) and from interventions affecting the nervous system directly (i.e., neuroprotection or regeneration)...
  81. doi request reprint Symptomatic treatment and management of multiple sclerosis
    Ahmed Toosy
    Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, Queen Square, London, UK
    Handb Clin Neurol 122:513-62. 2014
    ..More interventional therapies related to symptoms that are refractory to pharmacotherapy will also be discussed, where relevant. ..
  82. doi request reprint Predicting progression in primary progressive multiple sclerosis: a 10-year multicenter study
    Zhaleh Khaleeli
    Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, London, United Kingdom
    Ann Neurol 63:790-3. 2008
    ..These predictors of long-term disability provide some insight into disease progression...
  83. doi request reprint Longitudinal evaluation of clinically early relapsing-remitting multiple sclerosis with diffusion tensor imaging
    Waqar Rashid
    MS NMR Research Unit, Dept of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, United Kingdom
    J Neurol 255:390-7. 2008
    ..In conclusion, although subtle NABT abnormalities were detected in early RR MS, the absence of longitudinal change suggests a limited role for global DTI assessment of NABT in following the early disease course...
  84. doi request reprint Atopic myelitis in a European woman residing in Japan
    Jeremy D Isaacs
    National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    J Neurol Neurosurg Psychiatry 82:1022-4. 2011
    ..Further studies are required to fully elucidate the relationship between atopy and the incidence and severity of CNS inflammatory disorders...
  85. ncbi request reprint Two-dimensional population map of cortical connections in the human internal capsule
    Mojtaba Zarei
    Centre for Functional MRI of the Brain, Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    J Magn Reson Imaging 25:48-54. 2007
    ..To exploit diffusion imaging tractography to produce a two-dimensional (xy) probabilistic population map of the cortical connections within the human internal capsule (IC)...
  86. ncbi request reprint MRI criteria for multiple sclerosis in patients presenting with clinically isolated syndromes: a multicentre retrospective study
    Josephine K Swanton
    Nuclear Magnetic Resonance Research Unit, Department of Neuroinflammation and Headache, Institute of Neurology, University College London, London, UK
    Lancet Neurol 6:677-86. 2007
    ..We applied all three criteria in a large cohort of CIS patients to assess their performance by use of conversion to clinically definite multiple sclerosis (CDMS) as the outcome...
  87. pmc Functional anatomy of interhemispheric cortical connections in the human brain
    Mojtaba Zarei
    Oxford Centre for Functional MRI of the Brain, Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Oxford, UK
    J Anat 209:311-20. 2006
    ..Our map showed high consistency across individuals. We propose that this map might be useful in the study of the effects of damage to human CC in neurodegenerative and cognitive disorders...
  88. doi request reprint Gray matter atrophy is related to long-term disability in multiple sclerosis
    Leonora K Fisniku
    Nuclear Magnetic Resonance Research Unit, Institute of Neurology, University College London, UK
    Ann Neurol 64:247-54. 2008
    ..To determine the relation of gray matter (GM) and white matter (WM) brain volumes, and WM lesion load, with clinical outcomes 20 years after first presentation with clinically isolated syndrome suggestive of multiple sclerosis (MS)...
  89. ncbi request reprint Normal-appearing brain t1 relaxation time predicts disability in early primary progressive multiple sclerosis
    Francesco Manfredonia
    Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, London, England
    Arch Neurol 64:411-5. 2007
    ....
  90. pmc Longitudinal changes in cerebral response to proprioceptive input in individual patients after stroke: an FMRI study
    Nick S Ward
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London, UK
    Neurorehabil Neural Repair 20:398-405. 2006
    ..The authors set out to demonstrate the feasibility of using fMRI to investigate mechanisms of recovery in individual patients presenting with severe motor impairment...
  91. ncbi request reprint Localization of grey matter atrophy in early RRMS : A longitudinal study
    Bertrand Audoin
    NMR Research Group, Institute of Neurology, Queen Square, London, UK
    J Neurol 253:1495-501. 2006
    ..This study suggests that early in the clinical course of RRMS, the thalamic atrophy is more consistently apparent than regional cortical atrophy...
