Michael J A Tanner

Summary

Affiliation: University of Bristol
Country: UK

Publications

  1. ncbi request reprint Band 3 anion exchanger and its involvement in erythrocyte and kidney disorders
    Michael J A Tanner
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol, UK
    Curr Opin Hematol 9:133-9. 2002
  2. ncbi request reprint Protein-4.2 association with band 3 (AE1, SLCA4) in Xenopus oocytes: effects of three natural protein-4.2 mutations associated with hemolytic anemia
    Ashley M Toye
    Department of Biochemistry, School of Medical Sciences, University of Bristol, BS8 1TD, United Kingdom
    Blood 105:4088-95. 2005
  3. ncbi request reprint A band 3-based macrocomplex of integral and peripheral proteins in the RBC membrane
    Lesley J Bruce
    Department of Biochemistry, University of Bristol, United Kingom
    Blood 101:4180-8. 2003
  4. pmc A conductive pathway generated from fragments of the human red cell anion exchanger AE1
    Mark D Parker
    Department of Biochemistry, University of Bristol, University Walk, Bristol, BS8 1TD, UK
    J Physiol 581:33-50. 2007
  5. ncbi request reprint Distinct regions of human glycophorin A enhance human red cell anion exchanger (band 3; AE1) transport function and surface trafficking
    Mark T Young
    Department of Biochemistry, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, United Kingdom
    J Biol Chem 278:32954-61. 2003
  6. ncbi request reprint Altered structure and anion transport properties of band 3 (AE1, SLC4A1) in human red cells lacking glycophorin A
    Lesley J Bruce
    Department of Biochemistry, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Biol Chem 279:2414-20. 2004
  7. ncbi request reprint An N-terminal GFP tag does not alter the functional expression to the plasma membrane of red cell and kidney anion exchanger (AE1) in mammalian cells
    Roland Beckmann
    Department of Biochemistry, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    Mol Membr Biol 19:187-200. 2002
  8. ncbi request reprint The disruption of the third extracellular loop of the red cell anion exchanger AE1 does not affect electroneutral Cl-/HCO3- exchange activity
    Mark D Parker
    Department of Biochemistry, University of Bristol, Bristol BS8 1TD, UK
    Blood Cells Mol Dis 32:379-83. 2004
  9. ncbi request reprint Absence of CD47 in protein 4.2-deficient hereditary spherocytosis in man: an interaction between the Rh complex and the band 3 complex
    Lesley J Bruce
    Department of Biochemistry, University of Bristol, and International Blood Group Reference Laboratory, Bristol, United Kingdom
    Blood 100:1878-85. 2002
  10. ncbi request reprint Regions of human kidney anion exchanger 1 (kAE1) required for basolateral targeting of kAE1 in polarised kidney cells: mis-targeting explains dominant renal tubular acidosis (dRTA)
    Ashley M Toye
    Department of Biochemistry, University of Bristol, University Walk, Bristol BS8 1TD, UK
    J Cell Sci 117:1399-410. 2004