  92. ncbi request reprint Regional gray matter atrophy in early primary progressive multiple sclerosis: a voxel-based morphometry study
    Jorge Sepulcre
    Institute of Neurology, University College of London, 23 Queen Square, London WC1N 3BG, England
    Arch Neurol 63:1175-80. 2006
    ..Gray matter (GM) atrophy has been reported in multiple sclerosis (MS). However, little is known about its regional distribution...
  93. doi request reprint Large-scale, multicentre, quantitative MRI study of brain and cord damage in primary progressive multiple sclerosis
    Marco Rovaris
    Neuroimaging Research Unit, Department of Neurology, San Raffaele Scientific Institute, Milan, Italy
    Mult Scler 14:455-64. 2008
    ..Sequence-related variability of measurements makes the standardization of MT MRI acquisition essential for the design of multicentre studies...
  94. pmc The relationship between brain activity and peak grip force is modulated by corticospinal system integrity after subcortical stroke
    Nick S Ward
    Wellcome Department of Imaging Neuroscience, and Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, London, UK
    Eur J Neurosci 25:1865-73. 2007
    ..These findings suggest that the premotor cortices might play a new and functionally relevant role in controlling force production in patients with more severe corticospinal system disruption...
  95. ncbi request reprint The reproducibility and sensitivity of brain tissue volume measurements derived from an SPM-based segmentation methodology
    Declan T Chard
    NMR Research Unit, Department of Clinical Neurology, Institute of Neurology, University College London, London, UK
    J Magn Reson Imaging 15:259-67. 2002
    ....
  96. ncbi request reprint Overview of London trial of intramuscular interferon-beta Ia in primary-progressive multiple sclerosis
    David H Miller
    Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Mult Scler 10:S56-7. 2004
    ..A larger study would be required to evaluate treatment on disability in this patient cohort and further work is needed to elucidate the relationship between quantitative MR and clinical measures over the longer term...
  97. pmc The influence of time after stroke on brain activations during a motor task
    Nick S Ward
    Wellcome Department of Imaging Neuroscience, University College London, London, United Kingdom
    Ann Neurol 55:829-34. 2004
    ..Thus, in those patients with the most to gain from rehabilitation, different therapeutic approaches may be required at different stages after stroke...
  98. ncbi request reprint Exploring rating scale responsiveness: does the total score reflect the sum of its parts?
    Rory J O'Connor
    Neurological Outcome Measures Unit, Institute of Neurology, University College London, UK
    Neurology 62:1842-4. 2004
    ..09). Item-level effect sizes (0.13 to 1.16) reveal floor (3.5 to 82.3%) and ceiling (9.7 to 95.4%) effects. Results suggest BI total score effect sizes may hide item-level weaknesses and may underestimate the impact of rehabilitation...
  99. ncbi request reprint Grey and white matter atrophy in early clinical stages of primary progressive multiple sclerosis
    Jaume Sastre-Garriga
    Institute of Neurology, UCL, 23 Queen Square, London WC1N 3BG, UK
    Neuroimage 22:353-9. 2004
    ..There is little information available on grey and white matter (GM and WM) atrophy in primary progressive multiple sclerosis (PPMS) and on their relationships with clinical and other magnetic resonance imaging (MRI) measures...
  100. ncbi request reprint Magnetic resonance imaging in primary progressive multiple sclerosis
    Gordon T Ingle
    NMR Research Unit, Institute of Neurology, London, United Kingdom
    J Rehabil Res Dev 39:261-71. 2002
    ..These techniques are sensitive to a wider range of abnormalities within tissue, and their increased pathological specificity may be helpful in clarifying the underlying pathology of the condition...
  101. ncbi request reprint Specificity of Barkhof criteria in predicting conversion to multiple sclerosis when applied to clinically isolated brainstem syndromes
    Jaume Sastre-Garriga
    Unitat de Neuroimmunologia Clinica, Hospital Universitari Vall d Hebron, Barcelona, Spain
    Arch Neurol 61:222-4. 2004
    ....