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Band 3 anion exchanger and its involvement in erythrocyte and kidney disorders
    Michael J A Tanner
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol, UK
    Curr Opin Hematol 9:133-9. 2002
    ..The article discusses a likely mechanism for dominant distal renal tubular acidosis in which associations between the normal and mutant protein alter the plasma membrane targeting of the normal protein in the kidney...
  2. ncbi request reprint Protein-4.2 association with band 3 (AE1, SLCA4) in Xenopus oocytes: effects of three natural protein-4.2 mutations associated with hemolytic anemia
    Ashley M Toye
    Department of Biochemistry, School of Medical Sciences, University of Bristol, BS8 1TD, United Kingdom
    Blood 105:4088-95. 2005
    ..2 based on the structure of the sequence-related protein transglutaminase. Using our results in oocytes and this homology model we speculate how these mutations affect protein 4.2 and result in hereditary spherocytosis...
  3. ncbi request reprint A band 3-based macrocomplex of integral and peripheral proteins in the RBC membrane
    Lesley J Bruce
    Department of Biochemistry, University of Bristol, United Kingom
    Blood 101:4180-8. 2003
    ..We speculate that this macrocomplex may function as an integrated CO(2)/O(2) gas exchange unit (metabolon) in the erythrocyte...
  4. pmc A conductive pathway generated from fragments of the human red cell anion exchanger AE1
    Mark D Parker
    Department of Biochemistry, University of Bristol, University Walk, Bristol, BS8 1TD, UK
    J Physiol 581:33-50. 2007
    ..Although this conductive pathway is not a usual feature of intact mammalian AE1, it shares many properties with the anion-conductive pathways intrinsic to two other Cl-HCO3- exchangers, trout AE1 and mammalian SLC26A7...
  5. ncbi request reprint Distinct regions of human glycophorin A enhance human red cell anion exchanger (band 3; AE1) transport function and surface trafficking
    Mark T Young
    Department of Biochemistry, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, United Kingdom
    J Biol Chem 278:32954-61. 2003
    ....
  6. ncbi request reprint Altered structure and anion transport properties of band 3 (AE1, SLC4A1) in human red cells lacking glycophorin A
    Lesley J Bruce
    Department of Biochemistry, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Biol Chem 279:2414-20. 2004
    ..Our results suggest that band 3 in the red cell can take up two different structures: one with high anion transport activity when GPA is present and one with lower anion transport activity when GPA is absent...
  7. ncbi request reprint An N-terminal GFP tag does not alter the functional expression to the plasma membrane of red cell and kidney anion exchanger (AE1) in mammalian cells
    Roland Beckmann
    Department of Biochemistry, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    Mol Membr Biol 19:187-200. 2002
    ..This will help elucidate how band 3 mutations can cause human diseases such as hereditary spherocytosis and distal renal tubular acidosis...
  8. ncbi request reprint The disruption of the third extracellular loop of the red cell anion exchanger AE1 does not affect electroneutral Cl-/HCO3- exchange activity
    Mark D Parker
    Department of Biochemistry, University of Bristol, Bristol BS8 1TD, UK
    Blood Cells Mol Dis 32:379-83. 2004
    ..This provides further evidence that the 1:5 and 6:14 regions of the protein form discrete folding domains and confirms that the third extracellular loop does not play a pivotal role in AE1 transport function...
  9. ncbi request reprint Absence of CD47 in protein 4.2-deficient hereditary spherocytosis in man: an interaction between the Rh complex and the band 3 complex
    Lesley J Bruce
    Department of Biochemistry, University of Bristol, and International Blood Group Reference Laboratory, Bristol, United Kingdom
    Blood 100:1878-85. 2002
    ..2, glycophorin A) and the Rh complex (Rh-associated glycoprotein, Rh polypeptides, glycophorin B, CD47, LW) and define a point of attachment between the Rh complex and the red cell cytoskeleton...
  10. ncbi request reprint Regions of human kidney anion exchanger 1 (kAE1) required for basolateral targeting of kAE1 in polarised kidney cells: mis-targeting explains dominant renal tubular acidosis (dRTA)
    Ashley M Toye
    Department of Biochemistry, University of Bristol, University Walk, Bristol BS8 1TD, UK
    J Cell Sci 117:1399-410. 2004
    ..These results suggest that a determinant within the kAE1 N-terminus co-operates with the C-terminus for kAE1 basolateral localisation...
  11. ncbi request reprint Band 3 Walton, a C-terminal deletion associated with distal renal tubular acidosis, is expressed in the red cell membrane but retained internally in kidney cells
    Ashley M Toye
    Department of Biochemistry, School of Medical Sciences, University of Bristol, United Kingdom
    Blood 99:342-7. 2002
    ..It is suggested that this results from the association of the normal and mutant proteins in band 3 hetero-oligomers, which causes the intracellular retention of normal band 3 with the mutant protein...
  12. ncbi request reprint The N-terminal region of the transmembrane domain of human erythrocyte band 3. Residues critical for membrane insertion and transport activity
    Tomotake Kanki
    Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Biol Chem 278:5564-73. 2003
    ..Finally, deletion of the cytoplasmic surface sequence G(381)LVRD abolished chloride transport, but not surface expression, indicating that this sequence makes an essential structural contribution to the anion transport site of band 3...
  13. ncbi request reprint Recessive distal renal tubular acidosis in Sarawak caused by AE1 mutations
    Keng E Choo
    Department of Paediatrics and Child Health, Universiti Malaysia Sarawak, Kuching, Sarawak, Malaysia
    Pediatr Nephrol 21:212-7. 2006
    ..In addition, one boy had a DNA sequence abnormality of band 3 residue (G701D), which has been reported from elsewhere in Southeast Asia. The other boy had the novel sequence abnormality of band 3 (Q759H) and profound hemolytic anemia...
  14. ncbi request reprint Flexible regions within the membrane-embedded portions of polytopic membrane proteins
    Naotaka Hamasaki
    Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Biochemistry 41:3852-4. 2002
    ..These flexible substructures may have important functional roles in membrane proteins, particularly in the mechanisms of membrane transporters and channels...
  15. ncbi request reprint Molecular basis and functional consequences of the dominant effects of the mutant band 3 on the structure of normal band 3 in Southeast Asian ovalocytosis
    Hiroyuki Kuma
    Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Biochemistry 41:3311-20. 2002
    ..Our approach provides a sensitive method for studying structural changes in polytopic membrane proteins...
  16. ncbi request reprint Band 3 mutations, distal renal tubular acidosis, and Southeast Asian ovalocytosis
    Oliver Wrong
    Centre for Nephrology, Royal Free and University College Medical School, Middlesex Hospital, Mortimer Street, London W1W 7EY, England, UK
    Kidney Int 62:10-9. 2002
    ....